Published in Oncogene on October 18, 2004
Molecular aspects of thyroid hormone actions. Endocr Rev (2010) 3.29
B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progression. Proc Natl Acad Sci U S A (2010) 2.10
STAT3 signaling: anticancer strategies and challenges. Mol Interv (2011) 1.95
The role of adiponectin in cancer: a review of current evidence. Endocr Rev (2012) 1.78
A unique platform for H-Ras signaling involving clathrin-independent endocytosis. Mol Biol Cell (2007) 1.73
A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction. Aging (Albany NY) (2010) 1.70
Nonreceptor tyrosine kinases in prostate cancer. Neoplasia (2007) 1.50
An essential role for SRC-activated STAT-3 in 14,15-EET-induced VEGF expression and angiogenesis. Blood (2008) 1.46
Antiangiogenic and antitumor effects of SRC inhibition in ovarian carcinoma. Cancer Res (2006) 1.38
Signal transduction in pancreatic stellate cells. J Gastroenterol (2009) 1.36
Microenvironment and pathogenesis of epithelial ovarian cancer. Horm Cancer (2010) 1.30
Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6. Breast Cancer Res (2007) 1.27
Epidermal growth factor receptor inhibition in lung cancer: the evolving role of individualized therapy. Cancer Metastasis Rev (2010) 1.26
STAT3 can serve as a hit in the process of malignant transformation of primary cells. Cell Death Differ (2012) 1.24
ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression. Oncogene (2008) 1.21
Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer. Mol Syst Biol (2014) 1.21
Src-dependent STAT-3-mediated expression of monocyte chemoattractant protein-1 is required for 15(S)-hydroxyeicosatetraenoic acid-induced vascular smooth muscle cell migration. J Biol Chem (2009) 1.20
In vivo identification of novel STAT5 target genes. Nucleic Acids Res (2008) 1.19
Frequent genetic abnormalities of the PI3K/AKT pathway in primary ovarian cancer predict patient outcome. Genes Chromosomes Cancer (2011) 1.18
Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention. Cancers (Basel) (2014) 1.17
The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancer-associated EGF receptor mutants. Oncogene (2009) 1.16
The C-kit receptor-mediated signal transduction and tumor-related diseases. Int J Biol Sci (2013) 1.13
Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer. Oncogene (2014) 1.11
Pre-treatment of recombinant mouse MFG-E8 downregulates LPS-induced TNF-α production in macrophages via STAT3-mediated SOCS3 activation. PLoS One (2011) 1.10
Characterization of STAT3 activation and expression in canine and human osteosarcoma. BMC Cancer (2009) 1.10
ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells. Mol Cancer Res (2009) 1.09
Substance P stimulates cyclooxygenase-2 and prostaglandin E2 expression through JAK-STAT activation in human colonic epithelial cells. J Immunol (2006) 1.08
A STAT3-decoy oligonucleotide induces cell death in a human colorectal carcinoma cell line by blocking nuclear transfer of STAT3 and STAT3-bound NF-κB. BMC Cell Biol (2011) 1.07
Lyn kinase promotes erythroblast expansion and late-stage development. Blood (2006) 1.06
Protein-tyrosine phosphatase PTPN9 negatively regulates ErbB2 and epidermal growth factor receptor signaling in breast cancer cells. J Biol Chem (2010) 1.05
Signal transducers and activators of transcription mediate fibroblast growth factor-induced vascular endothelial morphogenesis. Cancer Res (2009) 1.04
Targeting JAK kinase in solid tumors: emerging opportunities and challenges. Oncogene (2015) 1.03
Nucleic acid-based approaches to STAT inhibition. JAKSTAT (2012) 1.02
STAT3 and cardiac remodeling. Heart Fail Rev (2011) 1.01
Signal transducer and activator of transcription 5 as a key signaling pathway in normal mammary gland developmental biology and breast cancer. Breast Cancer Res (2011) 1.01
The diverse functions of Src family kinases in macrophages. Front Biosci (2008) 1.01
STAT5A-mediated SOCS2 expression regulates Jak2 and STAT3 activity following c-Src inhibition in head and neck squamous carcinoma. Clin Cancer Res (2011) 0.99
Identification of a Src tyrosine kinase/SIAH2 E3 ubiquitin ligase pathway that regulates C/EBPδ expression and contributes to transformation of breast tumor cells. Mol Cell Biol (2011) 0.97
Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening. Cell Death Dis (2014) 0.97
The human splice variant Δ16HER2 induces rapid tumor onset in a reporter transgenic mouse. PLoS One (2011) 0.97
Randomized, Double-Blind, Phase II Study of Ruxolitinib or Placebo in Combination With Capecitabine in Patients With Metastatic Pancreatic Cancer for Whom Therapy With Gemcitabine Has Failed. J Clin Oncol (2015) 0.97
The prostaglandin E2 receptor, EP2, stimulates keratinocyte proliferation in mouse skin by G protein-dependent and {beta}-arrestin1-dependent signaling pathways. J Biol Chem (2010) 0.96
Hepatitis C virus network based classification of hepatocellular cirrhosis and carcinoma. PLoS One (2012) 0.96
Apoptosis Induced by Tanshinone IIA and Cryptotanshinone Is Mediated by Distinct JAK/STAT3/5 and SHP1/2 Signaling in Chronic Myeloid Leukemia K562 Cells. Evid Based Complement Alternat Med (2013) 0.92
High-content pSTAT3/1 imaging assays to screen for selective inhibitors of STAT3 pathway activation in head and neck cancer cell lines. Assay Drug Dev Technol (2013) 0.91
The Multifaceted Roles of STAT3 Signaling in the Progression of Prostate Cancer. Cancers (Basel) (2014) 0.91
Targeting Stat3 and Smad7 to restore TGF-β cytostatic regulation of tumor cells in vitro and in vivo. Oncogene (2012) 0.90
Epidermal growth factor receptor signaling pathway is frequently altered in ampullary carcinoma at protein and genetic levels. Mod Pathol (2013) 0.89
Molecular mechanisms of estrogen receptors' suppression of lipogenesis in pancreatic β-cells. Endocrinology (2012) 0.88
Nuclear EGFRvIII-STAT5b complex contributes to glioblastoma cell survival by direct activation of the Bcl-XL promoter. Int J Cancer (2012) 0.88
STAT3 interrupts ATR-Chk1 signaling to allow oncovirus-mediated cell proliferation. Proc Natl Acad Sci U S A (2014) 0.87
Trefoil factor 3 promotes metastatic seeding and predicts poor survival outcome of patients with mammary carcinoma. Breast Cancer Res (2014) 0.87
Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling. Mol Oncol (2012) 0.86
Direct activation of STAT5 by ETV6-LYN fusion protein promotes induction of myeloproliferative neoplasm with myelofibrosis. Br J Haematol (2011) 0.86
STAT3 signaling is induced by intercellular adhesion in squamous cell carcinoma cells. Exp Cell Res (2007) 0.85
STAT3 mutations are present in aggressive B-cell lymphomas including a subset of diffuse large B-cell lymphomas with CD30 expression. Haematologica (2014) 0.85
A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway. Oncotarget (2016) 0.85
Phase I study of OPB-51602, an oral inhibitor of signal transducer and activator of transcription 3, in patients with relapsed/refractory hematological malignancies. Cancer Sci (2015) 0.84
STAT5A/B gene locus undergoes amplification during human prostate cancer progression. Am J Pathol (2013) 0.84
Unremitting cell proliferation in the secretory phase of eutopic endometriosis: involvement of pAkt and pGSK3β. Reprod Sci (2014) 0.84
Characterization of STAT3 expression, signaling and inhibition in feline oral squamous cell carcinoma. BMC Vet Res (2015) 0.84
Prolactin-growth factor crosstalk reduces mammary estrogen responsiveness despite elevated ERalpha expression. Am J Pathol (2009) 0.83
Areca nut components stimulate ADAM17, IL-1α, PGE2 and 8-isoprostane production in oral keratinocyte: role of reactive oxygen species, EGF and JAK signaling. Oncotarget (2016) 0.83
Significance and relationship between Cripto-1 and p-STAT3 expression in gastric cancer and precancerous lesions. World J Gastroenterol (2010) 0.82
A switch role of Src in the biphasic EGF signaling of ER-negative breast cancer cells. PLoS One (2012) 0.82
High speed digital protein interaction analysis using microfluidic single molecule detection system. Lab Chip (2010) 0.82
STAT3 in the systemic inflammation of cancer cachexia. Semin Cell Dev Biol (2016) 0.82
p53 regulation of podosome formation and cellular invasion in vascular smooth muscle cells. Cell Adh Migr (2011) 0.82
mTOR signaling feedback modulates mammary epithelial differentiation and restrains invasion downstream of PTEN loss. Cancer Res (2013) 0.82
S731 in the transactivation domain modulates STAT5b activity. Biochem Biophys Res Commun (2007) 0.81
Nexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutants. World J Clin Oncol (2014) 0.81
Autocrine-derived epidermal growth factor receptor ligands contribute to recruitment of tumor-associated macrophage and growth of basal breast cancer cells in vivo. Oncol Res (2013) 0.80
STAT-Related Profiles Are Associated with Patient Response to Targeted Treatments in Locally Advanced SCCHN. Transl Oncol (2011) 0.79
Role of STAT3 pathway in genitourinary tumors. Future Sci OA (2015) 0.79
GBF-dependent family genes morphologically suppress the partially active Dictyostelium STATa strain. Dev Genes Evol (2008) 0.78
Rapid detection of two-protein interaction with a single fluorophore by using a microfluidic device. Analyst (2010) 0.78
Cucurbitacin I blocks cerebrospinal fluid and platelet derived growth factor-BB stimulation of leptomeningeal and meningioma DNA synthesis. BMC Complement Altern Med (2013) 0.78
Overexpression of Bcl-2 induces STAT-3 activation via an increase in mitochondrial superoxide. Oncotarget (2015) 0.78
Role of Src family kinases in regulation of intestinal epithelial homeostasis. Mol Cell Biol (2016) 0.78
Cripto-1 Ablation Disrupts Alveolar Development in the Mouse Mammary Gland through a Progesterone Receptor-Mediated Pathway. Am J Pathol (2015) 0.77
Gallic acid inhibition of Src-Stat3 signaling overcomes acquired resistance to EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer. Oncotarget (2016) 0.77
The NADPH Oxidases DUOX1 and NOX2 Play Distinct Roles in Redox Regulation of Epidermal Growth Factor Receptor Signaling. J Biol Chem (2016) 0.77
Molecular characterization of c-Abl/c-Src kinase inhibitors targeted against murine tumour progenitor cells that express stem cell markers. PLoS One (2010) 0.77
Transcriptome analysis of Wnt3a-treated triple-negative breast cancer cells. PLoS One (2015) 0.76
TOM1L is involved in a novel signaling pathway important for the IL-2 production in Jurkat T cells stimulated by CD3/CD28 co-ligation. Mediators Inflamm (2010) 0.76
Src family kinases interfere with dimerization of STAT5A through a phosphotyrosine-SH2 domain interaction. Cell Commun Signal (2015) 0.76
Polymorphisms in innate immunity genes and risk of childhood leukemia. Hum Immunol (2010) 0.76
c-Src tyrosine kinase co-associates with and phosphorylates signal transducer and activator of transcription 5b which mediates the proliferation of normal human B lymphocytes. Clin Exp Immunol (2009) 0.75
Tumor growth suppressive effect of IL-4 through p21-mediated activation of STAT6 in IL-4Rα overexpressed melanoma models. Oncotarget (2016) 0.75
In vivo and in vitro estrogenic and progestagenic actions of Tibolone. Biol Res (2005) 0.75
Increased thrombosis susceptibility and altered fibrin formation in STAT5-deficient mice. Blood (2010) 0.75
Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation. Biol Reprod (2016) 0.75
A Central Role for STAT3 in Gammaherpesvirus-Life Cycle and -Diseases. Front Microbiol (2016) 0.75
Jak1-STAT3 Signals Are Essential Effectors of the USP6/TRE17 Oncogene in Tumorigenesis. Cancer Res (2016) 0.75
Tumor-suppressor activity of RRIG1 in breast cancer. BMC Cancer (2011) 0.75
Cytotoxicity of the Sesquiterpene Lactones Neoambrosin and Damsin from Ambrosia maritima Against Multidrug-Resistant Cancer Cells. Front Pharmacol (2015) 0.75
The Rho guanine nucleotide exchange factor ARHGEF5 promotes tumor malignancy via epithelial-mesenchymal transition. Oncogenesis (2016) 0.75
Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget (2016) 0.75