Published in Life Sci on November 19, 2004
An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss. Genome Biol (2015) 1.19
Dehydroepiandrosterone protects against oxidative stress-induced endothelial dysfunction in ovariectomized rats. J Physiol (2011) 0.91
Diabetes alters vascular mechanotransduction: pressure-induced regulation of mitogen activated protein kinases in the rat inferior vena cava. Cardiovasc Diabetol (2006) 0.86
DHEA supplementation in ovariectomized rats reduces impaired glucose-stimulated insulin secretion induced by a high-fat diet. FEBS Open Bio (2014) 0.85
Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans. Aging (Albany NY) (2011) 0.84
Activation of p38MAPK contributes to expanded polyglutamine-induced cytotoxicity. PLoS One (2008) 0.77
Dehydroepiandrosterone Supplementation Combined with Whole-Body Vibration Training Affects Testosterone Level and Body Composition in Mice. Int J Med Sci (2016) 0.75
Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology (2005) 4.35
Endoplasmic reticulum stress, obesity and diabetes. Trends Mol Med (2011) 1.95
Retracted Deletion of tumor necrosis factor-alpha receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis. J Biol Chem (2009) 1.88
High-fat diet induces apoptosis of hypothalamic neurons. PLoS One (2009) 1.73
Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity. PLoS One (2012) 1.47
Interleukin-10 is a protective factor against diet-induced insulin resistance in liver. J Hepatol (2008) 1.47
Pancreatic beta-cells express phagocyte-like NAD(P)H oxidase. Diabetes (2003) 1.46
Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver. Diabetes (2012) 1.27
RhoA/ROCK signaling is critical to FAK activation by cyclic stretch in cardiac myocytes. Am J Physiol Heart Circ Physiol (2005) 1.25
The thymus is a common target in malnutrition and infection. Br J Nutr (2007) 1.22
Novel signal transduction pathway for luteinizing hormone and its interaction with insulin: activation of Janus kinase/signal transducer and activator of transcription and phosphoinositol 3-kinase/Akt pathways. Endocrinology (2003) 1.18
Antiobesity effects of yerba maté extract (Ilex paraguariensis) in high-fat diet-induced obese mice. Obesity (Silver Spring) (2009) 1.15
Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance. Endocrinology (2013) 1.15
Maternal high-fat feeding through pregnancy and lactation predisposes mouse offspring to molecular insulin resistance and fatty liver. J Nutr Biochem (2011) 1.15
Low-grade hypothalamic inflammation leads to defective thermogenesis, insulin resistance, and impaired insulin secretion. Endocrinology (2011) 1.12
Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the phosphatidylinositol 3-kinase/Akt-1 pathway. Eur J Endocrinol (2002) 1.10
Oxidative stress and inflammatory mediators contribute to endothelial dysfunction in high-fat diet-induced obesity in mice. J Hypertens (2010) 1.10
New insights into fatty acid modulation of pancreatic beta-cell function. Int Rev Cytol (2006) 1.06
Obesity induced by high-fat diet promotes insulin resistance in the ovary. J Endocrinol (2010) 1.03
UPR induces transient burst of apoptosis in islets of early lactating rats through reduced AKT phosphorylation via ATF4/CHOP stimulation of TRB3 expression. Am J Physiol Regul Integr Comp Physiol (2010) 1.02
Retracted Chaperone insufficiency links TLR4 protein signaling to endoplasmic reticulum stress. J Biol Chem (2012) 1.01
The crosstalk between insulin and renin-angiotensin-aldosterone signaling systems and its effect on glucose metabolism and diabetes prevention. Curr Vasc Pharmacol (2008) 1.00
Hypothalamic actions of tumor necrosis factor alpha provide the thermogenic core for the wastage syndrome in cachexia. Endocrinology (2009) 0.98
Central leptin action improves skeletal muscle AKT, AMPK, and PGC1 alpha activation by hypothalamic PI3K-dependent mechanism. Mol Cell Endocrinol (2009) 0.97
Partial reversibility of hypothalamic dysfunction and changes in brain activity after body mass reduction in obese subjects. Diabetes (2011) 0.93
Neuroendocrine body weight regulation: integration between fat tissue, gastrointestinal tract, and the brain. Endokrynol Pol (2010) 0.92
Quercetin decreases inflammatory response and increases insulin action in skeletal muscle of ob/ob mice and in L6 myotubes. Eur J Pharmacol (2012) 0.92
Fructose-induced hypothalamic AMPK activation stimulates hepatic PEPCK and gluconeogenesis due to increased corticosterone levels. Endocrinology (2012) 0.91
Concern Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats. J Physiol (2009) 0.91
Tumor necrosis factor-alpha activates signal transduction in hypothalamus and modulates the expression of pro-inflammatory proteins and orexigenic/anorexigenic neurotransmitters. J Neurochem (2006) 0.90
Melatonin improves insulin sensitivity independently of weight loss in old obese rats. J Pineal Res (2013) 0.89
Up-regulation of the phosphatidylinositol 3-kinase/protein kinase B pathway in the ovary of rats by chronic treatment with hCG and insulin. J Endocrinol (2006) 0.88
Disruption of metabolic pathways--perspectives for the treatment of cancer. Curr Cancer Drug Targets (2006) 0.87
Time-dependent effects of fatty acids on skeletal muscle metabolism. J Cell Physiol (2007) 0.87
The immunosuppressant drug, thalidomide, improves hepatic alterations induced by a high-fat diet in mice. Liver Int (2010) 0.87
Defective insulin and acetylcholine induction of endothelial cell-nitric oxide synthase through insulin receptor substrate/Akt signaling pathway in aorta of obese rats. Diabetes (2007) 0.86
Involvement of phosphatidylinositol-3 kinase/AKT/PKCzeta/lambda pathway in the effect of palmitate on glucose-induced insulin secretion. Pancreas (2008) 0.86
Retracted Diacerhein attenuates the inflammatory response and improves survival in a model of severe sepsis. Crit Care (2012) 0.86
Intracerebroventricular injection of citrate inhibits hypothalamic AMPK and modulates feeding behavior and peripheral insulin signaling. J Endocrinol (2008) 0.86
Topiramate treatment improves hypothalamic insulin and leptin signaling and action and reduces obesity in mice. Endocrinology (2012) 0.86
Reversal of denervation-induced insulin resistance by SHIP2 protein synthesis blockade. Am J Physiol Endocrinol Metab (2002) 0.85
Effect of eccentric exercise velocity on akt/mtor/p70(s6k) signaling in human skeletal muscle. Appl Physiol Nutr Metab (2011) 0.85
Role of fatty acids in the transition from anaerobic to aerobic metabolism in skeletal muscle during exercise. Cell Biochem Funct (2006) 0.85
Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits inositide trisphosphate accumulation in hypothalamus and regulates food intake and body weight. Endocrinology (2006) 0.85
Taurine supplementation modulates glucose homeostasis and islet function. J Nutr Biochem (2008) 0.84
Inducible-NOS but not neuronal-NOS participate in the acute effect of TNF-alpha on hypothalamic insulin-dependent inhibition of food intake. FEBS Lett (2006) 0.84
Defective regulation of the ubiquitin/proteasome system in the hypothalamus of obese male mice. Endocrinology (2014) 0.84
Modulation of growth hormone signal transduction in kidneys of streptozotocin-induced diabetic animals: effect of a growth hormone receptor antagonist. Diabetes (2002) 0.83
In vivo activation of insulin receptor tyrosine kinase by melatonin in the rat hypothalamus. J Neurochem (2004) 0.83
High-fat diet associated with obesity induces impairment of mouse corpus cavernosum responses. BJU Int (2010) 0.83
Changes in the vascular beta-adrenoceptor-activated signalling pathway in 2Kidney-1Clip hypertensive rats. Br J Pharmacol (2004) 0.81
ERK3 associates with MAP2 and is involved in glucose-induced insulin secretion. Mol Cell Endocrinol (2006) 0.81
Ablation of primary afferent neurons by neonatal capsaicin treatment reduces the susceptibility of the portal hypertensive gastric mucosa to ethanol-induced injury in cirrhotic rats. Eur J Pharmacol (2008) 0.80
The influence of ageing on the insulin signalling system in rat lacrimal and salivary glands. Acta Ophthalmol Scand (2003) 0.80
Palmitate modulates the early steps of insulin signalling pathway in pancreatic islets. FEBS Lett (2003) 0.80
TLR4 expression in bone marrow-derived cells is both necessary and sufficient to produce the insulin resistance phenotype in diet-induced obesity. Endocrinology (2015) 0.80
Intermittent fasting induces hypothalamic modifications resulting in low feeding efficiency, low body mass and overeating. Endocrinology (2014) 0.80
Hypothalamic inflammation and thermogenesis: the brown adipose tissue connection. J Bioenerg Biomembr (2011) 0.79
Solidago chilensis Meyen hydroalcoholic extract reduces JNK/IκB pathway activation and ameliorates insulin resistance in diet-induced obesity mice. Exp Biol Med (Maywood) (2011) 0.79
Hypothalamic inhibition of acetyl-CoA carboxylase stimulates hepatic counter-regulatory response independent of AMPK activation in rats. PLoS One (2013) 0.79
Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in growth hormone treated animals. FEBS Lett (2005) 0.79
Insulin temporal sensitivity and its signaling pathway in the rat pineal gland. Life Sci (2010) 0.79
Distinct subsets of hypothalamic genes are modulated by two different thermogenesis-inducing stimuli. Obesity (Silver Spring) (2008) 0.78
Taurine enhances the anorexigenic effects of insulin in the hypothalamus of rats. Amino Acids (2011) 0.78
Low proliferation capacity of lymphocytes from alloxan-diabetic rats: involvement of high glucose and tyrosine phosphorylation of Shc and IRS-1. Life Sci (2002) 0.78
Dehydroepiandrosterone increases beta-cell mass and improves the glucose-induced insulin secretion by pancreatic islets from aged rats. FEBS Lett (2005) 0.78
Infliximab prevents increased systolic blood pressure and upregulates the AKT/eNOS pathway in the aorta of spontaneously hypertensive rats. Eur J Pharmacol (2012) 0.78
Diet-induced obesity impairs AKT signalling in the retina and causes retinal degeneration. Cell Biochem Funct (2012) 0.78
[Hypothalamic dysfunction in obesity]. Arq Bras Endocrinol Metabol (2012) 0.78
Distinct regulation of IRS proteins in adipose tissue from obese aged and dexamethasone-treated rats. Endocrine (2006) 0.78
Postpartum glycemic homeostasis in early lactating rats is accompanied by transient and specific increase of soleus insulin response through IRS2/AKT pathway. Am J Physiol Regul Integr Comp Physiol (2007) 0.78
Hypothalamic action of glutamate leads to body mass reduction through a mechanism partially dependent on JAK2. J Cell Biochem (2012) 0.77
Ouabain-induced hypertension enhances left ventricular contractility in rats. Life Sci (2006) 0.77
Modulation of the oscillatory mechanics of lung tissue and the oxidative stress response induced by arginase inhibition in a chronic allergic inflammation model. BMC Pulm Med (2013) 0.77
Physical exercise and pancreatic islets: acute and chronic actions on insulin secretion. Islets (2012) 0.77
Delta cell death in the islet of Langerhans and the progression from normal glucose tolerance to type 2 diabetes in non-human primates (baboon, Papio hamadryas). Diabetologia (2015) 0.77
Citrate diminishes hypothalamic acetyl-CoA carboxylase phosphorylation and modulates satiety signals and hepatic mechanisms involved in glucose homeostasis in rats. Life Sci (2008) 0.77
Palmitate activates insulin signaling pathway in pancreatic rat islets. Pancreas (2009) 0.77