Published in Breast Cancer Res on January 01, 2007
Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRK. Biochim Biophys Acta (2010) 1.32
STAT inhibitors for cancer therapy. J Hematol Oncol (2013) 1.16
PTK6 regulates IGF-1-induced anchorage-independent survival. PLoS One (2010) 1.15
Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells. Breast Cancer Res (2010) 1.14
Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT. Oncogene (2012) 1.13
Prognostic value of protein tyrosine kinase 6 (PTK6) for long-term survival of breast cancer patients. Br J Cancer (2008) 1.09
Brk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transition. Cancer Biol Ther (2013) 1.06
Brk/PTK6 signaling in normal and cancer cell models. Curr Opin Pharmacol (2010) 1.02
Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR. Oncogene (2012) 1.02
Mechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progression. Horm Cancer (2012) 0.99
PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1. J Biol Chem (2010) 0.97
Safe and targeted anticancer efficacy of a novel class of antioxidant-conjugated difluorodiarylidenyl piperidones: differential cytotoxicity in healthy and cancer cells. Free Radic Biol Med (2010) 0.97
Cytoplasmic retention of protein tyrosine kinase 6 promotes growth of prostate tumor cells. Cell Cycle (2010) 0.95
Protein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrate. J Biol Chem (2011) 0.94
In situ quantification of HER2-protein tyrosine kinase 6 (PTK6) protein-protein complexes in paraffin sections from breast cancer tissues. Br J Cancer (2010) 0.94
Disruption of the mouse protein tyrosine kinase 6 gene prevents STAT3 activation and confers resistance to azoxymethane. Gastroenterology (2011) 0.90
Methylsulfonylmethane suppresses breast cancer growth by down-regulating STAT3 and STAT5b pathways. PLoS One (2012) 0.90
Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK. Breast Cancer Res (2011) 0.90
RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK. Cell Cycle (2009) 0.90
A novel role for signal transducer and activator of transcription 5b (STAT5b) in beta1-integrin-mediated human breast cancer cell migration. Breast Cancer Res (2009) 0.88
Context-specific protein tyrosine kinase 6 (PTK6) signalling in prostate cancer. Eur J Clin Invest (2013) 0.86
Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells. J Biol Chem (2010) 0.86
Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models. Oncogenesis (2013) 0.85
PTK6 inhibition promotes apoptosis of Lapatinib-resistant Her2(+) breast cancer cells by inducing Bim. Breast Cancer Res (2015) 0.83
Resveratrol attenuates constitutive STAT3 and STAT5 activation through induction of PTPε and SHP-2 tyrosine phosphatases and potentiates sorafenib-induced apoptosis in renal cell carcinoma. BMC Nephrol (2016) 0.82
Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3. J Biol Chem (2012) 0.82
BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration. PLoS One (2014) 0.81
S731 in the transactivation domain modulates STAT5b activity. Biochem Biophys Res Commun (2007) 0.81
The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts. BMC Cancer (2015) 0.78
Evolution of breast cancer therapeutics: Breast tumour kinase's role in breast cancer and hope for breast tumour kinase targeted therapy. World J Clin Oncol (2014) 0.77
Targeted proteomic approach in prostatic tissue: a panel of potential biomarkers for cancer detection. Oncoscience (2016) 0.75
Enabling dynamic network analysis through visualization in TVNViewer. BMC Bioinformatics (2012) 0.75
Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol (2002) 15.33
The STATs of cancer--new molecular targets come of age. Nat Rev Cancer (2004) 13.07
STATs in oncogenesis. Oncogene (2000) 8.60
Transcription factors as targets for cancer therapy. Nat Rev Cancer (2002) 7.27
Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res (2002) 5.84
STAT proteins and transcriptional responses to extracellular signals. Trends Biochem Sci (2000) 2.60
Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis. Oncogene (2004) 2.52
ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases. J Biol Chem (1999) 2.41
Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin. Mol Cell Biol (2004) 1.88
Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck. J Biol Chem (2003) 1.88
Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation. Mol Endocrinol (1996) 1.86
BRK tyrosine kinase expression in a high proportion of human breast carcinomas. Oncogene (1997) 1.77
Stat5 promotes homotypic adhesion and inhibits invasive characteristics of human breast cancer cells. Oncogene (2005) 1.76
Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells. Cancer Res (2007) 1.75
Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours. Oncogene (1994) 1.75
STAT5b, a Mediator of Synergism between c-Src and the Epidermal Growth Factor Receptor. J Biol Chem (2002) 1.60
BRK/Sik expression in the gastrointestinal tract and in colon tumors. Clin Cancer Res (1999) 1.59
Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor. J Biol Chem (1996) 1.56
Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation. Oncogene (2000) 1.48
Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression. J Biol Chem (2005) 1.47
Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases. Oncol Res (2003) 1.45
Identification of STAT3 as a specific substrate of breast tumor kinase. Oncogene (2006) 1.40
The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2. J Biol Chem (2004) 1.36
Elevated expression levels of NCOA3, TOP1, and TFAP2C in breast tumors as predictors of poor prognosis. Cancer (2003) 1.35
PTK (protein tyrosine kinase)-6 and HER2 and 4, but not HER1 and 3 predict long-term survival in breast carcinomas. Br J Cancer (2007) 1.34
Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition. J Biol Chem (2002) 1.31
Constitutive activation of Stat5b contributes to carcinogenesis in vivo. Cancer Res (2003) 1.30
Signal transducers and activators of transcription as regulators of growth, apoptosis and breast development. Breast Cancer Res (2000) 1.30
Simultaneous over-expression of the Her2/neu and PTK6 tyrosine kinases in archival invasive ductal breast carcinomas. J Pathol (2005) 1.30
Use of RNA interference to validate Brk as a novel therapeutic target in breast cancer: Brk promotes breast carcinoma cell proliferation. Oncogene (2003) 1.27
Erythropoietin stimulates growth and STAT5 phosphorylation in human prostate epithelial and prostate cancer cells. Prostate (2006) 1.09
A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK. Oncogene (2000) 1.07
Extracellular signal-regulated kinase 7, a regulator of hormone-dependent estrogen receptor destruction. Mol Cell Biol (2003) 1.03
Signal transduction pathways regulated by prolactin and Src result in different conformations of activated Stat5b. J Biol Chem (2003) 1.01
Novel activation of STAT5b in response to epidermal growth factor. J Biol Chem (2001) 0.99
Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes. Am J Pathol (2006) 0.97
Modulation of signal transducer and activator of transcription 5b activity in breast cancer cells by mutation of tyrosines within the transactivation domain. Mol Endocrinol (2006) 0.96
Estrogen negatively regulates epidermal growth factor (EGF)-mediated signal transducer and activator of transcription 5 signaling in human EGF family receptor-overexpressing breast cancer cells. Mol Endocrinol (2005) 0.95
Solution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domain. J Biol Chem (2004) 0.83
Characterization of the 5'-flanking region of the human PTK6 gene. Biochim Biophys Acta (2002) 0.79
STAT5b, a Mediator of Synergism between c-Src and the Epidermal Growth Factor Receptor. J Biol Chem (2002) 1.60
Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator. J Biol Chem (2005) 1.29
Transactivating agonists of the EGF receptor require Tyr 845 phosphorylation for induction of DNA synthesis. Mol Carcinog (2005) 1.27
Signal transducer and activator of transcription 5b, c-Src, and epidermal growth factor receptor signaling play integral roles in estrogen-stimulated proliferation of estrogen receptor-positive breast cancer cells. Mol Endocrinol (2008) 1.20
STAT6 expression in glioblastoma promotes invasive growth. BMC Cancer (2011) 1.05
Novel activation of STAT5b in response to epidermal growth factor. J Biol Chem (2001) 0.99
Modulation of signal transducer and activator of transcription 5b activity in breast cancer cells by mutation of tyrosines within the transactivation domain. Mol Endocrinol (2006) 0.96
Estrogen negatively regulates epidermal growth factor (EGF)-mediated signal transducer and activator of transcription 5 signaling in human EGF family receptor-overexpressing breast cancer cells. Mol Endocrinol (2005) 0.95
A novel role for signal transducer and activator of transcription 5b (STAT5b) in beta1-integrin-mediated human breast cancer cell migration. Breast Cancer Res (2009) 0.88
S731 in the transactivation domain modulates STAT5b activity. Biochem Biophys Res Commun (2007) 0.81
A mechanistic study of the effect of doxorubicin/adriamycin on the estrogen response in a breast cancer model. Oncology (2012) 0.76
Growth hormone signal transduction and possible defects in children. J Pediatr Endocrinol Metab (2002) 0.75