Emergence of constitutively active estrogen receptor-α mutations in pretreated advanced estrogen receptor-positive breast cancer.

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Published in Clin Cancer Res on January 07, 2014

Authors

Rinath Jeselsohn1,2, Roman Yelensky3, Gilles Buchwalter1,2, Garrett Frampton3, Funda Meric-Bernstam4, Ana Maria Gonzalez-Angulo5, Jaime Ferrer-Lozano6, Jose A Perez-Fidalgo7, Massimo Cristofanilli8, Henry Gómez9, Carlos L Arteaga10, Jennifer Giltnane10, Justin M Balko10, Maureen T Cronin3, Mirna Jarosz3, James Sun3, Matthew Hawryluk3, Doron Lipson3, Geoff Otto3, Jeffrey S Ross3, Addie Dvir11, Lior Soussan-Gutman11, Ido Wolf12, Tamar Rubinek12, Lauren Gilmore13, Stuart Schnitt13, Steven E Come14, Lajos Pusztai15, Philip Stephens3, Myles Brown1,2, Vincent A Miller3

Author Affiliations

1: Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, 450 Brookline Ave. Boston, MA 02215.
2: Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215.
3: Foundation Medicine, One Kendall Sq. Cambridge, MA 02139.
4: Departments of Investigational Cancer Therapeutics, Surgical Oncology, The University of MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030.
5: Departments of Systems Biology, and Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030.
6: Fundacion de Investigacion INCLIVA - Institute for Health Reseearch, Valencia, Spain.
7: Departments of Hematology-Oncology, Hospital Clinico Universitario de Valencia, Valencia, Spain.
8: Jefferson Breast Care Center, Kimmel Cancer Center, Thomas Jefferson University, 925 Chestnut St. Philadelphia, PA 19107.
9: Instituto Nacional de Enfermedades Neoplásicas (INEN), Lima, Perú.
10: Breast Cancer Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, 2220 Pierce Ave, Nashville, TN 37232.
11: Teva Pharmaceuticals, 5 Basel St. Petach Tikva, Israel 49131.
12: Oncology Division, Tel Aviv Sourasky Medical Center , 6 Weizmann St. Tel Aviv 64239, Israel.
13: Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave. Boston MA 02215.
14: Breast Medical Oncology Program, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave. Boston MA 02215.
15: Section of Breast Medical Oncology, Yale School of Medicine, New Haven, South Frontage Rd and Park St. CN, 06510.

Associated clinical trials:

Personalized Treatment Selection for Metastatic Breast Cancer | NCT00780676

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