Published in Tumour Biol on November 23, 2004
S100A4 accelerates tumorigenesis and invasion of human prostate cancer through the transcriptional regulation of matrix metalloproteinase 9. Proc Natl Acad Sci U S A (2006) 1.87
Deep depletion of abundant serum proteins reveals low-abundant proteins as potential biomarkers for human ovarian cancer. Proteomics Clin Appl (2009) 1.00
Expression of MMP-2, -7, -9, MT1-MMP and TIMP-1 and -2 has no prognostic relevance in patients with advanced epithelial ovarian cancer. Oncol Rep (2011) 0.88
Therapeutic effects of tyroservatide on metastasis of lung cancer and its mechanism affecting integrin-focal adhesion kinase signal transduction. Drug Des Devel Ther (2016) 0.76
Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIalpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab. Ann Oncol (2005) 4.00
Differential expression of matrix metalloproteinase (MMP)-2, MMP-9, and membrane type 1-MMP in hepatocellular and pancreatic adenocarcinoma: implications for tumor progression and clinical prognosis. Clin Cancer Res (2000) 1.63
A high number of tumor-infiltrating lymphocytes are associated with a small tumor size, low tumor stage, and a favorable prognosis in operated small cell lung carcinoma. Clin Cancer Res (2000) 1.53
Overexpression of peroxiredoxins I, II, III, V, and VI in malignant mesothelioma. J Pathol (2002) 1.52
NIH/3T3 cells transfected with human tumor DNA containing activated ras oncogenes express the metastatic phenotype in nude mice. Mol Cell Biol (1985) 1.48
Serum matrix metalloproteinases -2, -9 and tissue inhibitors of metalloproteinases -1, -2 in lung cancer--TIMP-1 as a prognostic marker. Anticancer Res (2000) 1.45
Matrix metalloproteinase-2 (MMP-2) is associated with survival in breast carcinoma. Br J Cancer (2003) 1.45
Omission of histologic grading from clinical decision making may result in overuse of adjuvant therapies in breast cancer: results from a nationwide study. J Clin Oncol (2001) 1.33
Matrix metalloproteinase-2 immunoreactive protein: a marker of aggressiveness in breast carcinoma. Cancer (1998) 1.32
Secretion of basement membrane collagen degrading enzyme and plasminogen activator by transformed cells--role in metastasis. Int J Cancer (1982) 1.31
Inducible nitric oxide synthase expression, apoptosis, and angiogenesis in in situ and invasive breast carcinomas. Clin Cancer Res (2000) 1.22
Enhanced apoptosis predicts shortened survival in non-small cell lung carcinoma. Cancer Res (1995) 1.19
A mutant TP53 gene status is associated with a poor prognosis and anthracycline-resistance in breast cancer patients. Eur J Cancer (2003) 1.18
Mutation screening of Mre11 complex genes: indication of RAD50 involvement in breast and ovarian cancer susceptibility. J Med Genet (2003) 1.15
Expression of collagenase IV (basement membrane collagenase) activity in murine tumor cell hybrids that differ in metastatic potential. J Natl Cancer Inst (1985) 1.14
Apoptotic activity is increased in the newly formed fibromyxoid connective tissue in bronchiolitis obliterans organizing pneumonia. Lung (1999) 1.14
Matrix metalloproteinase-2 (72 kD type IV collagenase) expression occurs in the early stage of human melanocytic tumour progression and may have prognostic value. J Pathol (1996) 1.13
Molecular cloning of chick lysyl hydroxylase. Little homology in primary structure to the two types of subunit of prolyl 4-hydroxylase. J Biol Chem (1991) 1.12
Malignant fibrous histiocytoma of the vulva. Gynecol Oncol (1987) 1.10
p53 and c-erbB-2 protein expression in adenocarcinomas and epithelial dysplasias of the gall bladder. J Pathol (1993) 1.09
Prognostic significance of matrix metalloproteinase-9 (MMP-9) in epithelial ovarian cancer. Gynecol Oncol (2006) 1.09
Laminin increases the release of type IV collagenase from malignant cells. J Biol Chem (1986) 1.09
Prognostic value of MMP-2 immunoreactive protein (72 kD type IV collagenase) in primary skin melanoma. J Pathol (1998) 1.08
Apoptosis during breast carcinoma progression. Clin Cancer Res (1999) 1.08
Prognostic factors in tongue cancer - relative importance of demographic, clinical and histopathological factors. Br J Cancer (2000) 1.05
Up-regulation of thioredoxin and thioredoxin reductase in human malignant pleural mesothelioma. Int J Cancer (2001) 1.04
Matrix metalloproteinase 2 (MMP-2) immunoreactive protein is associated with poor grade and survival in brain neoplasms. J Neurooncol (2000) 1.02
Elevated serum levels of type I collagen degradation marker ICTP and tissue inhibitor of metalloproteinase (TIMP) 1 are associated with poor prognosis in lung cancer. Clin Cancer Res (2001) 1.02
Tumor-promoting phorbol esters and cell proliferation stimulate secretion of basement membrane (type IV) collagen-degrading metalloproteinase by human fibroblasts. J Biol Chem (1985) 1.02
Expression of the laminin gamma2 chain in different histological types of lung carcinoma. A study by immunohistochemistry and in situ hybridization. J Pathol (1999) 1.02
Expression of caspases 3, 6 and 8 is increased in parallel with apoptosis and histological aggressiveness of the breast lesion. Br J Cancer (1999) 1.02
Serum concentrations of collagen degrading enzymes and their inhibitors after downhill running. Scand J Med Sci Sports (2001) 1.01
c-erbB-2 positivity is a factor for poor prognosis in breast cancer and poor response to hormonal or chemotherapy treatment in advanced disease. Eur J Cancer (2001) 1.00
Concurrent p53 expression in bronchial dysplasias and squamous cell lung carcinomas. Am J Pathol (1993) 0.99
Monoclonal antibodies to type IV collagenase recognize a protein with limited sequence homology to interstitial collagenase and stromelysin. FEBS Lett (1988) 0.98
Apoptotic index and apoptosis influencing proteins bcl-2, mcl-1, bax and caspases 3, 6 and 8 in pancreatic carcinoma. Histopathology (1998) 0.98
Gelatinases and their tissue inhibitors in ovarian tumors; TIMP-1 is a predictive as well as a prognostic factor. Gynecol Oncol (2005) 0.98
Sporadic and Thorotrast-induced angiosarcomas of the liver manifest frequent and multiple point mutations in K-ras-2. Lab Invest (1997) 0.98
Cell specific expression of peroxiredoxins in human lung and pulmonary sarcoidosis. Thorax (2002) 0.98
Matrix metalloproteinase-2 (MMP-2) is associated with the risk for a relapse in postmenopausal patients with node-positive breast carcinoma treated with antiestrogen adjuvant therapy. Breast Cancer Res Treat (2001) 0.96
Atypical bronchopulmonary carcinoids show a tendency toward increased apoptotic and proliferative activity. Cancer (2000) 0.96
Distribution and mRNA expression of tenascin-C in developing human lung. Am J Respir Cell Mol Biol (2001) 0.95
Modulation of type-IV collagenase activity and invasive behavior of metastatic human melanoma (A2058) cells in vitro by monoclonal antibodies to type-IV collagenase. Int J Cancer (1990) 0.95
Apoptosis in operated small cell lung carcinoma is inversely related to tumour necrosis and p53 immunoreactivity. J Pathol (1997) 0.92
Tenascin immunoreactivity as a prognostic marker in usual interstitial pneumonia. Am J Respir Crit Care Med (1996) 0.92
Regulation of the acute myeloid leukemia cell line OCI/AML-2 by endothelial nitric oxide synthase under the control of a vascular endothelial growth factor signaling system. Leukemia (2001) 0.92
Tenascin mRNA expression at the foci of recent injury in usual interstitial pneumonia. Am J Respir Crit Care Med (2000) 0.91
Manganese superoxide dismutase is increased in the airways of smokers' lungs. Eur Respir J (2004) 0.91
MMP-2 positivity and age less than 40 years increases the risk for recurrence in premenopausal patients with node-positive breast carcinoma. Breast Cancer Res Treat (1999) 0.91
Cytochrome P4502A6 (CYP2A6) expression in human hepatocellular carcinoma. Hepatology (1998) 0.91
Gelatinase A-immunoreactive protein in ovarian lesions- prognostic value in epithelial ovarian cancer. Gynecol Oncol (1999) 0.90
Expression of caspases-3, -6 and -8 and their relation to apoptosis in non-small cell lung carcinoma. Int J Cancer (2001) 0.90
Ovarian cancer cell invasion is inhibited by paclitaxel. Clin Exp Metastasis (1997) 0.89
Prognostic significance of extracellular matrix metalloproteinase inducer and matrix metalloproteinase 2 in epithelial ovarian cancer. Tumour Biol (2007) 0.89
Tenascin expression and distribution in pleural inflammatory and fibrotic diseases. J Histochem Cytochem (2000) 0.89
p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines. Carcinogenesis (1995) 0.89
Modulation of M(r) 72,000 and M(r) 92,000 type-IV collagenase (gelatinase A and B) gene expression by interferons alpha and gamma in human melanoma. Int J Cancer (1994) 0.89
Fibroblasts stimulate human ovarian cancer cell invasion and expression of 72-kDa gelatinase A (MMP-2). Gynecol Oncol (1997) 0.89
Protein synthesis but not DNA synthesis is required for tumor cell invasion in vitro. Invasion Metastasis (1984) 0.88
Matrix metalloproteinase-2 (MMP-2) immunoreactive protein--a new prognostic marker in uveal melanoma? J Pathol (1999) 0.88
The extent of apoptosis is inversely associated with bcl-2 expression in premalignant and malignant breast lesions. Histopathology (1997) 0.88
Expression and regulation of hemeoxygenase 1 in healthy human lung and interstitial lung disorders. Hum Pathol (2001) 0.88
Very high quantitative tumor HER2 content and outcome in early breast cancer. Ann Oncol (2011) 0.87
Evaluation of PAP and PSA gene expression in prostatic hyperplasia and prostatic carcinoma using northern-blot analyses, in situ hybridization and immunohistochemical stainings with monoclonal and bispecific antibodies. Int J Cancer (1993) 0.87
Explosive rise of serum CA 125 following the rupture of ovarian endometrioma. Hum Reprod (1998) 0.87
p53 mutations in cyclophosphamide-associated bladder cancer. Cancer Epidemiol Biomarkers Prev (1998) 0.87
Human papillomavirus DNA and abnormal p53 expression in carcinoma of the urinary bladder. APMIS (1995) 0.86
p53 protein accumulation and the presence of human papillomavirus DNA in bronchiolo-alveolar carcinoma correlate with poor prognosis. Int J Cancer (1995) 0.86
Low claudin expression is associated with high Gleason grade in prostate adenocarcinoma. Oncol Rep (2008) 0.86
High serum TIMP-1 correlates with poor prognosis in breast carcinoma - a validation study. Cancer Biomark (2007) 0.85
Increased amount of type III pN-collagen in human abdominal aortic aneurysms: evidence for impaired type III collagen fibrillogenesis. J Vasc Surg (2000) 0.85
The prognostic value of peritoneal cytology in ovarian cancer. Eur J Gynaecol Oncol (1999) 0.85
Cancer cells, components of basement membranes, and proteolytic enzymes. Int Rev Exp Pathol (1985) 0.85
p53 protein accumulation in lung carcinomas of patients exposed to asbestos and tobacco smoke. Am J Respir Crit Care Med (1994) 0.85
Proliferating cell nuclear antigen but not p53 or human papillomavirus DNA correlates with advanced clinical stage in renal cell carcinoma. Histopathology (1994) 0.84
Differential expression of adhesion molecules in lung tumours. Histopathology (2007) 0.84
Tumour infiltrating lymphocytes in relation to tumour angiogenesis, apoptosis and prognosis in patients with large cell lung carcinoma. Lung Cancer (1999) 0.84
Peroxiredoxins and antioxidant enzymes in pilocytic astrocytomas. Clin Neuropathol (2007) 0.84
Tissue MMP-2 and MMP-9 [corrected] are better prognostic factors than serum MMP-2/TIMP-2--complex or TIMP-1 [corrected] in stage [corrected] I-III lung carcinoma. Cancer Lett (2005) 0.84
MMP-2 expression associates with CA 125 and clinical course in endometrial carcinoma. Gynecol Oncol (2006) 0.84
Over-expression of tenascin-C in malignant pleural mesothelioma. Histopathology (2003) 0.83
Proliferation, apoptosis, and manganese superoxide dismutase in malignant mesothelioma. Int J Cancer (2000) 0.83
Matrix metalloproteinases-2 and -9 in cervical cancer: different roles in tumor progression. Int J Gynecol Cancer (2006) 0.83
Malignant fibrous histiocytoma. Heterogeneous patterns of intermediate filament proteins by immunohistochemistry. Arch Pathol Lab Med (1989) 0.83
High number of tumour-infiltrating lymphocytes is associated with apoptosis in non-small cell lung carcinoma. APMIS (2001) 0.83
Up-regulation of heme oxygenase-I in alveolar macrophages of newly diagnosed asthmatics. Respir Med (2002) 0.83
Localization of MT1-MMP, TIMP-1, TIMP-2, and TIMP-3 messenger RNA in normal, hyperplastic, and neoplastic endometrium. Enhanced expression by endometrial adenocarcinomas is associated with low differentiation. Am J Clin Pathol (2000) 0.83
Tenascin is increased in epithelial lining fluid in fibrotic lung disorders. Lung (1998) 0.83
The human embryo produces basement membrane collagen (type IV collagen)-degrading protease activity. Hum Reprod (1989) 0.83
Germ-line TP53 mutations in Finnish cancer families exhibiting features of the Li-Fraumeni syndrome and negative for BRCA1 and BRCA2. Cancer Genet Cytogenet (1999) 0.83
Claudins 1, 3, 4, 5 and 7 in esophageal cancer: loss of claudin 3 and 4 expression is associated with metastatic behavior. APMIS (2007) 0.82
Tumor tissue inhibitor of metalloproteinases-1 (TIMP-1) in hormone-independent breast cancer might originate in stromal cells, and improves stratification of prognosis together with nodal status. Exp Cell Res (2012) 0.82
Regulation of 72-kd type IV collagenase-matrix metalloproteinase-2 by estradiol and gonadotropin-releasing hormone agonist in human granulosa-lutein cells. Fertil Steril (1995) 0.82