Published in Chest on March 01, 1992
Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci U S A (1987) 8.53
Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell (1997) 5.99
An interleukin-4-induced transcription factor: IL-4 Stat. Science (1994) 4.71
A new method for the purification and identification of covalently closed circular DNA molcules. Nucleic Acids Res (1978) 4.09
Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA. Proc Natl Acad Sci U S A (1991) 3.98
The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface. Proc Natl Acad Sci U S A (1998) 3.83
Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J Clin Invest (1998) 3.51
tRNA transport from the nucleus in a eukaryotic cell: carrier-mediated translocation process. Proc Natl Acad Sci U S A (1983) 3.31
Peptides from frog skin. Annu Rev Biochem (1990) 2.67
The natural history of heterotopic ossification in patients who have fibrodysplasia ossificans progressiva. A study of forty-four patients. J Bone Joint Surg Am (1993) 2.45
tRNA nuclear transport: defining the critical regions of human tRNAimet by point mutagenesis. Cell (1985) 2.41
Structure and orientation of the antibiotic peptide magainin in membranes by solid-state nuclear magnetic resonance spectroscopy. Protein Sci (1993) 2.16
A supernatant factor involved in initiation complex formation with eukaryotic ribosomes. Proc Natl Acad Sci U S A (1971) 2.12
Epithelial antibiotic induced in states of disease. Proc Natl Acad Sci U S A (1997) 2.11
In vitro antibacterial properties of pexiganan, an analog of magainin. Antimicrob Agents Chemother (1999) 2.10
Comparative analysis of human chromosomal segments bearing nonallelic dispersed tRNAimet genes. Cell (1981) 2.09
The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene (2009) 1.97
Magainins and the disruption of membrane-linked free-energy transduction. Proc Natl Acad Sci U S A (1989) 1.86
Orientations of amphipathic helical peptides in membrane bilayers determined by solid-state NMR spectroscopy. J Biomol NMR (1991) 1.82
Eukaryotic pre-tRNA 5' processing nuclease: copurification with a complex cylindrical particle. Cell (1986) 1.80
Antibiotic magainins exert cytolytic activity against transformed cell lines through channel formation. Proc Natl Acad Sci U S A (1991) 1.80
Components of a Stat recognition code: evidence for two layers of molecular selectivity. Immunity (1995) 1.77
Impaired nuclear transport of a human variant tRNAiMet. Nature (1982) 1.75
Transcription, processing and nuclear transport of a B1 Alu RNA species complementary to an intron of the murine alpha-fetoprotein gene. Nature (1985) 1.71
A two-dimensional NMR study of the antimicrobial peptide magainin 2. FEBS Lett (1988) 1.69
Squalamine: an aminosterol antibiotic from the shark. Proc Natl Acad Sci U S A (1993) 1.67
Two-dimensional 1H NMR experiments show that the 23-residue magainin antibiotic peptide is an alpha-helix in dodecylphosphocholine micelles, sodium dodecylsulfate micelles, and trifluoroethanol/water solution. J Biomol NMR (1997) 1.66
NOD2-expressing bone marrow-derived cells appear to regulate epithelial innate immunity of the transplanted human small intestine. Gut (2007) 1.66
Potential therapeutic applications of magainins and other antimicrobial agents of animal origin. Ciba Found Symp (1994) 1.58
Antimicrobial properties of peptides from Xenopus granular gland secretions. FEBS Lett (1988) 1.55
Age- and joint-specific risk of initial heterotopic ossification in patients who have fibrodysplasia ossificans progressiva. Clin Orthop Relat Res (1994) 1.54
Purification and characterization of an endonuclease from Xenopus laevis ovaries which accurately processes the 3' terminus of human pre-tRNA-Met(i) (3' pre-tRNase). J Biol Chem (1985) 1.49
Some aspects of the acute phase response after a marathon race, and the effects of glutamine supplementation. Eur J Appl Physiol Occup Physiol (1997) 1.49
Human diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor. Science (1989) 1.46
Mechanism of synergism between antimicrobial peptides magainin 2 and PGLa. Biochemistry (1998) 1.45
Disruption of transforming growth factor-beta signaling through beta-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation. Oncogene (2007) 1.44
Magainin 2, a natural antibiotic from frog skin, forms ion channels in lipid bilayer membranes. Eur J Pharmacol (1992) 1.42
Effects of magainins and cecropins on the sporogonic development of malaria parasites in mosquitoes. Infect Immun (1989) 1.38
Three-dimensional solid-state NMR spectroscopy of a peptide oriented in membrane bilayers. J Biomol NMR (1995) 1.37
The 24-hour profile of adrenocorticotropin and cortisol in major depressive illness. J Clin Endocrinol Metab (1985) 1.37
Diagnosis and treatment of vitamin D deficiency. Expert Opin Pharmacother (2008) 1.37
Severe restriction in jaw movement after routine injection of local anesthetic in patients who have fibrodysplasia ossificans progressiva. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (1996) 1.35
Nucleosome structure, DNA folding, and gene activity. Cold Spring Harb Symp Quant Biol (1978) 1.32
Functional synergism of the magainins PGLa and magainin-2 in Escherichia coli, tumor cells and liposomes. Eur J Biochem (1995) 1.32
Structure and dynamics of the antibiotic peptide PGLa in membranes by solution and solid-state nuclear magnetic resonance spectroscopy. Biophys J (1998) 1.30
TRNA precursor transcribed from a mutant human gene inserted into a SV40 vector is processed incorrectly. Nature (1982) 1.30
Purification of eukaryotic initiation factor 1 (EIF1) from Artemia salina embryos. Methods Enzymol (1974) 1.27
Use of mercury-substituted ribonucleoside triphosphates can lead to artefacts in the analysis of in vitro chromatin transcrits. Biochem Biophys Res Commun (1977) 1.24
Anticancer efficacy of Magainin2 and analogue peptides. Cancer Res (1993) 1.23
Antimicrobial peptides in the stomach of Xenopus laevis. J Biol Chem (1991) 1.23
Expression of natural peptide antibiotics in human skin. Lancet (1997) 1.22
Transcription and precursor processing of normal and mutant human tRNAiMet genes in a homologous cell-free system. J Biol Chem (1982) 1.22
Structure and interactions of magainin antibiotic peptides in lipid bilayers: a solid-state nuclear magnetic resonance investigation. Biophys J (1992) 1.22
Analysis of in vitro transcription of duck reticulocyte chromatin using mercury-substituted ribonucleoside triphosphates. Biochemistry (1977) 1.21
Unique pathway of expression of an opal suppressor phosphoserine tRNA. Proc Natl Acad Sci U S A (1987) 1.20
24-hour profiles of adrenocorticotropin, cortisol, and growth hormone in major depressive illness: effect of antidepressant treatment. J Clin Endocrinol Metab (1987) 1.18
Paneth cell granule depletion in the human small intestine under infective and nutritional stress. Clin Exp Immunol (2004) 1.18
Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin. J Biol Chem (1994) 1.16
Raman spectroscopy of synthetic antimicrobial frog peptides magainin 2a and PGLa. Biochemistry (1990) 1.15
Reiteration frequency mapping: analysis of repetitive sequence organization within cloned DNA fragments containing the human initiator methionine tRNA gene. Proc Natl Acad Sci U S A (1980) 1.13
Generation of long read-through transcripts in vivo and in vitro by deletion of 3' termination and processing sequences in the human tRNAimet gene. Nucleic Acids Res (1984) 1.13
Orientations of helical peptides in membrane bilayers by solid state NMR spectroscopy. Solid State Nucl Magn Reson (1996) 1.13
Enhancement of mRNA nuclear transport by promoter elements. Cell (1987) 1.10
Polypeptide chain initiation in eukaryotes: functional identity of supernatant factor from various sources. Proc Natl Acad Sci U S A (1972) 1.10
Polypeptide chain initiation in eukaryotes. IV. Purification and properties of supernatant initiation factor from Artemia salina embryos. J Mol Biol (1973) 1.09
Pathway of B1-Alu expression in microinjected oocytes: Xenopus laevis proteins associated with nuclear precursor and processed cytoplasmic RNAs. Mol Cell Biol (1988) 1.08
Two nonallelic tRNAiMet genes are located in the p23 leads to q12 region of human chromosome 6. Proc Natl Acad Sci U S A (1983) 1.07
The hand and foot malformations in fibrodysplasia ossificans progressiva. Johns Hopkins Med J (1980) 1.03
Pepsin-mediated processing of the cytoplasmic histone H2A to strong antimicrobial peptide buforin I. J Immunol (2000) 1.01
Bacteriophages in sputum of patients with bronchopulmonary Pseudomonas infections. Infect Immun (1982) 1.00
Limited DNase I nicking as a probe of gene conformation. Proc Natl Acad Sci U S A (1980) 0.99
Biologic and biochemic properties of recombinant platelet factor 4 demonstrate identity with the native protein. Blood (1990) 0.98
Interactions between a new class of eukaryotic antimicrobial agents and isolated rat liver mitochondria. Biochim Biophys Acta (1989) 0.98
An essential amino acid induces epithelial beta -defensin expression. Proc Natl Acad Sci U S A (2000) 0.98
Squalamine inhibits angiogenesis and solid tumor growth in vivo and perturbs embryonic vasculature. Cancer Res (1998) 0.98
Aminosterols from the dogfish shark Squalus acanthias. J Nat Prod (2000) 0.97
The 24-hour profiles of cortisol, prolactin, and growth hormone secretion in mania. Arch Gen Psychiatry (1994) 0.97
Fibrodysplasia ossificans progressiva in two half-sisters: evidence for maternal mosaicism. Am J Med Genet (1996) 0.94
Squalamine treatment of human tumors in nu/nu mice enhances platinum-based chemotherapies. Clin Cancer Res (2001) 0.93
Microbiological profile of infected diabetic foot ulcers. Diabet Med (2002) 0.93
Circadian and sleep-related endocrine rhythms in schizophrenia. Arch Gen Psychiatry (1991) 0.91
A novel endopeptidase from Xenopus that recognizes alpha-helical secondary structure. Cell (1991) 0.91
A high-throughput STAT binding assay using fluorescence polarization. Anal Biochem (1997) 0.90
A novel peptide-producing cell in Xenopus: multinucleated gastric mucosal cell strikingly similar to the granular gland of the skin. J Histochem Cytochem (1992) 0.90
Urinary basic fibroblast growth factor. A biochemical marker for preosseous fibroproliferative lesions in patients with fibrodysplasia ossificans progressiva. Clin Orthop Relat Res (1998) 0.89
Magainin oligomers reversibly dissipate delta microH+ in cytochrome oxidase liposomes. Biochemistry (1994) 0.88
Limited dermal ossification: clinical features and natural history. J Pediatr (1986) 0.87
Non-enzymic binding of formylmethionyl-transfer RNAf to Artemia salina ribosomes. J Mol Biol (1973) 0.86
Association of polypeptide initiation factors with 30 S ribosomal subunits. FEBS Lett (1969) 0.86
Evaluation of Helicobacter pylori in gastric MALT-type lymphoma: differences between histologic and serologic diagnosis. Mod Pathol (1999) 0.85
Structure of the novel steroidal antibiotic squalamine determined by two-dimensional NMR spectroscopy. Steroids (1993) 0.84
Fifty cases of human immunodeficiency virus (HIV) infection: immunoultrastructural study of circulating lymphocytes. J Clin Pathol (1988) 0.84
A Paneth cell analogue in Xenopus small intestine expresses antimicrobial peptide genes: conservation of an intestinal host-defense system. J Histochem Cytochem (1994) 0.83
Polypeptide chain initiation and stepwise elongation with Artemia ribosomes and factors. Proc Natl Acad Sci U S A (1972) 0.83
[Functional MR urography in children]. J Radiol (2009) 0.83
Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3. Genomics (1991) 0.81
Squalamine, a novel cationic steroid, specifically inhibits the brush-border Na+/H+ exchanger isoform NHE3. Am J Physiol (1999) 0.80