Published in Endocr Rev on December 01, 2004
Biological determinants of endocrine resistance in breast cancer. Nat Rev Cancer (2009) 5.89
Estrogen receptors and human disease. J Clin Invest (2006) 4.91
Emergence of constitutively active estrogen receptor-α mutations in pretreated advanced estrogen receptor-positive breast cancer. Clin Cancer Res (2014) 2.92
Estrogen signaling multiple pathways to impact gene transcription. Curr Genomics (2006) 2.14
Pathways to tamoxifen resistance. Cancer Lett (2007) 2.12
Immunohistochemical expression of estrogen and progesterone receptors identifies a subset of NSCLCs and correlates with EGFR mutation. Clin Cancer Res (2009) 1.60
Advances in breast cancer: pathways to personalized medicine. Clin Cancer Res (2008) 1.59
Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma. Am J Pathol (2006) 1.57
Mechanisms of resistance to endocrine therapy in breast cancer: focus on signaling pathways, miRNAs and genetically based resistance. Int J Mol Sci (2012) 1.44
ERbeta in breast cancer--onlooker, passive player, or active protector? Steroids (2008) 1.42
Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-α. Oncogene (2011) 1.34
Estrogen receptor mutations and changes in downstream gene expression and signaling. Clin Cancer Res (2010) 1.34
Estradiol-induced estrogen receptor-alpha trafficking. J Neurosci (2009) 1.21
Signal transducer and activator of transcription 5b, c-Src, and epidermal growth factor receptor signaling play integral roles in estrogen-stimulated proliferation of estrogen receptor-positive breast cancer cells. Mol Endocrinol (2008) 1.20
Heterogeneity of estrogen receptor expression in circulating tumor cells from metastatic breast cancer patients. PLoS One (2013) 1.16
Association between the estrogen receptor alpha A908G mutation and outcomes in invasive breast cancer. Clin Cancer Res (2007) 1.15
Estrogen receptor-alpha hinge-region lysines 302 and 303 regulate receptor degradation by the proteasome. Mol Endocrinol (2008) 1.14
The estrogen receptor-alpha A908G (K303R) mutation occurs at a low frequency in invasive breast tumors: results from a population-based study. Breast Cancer Res (2005) 1.14
Leptin mediates tumor-stromal interactions that promote the invasive growth of breast cancer cells. Cancer Res (2012) 1.14
Functional regulation of oestrogen receptor pathway by the dynein light chain 1. EMBO Rep (2005) 1.10
Current research topics in endocrine therapy for breast cancer. Int J Clin Oncol (2008) 1.07
Growth factor-induced resistance to tamoxifen is associated with a mutation of estrogen receptor alpha and its phosphorylation at serine 305. Breast Cancer Res Treat (2009) 1.05
Estradiol rapidly regulates membrane estrogen receptor alpha levels in hypothalamic neurons. J Neurosci (2010) 1.04
A role for estrogen receptor phosphorylation in the resistance to tamoxifen. Int J Breast Cancer (2011) 1.02
OTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activity. J Biol Chem (2009) 1.02
Hypersensitive K303R oestrogen receptor-alpha variant not found in invasive carcinomas. Breast Cancer Res (2004) 1.00
Bortezomib enhances the efficacy of fulvestrant by amplifying the aggregation of the estrogen receptor, which leads to a proapoptotic unfolded protein response. Clin Cancer Res (2011) 0.97
Ligand-independent antiapoptotic function of estrogen receptor-beta in lung cancer cells. Mol Endocrinol (2010) 0.97
Positive association between nuclear Runx2 and oestrogen-progesterone receptor gene expression characterises a biological subtype of breast cancer. Eur J Cancer (2009) 0.97
Mechanisms and therapeutic advances in the management of endocrine-resistant breast cancer. World J Clin Oncol (2014) 0.97
Association of oestrogen receptor beta 2 (ER beta 2/ER beta cx) with outcome of adjuvant endocrine treatment for primary breast cancer--a retrospective study. BMC Cancer (2007) 0.95
Risk factors for breast cancer characterized by the estrogen receptor alpha A908G (K303R) mutation. Breast Cancer Res (2007) 0.93
Sex differences in estrogen receptor subcellular location and activity in lung adenocarcinoma cells. Am J Respir Cell Mol Biol (2009) 0.91
The Effects of 17β-estradiol in Cancer are Mediated by Estrogen Receptor Signaling at the Plasma Membrane. Front Physiol (2011) 0.90
In vitro mechanism for downregulation of ER-α expression by epigallocatechin gallate in ER+/PR+ human breast cancer cells. Mol Nutr Food Res (2013) 0.90
Estrogen receptor alpha 46 is reduced in tamoxifen resistant breast cancer cells and re-expression inhibits cell proliferation and estrogen receptor alpha 66-regulated target gene transcription. Mol Cell Endocrinol (2010) 0.89
Tamoxifen resistance and epigenetic modifications in breast cancer cell lines. Curr Med Chem (2007) 0.89
Differential expression of alpha 2 macroglobulin in response to dietylstilbestrol and in ovarian carcinomas in chickens. Reprod Biol Endocrinol (2011) 0.88
Estrogen receptor (ER) α mutations in breast cancer: hidden in plain sight. Breast Cancer Res Treat (2014) 0.87
Levels of estrogen receptors alpha and beta in frontal cortex of patients with Alzheimer's disease: relationship to Mini-Mental State Examination scores. Curr Alzheimer Res (2008) 0.87
Autocrine regulation of cell proliferation by estrogen receptor-alpha in estrogen receptor-alpha-positive breast cancer cell lines. BMC Cancer (2009) 0.87
ER and PR signaling nodes during mammary gland development. Breast Cancer Res (2012) 0.86
Novel oncogenic actions of TRbeta mutants in tumorigenesis. IUBMB Life (2009) 0.86
MiR-190b, the highest up-regulated miRNA in ERα-positive compared to ERα-negative breast tumors, a new biomarker in breast cancers? BMC Cancer (2015) 0.85
Dysregulation of estrogen receptor beta (ERβ), aromatase (CYP19A1), and ER co-activators in the middle frontal gyrus of autism spectrum disorder subjects. Mol Autism (2014) 0.85
Estrogen responses in killifish (Fundulus heteroclitus) from polluted and unpolluted environments are site- and gene-specific. Aquat Toxicol (2010) 0.84
Nutritional flavonoids impact on nuclear and extranuclear estrogen receptor activities. Genes Nutr (2006) 0.84
Effects of estradiol and medroxyprogesterone acetate on morphology, proliferation and apoptosis of human breast tissue in organ cultures. BMC Cancer (2006) 0.84
Estrogen receptor splice variants as a potential source of false-positive estrogen receptor status in breast cancer diagnostics. Breast Cancer Res Treat (2013) 0.83
Effects of two common polymorphisms in the 3' untranslated regions of estrogen receptor beta on mRNA stability and translatability. BMC Genet (2009) 0.83
Prepubertal exposure to elevated manganese results in estradiol regulated mammary gland ductal differentiation and hyperplasia in female rats. Exp Biol Med (Maywood) (2014) 0.82
Membrane-initiated estradiol signaling in immortalized hypothalamic N-38 neurons. Steroids (2013) 0.82
Evolutionary origins of the estrogen signaling system: insights from amphioxus. J Steroid Biochem Mol Biol (2011) 0.82
The molecular genetics of breast cancer and targeted therapy. Biologics (2007) 0.81
Analysis of estrogen receptor isoforms and variants in breast cancer cell lines. Exp Ther Med (2011) 0.81
Significance of rs1271572 in the estrogen receptor beta gene promoter and its correlation with breast cancer in a southwestern Chinese population. J Biomed Sci (2013) 0.80
Roles for miRNAs in endocrine resistance in breast cancer. Endocr Relat Cancer (2015) 0.80
Multiple structurally distinct ERα mRNA variants in zebrafish are differentially expressed by tissue type, stage of development and estrogen exposure. Gen Comp Endocrinol (2013) 0.80
Plant sterols as anticancer nutrients: evidence for their role in breast cancer. Nutrients (2013) 0.78
Estrogen receptors as the novel therapeutic biomarker in non-small cell lung cancer. World J Clin Oncol (2014) 0.78
Accelerated mammary maturation and differentiation, and delayed MMTVneu-induced tumorigenesis of K303R mutant ERalpha transgenic mice. Oncogene (2009) 0.77
Regulatory function of the P295-T311 motif of the estrogen receptor alpha - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses? Nucl Recept Signal (2008) 0.77
Diverse pathomechanisms leading to the breakdown of cellular estrogen surveillance and breast cancer development: new therapeutic strategies. Drug Des Devel Ther (2014) 0.77
Cloning of multiple ERα mRNA variants in killifish (Fundulus heteroclitus), and differential expression by tissue type, stage of reproduction, and estrogen exposure in fish from polluted and unpolluted environments. Aquat Toxicol (2014) 0.76
Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer. Oncogene (2016) 0.76
Familial Multiplicity of Estrogen Insensitivity Associated with a Loss-of-Function ESR1 Mutation. J Clin Endocrinol Metab (2016) 0.76
Combined Red Clover isoflavones and probiotics potently reduce menopausal vasomotor symptoms. PLoS One (2017) 0.75
Investigation on estrogen receptor alpha gene polymorphisms in Iranian women with recurrent pregnancy loss. Iran J Reprod Med (2014) 0.75
Alteration of ERβ gene RsaI polymorphism may contribute to reduced fertilization rate and embryonic developmental competence. Asian J Androl (2010) 0.75
Causal Therapy of Breast Cancer Irrelevant of Age, Tumor Stage and ER-Status: Stimulation of Estrogen Signaling Coupled With Breast Conserving Surgery. Recent Pat Anticancer Drug Discov (2016) 0.75
Expression of a dominant negative estrogen receptor alpha variant in transgenic mice accelerates uterine cancer induced by the potent estrogen diethylstilbestrol. Reprod Toxicol (2012) 0.75
Do Estrogen Receptor beta Polymorphisms Play A Role in the Pharmacogenetics of Estrogen Signaling? Curr Pharmacogenomics Person Med (2008) 0.75
Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth. Sci Rep (2016) 0.75
Single-nucleotide polymorphism in microRNA-binding site of SULF1 target gene as a protective factor against the susceptibility to breast cancer: a case-control study. Onco Targets Ther (2016) 0.75
DNA methylation in endometriosis (Review). Mol Med Rep (2016) 0.75
The ESR1 gene is associated with risk for canine mammary tumours. BMC Vet Res (2013) 0.75
DEFINING THE ROLE OF ESTROGEN RECEPTOR BETA IN THE REGULATION OF FEMALE FERTILITY. Endocrinology (2017) 0.75
Increased dietary levels of α-linoleic acid inhibit mammary tumor growth and metastasis. Eur J Nutr (2015) 0.75
The zinc-finger transcriptional factor Slug transcriptionally downregulates ERα by recruiting lysine-specific demethylase 1 in human breast cancer. Oncogenesis (2017) 0.75
Molecular cloning and tissue distribution of three estrogen receptors from the cyprinid fish Varicorhinus barbatulus. J Comp Physiol B (2007) 0.75
Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer. J Natl Cancer Inst (2003) 4.45
Loss of Rho GDIα and resistance to tamoxifen via effects on estrogen receptor α. J Natl Cancer Inst (2011) 1.84
Phosphorylation of estrogen receptor alpha blocks its acetylation and regulates estrogen sensitivity. Cancer Res (2004) 1.58
RNA sequencing of cancer reveals novel splicing alterations. Sci Rep (2013) 1.57
Low levels of estrogen receptor beta protein predict resistance to tamoxifen therapy in breast cancer. Clin Cancer Res (2004) 1.54
Evidence for diversity in transcriptional profiles of single hematopoietic stem cells. PLoS Genet (2006) 1.51
Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function. Mol Cell Biol (2002) 1.48
Breast cancer patients with progesterone receptor PR-A-rich tumors have poorer disease-free survival rates. Clin Cancer Res (2004) 1.42
Elevated expression of mitogen-activated protein kinase phosphatase 3 in breast tumors: a mechanism of tamoxifen resistance. Cancer Res (2006) 1.35
Androgen receptor overexpression induces tamoxifen resistance in human breast cancer cells. Breast Cancer Res Treat (2009) 1.35
Estrogen receptor mutations and changes in downstream gene expression and signaling. Clin Cancer Res (2010) 1.34
Negative regulation of estrogen receptor alpha transactivation functions by LIM domain only 4 protein. Cancer Res (2005) 1.25
Metastasis-associated protein 2 is a repressor of estrogen receptor alpha whose overexpression leads to estrogen-independent growth of human breast cancer cells. Mol Endocrinol (2006) 1.15
Association between the estrogen receptor alpha A908G mutation and outcomes in invasive breast cancer. Clin Cancer Res (2007) 1.15
Leptin mediates tumor-stromal interactions that promote the invasive growth of breast cancer cells. Cancer Res (2012) 1.14
G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells. Mol Endocrinol (2009) 1.14
Estrogen receptors in resistance to hormone therapy. Adv Exp Med Biol (2007) 1.10
Transcriptomic landscape of breast cancers through mRNA sequencing. Sci Rep (2012) 1.08
Leptin increases HER2 protein levels through a STAT3-mediated up-regulation of Hsp90 in breast cancer cells. Mol Oncol (2012) 1.05
Growth factor-induced resistance to tamoxifen is associated with a mutation of estrogen receptor alpha and its phosphorylation at serine 305. Breast Cancer Res Treat (2009) 1.05
Estrogen receptor alpha-negative breast cancer tissues express significant levels of estrogen-independent transcription factors, ERbeta1 and ERbeta5: potential molecular targets for chemoprevention. Clin Cancer Res (2005) 1.04
Expression of the K303R estrogen receptor-alpha breast cancer mutation induces resistance to an aromatase inhibitor via addiction to the PI3K/Akt kinase pathway. Cancer Res (2009) 1.03
Sp1 is essential for estrogen receptor alpha gene transcription. J Steroid Biochem Mol Biol (2002) 1.02
Cooperative action of tamoxifen and c-Src inhibition in preventing the growth of estrogen receptor-positive human breast cancer cells. Mol Cancer Ther (2006) 1.02
Insights into the role of progesterone receptors in breast cancer. J Clin Oncol (2005) 1.01
The promise of microarrays in the management and treatment of breast cancer. Breast Cancer Res (2005) 0.96
Resveratrol, through NF-Y/p53/Sin3/HDAC1 complex phosphorylation, inhibits estrogen receptor alpha gene expression via p38MAPK/CK2 signaling in human breast cancer cells. FASEB J (2011) 0.96
Regulation of the estrogen receptor alpha minimal promoter by Sp1, USF-1 and ERalpha. Breast Cancer Res Treat (2004) 0.95
Novel insights into breast cancer genetic variance through RNA sequencing. Sci Rep (2013) 0.92
Dicer-mediated upregulation of BCRP confers tamoxifen resistance in human breast cancer cells. Clin Cancer Res (2011) 0.92
The c-Yes 3'-UTR contains adenine/uridine-rich elements that bind AUF1 and HuR involved in mRNA decay in breast cancer cells. J Steroid Biochem Mol Biol (2005) 0.91
AR collaborates with ERα in aromatase inhibitor-resistant breast cancer. Breast Cancer Res Treat (2014) 0.90
In vitro mechanism for downregulation of ER-α expression by epigallocatechin gallate in ER+/PR+ human breast cancer cells. Mol Nutr Food Res (2013) 0.90
Combined low doses of PPARgamma and RXR ligands trigger an intrinsic apoptotic pathway in human breast cancer cells. Am J Pathol (2009) 0.88
Metastasis tumor-associated protein 2 enhances metastatic behavior and is associated with poor outcomes in estrogen receptor-negative breast cancer. Breast Cancer Res Treat (2013) 0.86
Tamoxifen through GPER upregulates aromatase expression: a novel mechanism sustaining tamoxifen-resistant breast cancer cell growth. Breast Cancer Res Treat (2014) 0.84
A hypersensitive estrogen receptor alpha mutation that alters dynamic protein interactions. Breast Cancer Res Treat (2009) 0.83
Role of MTA2 in human cancer. Cancer Metastasis Rev (2014) 0.82
Hormone Action and Clinical Significance of the Estrogen Receptor α. Cancer Treat Res (2009) 0.77
Targeting thyroid hormone receptor beta in triple-negative breast cancer. Breast Cancer Res Treat (2015) 0.76
Identification of a novel estrogen receptor-alpha variant and its upstream splicing regulator. Mol Endocrinol (2010) 0.76
Pharmacogenetics of breast cancer: toward the individualization of therapy. Cancer Invest (2009) 0.76