Published in J Mol Med (Berl) on October 27, 2004
Stable transmission of targeted gene modification using single-stranded oligonucleotides with flanking LNAs. Nucleic Acids Res (2005) 1.16
DNA breakage associated with targeted gene alteration directed by DNA oligonucleotides. Mutat Res (2009) 1.08
Enhanced gene repair mediated by methyl-CpG-modified single-stranded oligonucleotides. Nucleic Acids Res (2009) 1.05
Single-stranded oligonucleotide-mediated in vivo gene repair in the rd1 retina. Mol Vis (2007) 0.95
Emerging gene editing strategies for Duchenne muscular dystrophy targeting stem cells. Front Physiol (2014) 0.86
An update on targeted gene repair in mammalian cells: methods and mechanisms. J Biomed Sci (2011) 0.84
Strand bias influences the mechanism of gene editing directed by single-stranded DNA oligonucleotides. Nucleic Acids Res (2011) 0.77
SOAP: short oligonucleotide alignment program. Bioinformatics (2008) 68.13
The diploid genome sequence of an Asian individual. Nature (2008) 46.29
De novo assembly of human genomes with massively parallel short read sequencing. Genome Res (2009) 45.91
A human gut microbial gene catalogue established by metagenomic sequencing. Nature (2010) 43.63
SOAP2: an improved ultrafast tool for short read alignment. Bioinformatics (2009) 39.47
Evolution of genes and genomes on the Drosophila phylogeny. Nature (2007) 18.01
SNP detection for massively parallel whole-genome resequencing. Genome Res (2009) 15.96
The sequence and de novo assembly of the giant panda genome. Nature (2009) 15.76
WEGO: a web tool for plotting GO annotations. Nucleic Acids Res (2006) 13.06
A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature (2012) 11.68
Sequencing of 50 human exomes reveals adaptation to high altitude. Science (2010) 11.27
TreeFam: a curated database of phylogenetic trees of animal gene families. Nucleic Acids Res (2006) 8.83
The genome of the cucumber, Cucumis sativus L. Nat Genet (2009) 8.19
Ancient human genome sequence of an extinct Palaeo-Eskimo. Nature (2010) 7.51
Richness of human gut microbiome correlates with metabolic markers. Nature (2013) 6.93
TreeFam: 2008 Update. Nucleic Acids Res (2007) 6.63
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat Genet (2011) 5.73
Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor. Cell (2012) 5.62
Analyses of pig genomes provide insight into porcine demography and evolution. Nature (2012) 5.58
Building the sequence map of the human pan-genome. Nat Biotechnol (2009) 5.53
Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants. Nat Genet (2010) 5.44
Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm. Cell (2012) 5.16
Resequencing 50 accessions of cultivated and wild rice yields markers for identifying agronomically important genes. Nat Biotechnol (2011) 4.84
An Aboriginal Australian genome reveals separate human dispersals into Asia. Science (2011) 4.84
The DNA methylome of human peripheral blood mononuclear cells. PLoS Biol (2010) 4.25
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nat Genet (2011) 3.66
Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation. Proc Natl Acad Sci U S A (2004) 3.45
Deep RNA sequencing at single base-pair resolution reveals high complexity of the rice transcriptome. Genome Res (2010) 3.34
Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells. Nat Biotechnol (2002) 3.20
Snap: an integrated SNP annotation platform. Nucleic Acids Res (2006) 2.99
The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. Dev Cell (2002) 2.61
Persistent organic pollutant exposure leads to insulin resistance syndrome. Environ Health Perspect (2009) 2.57
Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de novo assembly. Nat Biotechnol (2011) 2.45
Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolism. Mol Cell Biol (2002) 2.44
Temporal dissection of tumorigenesis in primary cancers. Cancer Discov (2011) 2.40
Pigs in sequence space: a 0.66X coverage pig genome survey based on shotgun sequencing. BMC Genomics (2005) 2.34
Regulatory circuits controlling white versus brown adipocyte differentiation. Biochem J (2006) 2.23
Single base-resolution methylome of the silkworm reveals a sparse epigenomic map. Nat Biotechnol (2010) 2.03
Human gut microbes impact host serum metabolome and insulin sensitivity. Nature (2016) 1.85
Regulation of human skeletal stem cells differentiation by Dlk1/Pref-1. J Bone Miner Res (2004) 1.79
Human multipotent adipose-derived stem cells differentiate into functional brown adipocytes. Stem Cells (2009) 1.72
A microarray analysis of the rice transcriptome and its comparison to Arabidopsis. Genome Res (2005) 1.71
Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter. Hum Genet (2002) 1.69
Regulation of adipocyte differentiation and function by polyunsaturated fatty acids. Biochim Biophys Acta (2005) 1.63
A proteomic approach for identification of secreted proteins during the differentiation of 3T3-L1 preadipocytes to adipocytes. Mol Cell Proteomics (2002) 1.61
SOAPindel: efficient identification of indels from short paired reads. Genome Res (2012) 1.59
Origin and evolution of new exons in rodents. Genome Res (2005) 1.57
The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific. Aging Cell (2013) 1.56
Twin pregnancies with diploid hydatidiform mole and co-existing normal fetus may originate from one oocyte. Hum Reprod (2008) 1.55
Adipocyte differentiation of 3T3-L1 preadipocytes is dependent on lipoxygenase activity during the initial stages of the differentiation process. Biochem J (2003) 1.52
A population threshold for functional polymorphisms. Genome Res (2003) 1.52
State of the art de novo assembly of human genomes from massively parallel sequencing data. Hum Genomics (2010) 1.51
High-resolution mapping of genotype-phenotype relationships in cri du chat syndrome using array comparative genomic hybridization. Am J Hum Genet (2005) 1.51
Pig genome sequence--analysis and publication strategy. BMC Genomics (2010) 1.47
UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity. PLoS One (2010) 1.44
Whole-exome sequencing of 2,000 Danish individuals and the role of rare coding variants in type 2 diabetes. Am J Hum Genet (2013) 1.43
Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity. Obesity (Silver Spring) (2012) 1.41
[Unspecific effects of certain siRNA molecules used in the treatment of age related macular degeneration]. Ugeskr Laeger (2010) 1.40
Porcine transcriptome analysis based on 97 non-normalized cDNA libraries and assembly of 1,021,891 expressed sequence tags. Genome Biol (2007) 1.39
The gene encoding the Acyl-CoA-binding protein is activated by peroxisome proliferator-activated receptor gamma through an intronic response element functionally conserved between humans and rodents. J Biol Chem (2002) 1.36
Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns. Genome Biol (2012) 1.34
Effects of Wnt signaling on brown adipocyte differentiation and metabolism mediated by PGC-1alpha. Mol Cell Biol (2005) 1.31
Sequencing bias: comparison of different protocols of microRNA library construction. BMC Biotechnol (2010) 1.30
Side population cells in human and mouse epidermis lack stem cell characteristics. Exp Cell Res (2004) 1.24
Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes. Mol Cell Biol (2008) 1.23
Misfolding, degradation, and aggregation of variant proteins. The molecular pathogenesis of short chain acyl-CoA dehydrogenase (SCAD) deficiency. J Biol Chem (2003) 1.21
Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant. Sci Transl Med (2013) 1.21
Genetics of healthy aging in Europe: the EU-integrated project GEHA (GEnetics of Healthy Aging). Ann N Y Acad Sci (2007) 1.21
Nanomedicine: techniques, potentials, and ethical implications. J Biomed Biotechnol (2006) 1.20
Single-cell sequencing analysis characterizes common and cell-lineage-specific mutations in a muscle-invasive bladder cancer. Gigascience (2012) 1.18
Hemizygous minipigs produced by random gene insertion and handmade cloning express the Alzheimer's disease-causing dominant mutation APPsw. Transgenic Res (2009) 1.17
The ACADS gene variation spectrum in 114 patients with short-chain acyl-CoA dehydrogenase (SCAD) deficiency is dominated by missense variations leading to protein misfolding at the cellular level. Hum Genet (2008) 1.16
Dlk1/FA1 is a novel endocrine regulator of bone and fat mass and its serum level is modulated by growth hormone. Endocrinology (2007) 1.16
Are keratoacanthomas variants of squamous cell carcinomas? A comparison of chromosomal aberrations by comparative genomic hybridization. J Invest Dermatol (2006) 1.15
The sequence and analysis of a Chinese pig genome. Gigascience (2012) 1.15
Nutritional regulation and role of peroxisome proliferator-activated receptor delta in fatty acid catabolism in skeletal muscle. Biochim Biophys Acta (2003) 1.15
Estimation of tumor heterogeneity using CGH array data. BMC Bioinformatics (2009) 1.14
Cross talk between insulin and bone morphogenetic protein signaling systems in brown adipogenesis. Mol Cell Biol (2010) 1.13
Pig transgenesis by Sleeping Beauty DNA transposition. Transgenic Res (2010) 1.13
cAMP-dependent signaling regulates the adipogenic effect of n-6 polyunsaturated fatty acids. J Biol Chem (2007) 1.11
Clinical expression of Menkes disease in females with normal karyotype. Orphanet J Rare Dis (2012) 1.11
Peroxisome proliferator-activated receptor gamma recruits the positive transcription elongation factor b complex to activate transcription and promote adipogenesis. Mol Endocrinol (2006) 1.09
Expression and localization of peroxisome proliferator-activated receptors and nuclear factor kappaB in normal and lesional psoriatic skin. J Invest Dermatol (2003) 1.09
Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation. Biochem J (2002) 1.08
Mechanisms underlying targeted gene correction using chimeric RNA/DNA and single-stranded DNA oligonucleotides. J Mol Med (Berl) (2002) 1.08