Published in Bioorg Med Chem Lett on December 20, 2004
A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Science (2002) 9.59
A novel peroxisome proliferator-activated receptor delta antagonist, SR13904, has anti-proliferative activity in human cancer cells. Cancer Biol Ther (2009) 1.47
Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation. Brain (2009) 1.44
Toxicity after three-dimensional radiotherapy for prostate cancer on RTOG 9406 dose Level V. Int J Radiat Oncol Biol Phys (2005) 1.42
Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity. J Med Chem (2005) 1.22
Genotypic and phenotypic characterization of methicillin-susceptible Staphylococcus aureus isolates misidentified as methicillin-resistant Staphylococcus aureus by the BD GeneOhm MRSA assay. J Clin Microbiol (2011) 1.17
Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-kappaB through suppression of IkappaBalpha phosphorylation. Mol Cancer Ther (2004) 1.16
Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1. J Immunol (2005) 1.11
Atomic force mechanobiology of pluripotent stem cell-derived cardiomyocytes. PLoS One (2012) 1.11
Molecular mechanism of convergent regulation of brain Na(+) channels by protein kinase C and protein kinase A anchored to AKAP-15. Mol Cell Neurosci (2002) 1.10
NF-kappaB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells. Biol Chem (2005) 1.06
Neisserial outer membrane vesicles bind the coinhibitory receptor carcinoembryonic antigen-related cellular adhesion molecule 1 and suppress CD4+ T lymphocyte function. Infect Immun (2007) 1.03
Physical activity and the presence and extent of calcified coronary atherosclerosis. Med Sci Sports Exerc (2002) 1.01
CEACAM1 (CD66a) promotes human monocyte survival via a phosphatidylinositol 3-kinase- and AKT-dependent pathway. J Biol Chem (2006) 0.99
Differential profile of CRF receptor distribution in the rat stomach and duodenum assessed by newly developed CRF receptor antibodies. J Neurochem (2004) 0.99
Moraxella catarrhalis binding to host cellular receptors is mediated by sequence-specific determinants not conserved among all UspA1 protein variants. Infect Immun (2008) 0.99
Novel dihydropyrazine analogues as NPY antagonists. Bioorg Med Chem Lett (2002) 0.96
Conformationally restricted homotryptamines 3. Indole tetrahydropyridines and cyclohexenylamines as selective serotonin reuptake inhibitors. Bioorg Med Chem Lett (2007) 0.93
Operating on a suspicious lung mass without a preoperative tissue diagnosis: pros and cons. Eur J Cardiothorac Surg (2013) 0.93
The Adnectin CT-322 is a novel VEGF receptor 2 inhibitor that decreases tumor burden in an orthotopic mouse model of pancreatic cancer. BMC Cancer (2008) 0.92
Validation of the MEDFICTS dietary questionnaire: a clinical tool to assess adherence to American Heart Association dietary fat intake guidelines. Nutr J (2003) 0.92
An unusual cause of false-positive results with the BD GeneOhm Cdiff assay. J Clin Microbiol (2013) 0.92
Anti-tumor effect of CT-322 as an adnectin inhibitor of vascular endothelial growth factor receptor-2. MAbs (2011) 0.90
New targets of therapy in T-cell lymphomas. Curr Drug Targets (2010) 0.89
Brain biopterin and tyrosine hydroxylase in asymptomatic dopa-responsive dystonia. Ann Neurol (2002) 0.85
Enhanced gastrointestinal motility with orally active ghrelin receptor agonists. J Pharmacol Exp Ther (2009) 0.85
Polyvinylpyrrolidone microneedles enable delivery of intact proteins for diagnostic and therapeutic applications. Acta Biomater (2013) 0.84
Loss of metal transcription factor-1 suppresses tumor growth through enhanced matrix deposition. FASEB J (2004) 0.83
Hypoxia and differentiation in squamous cell carcinomas of the uterine cervix: pimonidazole and involucrin. Clin Cancer Res (2003) 0.83
Increase in tissue inhibitor of metalloproteinase-2 (TIMP-2) levels and inhibition of MMP-2 activity in a metastatic breast cancer cell line by an anti-invasive small molecule SR13179. Cancer Lett (2009) 0.83
Magnetic resonance imaging measurement of the contralateral normal meniscus is a more accurate method of determining meniscal allograft size than radiographic measurement of the recipient tibial plateau. Arthroscopy (2007) 0.83
Central G-Protein Coupled Receptors (GPCR)s as molecular targets for the treatment of obesity: assets, liabilities and development status. Curr Drug Targets CNS Neurol Disord (2004) 0.83
Synthesis, structure-activity relationships, and in vivo evaluation of N3-phenylpyrazinones as novel corticotropin-releasing factor-1 (CRF1) receptor antagonists. J Med Chem (2009) 0.83
Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y(1) receptor antagonist. Eur J Pharmacol (2008) 0.83
Synthesis and structure-activity relationships of N3-pyridylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists. Bioorg Med Chem Lett (2010) 0.82
Body weight regulation by selective MC4 receptor agonists and antagonists. Ann N Y Acad Sci (2003) 0.82
Differentially functionalized diamines as novel ligands for the NPY2 receptor. Bioorg Med Chem Lett (2003) 0.82
Brain proteasomal function in sporadic Parkinson's disease and related disorders. Ann Neurol (2002) 0.81
An effective procedure for the acylation of azaindoles at C-3. J Org Chem (2002) 0.81
Conformationally restricted homotryptamines. Part 4: Heterocyclic and naphthyl analogs of a potent selective serotonin reuptake inhibitor. Bioorg Med Chem Lett (2007) 0.80
Co-circulation of multiple genotypes of human rhinovirus during a large outbreak of respiratory illness in a veterans' long-term care home. J Clin Virol (2013) 0.80
Spatiotemporally and mechanically controlled triggering of mast cells using atomic force microscopy. Immunol Res (2014) 0.79
Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180). J Med Chem (2007) 0.79
The N1 domain of human lactoferrin is required for internalization by caco-2 cells and targeting to the nucleus. Biochemistry (2008) 0.79
(+)-Dinapsoline: an efficient synthesis and pharmacological profile of a novel dopamine agonist. J Med Chem (2002) 0.78
[18F](R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one: introduction of N3-phenylpyrazinones as potential CRF-R1 PET imaging agents. Bioorg Med Chem Lett (2012) 0.78
Dihydropyridine neuropeptide Y Y(1) receptor antagonists. Bioorg Med Chem Lett (2002) 0.78
Discovery of a fluoroindolo[2,3-a]carbazole clinical candidate with broad spectrum antitumor activity in preclinical tumor models superior to the marketed oncology drug, CPT-11. J Med Chem (2005) 0.77
Novel C-5 aminomethyl pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases. Bioorg Med Chem Lett (2007) 0.77
The metal-responsive transcription factor-1 protein is elevated in human tumors. Cancer Biol Ther (2010) 0.77
New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases. Bioorg Med Chem Lett (2007) 0.77
5-((4-Aminopiperidin-1-yl)methyl)pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases. Bioorg Med Chem Lett (2007) 0.77
Exploration of the diketoacid integrase inhibitor chemotype leading to the discovery of the anilide-ketoacids chemotype. Bioorg Med Chem Lett (2006) 0.77
Characterization of ermA in macrolide-susceptible strains of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (2009) 0.77
Smad-independent pathway involved in transforming growth factor β1-induced Nox4 expression and proliferation of endothelial cells. Naunyn Schmiedebergs Arch Pharmacol (2014) 0.77
Potential CRF1R PET imaging agents: N-fluoroalkyl-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethyl-N-alkylpyrazolo[1,5-a][1,3,5]triazin-4-amines. Bioorg Med Chem Lett (2011) 0.76
beta-alanine dipeptides as MC4R agonists. Bioorg Med Chem Lett (2003) 0.76
Application of solution-phase parallel synthesis to preparation of trisubstituted 1,2,4-triazoles. J Comb Chem (2004) 0.76
Homotryptamines as potent and selective serotonin reuptake inhibitors (SSRIs). Bioorg Med Chem Lett (2005) 0.76
Conformationally restricted homotryptamines. 2. Indole cyclopropylmethylamines as selective serotonin reuptake inhibitors. J Med Chem (2005) 0.76
Dihydropyridine neuropeptide Y Y1 receptor antagonists 2. bioisosteric urea replacements. Bioorg Med Chem (2004) 0.76
Identification of a nonbasic melanin hormone receptor 1 antagonist as an antiobesity clinical candidate. J Med Chem (2014) 0.76
Potential CRF1R PET imaging agents: 1-fluoroalkylsubstituted 5-halo-3-(arylamino)pyrazin-2(1H)-ones. Bioorg Med Chem Lett (2013) 0.75
Tetrazole based amides as growth hormone secretagogues. Bioorg Med Chem Lett (2008) 0.75
Discovery, synthesis, and structure-activity studies of tetrazole based growth hormone secretagogues. Bioorg Med Chem Lett (2007) 0.75
Discovery and optimization of (R)-prolinol-derived agonists of the Growth Hormone Secretagogue receptor (GHSR). Bioorg Med Chem Lett (2008) 0.75
Clustering analysis of seismicity and aftershock identification. Phys Rev Lett (2008) 0.75
Conformationally restricted homotryptamines. Part 5: 3-(trans-2-aminomethylcyclopentyl)indoles as potent selective serotonin reuptake inhibitors. Bioorg Med Chem Lett (2009) 0.75
Reductions in log P improved protein binding and clearance predictions enabling the prospective design of cannabinoid receptor (CB1) antagonists with desired pharmacokinetic properties. J Med Chem (2013) 0.75
Conformationally restricted homotryptamines. Part 6: indole-5-cycloalkyl methylamines as selective serotonin reuptake inhibitors. Bioorg Med Chem Lett (2013) 0.75
Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues. Bioorg Med Chem Lett (2005) 0.75
Conformationally restricted homotryptamines. Part 7: 3-cis-(3-aminocyclopentyl)indoles as potent selective serotonin reuptake inhibitors. J Med Chem (2010) 0.75
Full-vector multi-mode fiber modeling for short reach serdes links of 112Gbps and beyond. Opt Express (2016) 0.75
(D)-2-tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: synthesis and incorporation into the growth hormone secretagogues. Bioorg Med Chem Lett (2008) 0.75
Optimization of 1H-tetrazole-1-alkanenitriles as potent orally bioavailable growth hormone secretagogues. Bioorg Med Chem Lett (2008) 0.75
Utilization of an active site mutant receptor for the identification of potent and selective atypical 5-HT2C receptor agonists. J Med Chem (2017) 0.75
Synthesis and evaluation of 5,5-diphenylimidazolones as potent human neuropeptide Y5 receptor antagonists. Bioorg Med Chem (2006) 0.75
Heterocyclic modification of a novel bicyclo[3.1.0]hexane NPY1 receptor antagonist. Bioorg Med Chem Lett (2013) 0.75
Chronobiotic activity of N-[2-(2,7-dimethoxyfluoren-9-yl)ethyl]-propanamide. Synthesis and melatonergic pharmacology of fluoren-9-ylethyl amides. Bioorg Med Chem (2004) 0.75
Solid-phase synthesis and anti-infective activity of a combinatorial library based on the natural product anisomycin. Bioorg Med Chem Lett (2005) 0.75
Design and synthesis of tetrazole-based growth hormone secretagogue: the SAR studies of the O-benzyl serine side chain. Bioorg Med Chem Lett (2008) 0.75
Triketoacid inhibitors of HIV-integrase: a new chemotype useful for probing the integrase pharmacophore. Bioorg Med Chem Lett (2006) 0.75
Partial peroneus longus tendon rupture in professional basketball players: a report of 2 cases. Am J Orthop (Belle Mead NJ) (2002) 0.75
Synthesis and hSERT activity of homotryptamine analogs. Part 6: [3+2] dipolar cycloaddition of 3-vinylindoles. Bioorg Med Chem Lett (2009) 0.75