Published in Biochem J on November 15, 2007
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. BMC Syst Biol (2009) 1.94
SIRT1 negatively regulates the mammalian target of rapamycin. PLoS One (2010) 1.68
SirT1 regulates adipose tissue inflammation. Diabetes (2011) 1.39
NF-κB in Aging and Disease. Aging Dis (2011) 1.28
Biochemical effects of SIRT1 activators. Biochim Biophys Acta (2009) 1.16
SIRT1 stabilizes PML promoting its sumoylation. Cell Death Differ (2010) 1.10
The Roles of SIRT1 in Cancer. Genes Cancer (2013) 1.04
Human sirt-1: molecular modeling and structure-function relationships of an unordered protein. PLoS One (2008) 1.01
SIRT1 associates with eIF2-alpha and regulates the cellular stress response. Sci Rep (2011) 0.99
Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan. Int J Biochem Cell Biol (2007) 0.97
Genes regulated by caloric restriction have unique roles within transcriptional networks. Mech Ageing Dev (2008) 0.92
SIRT1 regulates dendritic development in hippocampal neurons. PLoS One (2012) 0.90
SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53. PLoS One (2010) 0.89
SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress. Genes Cancer (2013) 0.89
Sirtuin-1 is a nutrient-dependent modulator of inflammation. Adipocyte (2013) 0.88
Sirtuins in epigenetic regulation. Chem Rev (2015) 0.88
Notch- and transducin-like enhancer of split (TLE)-dependent histone deacetylation explain interleukin 12 (IL-12) p70 inhibition by zymosan. J Biol Chem (2011) 0.85
Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway. Proc Natl Acad Sci U S A (2016) 0.85
Lysine Acetylation of CREBH Regulates Fasting-Induced Hepatic Lipid Metabolism. Mol Cell Biol (2015) 0.82
Alcohol-induced sedation and synergistic interactions between alcohol and morphine: a key mechanistic role for Toll-like receptors and MyD88-dependent signaling. Brain Behav Immun (2014) 0.81
Synergism of heat shock protein 90 and histone deacetylase inhibitors in synovial sarcoma. Sarcoma (2009) 0.79
Prognostic and Clinicopathological Significance of Transducer-Like Enhancer of Split 1 Expression in Gastric Cancer. J Gastric Cancer (2016) 0.78
Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway. Nat Commun (2016) 0.76
Reversible modulation of SIRT1 activity in a mouse strain. PLoS One (2017) 0.75
Sirtuin 1 suppresses nuclear factor κB induced transactivation and pro-inflammatory cytokine expression in cat fibroblast cells. J Vet Med Sci (2015) 0.75
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature (2005) 18.41
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell (2001) 15.97
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J (2004) 11.00
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature (2004) 10.32
Shaping the nuclear action of NF-kappaB. Nat Rev Mol Cell Biol (2004) 6.88
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol (2003) 5.38
Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell (2004) 5.37
Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol Cell (2003) 5.23
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol Cell (2004) 3.73
FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J Biol Chem (2004) 3.39
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. J Biol Chem (2005) 3.38
Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol (2006) 3.37
Acetylation inactivates the transcriptional repressor BCL6. Nat Genet (2002) 3.00
Multiple tumor suppressor pathways negatively regulate telomerase. Cell (2003) 2.82
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem (2005) 2.59
Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. Biochem Biophys Res Commun (2003) 2.27
The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3. J Biol Chem (1997) 2.26
Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription. EMBO J (2001) 2.24
Conversion of dorsal from an activator to a repressor by the global corepressor Groucho. Genes Dev (1997) 1.99
Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression. J Biol Chem (2003) 1.93
Dorsal-mediated repression requires the formation of a multiprotein repression complex at the ventral silencer. Mol Cell Biol (1998) 1.71
Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NFkappaB-dependent transcription. Nat Cell Biol (2006) 1.62
SirT1 fails to affect p53-mediated biological functions. Aging Cell (2006) 1.33
Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats. J Biol Chem (2000) 1.17
The establishment and interpretation of transcription factor gradients in the Drosophila embryo. Biochim Biophys Acta (1995) 1.08
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature (2004) 10.32
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell (2008) 5.51
Interleukin-17 promotes angiogenesis and tumor growth. Blood (2002) 4.90
SirT1 regulates energy metabolism and response to caloric restriction in mice. PLoS One (2008) 3.66
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes (2009) 3.39
SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab (2008) 3.35
A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol (2005) 2.64
Prevalence of neutralizing antibodies to adenoviral serotypes 5 and 35 in the adult populations of The Gambia, South Africa, and the United States. Clin Diagn Lab Immunol (2004) 2.58
Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat Med (2009) 2.55
Protection of mice and poultry from lethal H5N1 avian influenza virus through adenovirus-based immunization. J Virol (2006) 2.47
Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth. Proc Natl Acad Sci U S A (2003) 2.35
SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol (2005) 2.24
Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage. Cell Cycle (2006) 2.17
Sirt1-deficient mice exhibit an altered cartilage phenotype. Joint Bone Spine (2013) 2.06
The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice. J Clin Invest (2009) 2.02
NF-κB inhibition delays DNA damage-induced senescence and aging in mice. J Clin Invest (2012) 1.91
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest (2012) 1.82
Exosomes as a short-range mechanism to spread alloantigen between dendritic cells during T cell allorecognition. J Immunol (2008) 1.77
Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis. J Immunol (2005) 1.74
SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci (2010) 1.71
SIRT1 negatively regulates the mammalian target of rapamycin. PLoS One (2010) 1.68
The roles of tumor-derived exosomes in cancer pathogenesis. Clin Dev Immunol (2011) 1.67
sirt1-null mice develop an autoimmune-like condition. Exp Cell Res (2008) 1.67
UpGene: Application of a web-based DNA codon optimization algorithm. Biotechnol Prog (2004) 1.67
Gene transfer to human joints: progress toward a gene therapy of arthritis. Proc Natl Acad Sci U S A (2005) 1.57
Effects of a SARS-associated coronavirus vaccine in monkeys. Lancet (2003) 1.49
Widespread and stable pancreatic gene transfer by adeno-associated virus vectors via different routes. Diabetes (2006) 1.45
SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis. Eur Heart J (2010) 1.40
Exosomes derived from genetically modified DC expressing FasL are anti-inflammatory and immunosuppressive. Mol Ther (2005) 1.38
Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model. Nat Commun (2012) 1.37
Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. Cell Host Microbe (2008) 1.35
Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD. Arch Biochem Biophys (2010) 1.34
SirT1 fails to affect p53-mediated biological functions. Aging Cell (2006) 1.33
Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-kappa B oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig. J Immunol (2002) 1.32
DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism. J Bone Miner Res (2013) 1.31
Effective treatment of inflammatory disease models with exosomes derived from dendritic cells genetically modified to express IL-4. J Immunol (2007) 1.30
The oxidative DNA lesions 8,5'-cyclopurines accumulate with aging in a tissue-specific manner. Aging Cell (2012) 1.30
NF-κB in Aging and Disease. Aging Dis (2011) 1.28
Indoleamine 2,3-dioxygenase expression in transplanted NOD Islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes. Diabetes (2002) 1.23
Amelioration of chronic murine colitis by peptide-mediated transduction of the IkappaB kinase inhibitor NEMO binding domain peptide. J Immunol (2007) 1.22
Efficiency of protein transduction is cell type-dependent and is enhanced by dextran sulfate. J Biol Chem (2002) 1.21
Arthritis gene therapy and its tortuous path into the clinic. Transl Res (2013) 1.18
Intratumoral delivery of dendritic cells engineered to secrete both interleukin (IL)-12 and IL-18 effectively treats local and distant disease in association with broadly reactive Tc1-type immunity. Cancer Res (2003) 1.18
Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models. Arthritis Rheum (2009) 1.18
Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia. FASEB J (2008) 1.17
Imaging secretory vesicles by fluorescent protein insertion in propeptide rather than mature secreted peptide. Traffic (2002) 1.17
Prevention of diabetes in NOD mice by administration of dendritic cells deficient in nuclear transcription factor-kappaB activity. Diabetes (2003) 1.15
Dual transduction of insulin-like growth factor-I and interleukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model. J Orthop Res (2005) 1.15
Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration. J Orthop Res (2013) 1.13
Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease. Cell Rep (2012) 1.12
Protection of islets by in situ peptide-mediated transduction of the Ikappa B kinase inhibitor Nemo-binding domain peptide. J Biol Chem (2003) 1.12
Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model. PLoS One (2011) 1.11
Adenoviral-mediated transfer of TGF-beta1 but not IGF-1 induces chondrogenic differentiation of human mesenchymal stem cells in pellet cultures. Exp Hematol (2005) 1.11
MHC class II+ exosomes in plasma suppress inflammation in an antigen-specific and Fas ligand/Fas-dependent manner. J Immunol (2007) 1.10
Dendritic cells transduced to express interleukin-4 prevent diabetes in nonobese diabetic mice with advanced insulitis. Hum Gene Ther (2003) 1.10
Silent information regulator 1 protects the brain against cerebral ischemic damage. Stroke (2013) 1.09
Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy. Mol Med (2011) 1.09
Effective treatment of established mouse collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express FasL. Mol Ther (2002) 1.09
Accelerated aging of intervertebral discs in a mouse model of progeria. J Orthop Res (2010) 1.08
Gene transfer of manganese superoxide dismutase extends islet graft function in a mouse model of autoimmune diabetes. Diabetes (2003) 1.08
Immunosuppressive effects of glucosamine. J Biol Chem (2002) 1.08
Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees. Arthritis Res Ther (2003) 1.07
SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice. Aging Cell (2013) 1.06
A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction. Proc Natl Acad Sci U S A (2011) 1.05
Sirtuin 1 in immune regulation and autoimmunity. Immunol Cell Biol (2011) 1.05
The insulin secretory granule is the major site of K(ATP) channels of the endocrine pancreas. Diabetes (2003) 1.04
Caspase-3 mediated cleavage of BRCA1 during UV-induced apoptosis. Oncogene (2002) 1.04
Broad cellular immunity with robust memory responses to simian immunodeficiency virus following serial vaccination with adenovirus 5- and 35-based vectors. J Gen Virol (2006) 1.03
Arthritis gene therapy's first death. Arthritis Res Ther (2008) 1.03
SIRT1-mediated acute cardioprotection. Am J Physiol Heart Circ Physiol (2011) 1.02
The fate of mesenchymal stem cells transplanted into immunocompetent neonatal mice: implications for skeletal gene therapy via stem cells. Mol Ther (2004) 1.01
Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation. Cancer Res (2010) 1.00
IL-1ra/IGF-1 gene therapy modulates repair of microfractured chondral defects. Clin Orthop Relat Res (2007) 1.00
PhiC31 integrase mediates integration in cultured synovial cells and enhances gene expression in rabbit joints. J Gene Med (2006) 1.00
SIRT1 associates with eIF2-alpha and regulates the cellular stress response. Sci Rep (2011) 0.99
CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins. Biochem Biophys Res Commun (2003) 0.98
Orthopedic gene therapy in 2008. Mol Ther (2008) 0.98
Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity. J Immunol (2003) 0.98
The 2003 Nicolas Andry Award. Orthopaedic gene therapy. Clin Orthop Relat Res (2004) 0.98
SIRT1 regulation of wakefulness and senescence-like phenotype in wake neurons. J Neurosci (2011) 0.98
Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan. Int J Biochem Cell Biol (2007) 0.97
Biologic response of human intervertebral disc cells to gene therapy cocktail. Spine (Phila Pa 1976) (2008) 0.96
Poly(D,L lactic-co-glycolic acid) microspheres as biodegradable microcarriers for pluripotent stem cells. Biomaterials (2004) 0.96
NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells. Biochem Biophys Res Commun (2012) 0.95
An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints. J Orthop Res (2013) 0.95
NF-κB negatively impacts the myogenic potential of muscle-derived stem cells. Mol Ther (2011) 0.95
Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis. Hum Gene Ther (2009) 0.95
Gene therapy for arthritis: what next? Arthritis Rheum (2006) 0.95
Intra-articular gene delivery and expression of interleukin-1Ra mediated by self-complementary adeno-associated virus. J Gene Med (2009) 0.95
Premature aging-related peripheral neuropathy in a mouse model of progeria. Mech Ageing Dev (2011) 0.94
Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model. Arthritis Rheum (2013) 0.94
Getting arthritis gene therapy into the clinic. Nat Rev Rheumatol (2010) 0.94
Identification of a synovial fibroblast-specific protein transduction domain for delivery of apoptotic agents to hyperplastic synovium. Mol Ther (2003) 0.94
ISSLS prize winner: inhibition of NF-κB activity ameliorates age-associated disc degeneration in a mouse model of accelerated aging. Spine (Phila Pa 1976) (2012) 0.94
Modulation of the immune response using dendritic cell-derived exosomes. Methods Mol Biol (2007) 0.94
Plasma-derived MHC class II+ exosomes from tumor-bearing mice suppress tumor antigen-specific immune responses. Eur J Immunol (2012) 0.93
Gene therapy in musculoskeletal repair. Ann N Y Acad Sci (2007) 0.93
AAV8-mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in NOD mice. Mol Ther (2008) 0.93
SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice. FASEB J (2011) 0.93
B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function. Eur J Immunol (2009) 0.93