Published in Curr Opin Investig Drugs on November 01, 2004
New drugs targeting Th2 lymphocytes in asthma. J Occup Med Toxicol (2008) 1.03
Modulation of LPS stimulated NF-kappaB mediated Nitric Oxide production by PKCepsilon and JAK2 in RAW macrophages. J Inflamm (Lond) (2007) 0.97
High-fat diet increases NF-κB signaling in the prostate of reporter mice. Prostate (2011) 0.96
Use of human bronchial epithelial cells (BEAS-2B) to study immunological markers resulting from exposure to PM(2.5) organic extract from Puerto Rico. Toxicol Appl Pharmacol (2009) 0.91
Treating COPD with PDE 4 inhibitors. Int J Chron Obstruct Pulmon Dis (2007) 0.83
Inflammatory Signaling Involved in High-Fat Diet Induced Prostate Diseases. J Urol Res (2015) 0.81
Combinations of indole-3-carbinol and silibinin suppress inflammation-driven mouse lung tumorigenesis by modulating critical cell cycle regulators. Carcinogenesis (2015) 0.80
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J (2013) 8.39
Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N Engl J Med (2005) 6.13
Glucocorticoid resistance in inflammatory diseases. Lancet (2009) 3.57
Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression. J Exp Med (2005) 2.72
Expression and activity of histone deacetylases in human asthmatic airways. Am J Respir Crit Care Med (2002) 2.40
A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. J Neurosci (2010) 2.22
Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. Nat Genet (2003) 2.21
Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J Exp Med (2004) 2.19
A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S A (2002) 2.17
Positional cloning of a novel gene influencing asthma from chromosome 2q14. Nat Genet (2003) 2.16
Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 2.06
Rhinovirus infection induces degradation of antimicrobial peptides and secondary bacterial infection in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 2.06
Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2011) 2.02
Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy. Am J Respir Crit Care Med (2005) 1.93
p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. J Allergy Clin Immunol (2002) 1.84
Update on glucocorticoid action and resistance. J Allergy Clin Immunol (2006) 1.80
Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Med (2011) 1.78
Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. Am J Physiol Lung Cell Mol Physiol (2004) 1.77
Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase. Lancet (2004) 1.71
p38 mitogen-activated protein kinase-γ inhibition by long-acting β2 adrenergic agonists reversed steroid insensitivity in severe asthma. Mol Pharmacol (2011) 1.70
Nitric oxide synthase isoenzyme expression and activity in peripheral lung tissue of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2009) 1.67
Epigenetic regulation of airway inflammation. Curr Opin Immunol (2007) 1.66
Increased p21(CIP1/WAF1) and B cell lymphoma leukemia-x(L) expression and reduced apoptosis in alveolar macrophages from smokers. Am J Respir Crit Care Med (2002) 1.65
Effects of glucocorticoids on gene transcription. Eur J Pharmacol (2004) 1.61
Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice. Am J Respir Crit Care Med (2009) 1.59
Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma. Am J Respir Crit Care Med (2004) 1.53
Rescue treatment in asthma. More than as-needed bronchodilation. Chest (2009) 1.52
Clinical definition of COPD exacerbations and classification of their severity. South Med J (2009) 1.52
A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9. FASEB J (2009) 1.47
NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription. J Immunol (2006) 1.46
The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity. J Biol Chem (2002) 1.45
MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy. PLoS One (2009) 1.44
Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: present and future. Eur J Clin Pharmacol (2009) 1.40
Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients. J Allergy Clin Immunol (2004) 1.38
Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease. J Pharmacol Exp Ther (2006) 1.29
How do corticosteroids work in asthma? Ann Intern Med (2003) 1.29
Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3. J Immunol (2007) 1.28
Application of 'omics technologies to biomarker discovery in inflammatory lung diseases. Eur Respir J (2013) 1.19
Corticosteroid inhibition of growth-related oncogene protein-alpha via mitogen-activated kinase phosphatase-1 in airway smooth muscle cells. J Immunol (2007) 1.18
An integrative systems biology approach to understanding pulmonary diseases. Chest (2010) 1.18
Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia. J Appl Physiol (1985) (2007) 1.18
Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress. Biochem Biophys Res Commun (2011) 1.18
The role of histone deacetylases in asthma and allergic diseases. J Allergy Clin Immunol (2008) 1.17
Histone deacetylation: an important mechanism in inflammatory lung diseases. COPD (2005) 1.17
Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease. J Allergy Clin Immunol (2005) 1.17
Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2. Biochem Biophys Res Commun (2009) 1.17
Airway smooth muscle hyperproliferation is regulated by microRNA-221 in severe asthma. Am J Respir Cell Mol Biol (2014) 1.16
Epigenetics and airways disease. Respir Res (2006) 1.16
Cytokine production by bronchoalveolar lavage T lymphocytes in chronic obstructive pulmonary disease. J Allergy Clin Immunol (2006) 1.15
Retracted Kinase inhibitors and airway inflammation. Eur J Pharmacol (2006) 1.15
Alteration of adenosine receptors in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2005) 1.13
Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon gamma is due to enhanced NF-kappaB binding and histone acetylation at specific kappaB sites. J Biol Chem (2009) 1.12
Cigarette smoke activates human monocytes by an oxidant-AP-1 signaling pathway: implications for steroid resistance. Mol Pharmacol (2005) 1.11
Defects of protein phosphatase 2A causes corticosteroid insensitivity in severe asthma. PLoS One (2011) 1.10
Retracted Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients. J Clin Invest (2011) 1.10
Treatment effects of low-dose theophylline combined with an inhaled corticosteroid in COPD. Chest (2010) 1.08
Restoration of corticosteroid sensitivity by p38 mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma. PLoS One (2012) 1.07
Sputum myeloperoxidase in chronic obstructive pulmonary disease. Eur J Med Res (2014) 1.07
The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells. Am J Pathol (2009) 1.07
MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients. Histopathology (2009) 1.06
Long-acting fluticasone furoate has a superior pharmacological profile to fluticasone propionate in human respiratory cells. Eur J Pharmacol (2011) 1.06
Impact of protein acetylation in inflammatory lung diseases. Pharmacol Ther (2007) 1.05
Attenuation of ozone-induced airway inflammation and hyper-responsiveness by c-Jun NH2 terminal kinase inhibitor SP600125. J Pharmacol Exp Ther (2007) 1.05
Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms. J Biol Chem (2008) 1.05
A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-κB inhibition. J Pharmacol Exp Ther (2013) 1.04
Inhibition of CD73 improves B cell-mediated anti-tumor immunity in a mouse model of melanoma. J Immunol (2012) 1.03
Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease. PLoS Med (2009) 1.03
IL-1 beta and TNF-alpha regulation of the adenosine receptor (A2A) expression: differential requirement for NF-kappa B binding to the proximal promoter. J Immunol (2006) 1.03
New drugs targeting Th2 lymphocytes in asthma. J Occup Med Toxicol (2008) 1.03
Chronic obstructive pulmonary disease and lung cancer: a lethal association. Am J Respir Crit Care Med (2011) 1.01
Immune response to Mycobacterium tuberculosis infection in the parietal pleura of patients with tuberculous pleurisy. PLoS One (2011) 1.00
A role for phosphoinositol 3-kinase delta in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol (2010) 0.99
Peroxynitrite elevation in exhaled breath condensate of COPD and its inhibition by fudosteine. Chest (2009) 0.99
Steroid resistance in asthma: a major problem requiring novel solutions or a non-issue? Curr Opin Pharmacol (2004) 0.98
Effect of interleukin-10 on the production of tumor necrosis factor-alpha by peripheral blood mononuclear cells from patients with chronic heart failure. Am J Cardiol (2002) 0.97
Modulation of LPS stimulated NF-kappaB mediated Nitric Oxide production by PKCepsilon and JAK2 in RAW macrophages. J Inflamm (Lond) (2007) 0.97
Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness. Eur J Pharmacol (2002) 0.96
Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer. Thorax (2011) 0.96
Role of non-coding RNAs in maintaining primary airway smooth muscle cells. Respir Res (2014) 0.95