Published in Mass Spectrom Rev on August 01, 2005
Metabolomics-based methods for early disease diagnostics. Expert Rev Mol Diagn (2008) 2.51
Metabolomics: Applications and Promise in Mycobacterial Disease. Ann Am Thorac Soc (2015) 1.96
Nonlinear data alignment for UPLC-MS and HPLC-MS based metabolomics: quantitative analysis of endogenous and exogenous metabolites in human serum. Anal Chem (2006) 1.81
Advances in structure elucidation of small molecules using mass spectrometry. Bioanal Rev (2010) 1.76
Analytical platform for metabolome analysis of microbial cells using methyl chloroformate derivatization followed by gas chromatography-mass spectrometry. Nat Protoc (2010) 1.67
Identifying decomposition products in extracts of cellular metabolites. Anal Biochem (2006) 1.62
Integration of metabolome data with metabolic networks reveals reporter reactions. Mol Syst Biol (2006) 1.60
Measurement of internal body time by blood metabolomics. Proc Natl Acad Sci U S A (2009) 1.56
MS/MS spectral tag-based annotation of non-targeted profile of plant secondary metabolites. Plant J (2009) 1.55
Metabolic fingerprinting of Lactobacillus paracasei: the optimal quenching strategy. Microb Cell Fact (2015) 1.40
Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol (2011) 1.36
Fluxome analysis using GC-MS. Microb Cell Fact (2007) 1.31
Variability analysis of human plasma and cerebral spinal fluid reveals statistical significance of changes in mass spectrometry-based metabolomics data. Anal Chem (2009) 1.30
Microbial metabolomics. Curr Genomics (2011) 1.17
Principal component directed partial least squares analysis for combining nuclear magnetic resonance and mass spectrometry data in metabolomics: application to the detection of breast cancer. Anal Chim Acta (2010) 1.13
PyMS: a Python toolkit for processing of gas chromatography-mass spectrometry (GC-MS) data. Application and comparative study of selected tools. BMC Bioinformatics (2012) 1.08
Shotgun metabolomics approach for the analysis of negatively charged water-soluble cellular metabolites from mouse heart tissue. Anal Chem (2007) 1.02
Bacterial population and biodegradation potential in chronically crude oil-contaminated marine sediments are strongly linked to temperature. Sci Rep (2015) 1.01
Alkylation or Silylation for Analysis of Amino and Non-Amino Organic Acids by GC-MS? Metabolites (2011) 1.01
13C labeling experiments at metabolic nonstationary conditions: an exploratory study. BMC Bioinformatics (2008) 0.98
Metabolic engineering in the -omics era: elucidating and modulating regulatory networks. Microbiol Mol Biol Rev (2005) 0.97
Small molecule metabolite extraction strategy for improving LC/MS detection of cancer cell metabolome. J Biomol Tech (2011) 0.95
Differential metabolomics unraveling light/dark regulation of metabolic activities in Arabidopsis cell culture. Planta (2007) 0.91
A (1)H NMR-Based Metabonomic Investigation of Time-Related Metabolic Trajectories of the Plasma, Urine and Liver Extracts of Hyperlipidemic Hamsters. PLoS One (2013) 0.91
An iterative block-shifting approach to retention time alignment that preserves the shape and area of gas chromatography-mass spectrometry peaks. BMC Bioinformatics (2008) 0.91
Fragmentation trees for the structural characterisation of metabolites. Rapid Commun Mass Spectrom (2012) 0.90
Antimicrobial active herbal compounds against Acinetobacter baumannii and other pathogens. Front Microbiol (2015) 0.89
Comprehensive and simultaneous coverage of lipid and polar metabolites for endogenous cellular metabolomics using HILIC-TOF-MS. Anal Bioanal Chem (2014) 0.88
Revisiting Protocols for the NMR Analysis of Bacterial Metabolomes. J Integr OMICS (2013) 0.87
Dynamics and control of the central carbon metabolism in hepatoma cells. BMC Syst Biol (2010) 0.86
Application of metabolomics in thyroid cancer research. Int J Endocrinol (2015) 0.84
Capillary LC-MS for high sensitivity metabolomic analysis of single islets of Langerhans. Anal Chem (2008) 0.84
Metabolic profiling of Escherichia coli by ion mobility-mass spectrometry with MALDI ion source. J Mass Spectrom (2010) 0.84
Combined fluxomics and transcriptomics analysis of glucose catabolism via a partially cyclic pentose phosphate pathway in Gluconobacter oxydans 621H. Appl Environ Microbiol (2013) 0.84
Phosphonium labeling for increasing metabolomic coverage of neutral lipids using electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom (2009) 0.83
Selective metabolite and peptide capture/mass detection using fluorous affinity tags. J Proteome Res (2007) 0.83
Gut Microbiota Profiling: Metabolomics Based Approach to Unravel Compounds Affecting Human Health. Front Microbiol (2016) 0.83
Highly-parallel metabolomics approaches using LC-MS for pharmaceutical and environmental analysis. Trends Analyt Chem (2007) 0.82
LacaScore: a novel plasma sample quality control tool based on ascorbic acid and lactic acid levels. Metabolomics (2016) 0.82
Integrated analysis of transcriptome and metabolome of Arabidopsis albino or pale green mutants with disrupted nuclear-encoded chloroplast proteins. Plant Mol Biol (2014) 0.82
Introduction to metabolomics and its applications in ophthalmology. Eye (Lond) (2016) 0.81
The use of mass spectrometry for analysing metabolite biomarkers in epidemiology: methodological and statistical considerations for application to large numbers of biological samples. Eur J Epidemiol (2016) 0.80
Efficient denoising algorithms for large experimental datasets and their applications in Fourier transform ion cyclotron resonance mass spectrometry. Proc Natl Acad Sci U S A (2014) 0.80
The Energy Metabolism in Caenorhabditis elegans under The Extremely Low-Frequency Electromagnetic Field Exposure. Sci Rep (2015) 0.79
Metabolomics Analysis Reveals the Participation of Efflux Pumps and Ornithine in the Response of Pseudomonas putida DOT-T1E Cells to Challenge with Propranolol. PLoS One (2016) 0.79
Metabolomics analysis of saliva from patients with primary Sjögren's syndrome. Clin Exp Immunol (2015) 0.79
Emerging applications of metabolomics in studying chemopreventive phytochemicals. AAPS J (2013) 0.79
Expression profiling in granulomatous lung disease. Proc Am Thorac Soc (2007) 0.79
Relative quantification of amine-containing metabolites using isobaric N,N-dimethyl leucine (DiLeu) reagents via LC-ESI-MS/MS and CE-ESI-MS/MS. Analyst (2015) 0.79
Potential biomarkers of fatigue identified by plasma metabolome analysis in rats. PLoS One (2015) 0.78
Mathematical Modeling and Dynamic Simulation of Metabolic Reaction Systems Using Metabolome Time Series Data. Front Mol Biosci (2016) 0.77
A medium-chain fatty acid as an alternative energy source in mouse preimplantation development. Sci Rep (2012) 0.77
Applications of Fourier Transform Ion Cyclotron Resonance (FT-ICR) and Orbitrap Based High Resolution Mass Spectrometry in Metabolomics and Lipidomics. Int J Mol Sci (2016) 0.77
Revealing the beneficial effect of protease supplementation to high gravity beer fermentations using "-omics" techniques. Microb Cell Fact (2011) 0.77
Targeted metabolomics of Gammarus pulex following controlled exposures to selected pharmaceuticals in water. Sci Total Environ (2016) 0.77
A Metabolomic Approach to Target Compounds from the Asteraceae Family for Dual COX and LOX Inhibition. Metabolites (2015) 0.77
Metabolomics profiling of extracellular metabolites in CHO-K1 cells cultured in different types of growth media. Cytotechnology (2012) 0.76
Understanding Metabolomics in Biomedical Research. Endocrinol Metab (Seoul) (2016) 0.76
Emerging Technologies for Gut Microbiome Research. Trends Microbiol (2016) 0.76
Liquid Chromatography-Mass Spectrometry-Based Rapid Secondary-Metabolite Profiling of Marine Pseudoalteromonas sp. M2. Mar Drugs (2016) 0.75
Etiological analysis of neurodevelopmental disabilities: single-center eight-year clinical experience in south China. J Biomed Biotechnol (2010) 0.75
Vinegar Metabolomics: An Explorative Study of Commercial Balsamic Vinegars Using Gas Chromatography-Mass Spectrometry. Metabolites (2016) 0.75
Metabolomics-Based Study of Logarithmic and Stationary Phases of Promastigotes in Leishmania major by 1H NMR Spectroscopy. Iran Biomed J (2015) 0.75
The use of functional genomics in conjunction with metabolomics for Mycobacterium tuberculosis research. Dis Markers (2014) 0.75
Fully Automated Trimethylsilyl (TMS) Derivatisation Protocol for Metabolite Profiling by GC-MS. Metabolites (2016) 0.75
A mass spectrometric study for comparative analysis and evaluation of metabolite recovery from plasma by various solvent systems. J Biomol Tech (2012) 0.75
Rapid Quantification of Major Volatile Metabolites in Fermented Food and Beverages Using Gas Chromatography-Mass Spectrometry. Metabolites (2017) 0.75
PCR and Omics Based Techniques to Study the Diversity, Ecology and Biology of Anaerobic Fungi: Insights, Challenges and Opportunities. Front Microbiol (2017) 0.75
Biomarker Research in Parkinson's Disease Using Metabolite Profiling. Metabolites (2017) 0.75
Genome-scale reconstruction of the Saccharomyces cerevisiae metabolic network. Genome Res (2003) 7.22
Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88. Nat Biotechnol (2007) 6.21
Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature (2013) 6.07
A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology. Nat Biotechnol (2008) 4.55
Uncovering transcriptional regulation of metabolism by using metabolic network topology. Proc Natl Acad Sci U S A (2005) 4.40
A community-driven global reconstruction of human metabolism. Nat Biotechnol (2013) 3.89
A proposed framework for the description of plant metabolomics experiments and their results. Nat Biotechnol (2004) 3.32
Saccharomyces cerevisiae phenotypes can be predicted by using constraint-based analysis of a genome-scale reconstructed metabolic network. Proc Natl Acad Sci U S A (2003) 3.15
Symptomatic atherosclerosis is associated with an altered gut metagenome. Nat Commun (2012) 2.84
Reproducibility of oligonucleotide microarray transcriptome analyses. An interlaboratory comparison using chemostat cultures of Saccharomyces cerevisiae. J Biol Chem (2002) 2.72
Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88. Gut (2011) 2.67
DTP vaccination and child survival in observational studies with incomplete vaccination data. Trop Med Int Health (2007) 2.64
Global metabolite analysis of yeast: evaluation of sample preparation methods. Yeast (2005) 2.64
Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. Mol Cell Proteomics (2013) 2.53
A comprehensive comparison of RNA-Seq-based transcriptome analysis from reads to differential gene expression and cross-comparison with microarrays: a case study in Saccharomyces cerevisiae. Nucleic Acids Res (2012) 2.53
Growth-rate regulated genes have profound impact on interpretation of transcriptome profiling in Saccharomyces cerevisiae. Genome Biol (2006) 2.43
Large-scale evaluation of in silico gene deletions in Saccharomyces cerevisiae. OMICS (2003) 2.31
Evolutionary programming as a platform for in silico metabolic engineering. BMC Bioinformatics (2005) 2.31
Modeling Lactococcus lactis using a genome-scale flux model. BMC Microbiol (2005) 2.14
Metabolic engineering of Saccharomyces cerevisiae: a key cell factory platform for future biorefineries. Cell Mol Life Sci (2012) 2.06
Enriching the gene set analysis of genome-wide data by incorporating directionality of gene expression and combining statistical hypotheses and methods. Nucleic Acids Res (2013) 2.05
Does vitamin A supplementation interact with routine vaccinations? An analysis of the Ghana Vitamin A Supplementation Trial. Am J Clin Nutr (2009) 2.04
Fungal metabolite screening: database of 474 mycotoxins and fungal metabolites for dereplication by standardised liquid chromatography-UV-mass spectrometry methodology. J Chromatogr A (2003) 2.03
Comparative genomics of citric-acid-producing Aspergillus niger ATCC 1015 versus enzyme-producing CBS 513.88. Genome Res (2011) 2.03
Genome-scale analysis of Streptomyces coelicolor A3(2) metabolism. Genome Res (2005) 2.03
Architecture of transcriptional regulatory circuits is knitted over the topology of bio-molecular interaction networks. BMC Syst Biol (2008) 2.02
The RAVEN toolbox and its use for generating a genome-scale metabolic model for Penicillium chrysogenum. PLoS Comput Biol (2013) 2.00
In silico aided metabolic engineering of Saccharomyces cerevisiae for improved bioethanol production. Metab Eng (2005) 1.96
Reconstruction of genome-scale active metabolic networks for 69 human cell types and 16 cancer types using INIT. PLoS Comput Biol (2012) 1.94
Linking high-resolution metabolic flux phenotypes and transcriptional regulation in yeast modulated by the global regulator Gcn4p. Proc Natl Acad Sci U S A (2009) 1.79
The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism. BMC Syst Biol (2008) 1.73
Assessing the human gut microbiota in metabolic diseases. Diabetes (2013) 1.64
De novo sequencing, assembly and analysis of the genome of the laboratory strain Saccharomyces cerevisiae CEN.PK113-7D, a model for modern industrial biotechnology. Microb Cell Fact (2012) 1.62
OptFlux: an open-source software platform for in silico metabolic engineering. BMC Syst Biol (2010) 1.61
Integration of metabolome data with metabolic networks reveals reporter reactions. Mol Syst Biol (2006) 1.60
Integration of gene expression data into genome-scale metabolic models. Metab Eng (2004) 1.59
The 2008 update of the Aspergillus nidulans genome annotation: a community effort. Fungal Genet Biol (2008) 1.56
A trispecies Aspergillus microarray: comparative transcriptomics of three Aspergillus species. Proc Natl Acad Sci U S A (2008) 1.56
Enhancing sesquiterpene production in Saccharomyces cerevisiae through in silico driven metabolic engineering. Metab Eng (2009) 1.55
BioMet Toolbox: genome-wide analysis of metabolism. Nucleic Acids Res (2010) 1.55
Sampling the solution space in genome-scale metabolic networks reveals transcriptional regulation in key enzymes. PLoS Comput Biol (2010) 1.52
High-throughput metabolic state analysis: the missing link in integrated functional genomics of yeasts. Biochem J (2005) 1.47
Metabolic model integration of the bibliome, genome, metabolome and reactome of Aspergillus niger. Mol Syst Biol (2008) 1.47
Use of genome-scale microbial models for metabolic engineering. Curr Opin Biotechnol (2004) 1.45
Increased female-male mortality ratio associated with inactivated polio and diphtheria-tetanus-pertussis vaccines: Observations from vaccination trials in Guinea-Bissau. Pediatr Infect Dis J (2007) 1.44
TBscore: Signs and symptoms from tuberculosis patients in a low-resource setting have predictive value and may be used to assess clinical course. Scand J Infect Dis (2008) 1.44
The metabolic response of heterotrophic Arabidopsis cells to oxidative stress. Plant Physiol (2006) 1.43
Fumonisin B2 production by Aspergillus niger. J Agric Food Chem (2007) 1.42
Characterization of different promoters for designing a new expression vector in Saccharomyces cerevisiae. Yeast (2010) 1.41
Microbial translocation correlates with the severity of both HIV-1 and HIV-2 infections. J Infect Dis (2010) 1.40
Characterization of global yeast quantitative proteome data generated from the wild-type and glucose repression saccharomyces cerevisiae strains: the comparison of two quantitative methods. J Proteome Res (2008) 1.39
Post-genomic insights into the plant polysaccharide degradation potential of Aspergillus nidulans and comparison to Aspergillus niger and Aspergillus oryzae. Fungal Genet Biol (2009) 1.35
Simultaneous analysis of amino and nonamino organic acids as methyl chloroformate derivatives using gas chromatography-mass spectrometry. Anal Biochem (2003) 1.33
Testing the hypothesis that diphtheria-tetanus-pertussis vaccine has negative non-specific and sex-differential effects on child survival in high-mortality countries. BMJ Open (2012) 1.33
Phenotypic taxonomy and metabolite profiling in microbial drug discovery. Nat Prod Rep (2005) 1.28
Systems biology of antibiotic production by microorganisms. Nat Prod Rep (2007) 1.27
A closer look at bacteroides: phylogenetic relationship and genomic implications of a life in the human gut. Microb Ecol (2011) 1.27
Establishing a platform cell factory through engineering of yeast acetyl-CoA metabolism. Metab Eng (2012) 1.27
Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling. Mol Syst Biol (2014) 1.26
Integration of clinical data with a genome-scale metabolic model of the human adipocyte. Mol Syst Biol (2013) 1.26
Production of plant sesquiterpenes in Saccharomyces cerevisiae: effect of ERG9 repression on sesquiterpene biosynthesis. Biotechnol Bioeng (2008) 1.26
Versatile enzyme expression and characterization system for Aspergillus nidulans, with the Penicillium brevicompactum polyketide synthase gene from the mycophenolic acid gene cluster as a test case. Appl Environ Microbiol (2011) 1.25
Sex differential effects of routine immunizations and childhood survival in rural Malawi. Pediatr Infect Dis J (2006) 1.25
From genomes to in silico cells via metabolic networks. Curr Opin Biotechnol (2005) 1.24
A systems biology approach to study glucose repression in the yeast Saccharomyces cerevisiae. Biotechnol Bioeng (2007) 1.23
In silico genome-scale reconstruction and validation of the Corynebacterium glutamicum metabolic network. Biotechnol Bioeng (2009) 1.22
EasyClone: method for iterative chromosomal integration of multiple genes in Saccharomyces cerevisiae. FEMS Yeast Res (2013) 1.22
Measuring enzyme activities under standardized in vivo-like conditions for systems biology. FEBS J (2010) 1.21
Analysis of Aspergillus nidulans metabolism at the genome-scale. BMC Genomics (2008) 1.20
Fifteen years of large scale metabolic modeling of yeast: developments and impacts. Biotechnol Adv (2011) 1.20
Correlation between the presence of neutralizing antibodies against porcine circovirus 2 (PCV2) and protection against replication of the virus and development of PCV2-associated disease. BMC Vet Res (2006) 1.20
Prospects of yeast systems biology for human health: integrating lipid, protein and energy metabolism. FEMS Yeast Res (2010) 1.20
Natural computation meta-heuristics for the in silico optimization of microbial strains. BMC Bioinformatics (2008) 1.20
Transcription factor control of growth rate dependent genes in Saccharomyces cerevisiae: a three factor design. BMC Genomics (2008) 1.19
Metabolic network driven analysis of genome-wide transcription data from Aspergillus nidulans. Genome Biol (2006) 1.19
Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains. Nat Commun (2010) 1.18
Characterization of chromosomal integration sites for heterologous gene expression in Saccharomyces cerevisiae. Yeast (2009) 1.18
The P450 monooxygenase BcABA1 is essential for abscisic acid biosynthesis in Botrytis cinerea. Appl Environ Microbiol (2004) 1.17
Molecular basis for mycophenolic acid biosynthesis in Penicillium brevicompactum. Appl Environ Microbiol (2011) 1.17
Genome-scale modeling of human metabolism - a systems biology approach. Biotechnol J (2013) 1.16
Genome-scale metabolic reconstructions of Pichia stipitis and Pichia pastoris and in silico evaluation of their potentials. BMC Syst Biol (2012) 1.16
Improved annotation through genome-scale metabolic modeling of Aspergillus oryzae. BMC Genomics (2008) 1.15
Genome-wide transcriptional response of a Saccharomyces cerevisiae strain with an altered redox metabolism. Biotechnol Bioeng (2004) 1.15
Identification of in vivo enzyme activities in the cometabolism of glucose and acetate by Saccharomyces cerevisiae by using 13C-labeled substrates. Eukaryot Cell (2003) 1.15
A functional genomics approach using metabolomics and in silico pathway analysis. Biotechnol Bioeng (2002) 1.14
Understanding the interactions between bacteria in the human gut through metabolic modeling. Sci Rep (2013) 1.14
Opportunities for yeast metabolic engineering: Lessons from synthetic biology. Biotechnol J (2011) 1.14
Improvement of galactose uptake in Saccharomyces cerevisiae through overexpression of phosphoglucomutase: example of transcript analysis as a tool in inverse metabolic engineering. Appl Environ Microbiol (2005) 1.14
Global transcriptional and physiological responses of Saccharomyces cerevisiae to ammonium, L-alanine, or L-glutamine limitation. Appl Environ Microbiol (2006) 1.13
Microbial isoprenoid production: an example of green chemistry through metabolic engineering. Adv Biochem Eng Biotechnol (2005) 1.13
Metabolic engineering of recombinant protein secretion by Saccharomyces cerevisiae. FEMS Yeast Res (2012) 1.12
Antibiotic overproduction in Streptomyces coelicolor A3 2 mediated by phosphofructokinase deletion. J Biol Chem (2008) 1.12
Metabolic engineering of ammonium assimilation in xylose-fermenting Saccharomyces cerevisiae improves ethanol production. Appl Environ Microbiol (2003) 1.12