Published in Mol Biol Cell on November 24, 2004
Coordinated protein sorting, targeting and distribution in polarized cells. Nat Rev Mol Cell Biol (2008) 3.63
Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids. Cell (2010) 2.83
Remodeling epithelial cell organization: transitions between front-rear and apical-basal polarity. Cold Spring Harb Perspect Biol (2009) 2.01
Lethal giant larvae proteins interact with the exocyst complex and are involved in polarized exocytosis. J Cell Biol (2005) 1.47
MARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cells. Mol Biol Cell (2006) 1.27
Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proc Natl Acad Sci U S A (2007) 1.25
LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo. Am J Physiol Endocrinol Metab (2010) 1.21
Transcriptomics-based identification of novel factors enhancing heterologous protein secretion in yeasts. Appl Environ Microbiol (2007) 1.12
The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe. BMC Genomics (2007) 1.04
Antagonistic functions of Par-1 kinase and protein phosphatase 2A are required for localization of Bazooka and photoreceptor morphogenesis in Drosophila. Dev Biol (2007) 1.04
Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein. BMC Neurosci (2008) 1.00
DAPK activates MARK1/2 to regulate microtubule assembly, neuronal differentiation, and tau toxicity. Cell Death Differ (2011) 0.99
Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transport. J Biol Chem (2012) 0.95
Solution structure of the kinase-associated domain 1 of mouse microtubule-associated protein/microtubule affinity-regulating kinase 3. Protein Sci (2006) 0.94
MAP/microtubule affinity-regulating kinases, microtubule dynamics, and spermatogenesis. J Endocrinol (2013) 0.93
Protein phosphatase type 1 directs chitin synthesis at the bud neck in Saccharomyces cerevisiae. Mol Biol Cell (2008) 0.93
The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold. Mol Cell (2012) 0.91
Caenorhabditis elegans PIG-1/MELK acts in a conserved PAR-4/LKB1 polarity pathway to promote asymmetric neuroblast divisions. Genetics (2012) 0.88
Dueling kinases regulate cell size at division through the SAD kinase Cdr2. Curr Biol (2014) 0.88
Mechanisms regulating the protein kinases of Saccharomyces cerevisiae. Eukaryot Cell (2007) 0.85
Polarization and myelination in myelinating glia. ISRN Neurol (2012) 0.82
Pichia pastoris Aft1--a novel transcription factor, enhancing recombinant protein secretion. Microb Cell Fact (2014) 0.81
par-1, atypical pkc, and PP2A/B55 sur-6 are implicated in the regulation of exocyst-mediated membrane trafficking in Caenorhabditis elegans. G3 (Bethesda) (2014) 0.81
Regulatory motifs in Chk1. Cell Cycle (2013) 0.81
A novel role for protein kinase Kin2 in regulating HAC1 mRNA translocation, splicing, and translation. Mol Cell Biol (2014) 0.78
Kin2, the Budding Yeast Ortholog of Animal MARK/PAR-1 Kinases, Localizes to the Sites of Polarized Growth and May Regulate Septin Organization and the Cell Wall. PLoS One (2016) 0.77
Spatial regulation of cytokinesis by the Kin1 and Pom1 kinases in fission yeast. Curr Genet (2006) 0.77
Structural insight into the mechanism of synergistic autoinhibition of SAD kinases. Nat Commun (2015) 0.76
Rab11-FIP1 phosphorylation by MARK2 regulates polarity in MDCK cells. Cell Logist (2017) 0.75
Molecular determinants of KA1 domain-mediated autoinhibition and phospholipid activation of MARK1 kinase. Biochem J (2016) 0.75
The Kinome of Edible and Medicinal Fungus Wolfiporia cocos. Front Microbiol (2016) 0.75
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science (1988) 35.59
High-efficiency transformation of yeast by electroporation. Methods Enzymol (1991) 7.99
The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis. EMBO J (1999) 5.35
Identification of genes required for cytoplasmic localization in early C. elegans embryos. Cell (1988) 4.98
MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Cell (1997) 4.75
Sec9 is a SNAP-25-like component of a yeast SNARE complex that may be the effector of Sec4 function in exocytosis. Cell (1994) 4.46
Yeast syntaxins Sso1p and Sso2p belong to a family of related membrane proteins that function in vesicular transport. EMBO J (1993) 4.27
Sec2p mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesicles. J Cell Biol (1997) 3.94
Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae. J Cell Biol (1995) 3.85
Homologs of the synaptobrevin/VAMP family of synaptic vesicle proteins function on the late secretory pathway in S. cerevisiae. Cell (1993) 3.67
Sec1p binds to SNARE complexes and concentrates at sites of secretion. J Cell Biol (1999) 3.31
Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells. Cell (2003) 2.88
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. Nat Cell Biol (2001) 2.69
Structure and expression of the SNF1 gene of Saccharomyces cerevisiae. Mol Cell Biol (1984) 2.69
Mechanisms of synaptic vesicle exocytosis. Annu Rev Cell Dev Biol (2000) 2.66
The Rho GTPase Rho3 has a direct role in exocytosis that is distinct from its role in actin polarity. Mol Biol Cell (1999) 2.41
Yeast homologues of tomosyn and lethal giant larvae function in exocytosis and are associated with the plasma membrane SNARE, Sec9. J Cell Biol (1999) 2.33
The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole. Cell (2000) 2.28
Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeleton. J Cell Biol (2004) 2.16
Rho3 of Saccharomyces cerevisiae, which regulates the actin cytoskeleton and exocytosis, is a GTPase which interacts with Myo2 and Exo70. Mol Cell Biol (1999) 2.15
Regulation of releasable vesicle pool sizes by protein kinase A-dependent phosphorylation of SNAP-25. Neuron (2004) 2.04
Yeast Cdc42 functions at a late step in exocytosis, specifically during polarized growth of the emerging bud. J Cell Biol (2001) 1.94
Subunit structure of the mammalian exocyst complex. Proc Natl Acad Sci U S A (1997) 1.87
Control of the terminal step of intracellular membrane fusion by protein phosphatase 1. Science (1999) 1.75
The role of PAR-1 in regulating the polarised microtubule cytoskeleton in the Drosophila follicular epithelium. Development (2003) 1.74
Analysis of a yeast SNARE complex reveals remarkable similarity to the neuronal SNARE complex and a novel function for the C terminus of the SNAP-25 homolog, Sec9. J Biol Chem (1997) 1.61
Genetic analysis of the Saccharomyces cerevisiae RHO3 gene, encoding a rho-type small GTPase, provides evidence for a role in bud formation. Genetics (1996) 1.59
Insights into autoregulation from the crystal structure of twitchin kinase. Nature (1994) 1.55
Mammalian homologues of C. elegans PAR-1 are asymmetrically localized in epithelial cells and may influence their polarity. Curr Biol (1997) 1.55
Genetic requirements for PIE-1 localization and inhibition of gene expression in the embryonic germ lineage of Caenorhabditis elegans. Dev Biol (1998) 1.51
A putative protein kinase gene (kin1+) is important for growth polarity in Schizosaccharomyces pombe. Proc Natl Acad Sci U S A (1990) 1.51
A Drosophila melanogaster homologue of Caenorhabditis elegans par-1 acts at an early step in embryonic-axis formation. Nat Cell Biol (2000) 1.49
Drosophila par-1 is required for oocyte differentiation and microtubule organization. Curr Biol (2001) 1.37
Genetic evidence for Pak1 autoinhibition and its release by Cdc42. Mol Cell Biol (1999) 1.32
Protein kinase C-dependent phosphorylation of synaptosome-associated protein of 25 kDa at Ser187 potentiates vesicle recruitment. J Neurosci (2002) 1.30
Differential phosphorylation of syntaxin and synaptosome-associated protein of 25 kDa (SNAP-25) isoforms. J Neurochem (1999) 1.30
Multiple regulatory domains on the Byr2 protein kinase. Mol Cell Biol (1997) 1.25
PAR-1 is required for the maintenance of oocyte fate in Drosophila. Development (2001) 1.24
Binary interactions of the SNARE proteins syntaxin-4, SNAP23, and VAMP-2 and their regulation by phosphorylation. Biochemistry (1998) 1.21
Two yeast genes that encode unusual protein kinases. Proc Natl Acad Sci U S A (1987) 1.18
t-SNARE dephosphorylation promotes SNARE assembly and exocytosis in yeast. EMBO J (2001) 1.16
Formation of a yeast SNARE complex is accompanied by significant structural changes. FEBS Lett (1997) 1.15
Phosphorylation of SNAP-23 in activated human platelets. J Biol Chem (2003) 1.15
Ca2+-dependent phosphorylation of syntaxin-1A by the death-associated protein (DAP) kinase regulates its interaction with Munc18. J Biol Chem (2003) 1.07
Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha. Mol Cell Biol (2001) 0.99
Protein kinase C phosphorylation of syntaxin 4 in thrombin-activated human platelets. J Biol Chem (2000) 0.99
Phosphorylation of SNAP-23 by the novel kinase SNAK regulates t-SNARE complex assembly. Mol Biol Cell (1999) 0.97
Nerve growth factor-induced phosphorylation of SNAP-25 in PC12 cells: a possible involvement in the regulation of SNAP-25 localization. J Neurochem (2000) 0.94
The fusome and microtubules enrich Par-1 in the oocyte, where it effects polarization in conjunction with Par-3, BicD, Egl, and dynein. Curr Biol (2002) 0.88
IgE receptor type I-dependent regulation of a Rab3D-associated kinase: a possible link in the calcium-dependent assembly of SNARE complexes. J Biol Chem (2001) 0.88
Changes of synaptotagmin interaction with t-SNARE proteins in vitro after calcium/calmodulin-dependent phosphorylation. J Neurochem (2000) 0.87
KIN1 and KIN2 protein kinases localize to the cytoplasmic face of the yeast plasma membrane. Exp Cell Res (1994) 0.80
Characterization of the KIN2 gene product in Saccharomyces cerevisiae and comparison between the kinase activities of p145KIN1 and p145KIN2. Yeast (1994) 0.79
The product of the KIN1 locus in Saccharomyces cerevisiae is a serine/threonine-specific protein kinase. Yeast (1991) 0.78
Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1. Nat Cell Biol (2010) 2.61
The ghost in the machine: small GTPases as spatial regulators of exocytosis. Trends Cell Biol (2008) 1.75
The yeast lgl family member Sro7p is an effector of the secretory Rab GTPase Sec4p. J Cell Biol (2006) 1.54
Rho GTPase regulation of exocytosis in yeast is independent of GTP hydrolysis and polarization of the exocyst complex. J Cell Biol (2005) 1.51
Lethal giant larvae proteins interact with the exocyst complex and are involved in polarized exocytosis. J Cell Biol (2005) 1.47
The Exo70 subunit of the exocyst is an effector for both Cdc42 and Rho3 function in polarized exocytosis. Mol Biol Cell (2009) 1.27
Tumor suppressor scribble regulates assembly of tight junctions in the intestinal epithelium. Am J Pathol (2009) 1.07
Structurally conserved interaction of Lgl family with SNAREs is critical to their cellular function. Curr Biol (2005) 1.01
Spatial regulation of exocytosis and cell polarity: yeast as a model for animal cells. FEBS Lett (2007) 1.00
Yeast homologues of lethal giant larvae and type V myosin cooperate in the regulation of Rab-dependent vesicle clustering and polarized exocytosis. Mol Biol Cell (2011) 0.92
The function of two Rho family GTPases is determined by distinct patterns of cell surface localization. Mol Cell Biol (2010) 0.90
The yeast tumor suppressor homologue Sro7p is required for targeting of the sodium pumping ATPase to the cell surface. Mol Biol Cell (2006) 0.90
Quantitative analysis of membrane trafficking in regulation of Cdc42 polarity. Traffic (2014) 0.85
Quantitative proteomics of yeast post-Golgi vesicles reveals a discriminating role for Sro7p in protein secretion. Traffic (2011) 0.83