Published in Gastroenterology on October 01, 2004
Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study. Diabetologia (2009) 7.06
Risk of cancer in patients on insulin glargine and other insulin analogues in comparison with those on human insulin: results from a large population-based follow-up study. Diabetologia (2011) 3.52
Metformin and the risk of cancer: time-related biases in observational studies. Diabetes Care (2012) 3.11
Metformin associated with lower cancer mortality in type 2 diabetes: ZODIAC-16. Diabetes Care (2009) 2.90
Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis. PLoS One (2012) 2.84
Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals. BMC Cancer (2011) 2.30
Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes: a meta-analysis. Oncologist (2012) 1.79
Is diabetes mellitus an independent risk factor for colon cancer and rectal cancer? Am J Gastroenterol (2011) 1.78
Type 2 diabetes and the risk of colorectal adenomas: Black Women's Health Study. Am J Epidemiol (2013) 1.72
Reduced risk of colorectal cancer with metformin therapy in patients with type 2 diabetes: a meta-analysis. Diabetes Care (2011) 1.65
Growth hormone, the insulin-like growth factor axis, insulin and cancer risk. Nat Rev Endocrinol (2010) 1.61
Diabetes mellitus and the incidence of colorectal cancer: an updated systematic review and meta-analysis. Dig Dis Sci (2012) 1.56
Lower risk of cancer in patients on metformin in comparison with those on sulfonylurea derivatives: results from a large population-based follow-up study. Diabetes Care (2011) 1.52
Elevated HbA1c is an independent predictor of aggressive clinical behavior in patients with colorectal cancer: a case-control study. Dig Dis Sci (2008) 1.38
Metformin and cancer risk and mortality: a systematic review and meta-analysis taking into account biases and confounders. Cancer Prev Res (Phila) (2014) 1.38
Visceral adiposity, insulin resistance and cancer risk. Diabetol Metab Syndr (2011) 1.26
Metabolic syndrome and cancer. Metab Syndr Relat Disord (2009) 1.24
Diabetes, insulin use, and cancer risk: are observational studies part of the solution-or part of the problem? Diabetes (2010) 1.13
Diabetes and risk of incident colorectal cancer in a prospective cohort of women. Cancer Causes Control (2010) 1.13
Diabetes and cancer: two diseases with obesity as a common risk factor. Diabetes Obes Metab (2013) 1.11
The association between diabetes, insulin use, and colorectal cancer among Whites and African Americans. Cancer Epidemiol Biomarkers Prev (2009) 1.10
Beyond metformin: safety considerations in the decision-making process for selecting a second medication for type 2 diabetes management: reflections from a diabetes care editors' expert forum. Diabetes Care (2014) 1.07
Insulin resistance and hyperinsulinaemia in the development and progression of cancer. Clin Sci (Lond) (2009) 1.06
Is diabetes a causal agent for colorectal cancer? Pathophysiological and molecular mechanisms. World J Gastroenterol (2011) 1.06
No increased risk of myocardial infarction among patients with ulcerative colitis or Crohn's disease. Clin Gastroenterol Hepatol (2011) 1.05
Use of insulin and insulin analogs and risk of cancer - systematic review and meta-analysis of observational studies. Curr Drug Saf (2013) 1.05
Survival benefits of metformin for colorectal cancer patients with diabetes: a systematic review and meta-analysis. PLoS One (2014) 1.04
Diabetes and thyroid cancer risk: literature review. Exp Diabetes Res (2012) 1.02
Latest insights into the risk of cancer in diabetes. J Diabetes Investig (2013) 1.01
Importance of hepatitis C virus-associated insulin resistance: therapeutic strategies for insulin sensitization. World J Gastroenterol (2010) 0.97
Development of GMDR-GPU for gene-gene interaction analysis and its application to WTCCC GWAS data for type 2 diabetes. PLoS One (2013) 0.95
A twenty-first century cancer epidemic caused by obesity: the involvement of insulin, diabetes, and insulin-like growth factors. Int J Endocrinol (2013) 0.93
Comorbidity, age, race and stage at diagnosis in colorectal cancer: a retrospective, parallel analysis of two health systems. BMC Cancer (2008) 0.93
Dietary insulin load, dietary insulin index, and colorectal cancer. Cancer Epidemiol Biomarkers Prev (2010) 0.92
The links between insulin resistance, diabetes, and cancer. Curr Diab Rep (2013) 0.92
Insulin therapy contributes to the increased risk of colorectal cancer in diabetes patients: a meta-analysis. Diagn Pathol (2013) 0.92
Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients: a systemic review and meta-analysis. Diagn Pathol (2014) 0.91
14-Year risk of all-cause mortality according to hypoglycaemic drug exposure in a general population. PLoS One (2014) 0.90
Metformin Is Associated With Slightly Reduced Risk of Colorectal Cancer and Moderate Survival Benefits in Diabetes Mellitus: A Meta-Analysis. Medicine (Baltimore) (2016) 0.90
Hepatitis C virus induced insulin resistance impairs response to anti viral therapy. World J Gastroenterol (2012) 0.90
Decreased expression of insulin-like growth factor binding protein 7 in human colorectal carcinoma is related to DNA methylation. J Cancer Res Clin Oncol (2006) 0.88
Insulin therapy and colorectal adenomas in patients with diabetes mellitus. Cancer Epidemiol Biomarkers Prev (2012) 0.88
Thiazolidinedione therapy is not associated with increased colonic neoplasia risk in patients with diabetes mellitus. Gastroenterology (2008) 0.88
Insulin resistance and chronic liver disease. World J Hepatol (2011) 0.88
Morbidity risks among older adults with pre-existing age-related diseases. Exp Gerontol (2013) 0.87
Hyperinsulinemia, insulin resistance, vitamin D, and colorectal cancer among whites and African Americans. Dig Dis Sci (2012) 0.87
Long-term use of metformin and colorectal cancer risk in type II diabetics: a population-based case-control study. Cancer Med (2014) 0.85
Increased risk of colorectal cancer in type 2 diabetes is independent of diet quality. PLoS One (2013) 0.85
Type 2 diabetes mellitus is associated with increased mortality in Chinese patients receiving curative surgery for colon cancer. Oncologist (2014) 0.85
Serial glycosylated hemoglobin levels and risk of colorectal neoplasia among patients with type 2 diabetes mellitus. Cancer Epidemiol Biomarkers Prev (2010) 0.85
Increased risk of colon cancer in men in the pre-diabetes phase. PLoS One (2013) 0.85
The Insulin/IGF System in Colorectal Cancer Development and Resistance to Therapy. Front Oncol (2015) 0.85
Insulin therapy and the risk of colorectal cancer in patients with type 2 diabetes: a meta-analysis of observational studies. Br J Clin Pharmacol (2014) 0.84
Metformin for primary colorectal cancer prevention in patients with diabetes: a case-control study in a US population. Cancer (2014) 0.84
Diabetes, insulin therapy, and colorectal cancer. BMJ (2005) 0.83
Cancer risk in type 2 diabetes mellitus: metabolic links and therapeutic considerations. J Nutr Metab (2011) 0.83
High Blood Glucose Levels Correlate with Tumor Malignancy in Colorectal Cancer Patients. Med Sci Monit (2015) 0.82
Effects of Physical Activity on Risk of Colorectal Cancer: A Case-control Study. Int J Prev Med (2016) 0.82
Diabetes mellitus increases risk for colorectal adenomas in younger patients. World J Gastroenterol (2014) 0.82
Insulin therapy and cancer in type 2 diabetes. ISRN Endocrinol (2012) 0.82
Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications. J Biol Chem (2009) 0.81
Obesity and colorectal cancer. Clin Colon Rectal Surg (2011) 0.80
Preoperative serum retinol-binding protein 4 is associated with the prognosis of patients with hepatocellular carcinoma after curative resection. J Cancer Res Clin Oncol (2010) 0.80
Early insulin use in type 2 diabetes: what are the cons? Diabetes Care (2009) 0.79
Metformin and breast and gynecological cancer risk among women with diabetes. BMJ Open Diabetes Res Care (2015) 0.79
Metabolic Syndrome and Breast Cancer Risk: Is There a Role for Metformin? Curr Breast Cancer Rep (2011) 0.79
Diabetes but not insulin is associated with higher colon cancer mortality. World J Gastroenterol (2012) 0.79
Visceral fat accumulation is associated with colorectal cancer in postmenopausal women. PLoS One (2014) 0.78
Diabetes promotes DMH-induced colorectal cancer by increasing the activity of glycolytic enzymes in rats. PLoS One (2014) 0.78
Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation. Nucleic Acids Res (2015) 0.78
Metformin and cancer. Rev Diabet Stud (2014) 0.78
2017 update on the relationship between diabetes and colorectal cancer: epidemiology, potential molecular mechanisms and therapeutic implications. Oncotarget (2017) 0.77
Type 2 diabetes mellitus and risk of colorectal adenoma: a meta-analysis of observational studies. BMC Cancer (2016) 0.77
Metabolic syndrome and colorectal cancer: is hyperinsulinemia/insulin receptor-mediated angiogenesis a critical process? J Geriatr Oncol (2013) 0.77
The Activation of ERK1/2 and JNK MAPK Signaling by Insulin/IGF-1 Is Responsible for the Development of Colon Cancer with Type 2 Diabetes Mellitus. PLoS One (2016) 0.77
Diabetes-induced mechanophysiological changes in the small intestine and colon. World J Diabetes (2017) 0.76
Use of noninsulin anti diabetics for prevention and treatment of cancer- narrative review article. Iran J Public Health (2015) 0.75
Colorectal cancer risk reduction following macrogol exposure: a cohort and nested case control study in the UK. PLoS One (2013) 0.75
Prognostic value of glycated hemoglobin in colorectal cancer. World J Gastroenterol (2016) 0.75
Metformin-associated lactic acidosis and temporary ileostomy: a case report. J Med Case Rep (2014) 0.75
A Population-Based Cohort Study of All-Cause and Site-Specific Cancer Incidence Among Patients With Type 1 Diabetes Mellitus in Taiwan. J Epidemiol (2015) 0.75
Thyroid dysfunction, thyroid hormone replacement and colorectal cancer risk. J Natl Cancer Inst (2015) 0.75
Lack of association between insulin sensitivity and colorectal adenoma risk. Nutr Cancer (2011) 0.75
A possible link between insulin glargine and malignancy: the facts. Cardiovasc J Afr (2009) 0.75
Metformin- A Promising Agent for Chemoprevention in BRCA1 Carriers. Hereditary Genet (2012) 0.75
Metformin therapy and risk of colorectal adenomas and colorectal cancer in type 2 diabetes mellitus patients: A systematic review and meta-analysis. Oncotarget (2016) 0.75
Single nucleotide polymorphisms in the IGF-IRS pathway are associated with outcome in mCRC patients enrolled in the FIRE-3 trial. Int J Cancer (2017) 0.75
Linking long-term dietary patterns with gut microbial enterotypes. Science (2011) 17.30
Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA (2006) 9.53
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med (2013) 9.44
Absence of cross-reactivity between sulfonamide antibiotics and sulfonamide nonantibiotics. N Engl J Med (2003) 5.09
The association between hepatitis C infection and survival after orthotopic liver transplantation. Gastroenterology (2002) 4.98
Sampling and pyrosequencing methods for characterizing bacterial communities in the human gut using 16S sequence tags. BMC Microbiol (2010) 4.97
Design of a national distributed health data network. Ann Intern Med (2009) 4.09
Initiation of tumor necrosis factor-α antagonists and the risk of hospitalization for infection in patients with autoimmune diseases. JAMA (2011) 3.58
The human gut virome: inter-individual variation and dynamic response to diet. Genome Res (2011) 3.32
Unintended effects of a computerized physician order entry nearly hard-stop alert to prevent a drug interaction: a randomized controlled trial. Arch Intern Med (2010) 3.31
Comparative risk for angioedema associated with the use of drugs that target the renin-angiotensin-aldosterone system. Arch Intern Med (2012) 3.08
Efficacy of anti-tumor necrosis factor therapy in patients with ulcerative colitis. Am J Gastroenterol (2002) 3.01
Mortality associated with medical therapy versus elective colectomy in ulcerative colitis: a cohort study. Ann Intern Med (2014) 2.73
The U.S. Food and Drug Administration's Mini-Sentinel program: status and direction. Pharmacoepidemiol Drug Saf (2012) 2.70
Rapid evolution of the human gut virome. Proc Natl Acad Sci U S A (2013) 2.53
Association between vaccination for herpes zoster and risk of herpes zoster infection among older patients with selected immune-mediated diseases. JAMA (2012) 2.51
Use of abdominopelvic computed tomography in emergency departments and rates of urgent diagnoses in Crohn's disease. Clin Gastroenterol Hepatol (2011) 2.40
The risk of mortality in patients with psoriasis: results from a population-based study. Arch Dermatol (2007) 2.32
Incidence and mortality of colorectal adenocarcinoma in persons with inflammatory bowel disease from 1998 to 2010. Gastroenterology (2012) 2.26
Development of an internet-based cohort of patients with inflammatory bowel diseases (CCFA Partners): methodology and initial results. Inflamm Bowel Dis (2012) 2.23
Incidence and risk factors for herpes zoster among patients with inflammatory bowel disease. Clin Gastroenterol Hepatol (2006) 2.16
Increased risk for demyelinating diseases in patients with inflammatory bowel disease. Gastroenterology (2005) 2.15
Rates of malignancy associated with juvenile idiopathic arthritis and its treatment. Arthritis Rheum (2012) 2.15
Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: a meta-analysis. Gastroenterology (2006) 2.14
Initiation of anti-TNF therapy and the risk of optic neuritis: from the safety assessment of biologic ThERapy (SABER) Study. Am J Ophthalmol (2012) 2.14
AGA medical position statement on the diagnosis and management of colorectal neoplasia in inflammatory bowel disease. Gastroenterology (2010) 2.09
An optimized patient-reported ulcerative colitis disease activity measure derived from the Mayo score and the simple clinical colitis activity index. Inflamm Bowel Dis (2014) 2.05
Risks of herpes zoster in patients with rheumatoid arthritis according to biologic disease-modifying therapy. Arthritis Care Res (Hoboken) (2015) 2.03
Proton-pump inhibitor use and the risk for community-acquired pneumonia. Ann Intern Med (2008) 1.99
Corticosteroids and immunomodulators: postoperative infectious complication risk in inflammatory bowel disease patients. Gastroenterology (2003) 1.94
Trends in the use of biologic agents among rheumatoid arthritis patients enrolled in the US medicare program. Arthritis Care Res (Hoboken) (2013) 1.92
Risk of kidney injury following oral phosphosoda bowel preparations. J Am Soc Nephrol (2007) 1.89
Renal function after orthotopic liver transplantation is predicted by duration of pretransplantation creatinine elevation. Liver Transpl (2005) 1.87
Cardiovascular events and death in children exposed and unexposed to ADHD agents. Pediatrics (2011) 1.84
Cohort study of pioglitazone and cancer incidence in patients with diabetes. Diabetes Care (2011) 1.83
Time trends in therapies and outcomes for adult inflammatory bowel disease, Northern California, 1998-2005. Gastroenterology (2009) 1.74
Incidence and prevalence of inflammatory bowel disease in a Northern California managed care organization, 1996-2002. Am J Gastroenterol (2008) 1.72
On the estimation and use of propensity scores in case-control and case-cohort studies. Am J Epidemiol (2007) 1.71
Association between longer therapy with thiazolidinediones and risk of bladder cancer: a cohort study. J Natl Cancer Inst (2012) 1.69
Health care for older Americans with multiple chronic conditions: a research agenda. J Am Geriatr Soc (2007) 1.65
Cancer incidence in The Health Improvement Network. Pharmacoepidemiol Drug Saf (2009) 1.65
Archaea and fungi of the human gut microbiome: correlations with diet and bacterial residents. PLoS One (2013) 1.64
Antidepressants and the risk of sudden cardiac death and ventricular arrhythmia. Pharmacoepidemiol Drug Saf (2011) 1.63
Validity of The Health Improvement Network (THIN) for epidemiologic studies of hepatitis C virus infection. Pharmacoepidemiol Drug Saf (2009) 1.61
Hypervariable loci in the human gut virome. Proc Natl Acad Sci U S A (2012) 1.58
Antidepressant-warfarin interaction and associated gastrointestinal bleeding risk in a case-control study. PLoS One (2011) 1.54
Location, location, location: geographic clustering of lower-extremity amputation among Medicare beneficiaries with diabetes. Diabetes Care (2011) 1.54
Identifying potential adverse effects using the web: a new approach to medical hypothesis generation. J Biomed Inform (2011) 1.52
A meta-analysis of the placebo rates of remission and response in clinical trials of active Crohn's disease. Gastroenterology (2004) 1.51
Anti-TNF antibodies for Crohn's disease--in pursuit of the perfect clinical trial. N Engl J Med (2007) 1.50
Structure-constrained sparse canonical correlation analysis with an application to microbiome data analysis. Biostatistics (2012) 1.49
Influence of alcohol use, race, and viral coinfections on spontaneous HCV clearance in a US veteran population. Hepatology (2004) 1.49
Communication outcomes in audiologic reporting. J Am Acad Audiol (2011) 1.48
Association between the initiation of anti-tumor necrosis factor therapy and the risk of herpes zoster. JAMA (2013) 1.45
Represcription of penicillin after allergic-like events. J Allergy Clin Immunol (2004) 1.44
Rates of hospitalized bacterial infection associated with juvenile idiopathic arthritis and its treatment. Arthritis Rheum (2012) 1.43
Methylphenidate and risk of serious cardiovascular events in adults. Am J Psychiatry (2012) 1.42
Role of thiopurine and anti-TNF therapy in lymphoma in inflammatory bowel disease. Am J Gastroenterol (2011) 1.39
A meta-analysis of the placebo rates of remission and response in clinical trials of active ulcerative colitis. Gastroenterology (2006) 1.39
Is improved survival a class effect of angiotensin-converting enzyme inhibitors? Ann Intern Med (2004) 1.35
Quality indicators for inflammatory bowel disease: development of process and outcome measures. Inflamm Bowel Dis (2013) 1.33
The impact of increased body mass index on the clinical course of Crohn's disease. Clin Gastroenterol Hepatol (2006) 1.32
Study design for a comprehensive assessment of biologic safety using multiple healthcare data systems. Pharmacoepidemiol Drug Saf (2011) 1.30
Incidence, prevalence, and time trends of pediatric inflammatory bowel disease in Northern California, 1996 to 2006. J Pediatr (2010) 1.30
Trends in hospitalization rates for inflammatory bowel disease in the United States. Clin Gastroenterol Hepatol (2007) 1.30
Online discussion of drug side effects and discontinuation among breast cancer survivors. Pharmacoepidemiol Drug Saf (2013) 1.28
Potential association between the oral tetracycline class of antimicrobials used to treat acne and inflammatory bowel disease. Am J Gastroenterol (2010) 1.28
Dietary patterns and self-reported associations of diet with symptoms of inflammatory bowel disease. Dig Dis Sci (2012) 1.27
Medication safety in older adults: home-based practice patterns. J Am Geriatr Soc (2005) 1.24
Validity of diagnostic codes to identify cases of severe acute liver injury in the US Food and Drug Administration's Mini-Sentinel Distributed Database. Pharmacoepidemiol Drug Saf (2013) 1.23
A tool kit for quantifying eukaryotic rRNA gene sequences from human microbiome samples. Genome Biol (2012) 1.17
Risk of hip fracture associated with hepatitis C virus infection and hepatitis C/human immunodeficiency virus coinfection. Hepatology (2012) 1.16
The London position statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's and Colitis Organisation: safety. Am J Gastroenterol (2011) 1.15
Rhinitis therapy and the prevention of hospital care for asthma: a case-control study. J Allergy Clin Immunol (2004) 1.14
Is there cross-reactivity between penicillins and cephalosporins? Am J Med (2006) 1.13
Chronic proton pump inhibitor therapy and the risk of colorectal cancer. Gastroenterology (2007) 1.13
Randomized clinical trial of a customized electronic alert requiring an affirmative response compared to a control group receiving a commercial passive CPOE alert: NSAID--warfarin co-prescribing as a test case. J Am Med Inform Assoc (2010) 1.12
Type 2 diabetes mellitus and the risk of colorectal cancer. Clin Gastroenterol Hepatol (2005) 1.12
Fungi of the murine gut: episodic variation and proliferation during antibiotic treatment. PLoS One (2013) 1.11
Fibrate/Statin initiation in warfarin users and gastrointestinal bleeding risk. Am J Med (2010) 1.11
Proton pump inhibitors and traditional nonsteroidal anti-inflammatory drugs and the risk of acute interstitial nephritis and acute kidney injury. Pharmacoepidemiol Drug Saf (2012) 1.11
Validation of The Health Improvement Network (THIN) database for epidemiologic studies of chronic kidney disease. Pharmacoepidemiol Drug Saf (2011) 1.11
Risk of mortality in patients with psoriatic arthritis, rheumatoid arthritis and psoriasis: a longitudinal cohort study. Ann Rheum Dis (2012) 1.08
The impact of bariatric surgery on menstrual patterns. Obes Surg (2006) 1.08
Prevalence of colorectal cancer surveillance for ulcerative colitis in an integrated health care delivery system. Gastroenterology (2010) 1.07
No increased risk of myocardial infarction among patients with ulcerative colitis or Crohn's disease. Clin Gastroenterol Hepatol (2011) 1.05
Patient preferences for surgical versus medical therapy for ulcerative colitis. Inflamm Bowel Dis (2014) 1.05
Diagnostic E-codes for commonly used, narrow therapeutic index medications poorly predict adverse drug events. J Clin Epidemiol (2008) 1.05
Adherence, discontinuation, and switching of biologic therapies in medicaid enrollees with rheumatoid arthritis. Value Health (2010) 1.05
Validity of psoriatic arthritis and capture of disease modifying antirheumatic drugs in the health improvement network. Pharmacoepidemiol Drug Saf (2014) 1.04
Hospitalization costs associated with warfarin-related bleeding events among older community-dwelling adults. Pharmacoepidemiol Drug Saf (2010) 1.04
Leaf respiration at different canopy positions in sweetgum (Liquidambar styraciflua) grown in ambient and elevated concentrations of carbon dioxide in the field. Tree Physiol (2002) 1.04
Natural supplements for H1N1 influenza: retrospective observational infodemiology study of information and search activity on the Internet. J Med Internet Res (2011) 1.03
Severe cutaneous reactions requiring hospitalization in allopurinol initiators: a population-based cohort study. Arthritis Care Res (Hoboken) (2013) 1.03
Safety profile of IBD: lymphoma risks. Gastroenterol Clin North Am (2009) 1.02
Gastroenterologists' attitudes and self-reported practices regarding inflammatory bowel disease. Inflamm Bowel Dis (2008) 1.02
Cardiovascular risk in rheumatoid arthritis: comparing TNF-α blockade with nonbiologic DMARDs. Am J Med (2013) 1.01
Researchers and HIPAA. Epidemiology (2007) 1.01