Published in FASEB J on April 17, 2009
Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55
Regulation of SIRT1 in cellular functions: role of polyphenols. Arch Biochem Biophys (2010) 1.91
Microglial activation in stroke: therapeutic targets. Neurotherapeutics (2010) 1.84
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest (2012) 1.82
SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress. FASEB J (2010) 1.54
Janus-faced role of SIRT1 in tumorigenesis. Ann N Y Acad Sci (2012) 1.43
Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease. Toxicol Appl Pharmacol (2011) 1.35
Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD. Arch Biochem Biophys (2010) 1.34
miR-520c and miR-373 upregulate MMP9 expression by targeting mTOR and SIRT1, and activate the Ras/Raf/MEK/Erk signaling pathway and NF-κB factor in human fibrosarcoma cells. J Cell Physiol (2012) 1.29
Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress. Biochem Biophys Res Commun (2011) 1.18
Regulation of matrix metalloproteinase-9 by epigenetic modifications and the development of diabetic retinopathy. Diabetes (2013) 1.14
Biomarkers of progression of chronic obstructive pulmonary disease (COPD). J Thorac Dis (2014) 1.14
SIRT1 as a therapeutic target in inflammaging of the pulmonary disease. Prev Med (2011) 1.10
Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence. Biochem Pharmacol (2012) 1.06
SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol. Biochem Biophys Res Commun (2010) 1.04
Dysfunction of endothelial progenitor cells from smokers and chronic obstructive pulmonary disease patients due to increased DNA damage and senescence. Stem Cells (2013) 1.04
Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression. Respir Res (2010) 1.02
Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1. PLoS One (2012) 1.02
Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases. Antioxid Redox Signal (2012) 1.01
FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease. J Immunol (2011) 0.98
Inflammation in chronic obstructive pulmonary disease and its role in cardiovascular disease and lung cancer. Clin Transl Med (2015) 0.95
SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism. Am J Physiol Lung Cell Mol Physiol (2014) 0.91
Capsaicin suppresses the migration of cholangiocarcinoma cells by down-regulating matrix metalloproteinase-9 expression via the AMPK-NF-κB signaling pathway. Clin Exp Metastasis (2014) 0.89
PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity. Biochem Biophys Res Commun (2010) 0.89
Lung cancer and its association with chronic obstructive pulmonary disease: update on nexus of epigenetics. Curr Opin Pulm Med (2011) 0.89
Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes. Mol Aspects Med (2013) 0.89
A novel macrolide/fluoroketolide, solithromycin (CEM-101), reverses corticosteroid insensitivity via phosphoinositide 3-kinase pathway inhibition. Br J Pharmacol (2013) 0.88
Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease. Int J Chron Obstruct Pulmon Dis (2012) 0.87
Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice. Am J Physiol Lung Cell Mol Physiol (2012) 0.86
Oxidative stress-induced inhibition of Sirt1 by caveolin-1 promotes p53-dependent premature senescence and stimulates the secretion of interleukin 6 (IL-6). J Biol Chem (2014) 0.85
SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. Am J Physiol Lung Cell Mol Physiol (2013) 0.84
DNA damage due to oxidative stress in Chronic Obstructive Pulmonary Disease (COPD). Int J Mol Sci (2012) 0.83
Disruption of Sirtuin 1-Mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol (2015) 0.83
Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II-Induced Hypertension. J Am Heart Assoc (2015) 0.83
Macrophage-specific NOX2 contributes to the development of lung emphysema through modulation of SIRT1/MMP-9 pathways. J Pathol (2014) 0.82
Bromodomain and extraterminal proteins suppress NF-E2-related factor 2-mediated antioxidant gene expression. J Immunol (2014) 0.81
Epigenetic targets for novel therapies of lung diseases. Pharmacol Ther (2014) 0.81
SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-κB pathway. Braz J Med Biol Res (2013) 0.81
Sirt1 inhibits resistin expression in aortic stenosis. PLoS One (2012) 0.81
Combined exercise and insulin-like growth factor-1 supplementation induces neurogenesis in old rats, but do not attenuate age-associated DNA damage. Rejuvenation Res (2011) 0.80
Resveratrol Targeting of Carcinogen-Induced Brain Endothelial Cell Inflammation Biomarkers MMP-9 and COX-2 is Sirt1-Independent. Drug Target Insights (2012) 0.80
Regulation of SIRT1 by oxidative stress-responsive miRNAs and a systematic approach to identify its role in the endothelium. Antioxid Redox Signal (2013) 0.79
Sirtuin 1 and aging theory for chronic obstructive pulmonary disease. Anal Cell Pathol (Amst) (2015) 0.79
Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection. PLoS One (2013) 0.78
Genome Expression Profiling-Based Identification and Administration Efficacy of Host-Directed Antimicrobial Drugs against Respiratory Infection by Nontypeable Haemophilus influenzae. Antimicrob Agents Chemother (2015) 0.77
Gene expression analysis of the microdissected trophoblast layer of human placenta after the spontaneous onset of labor. PLoS One (2013) 0.76
Practical alternatives to chronic caloric restriction for optimizing vascular function with ageing. J Physiol (2016) 0.75
Erythromycin enhances the anti-inflammatory activity of budesonide in COPD rat model. Int J Clin Exp Med (2015) 0.75
Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells. Sci Rep (2016) 0.75
Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease. Respir Res (2016) 0.75
Dietary polyphenols, deacetylases and chromatin remodeling in inflammation. J Nutrigenet Nutrigenomics (2011) 0.75
Advanced glycation end products and lipopolysaccharides stimulate interleukin-6 secretion via the RAGE/TLR4-NF-κB-ROS pathways and resveratrol attenuates these inflammatory responses in mouse macrophages. Exp Ther Med (2017) 0.75
Resveratrol therapeutics combines both antimicrobial and immunomodulatory properties against respiratory infection by nontypeable Haemophilus influenzae. Sci Rep (2017) 0.75
Effect of Nasal CPAP on SIRT1 and Endothelial Function in Obstructive Sleep Apnea Syndrome. Lung (2015) 0.75
Decreased Serum Sirtuin-1 in COPD. Chest (2017) 0.75
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med (2007) 47.86
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med (2012) 22.96
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell (2006) 19.16
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature (2009) 10.59
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature (2007) 10.21
Chronic obstructive pulmonary disease in non-smokers. Lancet (2009) 6.41
Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N Engl J Med (2005) 6.13
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab (2008) 5.44
Retracted Expression of concern: Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. Am J Respir Crit Care Med (2008) 3.93
Increased 8-isoprostane and interleukin-6 in breath condensate of obstructive sleep apnea patients. Chest (2002) 3.05
Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancer. J Clin Oncol (2004) 3.02
Isoprostanes: markers and mediators of oxidative stress. FASEB J (2004) 2.83
Sex differences in severe pulmonary emphysema. Am J Respir Crit Care Med (2007) 2.77
SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Mol Cell Biol (2008) 2.73
Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression. J Exp Med (2005) 2.72
Retracted The effects of a monoclonal antibody directed against tumor necrosis factor-alpha in asthma. Am J Respir Crit Care Med (2006) 2.72
A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. Am J Respir Crit Care Med (2009) 2.56
COPD as a disease of accelerated lung aging. Chest (2009) 2.56
Regional lung deposition and bronchodilator response as a function of beta2-agonist particle size. Am J Respir Crit Care Med (2005) 2.43
Expression and activity of histone deacetylases in human asthmatic airways. Am J Respir Crit Care Med (2002) 2.40
SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab (2009) 2.25
A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. J Neurosci (2010) 2.22
Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. Nat Genet (2003) 2.21
Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J Exp Med (2004) 2.19
A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S A (2002) 2.17
Positional cloning of a novel gene influencing asthma from chromosome 2q14. Nat Genet (2003) 2.16
Black pleural effusion. Am J Med (2013) 2.11
Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 2.06
Rhinovirus infection induces degradation of antimicrobial peptides and secondary bacterial infection in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 2.06
Molecular mechanisms of corticosteroid resistance. Chest (2008) 2.06
Neutrophil chemotactic activity of sputum from patients with COPD: role of interleukin 8 and leukotriene B4. Chest (2003) 2.04
The European Respiratory Society plans its future: the 2013-2018 strategic plan. Eur Respir J (2014) 2.02
Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2011) 2.02
Release and activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by alveolar macrophages from patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2002) 2.00
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. BMC Syst Biol (2009) 1.94
Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy. Am J Respir Crit Care Med (2005) 1.93
p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. J Allergy Clin Immunol (2002) 1.84
Effect of theophylline on induced sputum inflammatory indices and neutrophil chemotaxis in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2002) 1.84
Stressors, burnout and social support: nurses in acute mental health settings. J Adv Nurs (2004) 1.83
Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2002) 1.82
Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. Am J Physiol Lung Cell Mol Physiol (2004) 1.77
Glucocorticoids: effects on gene transcription. Proc Am Thorac Soc (2004) 1.73
Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase. Lancet (2004) 1.71
Is exposure to biomass smoke the biggest risk factor for COPD globally? Chest (2010) 1.71
p38 mitogen-activated protein kinase-γ inhibition by long-acting β2 adrenergic agonists reversed steroid insensitivity in severe asthma. Mol Pharmacol (2011) 1.70
Increasing doses of inhaled corticosteroids compared to adding long-acting inhaled beta2-agonists in achieving asthma control. Chest (2008) 1.67
Nitric oxide synthase isoenzyme expression and activity in peripheral lung tissue of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2009) 1.67
Epigenetic regulation of airway inflammation. Curr Opin Immunol (2007) 1.66
Imputing cross-sectional missing data: comparison of common techniques. Aust N Z J Psychiatry (2005) 1.65
Increased p21(CIP1/WAF1) and B cell lymphoma leukemia-x(L) expression and reduced apoptosis in alveolar macrophages from smokers. Am J Respir Crit Care Med (2002) 1.65
An Official American Thoracic Society/European Respiratory Society Statement: Research questions in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2015) 1.63
Effects of glucocorticoids on gene transcription. Eur J Pharmacol (2004) 1.61
Crystal structures of human SIRT3 displaying substrate-induced conformational changes. J Biol Chem (2009) 1.60
Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice. Am J Respir Crit Care Med (2009) 1.59
Chronic idiopathic cough: a discrete clinical entity? Chest (2005) 1.59
Maternally imprinted microRNAs are differentially expressed during mouse and human lung development. Dev Dyn (2007) 1.57
Treatment of airway mucus hypersecretion. Ann Med (2006) 1.55
Increased exhaled cysteinyl-leukotrienes and 8-isoprostane in aspirin-induced asthma. Am J Respir Crit Care Med (2002) 1.54
Oral resveratrol reduces neuronal damage in a model of multiple sclerosis. J Neuroophthalmol (2010) 1.54
Alveolar macrophage-mediated elastolysis: roles of matrix metalloproteinases, cysteine, and serine proteases. Am J Physiol Lung Cell Mol Physiol (2002) 1.53
Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma. Am J Respir Crit Care Med (2004) 1.53
Rescue treatment in asthma. More than as-needed bronchodilation. Chest (2009) 1.52
Comparison of the effects of salmeterol and formoterol in patients with severe asthma. Chest (2002) 1.50
3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands. J Med Chem (2011) 1.48
Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3. Protein Sci (2009) 1.46
NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription. J Immunol (2006) 1.46
Biomarkers of some pulmonary diseases in exhaled breath. Biomarkers (2002) 1.45
SIRT1 activation confers neuroprotection in experimental optic neuritis. Invest Ophthalmol Vis Sci (2007) 1.41
The MMPI-2 as a predictor of symptom change following treatment for posttraumatic stress disorder. J Pers Assess (2002) 1.41
Evidence for vascular spread of varicella zoster-associated vasculopathy. Ann Intern Med (2006) 1.39
Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients. J Allergy Clin Immunol (2004) 1.38
Effects of obstructive sleep apnea on circulating ICAM-1, IL-8, and MCP-1. J Appl Physiol (1985) (2002) 1.38
Oxidative stress in COPD. Chest (2013) 1.37
Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma. Am J Respir Crit Care Med (2006) 1.37
Exhaled biomarkers. Chest (2006) 1.36
Transcriptome analysis shows activation of circulating CD8+ T cells in patients with severe asthma. J Allergy Clin Immunol (2011) 1.35
The role of oxidative stress in chronic obstructive pulmonary disease. COPD (2004) 1.33