Published in Cancer Discov on June 29, 2011
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. Nat Biotechnol (2013) 16.13
Clonal evolution in cancer. Nature (2012) 11.07
Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. Nat Genet (2013) 3.51
Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin. Science (2015) 3.29
Evolution of the cancer genome. Nat Rev Genet (2012) 3.24
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci U S A (2011) 3.10
A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers. J Clin Invest (2012) 2.42
Evolutionary pathways in BRCA1-associated breast tumors. Cancer Discov (2012) 2.01
Mutational landscape of aggressive cutaneous squamous cell carcinoma. Clin Cancer Res (2014) 1.47
Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine. Genome Biol (2014) 1.44
Single-cell genetic analysis reveals the composition of initiating clones and phylogenetic patterns of branching and parallel evolution in myeloma. Leukemia (2014) 1.43
NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis. J Invest Dermatol (2014) 1.40
Mutational landscape of basal cell carcinomas by whole-exome sequencing. J Invest Dermatol (2013) 1.38
Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms. Blood (2013) 1.34
Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations. Nat Genet (2016) 1.15
What are we learning from the cancer genome? Nat Rev Clin Oncol (2012) 1.13
Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma. Nat Genet (2014) 1.09
The cellular origin for malignant glioma and prospects for clinical advancements. Expert Rev Mol Diagn (2012) 1.02
Receptor protein tyrosine phosphatases and cancer: new insights from structural biology. Cell Adh Migr (2012) 1.00
Combinatorial therapies to overcome B-RAF inhibitor resistance in melanomas. Pharmacogenomics (2012) 1.00
The mathematics of cancer: integrating quantitative models. Nat Rev Cancer (2015) 1.00
Protein domain-level landscape of cancer-type-specific somatic mutations. PLoS Comput Biol (2015) 0.97
Glutamate signaling in benign and malignant disorders: current status, future perspectives, and therapeutic implications. Int J Biol Sci (2013) 0.96
A general framework for analyzing tumor subclonality using SNP array and DNA sequencing data. Genome Biol (2014) 0.96
Genomic analysis of metastatic cutaneous squamous cell carcinoma. Clin Cancer Res (2015) 0.96
Reconstructing cancer genomes from paired-end sequencing data. BMC Bioinformatics (2012) 0.93
Genetics and epigenetics of the skin meet deep sequence. J Invest Dermatol (2012) 0.93
Estimating the order of mutations during tumorigenesis from tumor genome sequencing data. Bioinformatics (2012) 0.92
Deciphering clonality in aneuploid breast tumors using SNP array and sequencing data. Genome Biol (2014) 0.92
Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans. Cancer Prev Res (Phila) (2015) 0.89
Lessons learned from next-generation sequencing in head and neck cancer. Head Neck (2012) 0.88
Refining the role for adult stem cells as cancer cells of origin. Trends Cell Biol (2014) 0.88
Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5. J Mol Signal (2012) 0.86
Molecular cancer prevention: Current status and future directions. CA Cancer J Clin (2015) 0.86
Age-related mutations and chronic myelomonocytic leukemia. Leukemia (2015) 0.86
Intra-relation reconstruction from inter-relation: miRNA to gene expression. BMC Syst Biol (2013) 0.86
Squamous cell carcinoma of the skin: Emerging need for novel biomarkers. World J Clin Oncol (2013) 0.85
The relative timing of mutations in a breast cancer genome. PLoS One (2013) 0.84
Key differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling. Br J Cancer (2013) 0.83
Clonality and evolutionary history of rhabdomyosarcoma. PLoS Genet (2015) 0.83
Tousled-like kinase-dependent phosphorylation of Rad9 plays a role in cell cycle progression and G2/M checkpoint exit. PLoS One (2013) 0.83
Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma. Nat Genet (2016) 0.82
Oral cavity and oropharyngeal squamous cell carcinoma genomics. Otolaryngol Clin North Am (2013) 0.82
Analysis of Tp53 codon 72 polymorphisms, Tp53 mutations, and HPV infection in cutaneous squamous cell carcinomas. PLoS One (2012) 0.82
EphB2 Promotes Progression of Cutaneous Squamous Cell Carcinoma. J Invest Dermatol (2015) 0.82
Methods and challenges in timing chromosomal abnormalities within cancer samples. Bioinformatics (2013) 0.81
Oxidative Stress-Induced Protein Damage Inhibits DNA Repair and Determines Mutation Risk and Therapeutic Efficacy. Mol Cancer Res (2016) 0.81
Using passenger mutations to estimate the timing of driver mutations and identify mutator alterations. BMC Bioinformatics (2013) 0.78
Modeling cutaneous squamous carcinoma development in the mouse. Cold Spring Harb Perspect Med (2014) 0.78
Frequent DPH3 promoter mutations in skin cancers. Oncotarget (2015) 0.78
Loss of Nrf2 abrogates the protective effect of Keap1 downregulation in a preclinical model of cutaneous squamous cell carcinoma. Sci Rep (2016) 0.77
Cancer-Associated Mutations in Breast Tumor Kinase/PTK6 Differentially Affect Enzyme Activity and Substrate Recognition. Biochemistry (2015) 0.77
No evidence for integrated viral DNA in the genome sequence of cutaneous squamous cell carcinoma. J Invest Dermatol (2014) 0.77
Does Notch play a tumor suppressor role across diverse squamous cell carcinomas? Cancer Med (2016) 0.77
Novel CARD11 Mutations in Human Cutaneous Squamous Cell Carcinoma Lead to Aberrant NF-κB Regulation. Am J Pathol (2015) 0.76
Langerhans Cells Facilitate UVB-Induced Epidermal Carcinogenesis. J Invest Dermatol (2015) 0.76
OX40+ Regulatory T Cells in Cutaneous Squamous Cell Carcinoma Suppress Effector T-Cell Responses and Associate with Metastatic Potential. Clin Cancer Res (2016) 0.76
Exosomes: The Link between GPCR Activation and Metastatic Potential? Front Genet (2016) 0.76
Protein oxidation, UVA and human DNA repair. DNA Repair (Amst) (2016) 0.75
Regulation of mRNA expression in breast cancer - a cis-tematic trans-action. Breast Cancer Res (2012) 0.75
Clinical response to everolimus in a patient with Hodgkin's lymphoma harboring a TSC2 mutation. Blood Cancer J (2016) 0.75
Genetic alterations in seborrheic keratoses. Oncotarget (2017) 0.75
Differential mutation frequencies in metastatic cutaneous squamous cell carcinomas versus primary tumors. Cancer (2016) 0.75
Whole exome sequencing validates a preclinical mouse model for the prevention and treatment of cutaneous squamous cell carcinoma. Cancer Prev Res (Phila) (2016) 0.75
In Silico Analysis Validates Proteomic Findings of Formalin-fixed Paraffin Embedded Cutaneous Squamous Cell Carcinoma Tissue. Cancer Genomics Proteomics (2016) 0.75
Polμ tumor variants decrease the efficiency and accuracy of NHEJ. Nucleic Acids Res (2017) 0.75
Phosphoinositide 3-Kinase-Dependent Signalling Pathways in Cutaneous Squamous Cell Carcinomas. Cancers (Basel) (2017) 0.75
Somatic cancer mutations in the MLL1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR5/RBBP5/ASH2L complex. Mol Oncol (2017) 0.75
A new long noncoding RNA (LncRNA) is induced in cutaneous squamous cell carcinoma and downregulates several anticancer and cell-differentiation genes in mouse. J Biol Chem (2017) 0.75
A genetic model for colorectal tumorigenesis. Cell (1990) 44.37
A comprehensive catalogue of somatic mutations from a human cancer genome. Nature (2009) 24.27
Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature (2010) 19.68
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (2004) 18.84
The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature (2010) 12.43
ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol (2008) 11.86
COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer. Nucleic Acids Res (2009) 9.59
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell (2004) 8.48
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell (1999) 5.93
p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res (1990) 5.70
p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad Sci U S A (1994) 5.49
Sunburn and p53 in the onset of skin cancer. Nature (1995) 5.35
Progression model for pancreatic cancer. Clin Cancer Res (2000) 4.60
Accumulation of driver and passenger mutations during tumor progression. Proc Natl Acad Sci U S A (2010) 4.47
Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation. Cell (1991) 4.12
Non-melanoma skin cancer. Lancet (2010) 4.11
Frequent clones of p53-mutated keratinocytes in normal human skin. Proc Natl Acad Sci U S A (1996) 3.38
Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases. Genes Dev (2007) 2.61
Uniparental disomy in cancer. Trends Mol Med (2009) 1.99
Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma. Oncogene (2010) 1.73
Copy neutral loss of heterozygosity: a novel chromosomal lesion in myeloid malignancies. Blood (2010) 1.62
Benign clonal keratinocyte patches with p53 mutations show no genetic link to synchronous squamous cell precancer or cancer in human skin. Am J Pathol (1997) 1.23
The scientific basis of skin cancer. J Am Acad Dermatol (2000) 0.93
Proto-oncogenes and oncogenes in epidermal neoplasia. Exp Dermatol (1995) 0.83
The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res (2010) 97.51
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
MicroRNA expression profiles classify human cancers. Nature (2005) 69.12
A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat Genet (2011) 59.36
Diversity of the human intestinal microbial flora. Science (2005) 49.64
The diploid genome sequence of an Asian individual. Nature (2008) 46.29
Integrative genomics viewer. Nat Biotechnol (2011) 42.83
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell (2010) 39.09
The landscape of somatic copy-number alteration across human cancers. Nature (2010) 31.88
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature (2012) 31.78
Somatic mutations affect key pathways in lung adenocarcinoma. Nature (2008) 30.02
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell (2006) 27.36
International network of cancer genome projects. Nature (2010) 20.35
Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature (2013) 20.16
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med (2013) 19.87
Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments. BMC Bioinformatics (2010) 19.86
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (2004) 18.84
Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma. Proc Natl Acad Sci U S A (2007) 18.83
Initial genome sequencing and analysis of multiple myeloma. Nature (2011) 17.28
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Distinct sets of genetic alterations in melanoma. N Engl J Med (2005) 17.26
BRAF mutation predicts sensitivity to MEK inhibition. Nature (2005) 17.14
The mutational landscape of head and neck squamous cell carcinoma. Science (2011) 16.88
Characterizing the cancer genome in lung adenocarcinoma. Nature (2007) 16.48
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. Nat Biotechnol (2013) 16.13
Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell (2006) 16.05
The sequence and de novo assembly of the giant panda genome. Nature (2009) 15.76
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature (2005) 15.28
The genomic complexity of primary human prostate cancer. Nature (2011) 14.06
Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning. Nat Med (2002) 14.01
WEGO: a web tool for plotting GO annotations. Nucleic Acids Res (2006) 13.06
A landscape of driver mutations in melanoma. Cell (2012) 12.61
A network-based analysis of systemic inflammation in humans. Nature (2005) 12.60
High-resolution mapping of copy-number alterations with massively parallel sequencing. Nat Methods (2008) 12.56
The somatic genomic landscape of glioblastoma. Cell (2013) 11.73
Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell (2012) 11.69
The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet (2013) 11.29
Sequencing of 50 human exomes reveals adaptation to high altitude. Science (2010) 11.27
Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. Blood (2004) 11.07
SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med (2011) 11.07
Absolute quantification of somatic DNA alterations in human cancer. Nat Biotechnol (2012) 10.87
Advances in understanding cancer genomes through second-generation sequencing. Nat Rev Genet (2010) 10.15
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nat Genet (2012) 9.93
GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biol (2011) 9.60
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet (2009) 9.45
Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell (2004) 9.41
Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell (2013) 9.24
Induction of tumors in mice by genomic hypomethylation. Science (2003) 8.86
An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays. Cancer Res (2004) 8.86
TreeFam: a curated database of phylogenetic trees of animal gene families. Nucleic Acids Res (2006) 8.83
Dicer, Drosha, and outcomes in patients with ovarian cancer. N Engl J Med (2008) 8.77
Integrative analysis of the melanoma transcriptome. Genome Res (2010) 8.46
The genome of the cucumber, Cucumis sativus L. Nat Genet (2009) 8.19
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res (2008) 8.12
Outcome signature genes in breast cancer: is there a unique set? Bioinformatics (2004) 7.96
Reconstruction of functionally normal and malignant human breast tissues in mice. Proc Natl Acad Sci U S A (2004) 7.96
Melanoma genome sequencing reveals frequent PREX2 mutations. Nature (2012) 7.77
Sequence analysis of mutations and translocations across breast cancer subtypes. Nature (2012) 7.76
Pan-cancer patterns of somatic copy number alteration. Nat Genet (2013) 7.73
End-sequence profiling: sequence-based analysis of aberrant genomes. Proc Natl Acad Sci U S A (2003) 7.70
The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67
A simple spreadsheet-based, MIAME-supportive format for microarray data: MAGE-TAB. BMC Bioinformatics (2006) 7.53
SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet (2009) 7.48
Punctuated evolution of prostate cancer genomes. Cell (2013) 7.23
Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing. Proc Natl Acad Sci U S A (2012) 7.14
Chromosome aberrations in solid tumors. Nat Genet (2003) 7.01
Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N Engl J Med (2012) 6.90
Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia. N Engl J Med (2010) 6.84
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc Natl Acad Sci U S A (2006) 6.80
TreeFam: 2008 Update. Nucleic Acids Res (2007) 6.63
A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science (2004) 6.62
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet (2009) 6.42