Published in J Infect Dis on September 21, 2004
Efficacy of Fosmidomycin-Clindamycin for Treating Malaria in Gabonese Children | NCT00214643
Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biol (2009) 2.23
Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast. Antimicrob Agents Chemother (2007) 2.12
Fosmidomycin plus clindamycin for treatment of pediatric patients aged 1 to 14 years with Plasmodium falciparum malaria. Antimicrob Agents Chemother (2006) 1.35
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Antiapicoplast and gametocytocidal screening to identify the mechanisms of action of compounds within the malaria box. Antimicrob Agents Chemother (2013) 1.25
Randomized controlled trial of fosmidomycin-clindamycin versus sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria. Antimicrob Agents Chemother (2007) 1.12
A closer look at the spectroscopic properties of possible reaction intermediates in wild-type and mutant (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase. Biochemistry (2012) 1.06
A chemical rescue screen identifies a Plasmodium falciparum apicoplast inhibitor targeting MEP isoprenoid precursor biosynthesis. Antimicrob Agents Chemother (2014) 1.00
Short-course regimens of artesunate-fosmidomycin in treatment of uncomplicated Plasmodium falciparum malaria. Antimicrob Agents Chemother (2005) 0.99
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Whole-Genome Sequencing to Evaluate the Resistance Landscape Following Antimalarial Treatment Failure With Fosmidomycin-Clindamycin. J Infect Dis (2016) 0.93
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Inadequate efficacy of a new formulation of fosmidomycin-clindamycin combination in Mozambican children less than three years old with uncomplicated Plasmodium falciparum malaria. Antimicrob Agents Chemother (2012) 0.86
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Use of Broken-Symmetry Density Functional Theory To Characterize the IspH Oxidized State: Implications for IspH Mechanism and Inhibition. J Chem Theory Comput (2014) 0.79
Broken-Symmetry DFT Computations for the Reaction Pathway of IspH, an Iron-Sulfur Enzyme in Pathogenic Bacteria. Inorg Chem (2015) 0.78
Improved efficacy of fosmidomycin against Plasmodium and Mycobacterium species by combination with the cell-penetrating peptide octaarginine. Antimicrob Agents Chemother (2013) 0.78
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Macrolides and associated antibiotics based on similar mechanism of action like lincosamides in malaria. Malar J (2016) 0.76
Mimicking direct protein-protein and solvent-mediated interactions in the CDP-methylerythritol kinase homodimer: a pharmacophore-directed virtual screening approach. J Mol Model (2009) 0.76
Squalestatin is an inhibitor of carotenoid biosynthesis in Plasmodium falciparum. Antimicrob Agents Chemother (2015) 0.75
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Sub-inhibitory fosmidomycin exposures elicits oxidative stress in Salmonella enterica serovar Typhimurium LT2. PLoS One (2014) 0.75
Single-target high-throughput transcription analyses reveal high levels of alternative splicing present in the FPPS/GGPPS from Plasmodium falciparum. Sci Rep (2015) 0.75
Tropical medicine at the University of Tübingen. Wien Klin Wochenschr (2010) 0.75
First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children. N Engl J Med (2011) 10.79
A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants. N Engl J Med (2012) 6.64
Allergy, parasites, and the hygiene hypothesis. Science (2002) 5.01
Safety and immunogenicity of a novel multivalent OspA vaccine against Lyme borreliosis in healthy adults: a double-blind, randomised, dose-escalation phase 1/2 trial. Lancet Infect Dis (2013) 3.46
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Placental malaria increases malaria risk in the first 30 months of life. Clin Infect Dis (2008) 2.69
Amplification of Plasmodium falciparum multidrug resistance gene 1 in isolates from Gabon. J Infect Dis (2005) 2.58
Safety and efficacy of the RTS,S/AS01E candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a randomised, open-label, phase 2 trial. Lancet Infect Dis (2011) 2.54
Severe falciparum malaria in Gabonese children: clinical and laboratory features. Malar J (2005) 2.35
Microbial isoprenoid biosynthesis and human gammadelta T cell activation. FEBS Lett (2003) 2.30
Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infection. Clin Infect Dis (2008) 2.20
Fosmidomycin for malaria. Lancet (2002) 2.03
High prevalence of asymptomatic Plasmodium falciparum infection in Gabonese adults. Am J Trop Med Hyg (2007) 1.99
Intermittent preventive treatment against malaria in infants in Gabon--a randomized, double-blind, placebo-controlled trial. J Infect Dis (2007) 1.99
The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes. FEBS Lett (2004) 1.93
Microscopic and sub-microscopic Plasmodium falciparum infection, but not inflammation caused by infection, is associated with low birth weight. Am J Trop Med Hyg (2006) 1.88
Long-term treatment of intestinal helminths increases mite skin-test reactivity in Gabonese schoolchildren. J Infect Dis (2004) 1.85
A single, bi-functional aquaglyceroporin in blood-stage Plasmodium falciparum malaria parasites. J Biol Chem (2001) 1.83
Impact of the hepatitis B virus genotype and genotype mixtures on the course of liver disease in Vietnam. Hepatology (2006) 1.82
Prevalence of Plasmodium falciparum infection in pregnant women in Gabon. Malar J (2003) 1.70
Fixed-dose pyronaridine-artesunate combination for treatment of uncomplicated falciparum malaria in pediatric patients in Gabon. J Infect Dis (2008) 1.70
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Import and spread of Panton-Valentine Leukocidin-positive Staphylococcus aureus through nasal carriage and skin infections in travelers returning from the tropics and subtropics. Clin Infect Dis (2011) 1.67
In vitro and in vivo synergy of fosmidomycin, a novel antimalarial drug, with clindamycin. Antimicrob Agents Chemother (2002) 1.65
Increased specific T cell cytokine responses in patients with active pulmonary tuberculosis from Central Africa. Microbes Infect (2005) 1.63
Depressed natural killer cell cytotoxicity against Plasmodium falciparum-infected erythrocytes during first pregnancies. Clin Infect Dis (2004) 1.61
Management of imported malaria in Europe. Malar J (2012) 1.60
RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA. J Am Chem Soc (2010) 1.60
Intramuscular bioavailability and clinical efficacy of artesunate in gabonese children with severe malaria. Antimicrob Agents Chemother (2002) 1.59
Increased prevalence of intestinal helminth infection during pregnancy in a Sub-Saharan African community. Wien Klin Wochenschr (2007) 1.58
Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway. J Am Chem Soc (2008) 1.57
Impact of increasing consultation fees on malaria in Africa. Wien Klin Wochenschr (2004) 1.56
LytB protein catalyzes the terminal step of the 2-C-methyl-D-erythritol-4-phosphate pathway of isoprenoid biosynthesis. FEBS Lett (2002) 1.55
History and perspectives of medical research at the Albert Schweitzer Hospital in Lambaréné, Gabon. Wien Klin Wochenschr (2007) 1.52
Assessment of volume depletion in children with malaria. PLoS Med (2004) 1.51
Matrix metalloproteinases and their tissue inhibitors (TIMPs) in Plasmodium falciparum malaria: serum levels of TIMP-1 are associated with disease severity. J Infect Dis (2008) 1.51
Fosmidomycin, a novel chemotherapeutic agent for malaria. Antimicrob Agents Chemother (2003) 1.46
Socio-economic status is inversely related to bed net use in Gabon. Malar J (2008) 1.46
Adolescence as risk factor for adverse pregnancy outcome in Central Africa--a cross-sectional study. PLoS One (2010) 1.43
Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy. J Immunol (2007) 1.42
Effectiveness of rifaximin in prevention of diarrhoea in individuals travelling to south and southeast Asia: a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Infect Dis (2013) 1.41
Fosmidomycin for the treatment of malaria. Parasitol Res (2002) 1.40
Evidence of decline of malaria in the general hospital of Libreville, Gabon from 2000 to 2008. Malar J (2009) 1.40
Reduced cord blood immune effector-cell responsiveness mediated by CD4+ cells induced in utero as a consequence of placental Plasmodium falciparum infection. J Infect Dis (2005) 1.40
Plasmodium falciparum activates endogenous Cl(-) channels of human erythrocytes by membrane oxidation. EMBO J (2002) 1.40
Development of standardized laboratory methods and quality processes for a phase III study of the RTS, S/AS01 candidate malaria vaccine. Malar J (2011) 1.38
Genetic variants of the mannan-binding lectin are associated with immune reactivity to mannans in Crohn's disease. Gastroenterology (2004) 1.38
Differential regulation of beta-chemokines in children with Plasmodium falciparum malaria. Infect Immun (2005) 1.37
Clindamycin as an antimalarial drug: review of clinical trials. Antimicrob Agents Chemother (2002) 1.36
Elevated nitric oxide production in children with malarial anemia: hemozoin-induced nitric oxide synthase type 2 transcripts and nitric oxide in blood mononuclear cells. Infect Immun (2004) 1.35
Fosmidomycin plus clindamycin for treatment of pediatric patients aged 1 to 14 years with Plasmodium falciparum malaria. Antimicrob Agents Chemother (2006) 1.35
Fosmidomycin-clindamycin for Plasmodium falciparum Infections in African children. J Infect Dis (2004) 1.35
Malaria in pregnancy before and after the implementation of a national IPTp program in Gabon. Am J Trop Med Hyg (2007) 1.34