Published in Blood on November 16, 2004
Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives. Immunol Rev (2008) 4.40
Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes. Cancer Res (2009) 4.16
Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma. J Exp Med (2005) 3.80
Diversity and dialogue in immunity to helminths. Nat Rev Immunol (2011) 3.72
Obstacles and opportunities for understanding macrophage polarization. J Leukoc Biol (2011) 3.16
The phenotype of murine wound macrophages. J Leukoc Biol (2010) 3.13
Krüppel-like factor 4 regulates macrophage polarization. J Clin Invest (2011) 3.08
Arginase: an emerging key player in the mammalian immune system. Br J Pharmacol (2009) 2.59
A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1. J Clin Invest (2011) 2.52
Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells. Nat Med (2015) 2.21
A human promyelocytic-like population is responsible for the immune suppression mediated by myeloid-derived suppressor cells. Blood (2011) 2.03
Wound macrophages as key regulators of repair: origin, phenotype, and function. Am J Pathol (2010) 1.83
Alternatively activated and immunoregulatory monocytes in human filarial infections. J Infect Dis (2009) 1.82
Arginase activity mediates reversible T cell hyporesponsiveness in human pregnancy. Eur J Immunol (2007) 1.76
Macrophage phenotypes during tissue repair. J Leukoc Biol (2013) 1.67
Metabolism of L-arginine by myeloid-derived suppressor cells in cancer: mechanisms of T cell suppression and therapeutic perspectives. Immunol Invest (2012) 1.43
Neutrophils: Between host defence, immune modulation, and tissue injury. PLoS Pathog (2015) 1.35
Multifactorial etiology of gastric cancer. Methods Mol Biol (2012) 1.29
Local suppression of T cell responses by arginase-induced L-arginine depletion in nonhealing leishmaniasis. PLoS Negl Trop Dis (2009) 1.29
Immune suppression by neutrophils and granulocytic myeloid-derived suppressor cells: similarities and differences. Cell Mol Life Sci (2013) 1.26
A role for IL-18 in protective immunity against Mycobacterium tuberculosis. Eur J Immunol (2010) 1.22
Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype. PLoS One (2011) 1.21
Arginase and pulmonary diseases. Naunyn Schmiedebergs Arch Pharmacol (2008) 1.16
Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages. Front Immunol (2014) 1.15
MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana. PLoS Pathog (2010) 1.09
Arginase-1: a new immunohistochemical marker of hepatocytes and hepatocellular neoplasms. Am J Surg Pathol (2010) 1.07
Characterization of a novel population of low-density granulocytes associated with disease severity in HIV-1 infection. PLoS One (2012) 1.05
Increased level of arginase activity correlates with disease severity in HIV-seropositive patients. J Infect Dis (2010) 1.05
Arginase activity - a marker of disease status in patients with visceral leishmaniasis in ethiopia. PLoS Negl Trop Dis (2013) 1.04
Roles of arginase variants, atopy, and ozone in childhood asthma. J Allergy Clin Immunol (2009) 1.03
The role of leishmania proteophosphoglycans in sand fly transmission and infection of the Mammalian host. Front Microbiol (2012) 1.03
Role of arginase 1 from myeloid cells in th2-dominated lung inflammation. PLoS One (2013) 1.02
Arginase activity in the blood of patients with visceral leishmaniasis and HIV infection. PLoS Negl Trop Dis (2013) 0.99
L-arginine deprivation impairs Leishmania major-specific T-cell responses. Eur J Immunol (2009) 0.99
"Of mice and men": arginine metabolism in macrophages. Front Immunol (2014) 0.99
Modulation of specific and allergy-related immune responses by helminths. J Biomed Biotechnol (2011) 0.98
Arginase in parasitic infections: macrophage activation, immunosuppression, and intracellular signals. J Biomed Biotechnol (2009) 0.98
Monocytic cell differentiation from band-stage neutrophils under inflammatory conditions via MKK6 activation. Blood (2014) 0.96
Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses. J Immunol (2014) 0.96
Functional and phenotypic characteristics of alternative activation induced in human monocytes by interleukin-4 or the parasitic nematode Brugia malayi. Infect Immun (2011) 0.94
Arginase and arginine dysregulation in asthma. J Allergy (Cairo) (2011) 0.92
Differential impact of L-arginine deprivation on the activation and effector functions of T cells and macrophages. J Leukoc Biol (2008) 0.92
Myeloid derived suppressor cells (MDSCs) are increased and exert immunosuppressive activity together with polymorphonuclear leukocytes (PMNs) in chronic myeloid leukemia patients. PLoS One (2014) 0.92
Phenotypic alteration of neutrophils in the blood of HIV seropositive patients. PLoS One (2013) 0.90
Selective fusion of azurophilic granules with Leishmania-containing phagosomes in human neutrophils. J Biol Chem (2010) 0.89
A method for identification and analysis of non-overlapping myeloid immunophenotypes in humans. PLoS One (2015) 0.89
Shaping the murine macrophage phenotype: IL-4 and cyclic AMP synergistically activate the arginase I promoter. J Immunol (2013) 0.87
Characterization of neutrophil subsets in healthy human pregnancies. PLoS One (2014) 0.86
Macrophages in diabetic gastroparesis--the missing link? Neurogastroenterol Motil (2014) 0.86
Arginine depletion increases susceptibility to serious infections in preterm newborns. Pediatr Res (2014) 0.85
Depletion of L-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes. Autophagy (2012) 0.84
Cofilin: a redox sensitive mediator of actin dynamics during T-cell activation and migration. Immunol Rev (2013) 0.84
How Neutrophils Shape Adaptive Immune Responses. Front Immunol (2015) 0.84
Systemic arginine depletion after a murine model of surgery or trauma. JPEN J Parenter Enteral Nutr (2011) 0.84
Expression patterns of the immunomodulatory enzyme arginase 1 in blood, lymph nodes and tumor tissue of early-stage breast cancer patients. Oncoimmunology (2012) 0.82
Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity. Int J Parasitol (2008) 0.82
Cell- and isoform-specific increases in arginase expression in acute silica-induced pulmonary inflammation. J Toxicol Environ Health A (2007) 0.82
Arginase I release from activated neutrophils induces peripheral immunosuppression in a murine model of stroke. J Cereb Blood Flow Metab (2015) 0.82
Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma. J Hematol Oncol (2008) 0.81
Mature cystic fibrosis airway neutrophils suppress T cell function: evidence for a role of arginase 1 but not programmed death-ligand 1. J Immunol (2015) 0.81
Kinetic analysis of ex vivo human blood infection by Leishmania. PLoS Negl Trop Dis (2010) 0.81
Influence of human immune cells on cancer: studies at the University of Colorado. Immunol Res (2013) 0.80
PD-L1-expressing neutrophils as a novel indicator to assess disease activity and severity of systemic lupus erythematosus. Arthritis Res Ther (2016) 0.80
Brugia malayi microfilariae induce a regulatory monocyte/macrophage phenotype that suppresses innate and adaptive immune responses. PLoS Negl Trop Dis (2014) 0.80
Tumor macrophage redox and effector mechanisms associated with hypoxia. Free Radic Biol Med (2006) 0.80
Distinct Functions of Neutrophil in Cancer and Its Regulation. Mediators Inflamm (2015) 0.80
L-Arginine modulates neonatal lymphocyte proliferation through an interleukin-2 independent pathway. Immunology (2014) 0.80
Hyperargininemia: a family with a novel mutation in an unexpected site. JIMD Rep (2011) 0.79
Induction of human IL-10-producing neutrophils by LPS-stimulated Treg cells and IL-10. Mucosal Immunol (2015) 0.78
T cell hypo-responsiveness against Leishmania major in MAP kinase phosphatase (MKP) 2 deficient C57BL/6 mice does not alter the healer disease phenotype. PLoS Negl Trop Dis (2013) 0.78
Myeloid derived suppressor cells in chronic myeloid leukemia. Front Oncol (2015) 0.77
Increased plasma arginase activity in human sepsis: association with increased circulating neutrophils. Clin Chem Lab Med (2014) 0.77
Species differences in expression pattern of arginase isoenzymes and differential effects of arginase inhibition on collagen synthesis in human and rat pulmonary fibroblasts. Naunyn Schmiedebergs Arch Pharmacol (2010) 0.77
The pattern of GPI-80 expression is a useful marker for unusual myeloid maturation in peripheral blood. Clin Exp Immunol (2016) 0.76
Arginase I levels are decreased in the plasma of pediatric patients with atopic dermatitis. Ann Allergy Asthma Immunol (2014) 0.76
Protein energy malnutrition increases arginase activity in monocytes and macrophages. Nutr Metab (Lond) (2014) 0.76
Knowledge gaps to understanding cardiac macrophage polarization following myocardial infarction. Biochim Biophys Acta (2016) 0.76
Mesenchymal Stem Cells and Myeloid Derived Suppressor Cells: Common Traits in Immune Regulation. J Immunol Res (2016) 0.76
The prognostic value of the myeloid-mediated immunosuppression marker Arginase-1 in classic Hodgkin lymphoma. Oncotarget (2016) 0.76
Enforced Expression of Hoxa3 Inhibits Classical and Promotes Alternative Activation of Macrophages In Vitro and In Vivo. J Immunol (2016) 0.75
Candida albicans Chitin Increases Arginase-1 Activity in Human Macrophages, with an Impact on Macrophage Antimicrobial Functions. MBio (2017) 0.75
Common and small molecules as the ultimate regulatory and effector mediators of antigen-specific transplantation reactions. World J Transplant (2013) 0.75
Arginase as a new concern in blood transfusion. Blood Transfus (2013) 0.75
Self-harm to preferentially harm the pathogens within: non-specific stressors in innate immunity. Proc Biol Sci (2016) 0.75
Mouse versus Human Neutrophils in Cancer: A Major Knowledge Gap. Trends Cancer (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Replicative senescence of mesenchymal stem cells: a continuous and organized process. PLoS One (2008) 4.37
Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. Exp Hematol (2005) 4.27
DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells. Aging Cell (2009) 2.84
Aging and replicative senescence have related effects on human stem and progenitor cells. PLoS One (2009) 2.62
JAK2-V617F mutation in a patient with Philadelphia-chromosome-positive chronic myeloid leukaemia. Lancet Oncol (2007) 2.44
Administration of bortezomib before and after autologous stem cell transplantation improves outcome in multiple myeloma patients with deletion 17p. Blood (2011) 2.37
Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis. J Biol Chem (2004) 2.37
Targeting the BRAF V600E mutation in multiple myeloma. Cancer Discov (2013) 2.32
BRAF inhibition in refractory hairy-cell leukemia. N Engl J Med (2012) 2.25
Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo. FASEB J (2005) 2.16
Skeletal scintigraphy indicates disease severity of cardiac involvement in patients with senile systemic amyloidosis. Int J Cardiol (2011) 2.10
Steroid-refractory GVHD: T-cell attack within a vulnerable endothelial system. Blood (2011) 1.97
Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging. Blood (2011) 1.92
Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I. Immunity (2003) 1.89
Mesenchymal stem cell preparations--comparing apples and oranges. Stem Cell Rev (2007) 1.88
Inhibition of paraquat-induced autophagy accelerates the apoptotic cell death in neuroblastoma SH-SY5Y cells. Toxicol Sci (2007) 1.87
Suppression of T-cell functions by human granulocyte arginase. Blood (2006) 1.85
Progression in smoldering myeloma is independently determined by the chromosomal abnormalities del(17p), t(4;14), gain 1q, hyperdiploidy, and tumor load. J Clin Oncol (2013) 1.84
Longitudinal left ventricular function for prediction of survival in systemic light-chain amyloidosis: incremental value compared with clinical and biochemical markers. J Am Coll Cardiol (2012) 1.84
Arginase activity mediates reversible T cell hyporesponsiveness in human pregnancy. Eur J Immunol (2007) 1.76
Identification of griseofulvin as an inhibitor of centrosomal clustering in a phenotype-based screen. Cancer Res (2007) 1.69
Toll-like receptor 4 contributes to efficient control of infection with the protozoan parasite Leishmania major. Infect Immun (2004) 1.65
Retroviral vector integration occurs in preferred genomic targets of human bone marrow-repopulating cells. Blood (2002) 1.65
Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV. Blood (2011) 1.65
Assessment of morphological MRI for pulmonary changes in cystic fibrosis (CF) patients: comparison to thin-section CT and chest x-ray. Invest Radiol (2007) 1.64
Spatial separation of HLA-DM/HLA-DR interactions within MIIC and phagosome-induced immune escape. Immunity (2005) 1.64
Hematopoietic progenitor cells and cellular microenvironment: behavioral and molecular changes upon interaction. Stem Cells (2005) 1.62
Prognostic significance of focal lesions in whole-body magnetic resonance imaging in patients with asymptomatic multiple myeloma. J Clin Oncol (2010) 1.60
Mesenchymal stem cells are functionally abnormal in patients with immune thrombocytopenic purpura. Cytotherapy (2009) 1.60
High-dose cytarabine consolidation with or without additional amsacrine and mitoxantrone in acute myeloid leukemia: results of the prospective randomized AML2003 trial. J Clin Oncol (2013) 1.60
PIP2 signaling in lipid domains: a critical re-evaluation. EMBO J (2005) 1.59
Combining information regarding chromosomal aberrations t(4;14) and del(17p13) with the International Staging System classification allows stratification of myeloma patients undergoing autologous stem cell transplantation. Haematologica (2010) 1.58
Modeling of asymmetric cell division in hematopoietic stem cells--regulation of self-renewal is essential for efficient repopulation. Stem Cells Dev (2009) 1.57
The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF-beta/Smad signalling. Genes Cells (2002) 1.53
Functional diagnosis of residual lymphomas after radiochemotherapy with positron emission tomography comparing FDG- and FLT-PET. Leuk Lymphoma (2007) 1.53
Molecular evidence for stem cell function of the slow-dividing fraction among human hematopoietic progenitor cells by genome-wide analysis. Blood (2004) 1.51
Different facets of aging in human mesenchymal stem cells. Tissue Eng Part B Rev (2010) 1.51
Specific age-associated DNA methylation changes in human dermal fibroblasts. PLoS One (2011) 1.51
Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts. Blood (2006) 1.49
Induction of CD4+ T-cell anergy and apoptosis by activated human B cells. Blood (2008) 1.49
Quality of life of long-term survivors with Hodgkin lymphoma after high-dose chemotherapy, autologous stem cell transplantation, and conventional chemotherapy. Leuk Lymphoma (2010) 1.49
Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosis. J Exp Med (2004) 1.46
Molecular and secretory profiles of human mesenchymal stromal cells and their abilities to maintain primitive hematopoietic progenitors. Stem Cells (2007) 1.45
The metalloprotease ADAM8 is associated with and regulates the function of the adhesion receptor PSGL-1 through ERM proteins. Eur J Immunol (2011) 1.45
Supraphysiological nuclear export signals bind CRM1 independently of RanGTP and arrest at Nup358. EMBO J (2004) 1.44
Long-term remission of paraprotein-induced immunotactoid glomerulopathy after high-dose therapy and autologous blood stem cell transplantation. Ann Hematol (2007) 1.44
The impact of high-dose chemotherapy, autologous stem cell transplant and conventional chemotherapy on quality of life of long-term survivors with follicular lymphoma. Leuk Lymphoma (2011) 1.44
Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1. J Cell Biol (2009) 1.41
Cellular immune responses against the cancer-testis antigen SPAN-XB in healthy donors and patients with multiple myeloma. Leuk Lymphoma (2008) 1.40
Proteins required for centrosome clustering in cancer cells. Sci Transl Med (2010) 1.35
The heterogeneity of human mesenchymal stem cell preparations--evidence from simultaneous analysis of proteomes and transcriptomes. Exp Hematol (2006) 1.35
GSK-3 mediates differentiation and activation of proinflammatory dendritic cells. Blood (2006) 1.34
DNA damage-induced accumulation of centrosomal Chk1 contributes to its checkpoint function. Cell Cycle (2007) 1.34
Immunohistochemistry in the classification of systemic forms of amyloidosis: a systematic investigation of 117 patients. Blood (2011) 1.30
Haptoglobin is synthesized during granulocyte differentiation, stored in specific granules, and released by neutrophils in response to activation. Blood (2006) 1.27
Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice. J Cell Sci (2005) 1.27
Co-culture with mesenchymal stromal cells increases proliferation and maintenance of haematopoietic progenitor cells. J Cell Mol Med (2009) 1.25
Serum cytokeratin-18 fragments as quantitative markers of epithelial apoptosis in liver and intestinal graft-versus-host disease. Blood (2007) 1.24
Impact of individual platelet lysates on isolation and growth of human mesenchymal stromal cells. Cytotherapy (2010) 1.23
Biological activities, mechanisms of action and biomedical prospect of the antitumor ether phospholipid ET-18-OCH(3) (edelfosine), a proapoptotic agent in tumor cells. Curr Drug Metab (2002) 1.17
Adhesion of hematopoietic progenitor cells to human mesenchymal stem cells as a model for cell-cell interaction. Exp Hematol (2007) 1.17
Population dynamics of mesenchymal stromal cells during culture expansion. Cytotherapy (2011) 1.16
Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy. J Biol Chem (2005) 1.16
N-cadherin is expressed on human hematopoietic progenitor cells and mediates interaction with human mesenchymal stromal cells. Stem Cell Res (2010) 1.16
Targeted resequencing for analysis of clonal composition of recurrent gene mutations in chronic lymphocytic leukaemia. Br J Haematol (2013) 1.16
Combinatorial SNARE complexes modulate the secretion of cytoplasmic granules in human neutrophils. J Immunol (2006) 1.16
Inhibition of autophagy by TAB2 and TAB3. EMBO J (2011) 1.15
Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells. Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosis. J Biol Chem (2002) 1.15
Arginine transport via cationic amino acid transporter 2 plays a critical regulatory role in classical or alternative activation of macrophages. J Immunol (2006) 1.15
Identification of a new HLA-A2-restricted T-cell epitope within HM1.24 as immunotherapy target for multiple myeloma. Exp Hematol (2006) 1.14
Replicative senescence-associated gene expression changes in mesenchymal stromal cells are similar under different culture conditions. Haematologica (2010) 1.14
Poor mobilization of hematopoietic stem cells-definitions, incidence, risk factors, and impact on outcome of autologous transplantation. Biol Blood Marrow Transplant (2009) 1.14
Blastic plasmacytoid dendritic cell neoplasia (BPDC) in elderly patients: results of a treatment algorithm employing allogeneic stem cell transplantation with moderately reduced conditioning intensity. Biol Blood Marrow Transplant (2011) 1.13
Role of histone deacetylase inhibitors in the treatment of cancer (Review). Int J Oncol (2004) 1.12
Cytotoxicity of an anti-cancer lysophospholipid through selective modification of lipid raft composition. J Biol Chem (2005) 1.12
Aging of hematopoietic stem cells is regulated by the stem cell niche. Exp Gerontol (2008) 1.12
Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding. J Immunol (2007) 1.11
Increased levels of 2-hydroxyglutarate in AML patients with IDH1-R132H and IDH2-R140Q mutations. Eur J Haematol (2010) 1.11
Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo. Cancer Res (2008) 1.11
High-dose melphalan with autologous stem cell transplantation after VAD induction chemotherapy for treatment of amyloid light chain amyloidosis: a single centre prospective phase II study. Br J Haematol (2004) 1.11