Published in Biochem J on June 01, 2005
CAR and PXR: the xenobiotic-sensing receptors. Steroids (2006) 2.06
The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor. Mol Pharmacol (2008) 1.38
A single amino acid controls the functional switch of human constitutive androstane receptor (CAR) 1 to the xenobiotic-sensitive splicing variant CAR3. J Pharmacol Exp Ther (2009) 1.03
Post-translational and post-transcriptional modifications of pregnane X receptor (PXR) in regulation of the cytochrome P450 superfamily. Curr Drug Metab (2013) 0.90
The antiapoptotic factor growth arrest and DNA-damage-inducible 45 beta regulates the nuclear receptor constitutive active/androstane receptor-mediated transcription. Drug Metab Dispos (2008) 0.90
Liganded pregnane X receptor represses the human sulfotransferase SULT1E1 promoter through disrupting its chromatin structure. Nucleic Acids Res (2011) 0.86
Metformin represses drug-induced expression of CYP2B6 by modulating the constitutive androstane receptor signaling. Mol Pharmacol (2013) 0.83
Nuclear receptor CAR (NR1I3) is essential for DDC-induced liver injury and oval cell proliferation in mouse liver. Lab Invest (2011) 0.82
Deciphering the roles of the constitutive androstane receptor in energy metabolism. Acta Pharmacol Sin (2014) 0.82
Pregnane X receptor mediates dyslipidemia induced by the HIV protease inhibitor amprenavir in mice. Mol Pharmacol (2013) 0.81
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30
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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest (1998) 4.76
The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature (2000) 4.00
The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol Cell Biol (1998) 3.60
Orphan nuclear receptors: from gene to function. Endocr Rev (1999) 3.29
The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science (2001) 3.27
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. Nature (1998) 3.23
The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J Biol Chem (1999) 3.14
Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol Cell Biol (1999) 2.93
The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module. Mol Pharmacol (1999) 2.49
Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital. Mol Pharmacol (2002) 2.49
Induction of bilirubin clearance by the constitutive androstane receptor (CAR). Proc Natl Acad Sci U S A (2003) 2.44
Phenobarbital response elements of cytochrome P450 genes and nuclear receptors. Annu Rev Pharmacol Toxicol (2001) 1.83
The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. Hepatology (2001) 1.79
The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction. J Biol Chem (2004) 1.65
Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene. Mol Endocrinol (2000) 1.30
Selective LXXLL peptides antagonize transcriptional activation by the retinoid-related orphan receptor RORgamma. Biochem Biophys Res Commun (2004) 1.30
Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands. Proc Natl Acad Sci U S A (2001) 1.20
The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity. Arch Biochem Biophys (2003) 1.17
Residue threonine 350 confers steroid hormone responsiveness to the mouse nuclear orphan receptor CAR. Mol Pharmacol (2002) 0.95
Magnesium-induced assembly of a complete DNA polymerase catalytic complex. Structure (2006) 3.37
Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes. Mol Cell Biol (2004) 2.49
Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital. Mol Pharmacol (2002) 2.49
Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers. J Pharmacol Exp Ther (2006) 2.23
Chemical and molecular ecology of herbivore-induced plant volatiles: proximate factors and their ultimate functions. Plant Cell Physiol (2009) 2.17
The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice. Cancer Res (2004) 2.13
A closed conformation for the Pol lambda catalytic cycle. Nat Struct Mol Biol (2004) 2.07
CAR and PXR: the xenobiotic-sensing receptors. Steroids (2006) 2.06
Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity. J Biol Chem (2003) 2.04
The X family portrait: structural insights into biological functions of X family polymerases. DNA Repair (Amst) (2007) 1.98
A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression. J Biol Chem (2003) 1.96
Enzymatic redesigning of biologically active heparan sulfate. J Biol Chem (2005) 1.89
Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation. Mol Cell (2008) 1.88
A synergistic approach to protein crystallization: combination of a fixed-arm carrier with surface entropy reduction. Protein Sci (2010) 1.66
Structural insight into the substrate specificity of DNA Polymerase mu. Nat Struct Mol Biol (2006) 1.64
A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology. Mol Cell (2004) 1.64
Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta. Biochemistry (2007) 1.61
Energy analysis of chemistry for correct insertion by DNA polymerase beta. Proc Natl Acad Sci U S A (2006) 1.56
Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver. J Biol Chem (2007) 1.53
Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor. J Pharmacol Exp Ther (2006) 1.53
Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress. Cardiovasc Res (2011) 1.53
Changing green leaf volatile biosynthesis in plants: an approach for improving plant resistance against both herbivores and pathogens. Proc Natl Acad Sci U S A (2006) 1.51
(R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta. J Am Chem Soc (2007) 1.48
Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells. Mol Pharmacol (2003) 1.46
Anticoagulant heparan sulfate: structural specificity and biosynthesis. Appl Microbiol Biotechnol (2006) 1.42
Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1. J Biol Chem (2004) 1.41
Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase. Cell (2006) 1.41
The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor. Mol Pharmacol (2008) 1.38
Volatile C6-aldehydes and Allo-ocimene activate defense genes and induce resistance against Botrytis cinerea in Arabidopsis thaliana. Plant Cell Physiol (2005) 1.38
Crystal structure and mutational analysis of heparan sulfate 3-O-sulfotransferase isoform 1. J Biol Chem (2004) 1.38
Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital. FEBS Lett (2003) 1.37
The roles of nuclear receptors CAR and PXR in hepatic energy metabolism. Drug Metab Pharmacokinet (2008) 1.35
Drug-activated nuclear receptors CAR and PXR. Ann Med (2003) 1.34
Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function. Org Lett (2009) 1.34
Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase beta. Proc Natl Acad Sci U S A (2008) 1.33
Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. Drug Metab Dispos (2004) 1.32
Engineering sulfotransferases to modify heparan sulfate. Nat Chem Biol (2008) 1.32
Identification of a defect in the UGT1A1 gene promoter and its association with hyperbilirubinemia. Biochem Biophys Res Commun (2002) 1.32
Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha. Mol Pharmacol (2005) 1.31
Replication infidelity via a mismatch with Watson-Crick geometry. Proc Natl Acad Sci U S A (2011) 1.30
Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin. J Biol Chem (2004) 1.28
Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver. J Biol Chem (2004) 1.27
Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity. J Biol Chem (2006) 1.26
Mimicking of estradiol binding by flame retardants and their metabolites: a crystallographic analysis. Environ Health Perspect (2013) 1.25
CAR, driving into the future. Mol Endocrinol (2004) 1.25
Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter. Mol Pharmacol (2003) 1.25
DNA polymerase beta substrate specificity: side chain modulation of the "A-rule". J Biol Chem (2009) 1.25
Human nuclear pregnane X receptor cross-talk with CREB to repress cAMP activation of the glucose-6-phosphatase gene. Biochem J (2007) 1.23
Role of the catalytic metal during polymerization by DNA polymerase lambda. DNA Repair (Amst) (2007) 1.23
The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter. J Pharmacol Exp Ther (2005) 1.22
Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3). J Biol Chem (2009) 1.22
Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling. Sci Signal (2013) 1.22
Structure-function studies of DNA polymerase lambda. DNA Repair (Amst) (2005) 1.22
Halogenated beta,gamma-methylene- and ethylidene-dGTP-DNA ternary complexes with DNA polymerase beta: structural evidence for stereospecific binding of the fluoromethylene analogues. J Am Chem Soc (2010) 1.21
Crystal structure of an alpha 1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis. J Biol Chem (2003) 1.20
The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins. J Allergy Clin Immunol (2010) 1.20
Structural insight into the DNA polymerase beta deoxyribose phosphate lyase mechanism. DNA Repair (Amst) (2005) 1.19
Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction. J Biol Chem (2002) 1.19
Template strand scrunching during DNA gap repair synthesis by human polymerase lambda. Nat Struct Mol Biol (2009) 1.19
Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor. J Pharmacol Exp Ther (2003) 1.18
The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity. Arch Biochem Biophys (2003) 1.17
Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate. Structure (2005) 1.17
New insights on the xenobiotic-sensing nuclear receptors in liver diseases--CAR and PXR--. Curr Drug Metab (2008) 1.16
Crystallographic analysis of a hydroxylated polychlorinated biphenyl (OH-PCB) bound to the catalytic estrogen binding site of human estrogen sulfotransferase. Environ Health Perspect (2003) 1.15
Structural analysis by X-ray crystallography and calorimetry of a haemagglutinin component (HA1) of the progenitor toxin from Clostridium botulinum. Microbiology (2003) 1.14
Novel CAR-mediated mechanism for synergistic activation of two distinct elements within the human cytochrome P450 2B6 gene in HepG2 cells. J Biol Chem (2004) 1.14
Phenobarbital confers its diverse effects by activating the orphan nuclear receptor car. Drug Metab Rev (2006) 1.12
Dissecting the substrate recognition of 3-O-sulfotransferase for the biosynthesis of anticoagulant heparin. Proc Natl Acad Sci U S A (2012) 1.11
Extracellular signal-regulated kinase is an endogenous signal retaining the nuclear constitutive active/androstane receptor (CAR) in the cytoplasm of mouse primary hepatocytes. Mol Pharmacol (2007) 1.11
The NADPH:quinone oxidoreductase P1-zeta-crystallin in Arabidopsis catalyzes the alpha,beta-hydrogenation of 2-alkenals: detoxication of the lipid peroxide-derived reactive aldehydes. Plant Cell Physiol (2002) 1.11
Role of the lipoxygenase/lyase pathway of host-food plants in the host searching behavior of two parasitoid species, Cotesia glomerata and Cotesia plutellae. J Chem Ecol (2006) 1.10
Transcriptional regulation of cytochrome p450 2B genes by nuclear receptors. Curr Drug Metab (2003) 1.10
Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site. Nat Struct Mol Biol (2010) 1.08
Brachial-ankle pulse wave velocity predicts all-cause mortality in the general population: findings from the Takashima study, Japan. Hypertens Res (2010) 1.08