Published in Science on September 16, 1994
The JAK-STAT pathway at twenty. Immunity (2012) 4.41
Activation of nuclear factor kappa B inflammatory bowel disease. Gut (1998) 4.14
Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma. Proc Natl Acad Sci U S A (1996) 3.62
Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J Exp Med (1995) 3.37
Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation. Mol Cell Biol (1998) 3.23
The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci U S A (1996) 3.21
Krüppel-like factor 4 regulates macrophage polarization. J Clin Invest (2011) 3.08
Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity. Proc Natl Acad Sci U S A (1995) 2.92
The molecular basis of IL-21-mediated proliferation. Blood (2007) 2.90
Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J (1995) 2.90
Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Proc Natl Acad Sci U S A (1995) 2.79
Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci U S A (1996) 2.77
Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4. Proc Natl Acad Sci U S A (2002) 2.61
c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms. J Exp Med (1998) 2.58
Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc Natl Acad Sci U S A (1995) 2.52
A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6. EMBO J (1995) 2.52
Activation and association of Stat3 with Src in v-Src-transformed cell lines. Mol Cell Biol (1996) 2.47
Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15. Proc Natl Acad Sci U S A (1995) 2.19
Interleukin 4 (IL-4) or IL-7 prevents the death of resting T cells: stat6 is probably not required for the effect of IL-4. J Exp Med (1997) 2.15
Interleukin-3 signals through multiple isoforms of Stat5. EMBO J (1995) 2.12
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Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity. EMBO J (1995) 2.00
Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3. Proc Natl Acad Sci U S A (1995) 1.93
Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission. Proc Natl Acad Sci U S A (1995) 1.89
Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice. J Exp Med (1998) 1.88
Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response. Mol Cell Biol (1996) 1.86
Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins. Mol Cell Biol (1996) 1.85
Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Mol Cell Biol (1995) 1.85
Transcriptional regulation by STAT6. Immunol Res (2011) 1.81
Inteferons pen the JAK-STAT pathway. Semin Cell Dev Biol (2008) 1.79
Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4. J Clin Invest (2000) 1.76
Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells. Neurology (2009) 1.73
Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state. EMBO J (1996) 1.71
Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood (2009) 1.70
Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. EMBO J (2002) 1.65
Requirements for interleukin-4-induced gene expression and functional characterization of Stat6. Mol Cell Biol (1996) 1.64
Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor. Mol Cell Biol (1996) 1.64
Activating STAT6 mutations in follicular lymphoma. Blood (2014) 1.63
Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway. EMBO J (1996) 1.62
A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9. Mol Cell Biol (1996) 1.58
In vitro activation of Stat3 by epidermal growth factor receptor kinase. Proc Natl Acad Sci U S A (1996) 1.58
Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5. Proc Natl Acad Sci U S A (1996) 1.55
Thrombopoietin activates a STAT5-like factor in hematopoietic cells. EMBO J (1995) 1.55
Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J (1996) 1.51
Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression. Proc Natl Acad Sci U S A (1999) 1.50
Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation. EMBO J (1996) 1.49
Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators. J Clin Invest (1997) 1.48
T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and STAT6. EMBO J (1997) 1.47
Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription. Mol Cell Biol (1998) 1.45
The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals. EMBO J (1996) 1.45
Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. Mol Cell Biol (1997) 1.44
Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways. EMBO J (1995) 1.42
Impaired interleukin 4 signaling in T helper type 1 cells. J Exp Med (1998) 1.41
Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway. EMBO J (1996) 1.40
Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex. Mol Cell Biol (1996) 1.40
STAT1 from the cell membrane to the DNA. EMBO J (2001) 1.36
Therapeutic modulators of STAT signalling for human diseases. Nat Rev Drug Discov (2013) 1.33
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50. J Exp Med (1995) 1.33
Interleukin 2 signaling involves the phosphorylation of Stat proteins. Proc Natl Acad Sci U S A (1995) 1.32
Biology and significance of the JAK/STAT signalling pathways. Growth Factors (2012) 1.29
IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor gamma 1. Proc Natl Acad Sci U S A (2001) 1.26
Cytokine transcriptional events during helper T cell subset differentiation. J Exp Med (1996) 1.23
Intracellular Tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus: role of JAK/STAT signaling. J Virol (2006) 1.22
Unique signal transduction of Eyk: constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase. EMBO J (1996) 1.21
Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis. Mol Cell Biol (2002) 1.21
Regulation of inflammation by interleukin-4: a review of "alternatives". J Leukoc Biol (2012) 1.20
RNAs induced by Epstein-Barr virus nuclear antigen 2 in lymphoblastoid cell lines. Proc Natl Acad Sci U S A (2006) 1.17
Adjuvants targeting innate and adaptive immunity synergize to enhance tumor immunotherapy. Proc Natl Acad Sci U S A (2008) 1.16
Signaling through the interleukin 2 receptor beta chain activates a STAT-5-like DNA-binding activity. Proc Natl Acad Sci U S A (1995) 1.16
Stat proteins control lymphocyte proliferation by regulating p27Kip1 expression. Mol Cell Biol (1998) 1.15
Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7. J Exp Med (1995) 1.14
IL-4 and IL-13 activate the JAK2 tyrosine kinase and Stat6 in cultured human vascular endothelial cells through a common pathway that does not involve the gamma c chain. J Clin Invest (1996) 1.14
IL-4 protein expression and basal activation of Erk in vivo in follicular lymphoma. Blood (2008) 1.12
Functional differences between Stat3alpha and Stat3beta. Mol Cell Biol (1997) 1.11
Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary epithelial cells. Mol Cell Biol (1997) 1.11
Interleukin-13 selectively induces monocyte chemoattractant protein-1 synthesis and secretion by human endothelial cells. Involvement of IL-4R alpha and Stat6 phosphorylation. Immunology (1997) 1.11
Design of conditionally active STATs: insights into STAT activation and gene regulatory function. Mol Cell Biol (1999) 1.11
Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter. Mol Cell Biol (1996) 1.08
Induction of cell cycle regulatory proteins in anti-immunoglobulin-stimulated mature B lymphocytes. J Exp Med (1996) 1.08
The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor. Mol Cell Biol (1996) 1.07
Functional regions of the mouse interleukin-10 receptor cytoplasmic domain. Mol Cell Biol (1995) 1.07
The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes. Proc Natl Acad Sci U S A (1996) 1.06
Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease. Proc Natl Acad Sci U S A (2011) 1.05
Similarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of Janus kinase activation. Proc Natl Acad Sci U S A (1995) 1.05
Reflections on STAT3, STAT5, and STAT6 as fat STATs. Proc Natl Acad Sci U S A (1996) 1.05
Mechanisms of chronic JAK-STAT3-SOCS3 signaling in obesity. JAKSTAT (2013) 1.04
Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation. J Exp Med (2003) 1.04
Interleukin 4 signals through two related pathways. Proc Natl Acad Sci U S A (1995) 1.02
Regulation of 15-lipoxygenase expression in lung epithelial cells by interleukin-4. Biochem J (1996) 1.02
Genome-wide approaches reveal functional interleukin-4-inducible STAT6 binding to the vascular cell adhesion molecule 1 promoter. Mol Cell Biol (2011) 1.00
A novel STAT-like factor mediates lipopolysaccharide, interleukin 1 (IL-1), and IL-6 signaling and recognizes a gamma interferon activation site-like element in the IL1B gene. Mol Cell Biol (1996) 1.00
Live cell imaging reveals continuous STAT6 nuclear trafficking. J Immunol (2010) 1.00
Interleukin 2 activates STAT5 transcription factor (mammary gland factor) and specific gene expression in T lymphocytes. Proc Natl Acad Sci U S A (1995) 0.98
Systemic interferon-alpha (IFN-alpha) treatment leads to Stat3 inactivation in melanoma precursor lesions. Mol Med (1999) 0.97
Inhibition of cytokines and JAK-STAT activation by distinct signaling pathways. Proc Natl Acad Sci U S A (1996) 0.96
Interleukin-4-specific signal transduction events are driven by homotypic interactions of the interleukin-4 receptor alpha subunit. EMBO J (1996) 0.92
A penetrating ocular injury can affect the induction of anterior chamber-associated immune deviation. Mol Vis (2008) 0.92
Induction of uteroglobin-related protein 2 (Ugrp2) gene expression by the Th2 cytokines IL-4 and IL-13. J Immunol (2005) 0.92
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