Published in Am J Physiol Endocrinol Metab on November 26, 2002
Nur77 coordinately regulates expression of genes linked to glucose metabolism in skeletal muscle. Mol Endocrinol (2007) 1.63
Targeting the CNS to treat type 2 diabetes. Nat Rev Drug Discov (2009) 1.45
Discovery and development of small molecule SHIP phosphatase modulators. Med Res Rev (2013) 0.91
Impaired translocation of GLUT4 results in insulin resistance of atrophic soleus muscle. Biomed Res Int (2015) 0.77
SHIP2 on pI3K/Akt pathway in palmitic acid stimulated islet β cell. Int J Clin Exp Med (2015) 0.75
Retracted Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes (2007) 5.67
IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition. PLoS Biol (2010) 2.21
High- or low-salt diet from weaning to adulthood: effect on body weight, food intake and energy balance in rats. Nutr Metab Cardiovasc Dis (2005) 2.15
Endoplasmic reticulum stress, obesity and diabetes. Trends Mol Med (2011) 1.95
S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance. Diabetes (2005) 1.91
Retracted Deletion of tumor necrosis factor-alpha receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis. J Biol Chem (2009) 1.88
Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth. Clin Cancer Res (2011) 1.88
High-fat diet induces apoptosis of hypothalamic neurons. PLoS One (2009) 1.73
Retracted A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss. Diabetes (2007) 1.59
Retracted Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar rats. Diabetes (2006) 1.57
Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS-1 serine phosphorylation. J Physiol (2006) 1.56
Retracted Physical exercise reduces circulating lipopolysaccharide and TLR4 activation and improves insulin signaling in tissues of DIO rats. Diabetes (2011) 1.50
Cross-talk between the insulin and leptin signaling systems in rat hypothalamus. Obes Res (2005) 1.48
Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity. PLoS One (2012) 1.47
Interleukin-10 is a protective factor against diet-induced insulin resistance in liver. J Hepatol (2008) 1.47
Pancreatic beta-cells express phagocyte-like NAD(P)H oxidase. Diabetes (2003) 1.46
[Regulation of glucose and fatty acid metabolism in skeletal muscle during contraction]. Arq Bras Endocrinol Metabol (2011) 1.39
Acute physical exercise reverses S-nitrosation of the insulin receptor, insulin receptor substrate 1 and protein kinase B/Akt in diet-induced obese Wistar rats. J Physiol (2007) 1.38
Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver. Diabetes (2012) 1.27
RhoA/ROCK signaling is critical to FAK activation by cyclic stretch in cardiac myocytes. Am J Physiol Heart Circ Physiol (2005) 1.25
The thymus is a common target in malnutrition and infection. Br J Nutr (2007) 1.22
Inhibitory effects of leptin on pancreatic alpha-cell function. Diabetes (2009) 1.20
Novel signal transduction pathway for luteinizing hormone and its interaction with insulin: activation of Janus kinase/signal transducer and activator of transcription and phosphoinositol 3-kinase/Akt pathways. Endocrinology (2003) 1.18
Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action. FASEB J (2007) 1.17
The multi-faceted cross-talk between the insulin and angiotensin II signaling systems. Diabetes Metab Res Rev (2006) 1.16
Proteome analysis of the plant pathogen Xylella fastidiosa reveals major cellular and extracellular proteins and a peculiar codon bias distribution. Proteomics (2003) 1.16
Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance. Endocrinology (2013) 1.15
Maternal high-fat feeding through pregnancy and lactation predisposes mouse offspring to molecular insulin resistance and fatty liver. J Nutr Biochem (2011) 1.15
Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats. Endocrinology (2008) 1.14
Obesity-induced increase in tumor necrosis factor-α leads to development of colon cancer in mice. Gastroenterology (2012) 1.14
Targeted disruption of iNOS prevents LPS-induced S-nitrosation of IRbeta/IRS-1 and Akt and insulin resistance in muscle of mice. Am J Physiol Endocrinol Metab (2006) 1.13
Glucose induces opposite intracellular Ca2+ concentration oscillatory patterns in identified alpha- and beta-cells within intact human islets of Langerhans. Diabetes (2006) 1.13
Low-grade hypothalamic inflammation leads to defective thermogenesis, insulin resistance, and impaired insulin secretion. Endocrinology (2011) 1.12
Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the phosphatidylinositol 3-kinase/Akt-1 pathway. Eur J Endocrinol (2002) 1.10
Oxidative stress and inflammatory mediators contribute to endothelial dysfunction in high-fat diet-induced obesity in mice. J Hypertens (2010) 1.10
Retracted EGFR tyrosine kinase inhibitor (PD153035) improves glucose tolerance and insulin action in high-fat diet-fed mice. Diabetes (2009) 1.08
Cold exposure induces tissue-specific modulation of the insulin-signalling pathway in Rattus norvegicus. J Physiol (2003) 1.07
New insights into fatty acid modulation of pancreatic beta-cell function. Int Rev Cytol (2006) 1.06
Hepatocyte growth factor plays a key role in insulin resistance-associated compensatory mechanisms. Endocrinology (2012) 1.06
Central exercise action increases the AMPK and mTOR response to leptin. PLoS One (2008) 1.05
Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase-mediated signaling in rat liver. Biol Chem (2003) 1.03
Obesity induced by high-fat diet promotes insulin resistance in the ovary. J Endocrinol (2010) 1.03
Antineoplastic effect of rapamycin is potentiated by inhibition of IRS-1 signaling in prostate cancer cells xenografts. J Cancer Res Clin Oncol (2008) 1.03
Participation of prolactin receptors and phosphatidylinositol 3-kinase and MAP kinase pathways in the increase in pancreatic islet mass and sensitivity to glucose during pregnancy. J Endocrinol (2004) 1.02
Modulation of double-stranded RNA-activated protein kinase in insulin sensitive tissues of obese humans. Obesity (Silver Spring) (2013) 1.01
Double-stranded RNA-activated protein kinase is a key modulator of insulin sensitivity in physiological conditions and in obesity in mice. Endocrinology (2012) 1.01
Retracted Chaperone insufficiency links TLR4 protein signaling to endoplasmic reticulum stress. J Biol Chem (2012) 1.01
Topical insulin accelerates wound healing in diabetes by enhancing the AKT and ERK pathways: a double-blind placebo-controlled clinical trial. PLoS One (2012) 1.01
The clock gene Rev-erbα regulates pancreatic β-cell function: modulation by leptin and high-fat diet. Endocrinology (2011) 1.00
The role of gut microbiota on insulin resistance. Nutrients (2013) 0.99
Diacerhein improves glucose tolerance and insulin sensitivity in mice on a high-fat diet. Endocrinology (2011) 0.98
Short-term treatment with bisphenol-A leads to metabolic abnormalities in adult male mice. PLoS One (2012) 0.98
Hypothalamic actions of tumor necrosis factor alpha provide the thermogenic core for the wastage syndrome in cachexia. Endocrinology (2009) 0.98
Central leptin action improves skeletal muscle AKT, AMPK, and PGC1 alpha activation by hypothalamic PI3K-dependent mechanism. Mol Cell Endocrinol (2009) 0.97
Structural, enzymatic and biological properties of new PLA(2) isoform from Crotalus durissus terrificus venom. Toxicon (2003) 0.96
Cold-induced PGC-1alpha expression modulates muscle glucose uptake through an insulin receptor/Akt-independent, AMPK-dependent pathway. Am J Physiol Endocrinol Metab (2004) 0.96
Targeted disruption of inducible nitric oxide synthase protects against aging, S-nitrosation, and insulin resistance in muscle of male mice. Diabetes (2012) 0.96
Inhibition of Ca2+ signaling and glucagon secretion in mouse pancreatic alpha-cells by extracellular ATP and purinergic receptors. Am J Physiol Endocrinol Metab (2008) 0.95
Regulation of Cbl-associated protein/Cbl pathway in muscle and adipose tissues of two animal models of insulin resistance. Endocrinology (2003) 0.94
A central role for neuronal adenosine 5'-monophosphate-activated protein kinase in cancer-induced anorexia. Endocrinology (2007) 0.94
Partial reversibility of hypothalamic dysfunction and changes in brain activity after body mass reduction in obese subjects. Diabetes (2011) 0.93
Renal effects and vascular reactivity induced by Tityus serrulatus venom. Toxicon (2005) 0.93
Quercetin as an inhibitor of snake venom secretory phospholipase A2. Chem Biol Interact (2010) 0.93
Leptin inhibits apoptosis in thymus through a janus kinase-2-independent, insulin receptor substrate-1/phosphatidylinositol-3 kinase-dependent pathway. Endocrinology (2006) 0.93
Hypothalamic melanin-concentrating hormone is induced by cold exposure and participates in the control of energy expenditure in rats. Endocrinology (2003) 0.92
Neuroendocrine body weight regulation: integration between fat tissue, gastrointestinal tract, and the brain. Endokrynol Pol (2010) 0.92
Quercetin decreases inflammatory response and increases insulin action in skeletal muscle of ob/ob mice and in L6 myotubes. Eur J Pharmacol (2012) 0.92
Pharmacological and structural characterization of a novel phospholipase A2 from Micrurus dumerilii carinicauda venom. Toxicon (2005) 0.92
Identification of insulin in the tear film and insulin receptor and IGF-1 receptor on the human ocular surface. Invest Ophthalmol Vis Sci (2002) 0.92
The cross-talk between angiotensin and insulin differentially affects phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-mediated signaling in rat heart: implications for insulin resistance. Endocrinology (2003) 0.91
Fructose-induced hypothalamic AMPK activation stimulates hepatic PEPCK and gluconeogenesis due to increased corticosterone levels. Endocrinology (2012) 0.91
Concern Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats. J Physiol (2009) 0.91
Tumor necrosis factor-alpha activates signal transduction in hypothalamus and modulates the expression of pro-inflammatory proteins and orexigenic/anorexigenic neurotransmitters. J Neurochem (2006) 0.90
Altered glucose homeostasis and hepatic function in obese mice deficient for both kinin receptor genes. PLoS One (2012) 0.90
Systemic and local myotoxicity induced by snake venom group II phospholipases A2: comparison between crotoxin, crotoxin B and a Lys49 PLA2 homologue. Toxicon (2007) 0.89
Melatonin improves insulin sensitivity independently of weight loss in old obese rats. J Pineal Res (2013) 0.89
Retracted Tub has a key role in insulin and leptin signaling and action in vivo in hypothalamic nuclei. Diabetes (2012) 0.89
Purification and biological effects of Araucaria angustifolia (Araucariaceae) seed lectin. Biochem Biophys Res Commun (2006) 0.88
Exercise intensity, inflammatory signaling, and insulin resistance in obese rats. Med Sci Sports Exerc (2010) 0.88
Up-regulation of the phosphatidylinositol 3-kinase/protein kinase B pathway in the ovary of rats by chronic treatment with hCG and insulin. J Endocrinol (2006) 0.88
Nicotinamide induces differentiation of embryonic stem cells into insulin-secreting cells. Exp Cell Res (2007) 0.87
Disruption of metabolic pathways--perspectives for the treatment of cancer. Curr Cancer Drug Targets (2006) 0.87
The untiring search for the most complete proteome representation: reviewing the methods. Brief Funct Genomic Proteomic (2008) 0.87
Time-dependent effects of fatty acids on skeletal muscle metabolism. J Cell Physiol (2007) 0.87
Glucocorticoids in vivo induce both insulin hypersecretion and enhanced glucose sensitivity of stimulus-secretion coupling in isolated rat islets. Endocrinology (2009) 0.87
The immunosuppressant drug, thalidomide, improves hepatic alterations induced by a high-fat diet in mice. Liver Int (2010) 0.87
Human neutrophil migration in vitro induced by secretory phospholipases A2: a role for cell surface glycosaminoglycans. Biochem Pharmacol (2002) 0.86
Biochemical, pharmacological, and structural characterization of new basic PLA2 Bbil-TX from Bothriopsis bilineata snake venom. Biomed Res Int (2012) 0.86
Defective insulin and acetylcholine induction of endothelial cell-nitric oxide synthase through insulin receptor substrate/Akt signaling pathway in aorta of obese rats. Diabetes (2007) 0.86
Topiramate treatment improves hypothalamic insulin and leptin signaling and action and reduces obesity in mice. Endocrinology (2012) 0.86
Involvement of phosphatidylinositol-3 kinase/AKT/PKCzeta/lambda pathway in the effect of palmitate on glucose-induced insulin secretion. Pancreas (2008) 0.86