Published in J Biol Chem on October 12, 2004
Alternative splicing and differential gene expression in colon cancer detected by a whole genome exon array. BMC Genomics (2006) 5.59
CD98hc (SLC3A2) mediates integrin signaling. Proc Natl Acad Sci U S A (2004) 1.88
CD98 at the crossroads of adaptive immunity and cancer. J Cell Sci (2012) 1.24
CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice. J Clin Invest (2011) 1.23
Nonvesicular release of glutamate by glial xCT transporters suppresses glutamate receptor clustering in vivo. J Neurosci (2007) 1.20
ReCLIP (reversible cross-link immuno-precipitation): an efficient method for interrogation of labile protein complexes. PLoS One (2011) 1.09
CD98hc facilitates B cell proliferation and adaptive humoral immunity. Nat Immunol (2009) 1.00
Intestinal epithelial CD98: an oligomeric and multifunctional protein. Biochim Biophys Acta (2008) 0.97
The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1. Cell Res (2015) 0.90
Loss of the integrin-activating transmembrane protein Fam38A (Piezo1) promotes a switch to a reduced integrin-dependent mode of cell migration. PLoS One (2012) 0.90
Intestinal epithelial CD98 directly modulates the innate host response to enteric bacterial pathogens. Infect Immun (2013) 0.89
CD98hc (SLC3A2) drives integrin-dependent renal cancer cell behavior. Mol Cancer (2013) 0.87
Homeostatic and innate immune responses: role of the transmembrane glycoprotein CD98. Cell Mol Life Sci (2012) 0.87
CD98hc (SLC3A2) regulation of skin homeostasis wanes with age. J Exp Med (2013) 0.86
Discovery of SLC3A2 cell membrane protein as a potential gastric cancer biomarker: implications in molecular imaging. J Proteome Res (2012) 0.85
CD98hc (SLC3A2) loss protects against ras-driven tumorigenesis by modulating integrin-mediated mechanotransduction. Cancer Res (2014) 0.84
Intestinal epithelial CD98 synthesis specifically modulates expression of colonic microRNAs during colitis. Am J Physiol Gastrointest Liver Physiol (2012) 0.83
CD98 increases renal epithelial cell proliferation by activating MAPKs. PLoS One (2012) 0.83
Ubiquitylation of CD98 limits cell proliferation and clonal expansion. J Cell Sci (2015) 0.78
Inverse immunological responses induced by allergic rhinitis and head and neck squamous cell carcinoma. PLoS One (2014) 0.76
Integrins in the Spotlight of Cancer. Int J Mol Sci (2016) 0.75
CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia. Cancer Cell (2016) 0.75
Insights into a novel nuclear function for Fascin in the regulation of the amino-acid transporter SLC3A2. Sci Rep (2016) 0.75
Dominant Suppression of β1 Integrin by Ectopic CD98-ICD Inhibits Hepatocellular Carcinoma Progression. Int J Mol Sci (2016) 0.75
RalBP1 and p19-VHL play an oncogenic role, and p30-VHL plays a tumor suppressor role during the blebbishield emergency program. Cell Death Discov (2017) 0.75
Resolution of inflammation: state of the art, definitions and terms. FASEB J (2007) 5.12
The tail of integrins, talin, and kindlins. Science (2009) 4.51
Circulating microRNAs as potential markers of human drug-induced liver injury. Hepatology (2011) 4.06
Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis. Nat Med (2006) 3.79
Kindlin-2 controls bidirectional signaling of integrins. Genes Dev (2008) 3.15
Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity. J Hepatol (2012) 3.15
Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis. Am J Pathol (2008) 2.83
Galectin-3 regulates myofibroblast activation and hepatic fibrosis. Proc Natl Acad Sci U S A (2006) 2.75
A randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis. Am J Respir Crit Care Med (2010) 2.72
Circulating apoptotic and necrotic cell death markers in patients with acute liver injury. Liver Int (2011) 2.41
Regulation of alternative macrophage activation by galectin-3. J Immunol (2008) 2.28
Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis. Am J Respir Crit Care Med (2011) 2.15
Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3. Am J Respir Crit Care Med (2011) 2.09
Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity. Br J Clin Pharmacol (2012) 1.91
Sirt1 activation protects the mouse renal medulla from oxidative injury. J Clin Invest (2010) 1.90
Diagnostic importance of pulmonary interleukin-1beta and interleukin-8 in ventilator-associated pneumonia. Thorax (2009) 1.87
Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure. Gut (2006) 1.82
Human podocytes adhere to the KRGDS motif of the alpha3alpha4alpha5 collagen IV network. J Am Soc Nephrol (2008) 1.81
The regulation of inflammation by galectin-3. Immunol Rev (2009) 1.76
TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis. J Am Soc Nephrol (2010) 1.70
Cyclophilin A is a damage-associated molecular pattern molecule that mediates acetaminophen-induced liver injury. J Immunol (2011) 1.63
Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling. J Clin Invest (2014) 1.59
Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. J Clin Invest (2006) 1.59
Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity. Dev Biol (2008) 1.59
Neutrophil apoptosis: relevance to the innate immune response and inflammatory disease. J Innate Immun (2010) 1.57
Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature (2009) 1.55
Transforming growth factor beta induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeleton. Cancer Res (2009) 1.53
Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation. J Exp Med (2002) 1.51
Wogonin induces eosinophil apoptosis and attenuates allergic airway inflammation. Am J Respir Crit Care Med (2015) 1.49
Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipids. J Biol Chem (2005) 1.47
Prostaglandin E2-EP4 receptor promotes endothelial cell migration via ERK activation and angiogenesis in vivo. J Biol Chem (2007) 1.46
Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum. J Cell Sci (2010) 1.45
Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Mol Cell Biol (2007) 1.37
Differential expression of collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis. Am J Physiol Renal Physiol (2004) 1.34
Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis. Cancer Res (2010) 1.34
Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury. Am J Pathol (2004) 1.33
Glucocorticoids induce protein S-dependent phagocytosis of apoptotic neutrophils by human macrophages. J Immunol (2009) 1.30
Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function. Am J Pathol (2008) 1.28
Overdose pattern and outcome in paracetamol-induced acute severe hepatotoxicity. Br J Clin Pharmacol (2011) 1.27
beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity. Development (2009) 1.27
The cyclin-dependent kinase inhibitor R-roscovitine down-regulates Mcl-1 to override pro-inflammatory signalling and drive neutrophil apoptosis. Eur J Immunol (2010) 1.26
Novel pharmacological strategies for driving inflammatory cell apoptosis and enhancing the resolution of inflammation. Trends Pharmacol Sci (2008) 1.25
The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system. J Leukoc Biol (2006) 1.25
Proteolytic processing of laminin-5 by MT1-MMP in tissues and its effects on epithelial cell morphology. FASEB J (2003) 1.23
Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras. J Biol Chem (2007) 1.23
Human dendritic cells produce TGF-beta 1 under the influence of lung carcinoma cells and prime the differentiation of CD4+CD25+Foxp3+ regulatory T cells. J Immunol (2009) 1.22
Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant Inhibitor for integrin alphavbeta3. J Biol Chem (2006) 1.20
NPXY motifs in the beta1 integrin cytoplasmic tail are required for functional reovirus entry. J Virol (2008) 1.18
Inhibition of Pkhd1 impairs tubulomorphogenesis of cultured IMCD cells. Mol Biol Cell (2005) 1.17
Expression of the developmental Sonic hedgehog (Shh) signalling pathway is up-regulated in chronic lung fibrosis and the Shh receptor patched 1 is present in circulating T lymphocytes. J Pathol (2003) 1.17
Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells. Int J Cancer (2005) 1.14
How does TGF-β mediate tubulointerstitial fibrosis? Semin Nephrol (2012) 1.14
PAR1, but not PAR4, activates human platelets through a Gi/o/phosphoinositide-3 kinase signaling axis. Mol Pharmacol (2007) 1.13
Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis. EMBO J (2011) 1.12
CD133+ cancer stem-like cells in small cell lung cancer are highly tumorigenic and chemoresistant but sensitive to a novel neuropeptide antagonist. Cancer Res (2014) 1.12
Increased virulence of a fibronectin-binding protein mutant of Staphylococcus aureus in a rat model of pneumonia. Infect Immun (2002) 1.10
Anti-interleukin-8 autoantibodies in patients at risk for acute respiratory distress syndrome. Crit Care Med (2002) 1.07
Paracetamol pack size restriction: the impact on paracetamol poisoning and the over-the-counter supply of paracetamol, aspirin and ibuprofen. Pharmacoepidemiol Drug Saf (2002) 1.07
Phagocytosis of apoptotic cells by human macrophages: analysis by multiparameter flow cytometry. Cytometry A (2003) 1.06
Accuracy of the ALFSG index as a triage marker in acute liver failure. Gastroenterology (2012) 1.06
The role of integrin alpha8beta1 in fetal lung morphogenesis and injury. Dev Biol (2009) 1.04
CD98 modulates integrin beta1 function in polarized epithelial cells. J Cell Sci (2005) 1.04
Cross-linking CD98 promotes integrin-like signaling and anchorage-independent growth. Mol Biol Cell (2002) 1.04
Integrins in renal development. Pediatr Nephrol (2011) 1.03
Apoptosis of the thick ascending limb results in acute kidney injury. J Am Soc Nephrol (2008) 1.03
Inhibition of nuclear factor-kappaB activation un-masks the ability of TNF-alpha to induce human eosinophil apoptosis. Eur J Immunol (2002) 1.02
H-Ras, R-Ras, and TC21 differentially regulate ureteric bud cell branching morphogenesis. Mol Biol Cell (2006) 1.01
Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents. J Immunol (2002) 1.01
Angiotensin type 1 receptor blocker restores podocyte potential to promote glomerular endothelial cell growth. J Am Soc Nephrol (2006) 1.01
Extracellular matrix regulation of drug resistance in small-cell lung cancer. Clin Sci (Lond) (2002) 1.01
Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity. Blood (2009) 1.01
Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expression. Mol Cell Biol (2010) 1.00
ErbB4 isoforms selectively regulate growth factor induced Madin-Darby canine kidney cell tubulogenesis. Mol Biol Cell (2007) 1.00
Extracellular matrix receptors in branched organs. Curr Opin Cell Biol (2011) 0.98
Integrins: sensors of extracellular matrix and modulators of cell function. Nephron Exp Nephrol (2003) 0.98
Distinct roles for basal and induced COX-2 in podocyte injury. J Am Soc Nephrol (2009) 0.98
The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1. FEBS Lett (2009) 0.98
Integrin-dependent PLC-gamma1 phosphorylation mediates fibronectin-dependent adhesion. J Cell Sci (2005) 0.98
C5a-mediated neutrophil dysfunction is RhoA-dependent and predicts infection in critically ill patients. Blood (2011) 0.98
The epithelial cell and lung cancer: the link between chronic obstructive pulmonary disease and lung cancer. Respiration (2011) 0.98
Membrane-associated HB-EGF modulates HGF-induced cellular responses in MDCK cells. J Cell Sci (2004) 0.97
Functional analysis of the cytoplasmic domain of the integrin {alpha}1 subunit in endothelial cells. Blood (2008) 0.97