Published in Nat Rev Mol Cell Biol on November 01, 2004
Linking actin dynamics and gene transcription to drive cellular motile functions. Nat Rev Mol Cell Biol (2010) 4.12
Paxillin comes of age. J Cell Sci (2008) 3.57
Classification and nomenclature of all human homeobox genes. BMC Biol (2007) 2.61
The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression. Mol Cell Biol (2008) 2.00
Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins. EMBO Rep (2011) 1.96
Stc1: a critical link between RNAi and chromatin modification required for heterochromatin integrity. Cell (2010) 1.82
Control of final seed and organ size by the DA1 gene family in Arabidopsis thaliana. Genes Dev (2008) 1.75
Regulation of T cell receptor signaling by activation-induced zinc influx. J Exp Med (2011) 1.73
Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt. J Clin Invest (2005) 1.70
The vertebrate muscle Z-disc: sarcomere anchor for structure and signalling. J Muscle Res Cell Motil (2009) 1.70
Zyxin links fat signaling to the hippo pathway. PLoS Biol (2011) 1.68
Human but not mouse adipogenesis is critically dependent on LMO3. Cell Metab (2013) 1.57
Splice variants of enigma homolog, differentially expressed during heart development, promote or prevent hypertrophy. Cardiovasc Res (2010) 1.54
Functional anthology of intrinsic disorder. 2. Cellular components, domains, technical terms, developmental processes, and coding sequence diversities correlated with long disordered regions. J Proteome Res (2007) 1.48
Zasp is required for the assembly of functional integrin adhesion sites. J Cell Biol (2007) 1.46
Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy. J Clin Invest (2008) 1.46
Mutations of the FHL1 gene cause Emery-Dreifuss muscular dystrophy. Am J Hum Genet (2009) 1.44
Overexpression of LASP-1 mediates migration and proliferation of human ovarian cancer cells and influences zyxin localisation. Br J Cancer (2007) 1.41
Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans. PLoS Genet (2011) 1.40
Genome Wide Identification of LIM Genes in Cicer arietinum and Response of Ca-2LIMs in Development, Hormone and Pathogenic Stress. PLoS One (2015) 1.40
X-linked dominant scapuloperoneal myopathy is due to a mutation in the gene encoding four-and-a-half-LIM protein 1. Am J Hum Genet (2008) 1.40
Tobacco WLIM1 is a novel F-actin binding protein involved in actin cytoskeleton remodeling. Plant Cell (2006) 1.38
Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytes. Mol Cell Biol (2007) 1.30
Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. BMC Biol (2011) 1.30
Cardiac Z-disc signaling network. J Biol Chem (2011) 1.25
FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner. J Clin Invest (2005) 1.25
Two LIM domain proteins and UNC-96 link UNC-97/pinch to myosin thick filaments in Caenorhabditis elegans muscle. Mol Biol Cell (2007) 1.23
Mechanosensitivity and compositional dynamics of cell-matrix adhesions. EMBO Rep (2013) 1.22
The structural basis of integrin-linked kinase-PINCH interactions. Proc Natl Acad Sci U S A (2008) 1.21
LIM-domain-only proteins in cancer. Nat Rev Cancer (2013) 1.19
Domain architecture and biochemical characterization of vertebrate Mcm10. J Biol Chem (2007) 1.19
Rediscovery by Whole Genome Sequencing: Classical Mutations and Genome Polymorphisms in Neurospora crassa. G3 (Bethesda) (2011) 1.17
The LIM and SH3 domain protein family: structural proteins or signal transducers or both? Mol Cancer (2008) 1.17
Nuclear localization and cytosolic overexpression of LASP-1 correlates with tumor size and nodal-positivity of human breast carcinoma. BMC Cancer (2007) 1.14
Clinical, histological and genetic characterization of reducing body myopathy caused by mutations in FHL1. Brain (2009) 1.13
Extracellular inhibitors, repellents, and semaphorin/plexin/MICAL-mediated actin filament disassembly. Cytoskeleton (Hoboken) (2011) 1.12
A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics. J Biol Chem (2012) 1.12
The Rsu-1-PINCH1-ILK complex is regulated by Ras activation in tumor cells. Eur J Cell Biol (2008) 1.11
High-resolution structure of the catalytic region of MICAL (molecule interacting with CasL), a multidomain flavoenzyme-signaling molecule. Proc Natl Acad Sci U S A (2005) 1.11
Supervillin modulation of focal adhesions involving TRIP6/ZRP-1. J Cell Biol (2006) 1.11
Fhl2 deficiency results in osteopenia due to decreased activity of osteoblasts. EMBO J (2005) 1.11
Nucleocytoplasmic functions of the PDZ-LIM protein family: new insights into organ development. Bioessays (2010) 1.10
PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha. J Clin Invest (2010) 1.09
Mating induces an immune response and developmental switch in the Drosophila oviduct. Proc Natl Acad Sci U S A (2008) 1.09
Insights into the molecular evolution of the PDZ/LIM family and identification of a novel conserved protein motif. PLoS One (2007) 1.09
Early evolution of the LIM homeobox gene family. BMC Biol (2010) 1.08
Ajuba is required for Rac activation and maintenance of E-cadherin adhesion. J Cell Biol (2011) 1.08
Restriction to Fos family members of Trip6-dependent coactivation and glucocorticoid receptor-dependent trans-repression of activator protein-1. Mol Endocrinol (2008) 1.06
Proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor enhances androgen receptor functions through LIM-only coactivator, four-and-a-half LIM-only protein 2. Mol Endocrinol (2006) 1.06
ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers. PLoS One (2008) 1.06
Cell Adhesion and Transcriptional Activity - Defining the Role of the Novel Protooncogene LPP. Transl Oncol (2009) 1.05
Pdlim7 (LMP4) regulation of Tbx5 specifies zebrafish heart atrio-ventricular boundary and valve formation. Dev Biol (2009) 1.04
Schizosaccharomyces pombe Pxl1 is a paxillin homologue that modulates Rho1 activity and participates in cytokinesis. Mol Biol Cell (2008) 1.04
DNA methylation profiles of airway epithelial cells and PBMCs from healthy, atopic and asthmatic children. PLoS One (2012) 1.04
Zyxin mediates actin fiber reorganization in epithelial-mesenchymal transition and contributes to endocardial morphogenesis. Mol Biol Cell (2009) 1.04
Shelterin complex and associated factors at human telomeres. Nucleus (2011) 1.04
Protease activity, secretion, cell entry, cytotoxicity, and cellular targets of secreted autotransporter toxin of uropathogenic Escherichia coli. Infect Immun (2006) 1.03
A LIM domain protein from tobacco involved in actin-bundling and histone gene transcription. Mol Plant (2012) 1.03
MICALs in control of the cytoskeleton, exocytosis, and cell death. Cell Mol Life Sci (2011) 1.03
LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. Proc Natl Acad Sci U S A (2010) 1.03
Nuclear localisation of LASP-1 correlates with poor long-term survival in female breast cancer. Br J Cancer (2010) 1.02
The LIM domain of zyxin is sufficient for force-induced accumulation of zyxin during cell migration. Biophys J (2011) 1.01
Genes, proteins and complexes: the multifaceted nature of FHL family proteins in diverse tissues. J Cell Mol Med (2010) 1.01
Podocyte injury induces nuclear translocation of WTIP via microtubule-dependent transport. J Biol Chem (2010) 1.00
Differential regulation of Tbx5 protein expression and sub-cellular localization during heart development. Dev Biol (2006) 0.99
Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget (2012) 0.99
Skeletal muscle biopsy analysis in reducing body myopathy and other FHL1-related disorders. J Neuropathol Exp Neurol (2013) 0.99
The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. Nat Cell Biol (2012) 0.99
Requirement of the LIM homeodomain transcription factor tailup for normal heart and hematopoietic organ formation in Drosophila melanogaster. Mol Cell Biol (2007) 0.98
Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1. J Biol Chem (2012) 0.98
ALP/Enigma PDZ-LIM domain proteins in the heart. J Mol Cell Biol (2009) 0.97
The seven-pass transmembrane cadherin Flamingo controls dendritic self-avoidance via its binding to a LIM domain protein, Espinas, in Drosophila sensory neurons. Genes Dev (2011) 0.97
Force-dependent cell signaling in stem cell differentiation. Stem Cell Res Ther (2012) 0.97
Mutations in an Atypical TIR-NB-LRR-LIM Resistance Protein Confer Autoimmunity. Front Plant Sci (2011) 0.96
Stabilization of a binary protein complex by intein-mediated cyclization. Protein Sci (2006) 0.96
An evolutionarily conserved nuclear export signal facilitates cytoplasmic localization of the Tbx5 transcription factor. Mol Cell Biol (2007) 0.96
LMP4 regulates Tbx5 protein subcellular localization and activity. J Cell Biol (2006) 0.95
LIM-domain proteins TRIP6 and LPP associate with shelterin to mediate telomere protection. Aging (Albany NY) (2010) 0.95
Zinc in innate and adaptive tumor immunity. J Transl Med (2010) 0.95
Evolution of the eukaryotic dynactin complex, the activator of cytoplasmic dynein. BMC Evol Biol (2012) 0.94
Lmo genes regulate behavioral responses to ethanol in Drosophila melanogaster and the mouse. Alcohol Clin Exp Res (2011) 0.94
Nuclear and cytoplasmic LIMK1 enhances human breast cancer progression. Mol Cancer (2011) 0.93
Lmo4 in the nucleus accumbens regulates cocaine sensitivity. Genes Brain Behav (2010) 0.93
The LIM Protein Zyxin Binds CARP-1 and Promotes Apoptosis. Genes Cancer (2010) 0.93
Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A. J Biol Chem (2011) 0.92
Mechanotransduction at focal adhesions: integrating cytoskeletal mechanics in migrating cells. J Cell Mol Med (2013) 0.92
Lim homeobox genes in the Ctenophore Mnemiopsis leidyi: the evolution of neural cell type specification. Evodevo (2012) 0.92
LIM Protein Ajuba Participates in the Repression of the ATR-Mediated DNA Damage Response. Front Genet (2013) 0.91
Homeodomain proteins: an update. Chromosoma (2015) 0.91
The ALP-Enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegans. Mol Biol Cell (2009) 0.91
Csrp1 regulates dynamic cell movements of the mesendoderm and cardiac mesoderm through interactions with Dishevelled and Diversin. Proc Natl Acad Sci U S A (2007) 0.91
Development of a novel splice array platform and its application in the identification of alternative splice variants in lung cancer. BMC Genomics (2010) 0.91
Co-factors of LIM domains (Clims/Ldb/Nli) regulate corneal homeostasis and maintenance of hair follicle stem cells. Dev Biol (2007) 0.90
The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription. Circ Res (2008) 0.90
Nuclear signaling from cadherin adhesion complexes. Curr Top Dev Biol (2015) 0.90
Four and a half LIM protein 1C (FHL1C): a binding partner for voltage-gated potassium channel K(v1.5). PLoS One (2011) 0.90
PINCH1 is transcriptional regulator in podocytes that interacts with WT1 and represses podocalyxin expression. PLoS One (2011) 0.89
Age-dependent signature of metallothionein expression in primary CD4 T cell responses is due to sustained zinc signaling. Rejuvenation Res (2008) 0.89
The cytoskeletal regulator zyxin is required for viability in Drosophila melanogaster. Anat Rec (Hoboken) (2010) 0.89
FHL2 interacts with and acts as a functional repressor of Id2 in human neuroblastoma cells. Nucleic Acids Res (2009) 0.89
Striated muscle cytoarchitecture: an intricate web of form and function. Annu Rev Cell Dev Biol (2002) 3.66
Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement. J Cell Biol (2005) 3.13
Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors. Dev Cell (2003) 2.28
The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. J Biol Chem (2003) 1.97
The Rho/Rac-family guanine nucleotide exchange factor VAV-1 regulates rhythmic behaviors in C. elegans. Cell (2005) 1.93
Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling. J Cell Biol (2006) 1.83
Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers. J Biol Chem (2002) 1.62
A zyxin-mediated mechanism for actin stress fiber maintenance and repair. Dev Cell (2010) 1.62
Targeted disruption of the murine zyxin gene. Mol Cell Biol (2003) 1.51
From the membrane to the nucleus and back again: bifunctional focal adhesion proteins. Curr Opin Cell Biol (2006) 1.47
Doing (F/L)PPPPs: EVH1 domains and their proline-rich partners in cell polarity and migration. Curr Opin Cell Biol (2002) 1.41
Analysis of PINCH function in Drosophila demonstrates its requirement in integrin-dependent cellular processes. Development (2003) 1.36
Characterization of RACK1 function in Drosophila development. Dev Dyn (2007) 1.16
The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1. J Cell Biol (2004) 1.15
Supervillin modulation of focal adhesions involving TRIP6/ZRP-1. J Cell Biol (2006) 1.11
Opposing roles of zyxin/LPP ACTA repeats and the LIM domain region in cell-cell adhesion. J Biol Chem (2006) 1.11
Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators. Mol Biol Cell (2012) 1.10
The Drosophila muscle LIM protein, Mlp84B, cooperates with D-titin to maintain muscle structural integrity. J Cell Sci (2007) 1.05
The Drosophila muscle LIM protein, Mlp84B, is essential for cardiac function. J Exp Biol (2008) 1.01
LPP, a LIM protein highly expressed in smooth muscle. Am J Physiol Cell Physiol (2003) 0.99
TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness. FASEB J (2008) 0.96
Molecular characterization of the Caenorhabditis elegans ALP/Enigma gene alp-1. Dev Dyn (2006) 0.93
The LIM Protein Zyxin Binds CARP-1 and Promotes Apoptosis. Genes Cancer (2010) 0.93
Molecular and phylogenetic characterization of Zyx102, a Drosophila orthologue of the zyxin family that interacts with Drosophila Enabled. Gene (2003) 0.92
The ALP-Enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegans. Mol Biol Cell (2009) 0.91
The cytoskeletal regulator zyxin is required for viability in Drosophila melanogaster. Anat Rec (Hoboken) (2010) 0.89
Lateral communication between stress fiber sarcomeres facilitates a local remodeling response. Biophys J (2012) 0.89
A novel role for keratin 17 in coordinating oncogenic transformation and cellular adhesion in Ewing sarcoma. Mol Cell Biol (2013) 0.89
The EWS/FLI Oncogene Drives Changes in Cellular Morphology, Adhesion, and Migration in Ewing Sarcoma. Genes Cancer (2012) 0.88
Loss of the serum response factor cofactor, cysteine-rich protein 1, attenuates neointima formation in the mouse. Arterioscler Thromb Vasc Biol (2010) 0.83
ALP and MLP distribution during myofibrillogenesis in cultured cardiomyocytes. Cell Motil Cytoskeleton (2003) 0.83
A crucial role for Ras suppressor-1 (RSU-1) revealed when PINCH and ILK binding is disrupted. J Cell Sci (2012) 0.83
LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain. PLoS One (2013) 0.83
The cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiation. Mol Biol Cell (2007) 0.83
Expression of the gene encoding the LIM protein CRP2: a developmental profile. J Histochem Cytochem (2002) 0.82
Elevated expression of the integrin-associated protein PINCH suppresses the defects of Drosophila melanogaster muscle hypercontraction mutants. PLoS Genet (2013) 0.80
Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β. Cell Cycle (2013) 0.80
Prognostic significance of PINCH signalling in human pancreatic ductal adenocarcinoma. HPB (Oxford) (2010) 0.79
alpha-Actinin links LPP, but not zyxin, to cadherin-based junctions. Biochem Biophys Res Commun (2008) 0.78
Deletion of Drosophila muscle LIM protein decreases flight muscle stiffness and power generation. Am J Physiol Cell Physiol (2011) 0.75