Published in Clin Orthop Relat Res on December 01, 2004
Gene transfer to human joints: progress toward a gene therapy of arthritis. Proc Natl Acad Sci U S A (2005) 1.57
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Interleukin-17 promotes angiogenesis and tumor growth. Blood (2002) 4.90
Stem-like cells in bone sarcomas: implications for tumorigenesis. Neoplasia (2005) 2.62
Prevalence of neutralizing antibodies to adenoviral serotypes 5 and 35 in the adult populations of The Gambia, South Africa, and the United States. Clin Diagn Lab Immunol (2004) 2.58
Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat Med (2009) 2.55
Protection of mice and poultry from lethal H5N1 avian influenza virus through adenovirus-based immunization. J Virol (2006) 2.47
Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth. Proc Natl Acad Sci U S A (2003) 2.35
NF-κB inhibition delays DNA damage-induced senescence and aging in mice. J Clin Invest (2012) 1.91
Major biological obstacles for persistent cell-based regeneration of articular cartilage. Arthritis Res Ther (2007) 1.85
Exosomes as a short-range mechanism to spread alloantigen between dendritic cells during T cell allorecognition. J Immunol (2008) 1.77
Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis. J Immunol (2005) 1.74
SIRT1 negatively regulates the mammalian target of rapamycin. PLoS One (2010) 1.68
The roles of tumor-derived exosomes in cancer pathogenesis. Clin Dev Immunol (2011) 1.67
UpGene: Application of a web-based DNA codon optimization algorithm. Biotechnol Prog (2004) 1.67
Gene transfer to human joints: progress toward a gene therapy of arthritis. Proc Natl Acad Sci U S A (2005) 1.57
Effects of a SARS-associated coronavirus vaccine in monkeys. Lancet (2003) 1.49
Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma. Cancer Res (2009) 1.46
Widespread and stable pancreatic gene transfer by adeno-associated virus vectors via different routes. Diabetes (2006) 1.45
Exosomes derived from genetically modified DC expressing FasL are anti-inflammatory and immunosuppressive. Mol Ther (2005) 1.38
Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model. Nat Commun (2012) 1.37
Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer. Arthritis Res Ther (2009) 1.34
Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-kappa B oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig. J Immunol (2002) 1.32
DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism. J Bone Miner Res (2013) 1.31
Effective treatment of inflammatory disease models with exosomes derived from dendritic cells genetically modified to express IL-4. J Immunol (2007) 1.30
The oxidative DNA lesions 8,5'-cyclopurines accumulate with aging in a tissue-specific manner. Aging Cell (2012) 1.30
NF-κB in Aging and Disease. Aging Dis (2011) 1.28
Indoleamine 2,3-dioxygenase expression in transplanted NOD Islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes. Diabetes (2002) 1.23
Amelioration of chronic murine colitis by peptide-mediated transduction of the IkappaB kinase inhibitor NEMO binding domain peptide. J Immunol (2007) 1.22
Facilitated endogenous repair: making tissue engineering simple, practical, and economical. Tissue Eng (2007) 1.21
Efficiency of protein transduction is cell type-dependent and is enhanced by dextran sulfate. J Biol Chem (2002) 1.21
Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription. Biochem J (2007) 1.19
Arthritis gene therapy and its tortuous path into the clinic. Transl Res (2013) 1.18
Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models. Arthritis Rheum (2009) 1.18
Intratumoral delivery of dendritic cells engineered to secrete both interleukin (IL)-12 and IL-18 effectively treats local and distant disease in association with broadly reactive Tc1-type immunity. Cancer Res (2003) 1.18
Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia. FASEB J (2008) 1.17
Imaging secretory vesicles by fluorescent protein insertion in propeptide rather than mature secreted peptide. Traffic (2002) 1.17
Lentiviral-mediated gene delivery to synovium: potent intra-articular expression with amplification by inflammation. Mol Ther (2003) 1.15
Prevention of diabetes in NOD mice by administration of dendritic cells deficient in nuclear transcription factor-kappaB activity. Diabetes (2003) 1.15
Gene-induced chondrogenesis of primary mesenchymal stem cells in vitro. Mol Ther (2005) 1.15
Dual transduction of insulin-like growth factor-I and interleukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model. J Orthop Res (2005) 1.15
Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration. J Orthop Res (2013) 1.13
Transgene persistence and cell turnover in the diarthrodial joint: implications for gene therapy of chronic joint diseases. Mol Ther (2007) 1.12
Protection of islets by in situ peptide-mediated transduction of the Ikappa B kinase inhibitor Nemo-binding domain peptide. J Biol Chem (2003) 1.12
Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease. Cell Rep (2012) 1.12
Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model. PLoS One (2011) 1.11
Adenoviral-mediated transfer of TGF-beta1 but not IGF-1 induces chondrogenic differentiation of human mesenchymal stem cells in pellet cultures. Exp Hematol (2005) 1.11
MHC class II+ exosomes in plasma suppress inflammation in an antigen-specific and Fas ligand/Fas-dependent manner. J Immunol (2007) 1.10
Dendritic cells transduced to express interleukin-4 prevent diabetes in nonobese diabetic mice with advanced insulitis. Hum Gene Ther (2003) 1.10
In vivo gene delivery to synovium by lentiviral vectors. Mol Ther (2002) 1.09
Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy. Mol Med (2011) 1.09
Effective treatment of established mouse collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express FasL. Mol Ther (2002) 1.09
Accelerated aging of intervertebral discs in a mouse model of progeria. J Orthop Res (2010) 1.08
Gene transfer of manganese superoxide dismutase extends islet graft function in a mouse model of autoimmune diabetes. Diabetes (2003) 1.08
Immunosuppressive effects of glucosamine. J Biol Chem (2002) 1.08
Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees. Arthritis Res Ther (2003) 1.07
Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta. Arthritis Res Ther (2006) 1.06
The insulin secretory granule is the major site of K(ATP) channels of the endocrine pancreas. Diabetes (2003) 1.04
Broad cellular immunity with robust memory responses to simian immunodeficiency virus following serial vaccination with adenovirus 5- and 35-based vectors. J Gen Virol (2006) 1.03
Arthritis gene therapy's first death. Arthritis Res Ther (2008) 1.03
Enhanced in vitro chondrogenesis of primary mesenchymal stem cells by combined gene transfer. Tissue Eng Part A (2009) 1.02
The fate of mesenchymal stem cells transplanted into immunocompetent neonatal mice: implications for skeletal gene therapy via stem cells. Mol Ther (2004) 1.01
PhiC31 integrase mediates integration in cultured synovial cells and enhances gene expression in rabbit joints. J Gene Med (2006) 1.00
Gene transfer approaches to the healing of bone and cartilage. Mol Ther (2002) 1.00
IL-1ra/IGF-1 gene therapy modulates repair of microfractured chondral defects. Clin Orthop Relat Res (2007) 1.00
Genetically enhanced engineering of meniscus tissue using ex vivo delivery of transforming growth factor-beta 1 complementary deoxyribonucleic acid. Tissue Eng (2007) 0.99
SIRT1 associates with eIF2-alpha and regulates the cellular stress response. Sci Rep (2011) 0.99
Gene transfer to articular chondrocytes with recombinant adenovirus. Methods Mol Biol (2003) 0.99
Orthopedic gene therapy in 2008. Mol Ther (2008) 0.98
Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity. J Immunol (2003) 0.98
Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan. Int J Biochem Cell Biol (2007) 0.97
Biologic response of human intervertebral disc cells to gene therapy cocktail. Spine (Phila Pa 1976) (2008) 0.96
An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints. J Orthop Res (2013) 0.95
Intra-articular gene delivery and expression of interleukin-1Ra mediated by self-complementary adeno-associated virus. J Gene Med (2009) 0.95
Gene therapy for arthritis: what next? Arthritis Rheum (2006) 0.95
Indian hedgehog gene transfer is a chondrogenic inducer of human mesenchymal stem cells. Arthritis Res Ther (2012) 0.95
Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis. Hum Gene Ther (2009) 0.95
NF-κB negatively impacts the myogenic potential of muscle-derived stem cells. Mol Ther (2011) 0.95
Getting arthritis gene therapy into the clinic. Nat Rev Rheumatol (2010) 0.94
Identification of a synovial fibroblast-specific protein transduction domain for delivery of apoptotic agents to hyperplastic synovium. Mol Ther (2003) 0.94
Premature aging-related peripheral neuropathy in a mouse model of progeria. Mech Ageing Dev (2011) 0.94
ISSLS prize winner: inhibition of NF-κB activity ameliorates age-associated disc degeneration in a mouse model of accelerated aging. Spine (Phila Pa 1976) (2012) 0.94
Modulation of the immune response using dendritic cell-derived exosomes. Methods Mol Biol (2007) 0.94
Plasma-derived MHC class II+ exosomes from tumor-bearing mice suppress tumor antigen-specific immune responses. Eur J Immunol (2012) 0.93
Gene therapy in musculoskeletal repair. Ann N Y Acad Sci (2007) 0.93
AAV8-mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in NOD mice. Mol Ther (2008) 0.93
B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function. Eur J Immunol (2009) 0.93
Systemic delivery of NEMO binding domain/IKKγ inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology. Neurobiol Dis (2011) 0.92
Stroma formation and angiogenesis by overexpression of growth factors, cytokines, and proteolytic enzymes in human skin grafted to SCID mice. J Invest Dermatol (2003) 0.92
Expression and activity of the CDK inhibitor p57Kip2 in chondrocytes undergoing hypertrophic differentiation. J Bone Miner Res (2004) 0.92
Possible novel therapy for malignant gliomas with secretable trimeric TRAIL. PLoS One (2009) 0.92
Safety assessment of intradiscal gene transfer: a pilot study. Spine J (2006) 0.92
Hyperactive Himar1 transposase mediates transposition in cell culture and enhances gene expression in vivo. Hum Gene Ther (2006) 0.91