Published in Mol Immunol on November 01, 2004
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J Exp Med (2005) 4.06
Transcriptional regulation by AIRE: molecular mechanisms of central tolerance. Nat Rev Immunol (2008) 1.99
Interferon autoantibodies associated with AIRE deficiency decrease the expression of IFN-stimulated genes. Blood (2008) 1.12
The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance. Nat Immunol (2014) 0.96
Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes. Nat Genet (2015) 0.95
An evolutionarily conserved mutual interdependence between Aire and microRNAs in promiscuous gene expression. Eur J Immunol (2013) 0.91
Critical immunological pathways are downregulated in APECED patient dendritic cells. J Mol Med (Berl) (2008) 0.89
Expression of thyrotropin receptor, thyroglobulin, sodium-iodide symporter, and thyroperoxidase by fibrocytes depends on AIRE. J Clin Endocrinol Metab (2014) 0.84
Human self-protein CD8+ T-cell epitopes are both positively and negatively selected. Eur J Immunol (2009) 0.83
Human APECED; a Sick Thymus Syndrome? Front Immunol (2013) 0.82
Aire promotes the self-renewal of embryonic stem cells through Lin28. Stem Cells Dev (2012) 0.82
Models of aire-dependent gene regulation for thymic negative selection. Front Immunol (2011) 0.80
Expression of the autoimmune regulator gene and its relevance to the mechanisms of central and peripheral tolerance. Clin Dev Immunol (2012) 0.77
Autoimmune Regulator (AIRE) Is Expressed in Spermatogenic Cells, and It Altered the Expression of Several Nucleic-Acid-Binding and Cytoskeletal Proteins in Germ Cell 1 Spermatogonial (GC1-spg) Cells. Mol Cell Proteomics (2016) 0.75
Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity. J Immunol (2017) 0.75
Copy number variation and selection during reprogramming to pluripotency. Nature (2011) 8.24
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell (2011) 7.41
Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines. J Exp Med (2010) 3.93
Exosomes with immune modulatory features are present in human breast milk. J Immunol (2007) 3.47
High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity. Nat Biotechnol (2010) 3.21
Phased whole-genome genetic risk in a family quartet using a major allele reference sequence. PLoS Genet (2011) 3.20
Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases. Blood (2007) 2.82
Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J Exp Med (2008) 2.79
A practical comparison of methods for detecting transcription factor binding sites in ChIP-seq experiments. BMC Genomics (2009) 2.70
Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis. Proc Natl Acad Sci U S A (2005) 2.56
Bioportfolio: lifelong persistence of variant and prototypic erythrovirus DNA genomes in human tissue. Proc Natl Acad Sci U S A (2006) 2.51
Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study. Lancet Neurol (2013) 2.36
The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression. EMBO Rep (2008) 2.22
Genomic views of STAT function in CD4+ T helper cell differentiation. Nat Rev Immunol (2011) 2.09
Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type 1. PLoS Med (2006) 1.98
Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines. Cell Host Microbe (2008) 1.94
Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia. Cancer Discov (2013) 1.93
The hepatitis C virus non-structural NS5A protein inhibits activating protein-1 function by perturbing ras-ERK pathway signaling. J Biol Chem (2003) 1.93
Gene expression profiling during differentiation of human monocytes to macrophages or dendritic cells. J Leukoc Biol (2007) 1.90
Difference in gene expression between human fetal liver and adult bone marrow mesenchymal stem cells. Haematologica (2005) 1.90
Gene expression signatures of seven individual human embryonic stem cell lines. Stem Cells (2005) 1.86
Lymphotoxin pathway directs thymic Aire expression. Nat Immunol (2003) 1.79
High-throughput phosphotyrosine profiling using SH2 domains. Mol Cell (2007) 1.72
Timing of infant feeding in relation to childhood asthma and allergic diseases. J Allergy Clin Immunol (2012) 1.62
Abnormal tumor necrosis factor receptor I cell surface expression and NF-kappaB activation in tumor necrosis factor receptor-associated periodic syndrome. Arthritis Rheum (2008) 1.61
ErbB4 modulates tubular cell polarity and lumen diameter during kidney development. J Am Soc Nephrol (2011) 1.61
Rab10 is involved in basolateral transport in polarized Madin-Darby canine kidney cells. Traffic (2006) 1.61
Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific MicroRNA. J Virol (2008) 1.58
Systematic construction of gene coexpression networks with applications to human T helper cell differentiation process. Bioinformatics (2007) 1.54
Generation of single and double knockdowns in polarized epithelial cells by retrovirus-mediated RNA interference. Proc Natl Acad Sci U S A (2004) 1.54
Enterohaemorrhagic Escherichia coli exploits a tryptophan switch to hijack host f-actin assembly. Structure (2012) 1.47
Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation. Proc Natl Acad Sci U S A (2009) 1.46
The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation. Nucleic Acids Res (2009) 1.46
Low TNF-induced NF-kappaB and p38 phosphorylation levels in leucocytes in tumour necrosis factor receptor-associated periodic syndrome. Rheumatology (Oxford) (2010) 1.43
Galectin-4 and sulfatides in apical membrane trafficking in enterocyte-like cells. J Cell Biol (2005) 1.43
Integrating probe-level expression changes across generations of Affymetrix arrays. Nucleic Acids Res (2005) 1.42
FAPP2 is involved in the transport of apical cargo in polarized MDCK cells. J Cell Biol (2005) 1.40
MicroRNA expression profiles of human blood monocyte-derived dendritic cells and macrophages reveal miR-511 as putative positive regulator of Toll-like receptor 4. J Biol Chem (2011) 1.40
A new parvovirus genotype persistent in human skin. Virology (2002) 1.40
Genetic and epigenetic stability of human pluripotent stem cells. Nat Rev Genet (2012) 1.38
EORTC consensus recommendations for the treatment of mycosis fungoides/Sézary syndrome. Eur J Cancer (2006) 1.38
Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome. EMBO Rep (2006) 1.33
SH3 domain-mediated recruitment of host cell amphiphysins by alphavirus nsP3 promotes viral RNA replication. PLoS Pathog (2011) 1.32
Aire-deficient C57BL/6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype. J Immunol (2009) 1.32
Early target genes of IL-12 and STAT4 signaling in th cells. J Immunol (2004) 1.31
Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming. Immunity (2010) 1.28
Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization. Immunity (2013) 1.27
Depletion of apical transport proteins perturbs epithelial cyst formation and ciliogenesis. J Cell Sci (2008) 1.24
Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling. J Biol Chem (2007) 1.22
Genome-wide identification of novel genes involved in early Th1 and Th2 cell differentiation. J Immunol (2007) 1.21
Identification of novel IL-4/Stat6-regulated genes in T lymphocytes. J Immunol (2003) 1.20
Differential expression of IFN regulatory factor 4 gene in human monocyte-derived dendritic cells and macrophages. J Immunol (2005) 1.15
AIRE activated tissue specific genes have histone modifications associated with inactive chromatin. Hum Mol Genet (2009) 1.13
Detection and differentiation of human parvovirus variants by commercial quantitative real-time PCR tests. J Clin Microbiol (2004) 1.13
Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes. J Immunol (2009) 1.13
Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue. Cancer Res (2005) 1.12
Identification of genes involved in the initiation of human Th1 or Th2 cell commitment. Eur J Immunol (2005) 1.12
Interferon autoantibodies associated with AIRE deficiency decrease the expression of IFN-stimulated genes. Blood (2008) 1.12
Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role. Proc Natl Acad Sci U S A (2009) 1.12
Contributions of galectin-3 and -9 to epithelial cell adhesion analyzed by single cell force spectroscopy. J Biol Chem (2007) 1.10
Probe-level estimation improves the detection of differential splicing in Affymetrix exon array studies. Genome Biol (2009) 1.10
DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity. Biochim Biophys Acta (2007) 1.10
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy: known and novel aspects of the syndrome. Ann N Y Acad Sci (2011) 1.08
Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes. J Allergy Clin Immunol (2005) 1.08
HIV-1 Nef interacts with inositol trisphosphate receptor to activate calcium signaling in T cells. J Exp Med (2002) 1.08
PARP-14, a member of the B aggressive lymphoma family, transduces survival signals in primary B cells. Blood (2009) 1.08
Galectin-3 regulates integrin alpha2beta1-mediated adhesion to collagen-I and -IV. J Biol Chem (2008) 1.08
Modulation of Aire regulates the expression of tissue-restricted antigens. Mol Immunol (2007) 1.07
A crucial role in cell spreading for the interaction of Abl PxxP motifs with Crk and Nck adaptors. J Cell Sci (2008) 1.06
Th1 response and cytotoxicity genes are down-regulated in cutaneous T-cell lymphoma. Clin Cancer Res (2006) 1.05
Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon. J Immunol (2007) 1.05
Dystroglycan, Tks5 and Src mediated assembly of podosomes in myoblasts. PLoS One (2008) 1.05
Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling. J Immunol (2010) 1.05
Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors. J Virol (2004) 1.05
Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling. J Gen Virol (2005) 1.04
Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly. Proc Natl Acad Sci U S A (2010) 1.04
Reanalysis of RNA-sequencing data reveals several additional fusion genes with multiple isoforms. PLoS One (2012) 1.04
Tyrosine kinase 2 and interferon regulatory factor 5 polymorphisms are associated with discoid and subacute cutaneous lupus erythematosus. Exp Dermatol (2009) 1.03
Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens. Front Immunol (2012) 1.03
Modulation of cell spreading and cell-substrate adhesion dynamics by dystroglycan. J Cell Sci (2010) 1.03
AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity. J Biol Chem (2007) 1.03
Predominance of a rare type of HIV-1 in Estonia. J Acquir Immune Defic Syndr (2005) 1.02
Identification of novel genes regulated by IL-12, IL-4, or TGF-beta during the early polarization of CD4+ lymphocytes. J Immunol (2003) 1.02
Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner. J Biol Chem (2004) 1.02
Conformation of the dileucine-based sorting motif in HIV-1 Nef revealed by intermolecular domain assembly. Traffic (2011) 1.02
Gene expression profiling of immune-competent human cells exposed to engineered zinc oxide or titanium dioxide nanoparticles. PLoS One (2013) 1.02