Published in J Cell Sci on November 01, 2004
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science (2009) 4.72
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. EMBO J (2005) 4.31
Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. PLoS Biol (2007) 3.61
Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc Natl Acad Sci U S A (2006) 3.51
AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest (2006) 3.39
Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol (2005) 3.14
AMPK and cell proliferation--AMPK as a therapeutic target for atherosclerosis and cancer. J Physiol (2006) 3.11
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A (2010) 3.03
Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes. J Exp Med (2006) 2.69
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders. J Physiol (2006) 2.47
Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. J Leukoc Biol (2008) 2.34
Retracted GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress. Mol Cell (2009) 2.30
Understanding the benefit of metformin use in cancer treatment. BMC Med (2011) 2.28
Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure. Circ Res (2008) 2.19
Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1. Am J Physiol Endocrinol Metab (2005) 2.04
Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner. PLoS One (2010) 1.95
LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells. Eur J Immunol (2010) 1.94
Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers. J Nutr (2009) 1.94
Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis. Cancer Res (2009) 1.88
The coordination of nuclear and mitochondrial communication during aging and calorie restriction. Ageing Res Rev (2009) 1.79
Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver. Cancer Res (2008) 1.73
Adenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensing. Int J Mol Sci (2009) 1.67
Developing a head for energy sensing: AMP-activated protein kinase as a multifunctional metabolic sensor in the brain. J Physiol (2006) 1.67
AMPK as a therapeutic target in renal cell carcinoma. Cancer Biol Ther (2010) 1.66
Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis. Breast Cancer Res (2012) 1.65
Autophagy Blockade Sensitizes Prostate Cancer Cells towards Src Family Kinase Inhibitors. Genes Cancer (2010) 1.63
Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection. Mol Cell (2007) 1.60
AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes. J Biol Chem (2010) 1.60
PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment. Mol Cell Biol (2011) 1.52
Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency. Am J Hum Genet (2005) 1.51
Targeting the AMPK pathway for the treatment of Type 2 diabetes. Front Biosci (Landmark Ed) (2009) 1.51
Regulation of ERK1/2 by ouabain and Na-K-ATPase-dependent energy utilization and AMPK activation in parotid acinar cells. Am J Physiol Cell Physiol (2008) 1.49
APPL1: role in adiponectin signaling and beyond. Am J Physiol Endocrinol Metab (2008) 1.41
Diphosphoinositol polyphosphates: metabolic messengers? Mol Pharmacol (2009) 1.41
Hypoxia, glucose metabolism and the Warburg's effect. J Bioenerg Biomembr (2007) 1.37
AMP-activated protein kinase (AMPK) activating agents cause dephosphorylation of Akt and glycogen synthase kinase-3. Biochem Pharmacol (2006) 1.35
LKB1 is required for adiponectin-mediated modulation of AMPK-S6K axis and inhibition of migration and invasion of breast cancer cells. Oncogene (2009) 1.34
AMP-activated protein kinase mediates carotid body excitation by hypoxia. J Biol Chem (2006) 1.32
Thromboxane receptor activates the AMP-activated protein kinase in vascular smooth muscle cells via hydrogen peroxide. Circ Res (2007) 1.32
Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases. J Physiol (2009) 1.29
Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1. Proc Natl Acad Sci U S A (2013) 1.29
Autophagy, redox signaling, and ventricular remodeling. Antioxid Redox Signal (2009) 1.28
Diverse cytopathologies in mitochondrial disease are caused by AMP-activated protein kinase signaling. Mol Biol Cell (2007) 1.28
Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues. Cell Cycle (2008) 1.28
Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism. Mol Cell Biol (2007) 1.28
AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells. Am J Respir Cell Mol Biol (2009) 1.27
The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation. Biochem J (2006) 1.27
Resveratrol protects ROS-induced cell death by activating AMPK in H9c2 cardiac muscle cells. Genes Nutr (2008) 1.26
Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway. Neuro Oncol (2011) 1.25
Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia. Am J Physiol Renal Physiol (2011) 1.25
Mechanistic insight into control of CFTR by AMPK. J Biol Chem (2008) 1.21
Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling. J Biol Chem (2012) 1.20
Adiponectin modulates C-jun N-terminal kinase and mammalian target of rapamycin and inhibits hepatocellular carcinoma. Gastroenterology (2010) 1.20
Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes. J Biol Chem (2009) 1.20
Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1. Carcinogenesis (2010) 1.19
Apoptosis-induced mitochondrial dysfunction causes cytoplasmic lipid droplet formation. Cell Death Differ (2012) 1.19
The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to oxidative stress and for normal motility and foraging behavior. J Biol Chem (2008) 1.19
Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells. Proc Natl Acad Sci U S A (2007) 1.18
Regulation of mRNA translation in renal physiology and disease. Am J Physiol Renal Physiol (2009) 1.13
AMP-activated kinase (AMPK)-generated signals in malignant melanoma cell growth and survival. Biochem Biophys Res Commun (2010) 1.12
Heme oxygenase: the key to renal function regulation. Am J Physiol Renal Physiol (2009) 1.12
Fasting enhances the response of arcuate neuropeptide Y-glucose-inhibited neurons to decreased extracellular glucose. Am J Physiol Cell Physiol (2009) 1.12
AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass. Bone (2010) 1.11
Redox regulation of mitochondrial biogenesis. Free Radic Biol Med (2012) 1.11
AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases. J Lipid Res (2012) 1.10
Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes. Biochim Biophys Acta (2012) 1.10
Inhibition of the AMP-activated protein kinase-α2 accentuates agonist-induced vascular smooth muscle contraction and high blood pressure in mice. Hypertension (2011) 1.10
Isolation of AMP-activated protein kinase (AMPK) alleles required for neuronal maintenance in Drosophila melanogaster. Biol Open (2013) 1.09
The pan-deacetylase inhibitor panobinostat induces cell death and synergizes with everolimus in Hodgkin lymphoma cell lines. Blood (2012) 1.09
TRPM7 activates m-calpain by stress-dependent stimulation of p38 MAPK and c-Jun N-terminal kinase. J Mol Biol (2010) 1.07
AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress. Proc Natl Acad Sci U S A (2011) 1.07
Endurance factors improve hippocampal neurogenesis and spatial memory in mice. Learn Mem (2011) 1.07
Exercise, energy intake, glucose homeostasis, and the brain. J Neurosci (2014) 1.06
Mitochondrial energetics is impaired in vivo in aged skeletal muscle. Aging Cell (2013) 1.06
Effect of nonmotorized wheel running on mammary carcinogenesis: circulating biomarkers, cellular processes, and molecular mechanisms in rats. Cancer Epidemiol Biomarkers Prev (2008) 1.05
The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: implication for Krabbe disease. J Neurochem (2008) 1.05
The multiple actions of NO. Pflugers Arch (2009) 1.05
Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet. Acta Pharmacol Sin (2009) 1.04
Sepsis and AMPK Activation by AICAR Differentially Regulate FoxO-1, -3 and -4 mRNA in Striated Muscle. Int J Clin Exp Med (2008) 1.04
Unravelling mitochondrial pathways to Parkinson's disease. Br J Pharmacol (2014) 1.03
One-step preservation of phosphoproteins and tissue morphology at room temperature for diagnostic and research specimens. PLoS One (2011) 1.03
Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunit. EMBO J (2007) 1.03
Amino acid sensing and mTOR regulation: inside or out? Biochem Soc Trans (2009) 1.03
The role of p53 in cell metabolism. Acta Pharmacol Sin (2010) 1.03
p53: the attractive tumor suppressor in the cancer research field. J Biomed Biotechnol (2010) 1.02
Candidate mechanisms accounting for effects of physical activity on breast carcinogenesis. IUBMB Life (2009) 1.02
AKINbetagamma contributes to SnRK1 heterotrimeric complexes and interacts with two proteins implicated in plant pathogen resistance through its KIS/GBD sequence. Plant Physiol (2006) 1.01
Cadmium induces autophagy through ROS-dependent activation of the LKB1-AMPK signaling in skin epidermal cells. Toxicol Appl Pharmacol (2011) 1.01
IRE1-dependent activation of AMPK in response to nitric oxide. Mol Cell Biol (2011) 1.00
EphA2 as a promoter of melanoma tumorigenicity. Cancer Biol Ther (2009) 1.00
Metformin as an energy restriction mimetic agent for breast cancer prevention. J Carcinog (2011) 1.00
Dietary curcumin supplementation counteracts reduction in levels of molecules involved in energy homeostasis after brain trauma. Neuroscience (2009) 0.99
AMP-activated protein kinase suppresses the in vitro and in vivo proliferation of hepatocellular carcinoma. PLoS One (2014) 0.98
Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthase. J Biol Chem (2010) 0.98
Potentiation of insulin-stimulated glucose transport by the AMP-activated protein kinase. Am J Physiol Cell Physiol (2006) 0.98
Metabolic features of clear-cell renal cell carcinoma: mechanisms and clinical implications. Can Urol Assoc J (2011) 0.98
Physiological glucose is critical for optimized neuronal viability and AMPK responsiveness in vitro. J Neurosci Methods (2007) 0.98
Diphosphoinositol polyphosphates: what are the mechanisms? Adv Enzyme Regul (2010) 0.98
AMP-activated protein kinase: a master switch in glucose and lipid metabolism. Rev Endocr Metab Disord (2004) 1.18