Published in J Biol Chem on October 19, 2004
Macromolecular crowding and confinement: biochemical, biophysical, and potential physiological consequences. Annu Rev Biophys (2008) 7.77
Crowded, cell-like environment induces shape changes in aspherical protein. Proc Natl Acad Sci U S A (2008) 1.95
Attractive protein-polymer interactions markedly alter the effect of macromolecular crowding on protein association equilibria. Biophys J (2010) 1.30
The effects of macromolecular crowding on the mechanical stability of protein molecules. Protein Sci (2008) 1.12
Effect of mixed macromolecular crowding agents on protein folding. Proteins (2008) 1.11
Crowded cell-like environment accelerates the nucleation step of amyloidogenic protein misfolding. J Biol Chem (2009) 1.01
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The contrasting effect of macromolecular crowding on amyloid fibril formation. PLoS One (2012) 0.90
Serum albumin prevents protein aggregation and amyloid formation and retains chaperone-like activity in the presence of physiological ligands. J Biol Chem (2012) 0.90
Fibril formation of the rabbit/human/bovine prion proteins. Biophys J (2011) 0.87
Protein self-association in the cell: a mechanism for fine tuning the level of macromolecular crowding? Eur Biophys J (2005) 0.86
Understanding how the crowded interior of cells stabilizes DNA/DNA and DNA/RNA hybrids-in silico predictions and in vitro evidence. Nucleic Acids Res (2009) 0.82
The stability and formation of native proteins from unfolded monomers is increased through interactions with unrelated proteins. PLoS One (2007) 0.82
Chaperone-like effect of the linker on the isolated C-terminal domain of rabbit muscle creatine kinase. Biophys J (2012) 0.81
Cupric ions induce the oxidation and trigger the aggregation of human superoxide dismutase 1. PLoS One (2013) 0.77
The role of crowded physiological environments in prion and prion-like protein aggregation. Int J Mol Sci (2013) 0.75
Hydration shells of molecules in molecular association: A mechanism for biomolecular recognition. J Theor Biol (2012) 0.75
Oxidative folding of hirudin in human serum. Biochem J (2006) 0.75
WEGO: a web tool for plotting GO annotations. Nucleic Acids Res (2006) 13.06
MMDB: annotating protein sequences with Entrez's 3D-structure database. Nucleic Acids Res (2006) 7.57
A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms. Nature (2004) 5.24
MMDB: Entrez's 3D-structure database. Nucleic Acids Res (2002) 4.42
Sequence and analysis of rice chromosome 4. Nature (2002) 4.39
Clinical analyses of clustered microcalcifications after autologous fat injection for breast augmentation. Plast Reconstr Surg (2011) 3.96
Probing cellular protein complexes using single-molecule pull-down. Nature (2011) 3.92
Preferential occupancy of histone variant H2AZ at inactive promoters influences local histone modifications and chromatin remodeling. Proc Natl Acad Sci U S A (2005) 3.72
Aegilops tauschii draft genome sequence reveals a gene repertoire for wheat adaptation. Nature (2013) 3.40
Drug-eluting or bare-metal stents for acute myocardial infarction. N Engl J Med (2008) 3.29
A complex oscillating network of signaling genes underlies the mouse segmentation clock. Science (2006) 3.27
Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis. Blood (2002) 3.21
Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet (2010) 2.95
Proportion of different subtypes of stroke in China. Stroke (2003) 2.90
Draft genome of the wheat A-genome progenitor Triticum urartu. Nature (2013) 2.86
regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis. Diabetes (2004) 2.64
Solubility trapping in formation water as dominant CO(2) sink in natural gas fields. Nature (2009) 2.57
SilkDB: a knowledgebase for silkworm biology and genomics. Nucleic Acids Res (2005) 2.50
C. elegans Dynamin mediates the signaling of phagocytic receptor CED-1 for the engulfment and degradation of apoptotic cells. Dev Cell (2006) 2.41
Pharmacokinetics, safety and efficacy of lopinavir/ritonavir in infants less than 6 months of age: 24 week results. AIDS (2008) 2.35
Qualitative and quantitative assessment of meningococcal antigens to evaluate the potential strain coverage of protein-based vaccines. Proc Natl Acad Sci U S A (2010) 2.30
New direction in PACS education and training. Comput Med Imaging Graph (2003) 2.29
Detecting periodic patterns in unevenly spaced gene expression time series using Lomb-Scargle periodograms. Bioinformatics (2005) 2.22
Rapid transmission of hepatitis C virus among young injecting heroin users in Southern China. Int J Epidemiol (2004) 2.19
MMDB: 3D structures and macromolecular interactions. Nucleic Acids Res (2011) 2.06
Mining compact bag-of-patterns for low bit rate mobile visual search. IEEE Trans Image Process (2014) 2.05
Gastric intestinal metaplasia with basal gland atypia: a morphological and biologic evaluation in a large Chinese cohort. Hum Pathol (2012) 2.04
Pancreatic neuroendocrine tumors: the impact of surgical resection on survival. Cancer (2009) 2.01
miRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic cancer. Cancer Res (2010) 1.99
Early archiving and predominance of nonnucleoside reverse transcriptase inhibitor-resistant HIV-1 among recently infected infants born in the United States. J Infect Dis (2007) 1.96
[Dynamic simulation of nitrogen application level effects on rice yield and optimization analysis of fertilizer supply in paddy field]. Ying Yong Sheng Tai Xue Bao (2003) 1.93
Direct health care insurer and out-of-pocket expenditures of inflammatory bowel disease: evidence from a US national survey. Dig Dis Sci (2012) 1.93
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nat Med (2012) 1.87
A protein folding pathway with multiple folding intermediates at atomic resolution. Proc Natl Acad Sci U S A (2005) 1.82
Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization. Nat Cell Biol (2009) 1.80
Platelet-to-lymphocyte ratio acts as a prognostic factor for patients with advanced hepatocellular carcinoma. Tumour Biol (2014) 1.71
A powerful method combining homologous recombination and site-specific recombination for targeted mutagenesis in Drosophila. Proc Natl Acad Sci U S A (2008) 1.69
Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin. Nature (2012) 1.69
The draft genome of the fast-growing non-timber forest species moso bamboo (Phyllostachys heterocycla). Nat Genet (2013) 1.68
Phagocytic receptor CED-1 initiates a signaling pathway for degrading engulfed apoptotic cells. PLoS Biol (2008) 1.68
Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase. J Biol Chem (2010) 1.68
Long-term clinical outcomes after drug-eluting and bare-metal stenting in Massachusetts. Circulation (2008) 1.68
The miR-217 microRNA functions as a potential tumor suppressor in pancreatic ductal adenocarcinoma by targeting KRAS. Carcinogenesis (2010) 1.65
miR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2. Cancer Lett (2010) 1.64
Mammalian target of rapamycin regulates miRNA-1 and follistatin in skeletal myogenesis. J Cell Biol (2010) 1.63
mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells. Proc Natl Acad Sci U S A (2009) 1.63
Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis. Blood (2010) 1.63
PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1. Curr Biol (2003) 1.62
Does the center of resistance depend on the direction of tooth movement? Am J Orthod Dentofacial Orthop (2010) 1.62
IGF-II is regulated by microRNA-125b in skeletal myogenesis. J Cell Biol (2011) 1.62
Duration of rapamycin treatment has differential effects on metabolism in mice. Cell Metab (2013) 1.61
Lentiviral-mediated miRNA against osteopontin suppresses tumor growth and metastasis of human hepatocellular carcinoma. Hepatology (2008) 1.61
15N NMR spin relaxation dispersion study of the molecular crowding effects on protein folding under native conditions. J Am Chem Soc (2006) 1.60
Enhancement of radiation cytotoxicity in breast-cancer cells by localized attachment of gold nanoparticles. Small (2008) 1.60
Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins. Biochem J (2011) 1.59
Animal models of idiosyncratic drug reactions. Chem Biol Interact (2004) 1.59
Gold nanoparticle sensitize radiotherapy of prostate cancer cells by regulation of the cell cycle. Nanotechnology (2009) 1.58
Two PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cells. PLoS Biol (2012) 1.57
Dietary arginine supplementation attenuates renal damage after relief of unilateral ureteral obstruction in rats. Kidney Int (2005) 1.57
IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients. J Cell Biol (2003) 1.56
Constitutive androstane receptor and pregnane X receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels. Drug Metab Dispos (2003) 1.56
Saliva microbiomes distinguish caries-active from healthy human populations. ISME J (2011) 1.55
Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway. J Biol Chem (2007) 1.55
Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor. Nat Neurosci (2009) 1.54
Pulp revascularization of immature teeth with apical periodontitis: a clinical study. J Endod (2009) 1.54
Distribution of lymphoid neoplasms in China: analysis of 4,638 cases according to the World Health Organization classification. Am J Clin Pathol (2012) 1.53
Reconstitution of human Ero1-Lalpha/protein-disulfide isomerase oxidative folding pathway in vitro. Position-dependent differences in role between the a and a' domains of protein-disulfide isomerase. J Biol Chem (2008) 1.53
Coinfection with HIV and hepatitis C virus among injection drug users in southern China. Clin Infect Dis (2005) 1.52
Tetraalkylammonium amino acids as functionalized ionic liquids of low viscosity. Chem Commun (Camb) (2007) 1.51
Higher percentage of CD133+ cells is associated with poor prognosis in colon carcinoma patients with stage IIIB. J Transl Med (2009) 1.48
Networked data fusion with packet losses and variable delays. IEEE Trans Syst Man Cybern B Cybern (2009) 1.48
mTOR signaling: PLD takes center stage. Cell Cycle (2008) 1.47
Involvement of p38 mitogen-activated protein kinase pathway in honokiol-induced apoptosis in a human hepatoma cell line (hepG2). Liver Int (2008) 1.47
Comparison of current staging systems for advanced hepatocellular carcinoma not amendable to locoregional therapy as inclusion criteria for clinical trials. Asia Pac J Clin Oncol (2012) 1.47
Molecular footprints of domestication and improvement in soybean revealed by whole genome re-sequencing. BMC Genomics (2013) 1.46
Clinical research of Olanzapine for prevention of chemotherapy-induced nausea and vomiting. J Exp Clin Cancer Res (2009) 1.45
Nanoscale X-ray microscopic imaging of mammalian mineralized tissue. Microsc Microanal (2010) 1.45
ChickVD: a sequence variation database for the chicken genome. Nucleic Acids Res (2005) 1.45
Comparative efficacy of postoperative transarterial chemoembolization with or without antiviral therapy for hepatitis B virus-related hepatocellular carcinoma. Tumour Biol (2015) 1.45
Trends in atrial fibrillation complicating acute myocardial infarction. Am J Cardiol (2009) 1.45
Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity. Mol Cell Biol (2002) 1.44
Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope. EMBO J (2002) 1.42
The potential role of a self-management intervention for benign prostate hyperplasia. Urology (2012) 1.42
Use of preventive care services among Latino subgroups. Am J Prev Med (2010) 1.42
Two phase transitions of poly(N-isopropylacrylamide) brushes bound to gold nanoparticles. Langmuir (2004) 1.41
Nitric oxide-donating nonsteroidal anti-inflammatory drugs inhibit the growth of various cultured human cancer cells: evidence of a tissue type-independent effect. J Pharmacol Exp Ther (2002) 1.41
Cooperation between engulfment receptors: the case of ABCA1 and MEGF10. PLoS One (2006) 1.41
Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. PLoS Pathog (2010) 1.40
mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms. Am J Physiol Cell Physiol (2009) 1.40
GCN5 and E2F1 stimulate nucleotide excision repair by promoting H3K9 acetylation at sites of damage. Nucleic Acids Res (2010) 1.39
Physiological mechanisms underlying OsNAC5-dependent tolerance of rice plants to abiotic stress. Planta (2011) 1.39
Removal of Cr(VI) and Cr(lll) from aqueous solutions and industrial wastewaters by natural clino-pyrrhotite. Environ Sci Technol (2006) 1.39
A phosphatidylinositol 3-kinase/protein kinase B-independent activation of mammalian target of rapamycin signaling is sufficient to induce skeletal muscle hypertrophy. Mol Biol Cell (2010) 1.38
MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways. Cancer Lett (2013) 1.38
Clearance of apoptotic cells in Caenorhabditis elegans. Semin Cell Dev Biol (2005) 1.38
Interleukin-33 ameliorates experimental colitis through promoting Th2/Foxp3⁺ regulatory T-cell responses in mice. Mol Med (2012) 1.37
Correlation between local stress and strain and lamina cribrosa connective tissue volume fraction in normal monkey eyes. Invest Ophthalmol Vis Sci (2009) 1.37
A HIPAA-compliant architecture for securing clinical images. J Digit Imaging (2006) 1.37
Panorama phylogenetic diversity and distribution of Type A influenza virus. PLoS One (2009) 1.34
Molecular epidemiology of HIV-1 subtypes in southern China. J Acquir Immune Defic Syndr (2005) 1.33