Published in J Exp Med on December 13, 2004
TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab (2009) 6.91
The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism. FEBS J (2005) 2.12
An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2. FEBS J (2006) 1.75
Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis. Cell Rep (2014) 1.66
Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin. PLoS One (2009) 1.52
LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease. Proc Natl Acad Sci U S A (2007) 1.35
The nuclear receptor LRH-1 critically regulates extra-adrenal glucocorticoid synthesis in the intestine. J Exp Med (2006) 1.21
T-cell activation in the intestinal mucosa. Immunol Rev (2007) 1.20
TNF suppresses acute intestinal inflammation by inducing local glucocorticoid synthesis. J Exp Med (2010) 1.19
Extra-adrenal glucocorticoids and mineralocorticoids: evidence for local synthesis, regulation, and function. Am J Physiol Endocrinol Metab (2011) 1.18
The host response to the probiotic Escherichia coli strain Nissle 1917: specific up-regulation of the proinflammatory chemokine MCP-1. BMC Med Genet (2005) 1.01
Emerging actions of the nuclear receptor LRH-1 in the gut. Biochim Biophys Acta (2010) 1.01
Bim dictates naive CD4 T cell lifespan and the development of age-associated functional defects. J Immunol (2010) 0.98
Extra-adrenal glucocorticoid synthesis in the intestinal epithelium: more than a drop in the ocean? Semin Immunopathol (2009) 0.90
Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins. J Exp Med (2013) 0.88
Stress modulates intestinal secretory immunoglobulin A. Front Integr Neurosci (2013) 0.86
Shifting the feeding of mice to the rest phase creates metabolic alterations, which, on their own, shift the peripheral circadian clocks by 12 hours. Proc Natl Acad Sci U S A (2015) 0.83
The steroidogenic enzyme Cyp11a1 is essential for development of peanut-induced intestinal anaphylaxis. J Allergy Clin Immunol (2013) 0.82
The macrophage migration inhibitory factor homolog of Entamoeba histolytica binds to and immunomodulates host macrophages. Infect Immun (2014) 0.81
Mesenchymal stem cell therapy induces glucocorticoid synthesis in colonic mucosa and suppresses radiation-activated T cells: new insights into MSC immunomodulation. Mucosal Immunol (2013) 0.80
Glucocorticoid production and regulation in thymus: of mice and birds. Endocrinology (2009) 0.79
Metabolism: gut microbiota modulates diurnal secretion of glucocorticoids. Nat Rev Endocrinol (2013) 0.77
Hypophyseal corticosteroids stimulate somatotrope differentiation in the embryonic chicken pituitary gland. Histochem Cell Biol (2007) 0.77
Intestinal epithelium-specific knockout of the cytochrome P450 reductase gene exacerbates dextran sulfate sodium-induced colitis. J Pharmacol Exp Ther (2015) 0.76
Colon cancer cells produce immunoregulatory glucocorticoids. Oncoimmunology (2012) 0.76
Molecular cloning and expression patterns of the cholesterol side chain cleavage enzyme (CYP11A1) gene during the reproductive cycle in goose (Anas cygnoides). J Anim Sci Biotechnol (2015) 0.75
Local corticosterone production and angiotensin-I converting enzyme shedding in a mouse model of intestinal inflammation. World J Gastroenterol (2015) 0.75
Macrolides increase the expression of 11β-hydroxysteroid dehydrogenase 1 in human sinonasal epithelium, contributing to glucocorticoid activation in sinonasal mucosa. Br J Pharmacol (2015) 0.75
How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev (2000) 15.16
Regulatory T cells in the control of immune pathology. Nat Immunol (2001) 6.98
Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature (1995) 6.85
The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med (1995) 6.17
The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression. Endocr Rev (2003) 3.40
T cells in inflammatory bowel disease: protective and pathogenic roles. Immunity (1995) 3.40
Stress and glucocorticoids impair retrieval of long-term spatial memory. Nature (1998) 3.28
Glucocorticoids in T cell development and function*. Annu Rev Immunol (2000) 2.63
Nongenomic actions of steroid hormones. Nat Rev Mol Cell Biol (2003) 2.54
Stress-free T-cell development: glucocorticoids are not obligatory. Immunol Today (2000) 2.20
Regulatory T cells and inflammatory bowel disease. Immunol Today (1999) 1.94
Proliferative responses of human intraepithelial lymphocytes to various T-cell stimuli. Gastroenterology (1989) 1.73
Molecular determinants of glucocorticoid receptor mobility in living cells: the importance of ligand affinity. Mol Cell Biol (2003) 1.62
Transimmortalized mouse intestinal cells (m-ICc12) that maintain a crypt phenotype. Am J Physiol (1996) 1.51
Nonlymphocyte-derived tumor necrosis factor is required for induction of colitis in recombination activating gene (RAG)2(-/-) mice upon transfer of CD4(+)CD45RB(hi) T cells. J Exp Med (1999) 1.46
Glucocorticoids and immune function: unknown dimensions and new frontiers. Immunol Today (1997) 1.41
Steroid production in the thymus: implications for thymocyte selection. J Exp Med (1994) 1.39
Endogenous glucocorticoids protect against cytokine-mediated lethality during viral infection. J Immunol (1999) 1.26
Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp. J Endocrinol (1998) 1.21
Glucocorticoid-mediated control of the activation and clonal deletion of peripheral T cells in vivo. J Exp Med (1993) 1.20
Fas ligand- mediated killing by intestinal intraepithelial lymphocytes. Participation in intestinal graft-versus-host disease. J Clin Invest (1998) 1.20
Dose-dependent suppression of adrenocortical activity with metyrapone: effects on emotion and memory. Psychoneuroendocrinology (1996) 1.18
Isolation of intestinal epithelial cells for the study of differential gene expression along the crypt-villus axis. Am J Physiol (1991) 1.15
Extra-adrenal production of corticosteroids. Clin Exp Pharmacol Physiol (2003) 1.13
Intraepithelial lymphocytes: origins, distribution, and function. Crit Rev Immunol (1998) 1.11
Expression of 11beta-hydroxylase and aldosterone synthase genes in the rat brain. J Mol Endocrinol (2000) 1.09
T cell receptor-triggered activation of intraepithelial lymphocytes in vitro. Int Immunol (1993) 1.04
Thymus-derived glucocorticoids regulate antigen-specific positive selection. J Exp Med (1997) 1.02
Mortality in 7B2 null mice can be rescued by adrenalectomy: involvement of dopamine in ACTH hypersecretion. Proc Natl Acad Sci U S A (2002) 1.00
Disruption of glucocorticoid receptor exon 2 yields a ligand-responsive C-terminal fragment that regulates gene expression. Mol Endocrinol (2003) 0.99
Oral tolerance. Am J Respir Crit Care Med (2000) 0.98
Corticosteroid synthesis in the central nervous system. Endocr Res (1996) 0.94
Thymus-derived glucocorticoids set the thresholds for thymocyte selection by inhibiting TCR-mediated thymocyte activation. J Immunol (1999) 0.93
Regulation of cell death and survival in intestinal intraepithelial lymphocytes. Cell Death Differ (2001) 0.92
Enhancement of rat splenic lymphocyte mitogenesis after short term preexposure to corticosteroids in vitro. Endocrinology (1994) 0.88
Paracrine glucocorticoid activity produced by mouse thymic epithelial cells. FASEB J (1999) 0.88
Glucocorticoid production in the murine thymus. Eur J Immunol (2000) 0.88
Sensitizing antigen-specific CD8+ T cells for accelerated suicide causes immune incompetence. J Clin Invest (2003) 0.85
Cholesterol side-chain cleavage cytochrome P450 gene expression in the primitive gut of the mouse embryo does not require steroidogenic factor 1. Mol Endocrinol (1995) 0.85
Metyrapone is a competitive inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 reductase. J Steroid Biochem Mol Biol (1997) 0.84
A comparison of of the potency of some 11beta-hydroxylase inhibitors using rat and human adrenal tissue. J Endocrinol (1968) 0.83
High dose of dexamethasone upregulates TCR/CD3-induced calcium response independent of TCR zeta chain expression in human T lymphocytes. J Cell Biochem (2001) 0.79
Hormonal steroidogenesis in liver and small intestine of the green frog, Rana esculenta L. Life Sci (2001) 0.78
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol (2006) 9.36
Glycyrrhetinic acid food supplementation lowers serum potassium concentration in chronic hemodialysis patients. Kidney Int (2009) 2.39
miR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer. Cancer Res (2009) 2.39
Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand. J Exp Med (2008) 2.30
CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung. Nat Med (2002) 2.22
TREM-1--expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. J Clin Invest (2007) 2.08
Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice. Proc Natl Acad Sci U S A (2002) 1.73
In vitro model for the study of necrosis and apoptosis in native cartilage. J Pathol (2002) 1.69
Hydrogel-based engineered skeletal muscle grafts normalize heart function early after myocardial infarction. Artif Organs (2008) 1.61
Phot-LOV1: photocycle of a blue-light receptor domain from the green alga Chlamydomonas reinhardtii. Biophys J (2003) 1.56
TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality. J Clin Invest (2006) 1.55
Age-dependent decrease in 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) activity in hypertensive patients. Am J Hypertens (2008) 1.51
CD1d function is regulated by microsomal triglyceride transfer protein. Nat Med (2004) 1.49
Delineation of a CD1d-restricted antigen presentation pathway associated with human and mouse intestinal epithelial cells. Gastroenterology (2003) 1.45
Reduced 11beta-hydroxysteroid dehydrogenase activity in experimental nephrotic syndrome. Nephrol Dial Transplant (2002) 1.44
Recycling of the pulmonary valve: an elegant solution for secondary pulmonary regurgitation in patients with tetralogy of Fallot. Ann Thorac Surg (2012) 1.38
LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease. Proc Natl Acad Sci U S A (2007) 1.35
Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine. J Immunol (2005) 1.31
IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils. Blood (2008) 1.28
Transmembrane TNF induces an efficient cell-mediated immunity and resistance to Mycobacterium bovis bacillus Calmette-Guérin infection in the absence of secreted TNF and lymphotoxin-alpha. J Immunol (2002) 1.27
Three-dimensional imaging and cone beam volume CT in C-arm angiography with flat panel detector. Diagn Interv Radiol (2005) 1.24
The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6. J Clin Invest (2008) 1.24
Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophils. J Exp Med (2004) 1.22
The nuclear receptor LRH-1 critically regulates extra-adrenal glucocorticoid synthesis in the intestine. J Exp Med (2006) 1.21
Loss of the CBX7 protein expression correlates with a more aggressive phenotype in pancreatic cancer. Eur J Cancer (2010) 1.21
Contribution of transmembrane tumor necrosis factor to host defense against Mycobacterium bovis bacillus Calmette-guerin and Mycobacterium tuberculosis infections. Am J Pathol (2005) 1.21
TNF suppresses acute intestinal inflammation by inducing local glucocorticoid synthesis. J Exp Med (2010) 1.19
Intestinal macrophages: differentiation and involvement in intestinal immunopathologies. Semin Immunopathol (2009) 1.17
Fas (CD95/Apo-1) ligand regulation in T cell homeostasis, cell-mediated cytotoxicity and immune pathology. Semin Immunol (2003) 1.15
T2 star relaxation times for assessment of articular cartilage at 3 T: a feasibility study. Skeletal Radiol (2011) 1.15
CX3CR1 defines functionally distinct intestinal mononuclear phagocyte subsets which maintain their respective functions during homeostatic and inflammatory conditions. Eur J Immunol (2011) 1.14
Adaptations of intestinal macrophages to an antigen-rich environment. Semin Immunol (2006) 1.14
Role of an intact splenic microarchitecture in early lymphocytic choriomeningitis virus production. J Virol (2002) 1.14
Microsecond light-induced proton transfer to flavin in the blue light sensor plant cryptochrome. J Am Chem Soc (2009) 1.12
Acridine Orange/Ethidium Bromide (AO/EB) Staining to Detect Apoptosis. CSH Protoc (2006) 1.10
Thiazolides inhibit growth and induce glutathione-S-transferase Pi (GSTP1)-dependent cell death in human colon cancer cells. Int J Cancer (2008) 1.08
IRF4 regulates IL-17A promoter activity and controls RORγt-dependent Th17 colitis in vivo. Inflamm Bowel Dis (2011) 1.07
Detection of apoptosis in vivo using antibodies against caspase-induced neo-epitopes. Methods (2008) 1.04
Tumor necrosis factor-alpha: alternative role as an inhibitor of osteoclast formation in vitro. Bone (2006) 1.01
Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme. J Biol Chem (2004) 1.01
An essential role for transmembrane TNF in the resolution of the inflammatory lesion induced by Leishmania major infection. Eur J Immunol (2008) 0.99
Apoptosis in disease: about shortage and excess. Essays Biochem (2003) 0.99
Functional expression of CD134 by neutrophils. Eur J Immunol (2004) 0.98
Cell cycle-dependent regulation of extra-adrenal glucocorticoid synthesis in murine intestinal epithelial cells. FASEB J (2008) 0.95
Prematurity is related to high placental cortisol in preeclampsia. Pediatr Res (2009) 0.95
The phot LOV2 domain and its interaction with LOV1. Biophys J (2005) 0.95
Enhancement of Apo2L/TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-induced apoptosis in non-small cell lung cancer cell lines by chemotherapeutic agents without correlation to the expression level of cellular protease caspase-8 inhibitory protein. J Thorac Cardiovasc Surg (2002) 0.94
The mucosal immune system at the gastrointestinal barrier. Best Pract Res Clin Gastroenterol (2008) 0.94
Differential regulation of glucocorticoid synthesis in murine intestinal epithelial versus adrenocortical cell lines. Endocrinology (2006) 0.94
Impaired protein stability of 11beta-hydroxysteroid dehydrogenase type 2: a novel mechanism of apparent mineralocorticoid excess. J Am Soc Nephrol (2007) 0.93
Metabolic pathway and distribution of superparamagnetic iron oxide nanoparticles: in vivo study. Int J Nanomedicine (2011) 0.93
Macrophages induce neutrophil apoptosis through membrane TNF, a process amplified by Leishmania major. J Immunol (2006) 0.93
Lack of TNFR2 expression by CD4(+) T cells exacerbates experimental colitis. Eur J Immunol (2009) 0.92
Ligand-based virtual screening using Bayesian networks. J Chem Inf Model (2010) 0.92
Quality of training in radiation oncology in Germany. Results of a 2006 survey. Strahlenther Onkol (2008) 0.92
HVEM signalling promotes colitis. PLoS One (2011) 0.92
TRAIL-induced apoptosis: between tumor therapy and immunopathology. Ann N Y Acad Sci (2009) 0.91
Virus-induced activation of self-specific TCR alpha beta CD8 alpha alpha intraepithelial lymphocytes does not abolish their self-tolerance in the intestine. J Immunol (2004) 0.91
Effects of antiretroviral drugs on human immunodeficiency virus type 1-induced CD4(+) T-cell death. J Virol (2002) 0.91
Chenodeoxycholic acid and deoxycholic acid inhibit 11 beta-hydroxysteroid dehydrogenase type 2 and cause cortisol-induced transcriptional activation of the mineralocorticoid receptor. J Biol Chem (2002) 0.91
Velocity resolved REMPI spectroscopy: a new approach to the study of photodissociation dynamics. Phys Chem Chem Phys (2009) 0.91
Exclusive expression of transmembrane TNF-alpha in mice reduces the inflammatory response in early lipid lesions of aortic sinus. Atherosclerosis (2004) 0.91
Tumor necrosis factor α sensitizes primary murine hepatocytes to Fas/CD95-induced apoptosis in a Bim- and Bid-dependent manner. Hepatology (2010) 0.90
Production of interferon-gamma by activated T-cell receptor-alphabeta CD8alphabeta intestinal intraepithelial lymphocytes is required and sufficient for disruption of the intestinal barrier integrity. Immunology (2009) 0.90
Extra-adrenal glucocorticoid synthesis in the intestinal epithelium: more than a drop in the ocean? Semin Immunopathol (2009) 0.90
Analysis of DNA fragmentation using agarose gel electrophoresis. CSH Protoc (2006) 0.90
Clustering files of chemical structures using the Székely-Rizzo generalization of Ward's method. J Mol Graph Model (2009) 0.90
Multimodal treatment of locally advanced esophageal adenocarcinoma: which regimen should we choose? Outcome analysis of perioperative chemotherapy versus neoadjuvant chemoradiation in 105 patients. J Surg Oncol (2013) 0.88
Clinical significance of cell cycle- and apoptosis-related markers in biliary tract cancer: a tissue microarray-based approach revealing a distinctive immunophenotype for intrahepatic and extrahepatic cholangiocarcinomas. Am J Clin Pathol (2008) 0.88
Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy. Inflamm Bowel Dis (2011) 0.88
Elevated levels of serum-soluble triggering receptor expressed on myeloid cells-1 in patients with IBD do not correlate with intestinal TREM-1 mRNA expression and endoscopic disease activity. J Crohns Colitis (2012) 0.88
Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis. World J Gastroenterol (2011) 0.88
Mechanism of signal transduction of the LOV2-Jα photosensor from Avena sativa. Nat Commun (2010) 0.88
Differential cell cycle and proliferation marker expression in ductal pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia (PanIN). Pathology (2010) 0.87
Characterization of novel StAR (steroidogenic acute regulatory protein) mutations causing non-classic lipoid adrenal hyperplasia. PLoS One (2011) 0.87
Role of endogenous Fas (CD95/Apo-1) ligand in balloon-induced apoptosis, inflammation, and neointima formation. Circulation (2006) 0.87
Detection of perforin and granzyme B mRNA expressing cells in lichen sclerosus. Exp Dermatol (2007) 0.87
Irreversible photoreduction of flavin in a mutated Phot-LOV1 domain. Biochemistry (2003) 0.87
Glycyrrhetinic acid decreases plasma potassium concentrations in patients with anuria. J Am Soc Nephrol (2002) 0.86
Unraveling the flavin-catalyzed photooxidation of benzylic alcohol with transient absorption spectroscopy from sub-pico- to microseconds. Phys Chem Chem Phys (2011) 0.86
Role of DNA methylation in the tissue-specific expression of the CYP17A1 gene for steroidogenesis in rodents. J Endocrinol (2009) 0.85
Sensitizing antigen-specific CD8+ T cells for accelerated suicide causes immune incompetence. J Clin Invest (2003) 0.85
Transmembrane tumor necrosis factor is a potent inducer of colitis even in the absence of its secreted form. Gastroenterology (2004) 0.85