Published in J Biol Chem on October 31, 2005
Chemoenzymatic synthesis of homogeneous ultralow molecular weight heparins. Science (2011) 2.79
Using an enzymatic combinatorial approach to identify anticoagulant heparan sulfate structures. Chem Biol (2007) 2.20
Solution structures of chemoenzymatically synthesized heparin and its precursors. J Am Chem Soc (2008) 2.02
Chemoenzymatic design of heparan sulfate oligosaccharides. J Biol Chem (2010) 1.64
Anticoagulant heparan sulfate: structural specificity and biosynthesis. Appl Microbiol Biotechnol (2006) 1.42
Control of the heparosan N-deacetylation leads to an improved bioengineered heparin. Appl Microbiol Biotechnol (2011) 1.33
Enzymatic synthesis of heparin related polysaccharides on sensor chips: rapid screening of heparin-protein interactions. Biochem Biophys Res Commun (2005) 1.29
Using a 3-O-sulfated heparin octasaccharide to inhibit the entry of herpes simplex virus type 1. Biochemistry (2008) 1.21
Expression of heparan sulfate sulfotransferases in Kluyveromyces lactis and preparation of 3'-phosphoadenosine-5'-phosphosulfate. Glycobiology (2011) 1.19
Engineering of routes to heparin and related polysaccharides. Appl Microbiol Biotechnol (2011) 1.19
Oversulfated chondroitin sulfate interaction with heparin-binding proteins: new insights into adverse reactions from contaminated heparins. Biochem Pharmacol (2009) 1.12
Recent progress and applications in glycosaminoglycan and heparin research. Curr Opin Chem Biol (2009) 1.10
Metabolic engineering of Chinese hamster ovary cells: towards a bioengineered heparin. Metab Eng (2012) 1.09
Carbohydrate post-glycosylational modifications. Org Biomol Chem (2007) 1.02
Redirecting the substrate specificity of heparan sulfate 2-O-sulfotransferase by structurally guided mutagenesis. Proc Natl Acad Sci U S A (2008) 1.01
Enzymatic synthesis of glycosaminoglycan heparin. Semin Thromb Hemost (2007) 1.00
The Importance of Heparan Sulfate in Herpesvirus Infection. Virol Sin (2008) 0.97
Escherichia coli K5 heparosan fermentation and improvement by genetic engineering. Bioeng Bugs (2011) 0.97
Chemoenzymatic synthesis of heparin oligosaccharides with both anti-factor Xa and anti-factor IIa activities. J Biol Chem (2012) 0.96
Generating heparan sulfate saccharide libraries for glycomics applications. Nat Protoc (2010) 0.95
Molecular mechanism of substrate specificity for heparan sulfate 2-O-sulfotransferase. J Biol Chem (2014) 0.94
High cell density cultivation of a recombinant E. coli strain expressing a key enzyme in bioengineered heparin production. Appl Microbiol Biotechnol (2013) 0.93
Response surface optimization of the heparosan N-deacetylation in producing bioengineered heparin. J Biotechnol (2011) 0.90
Probing structural selectivity of synthetic heparin binding to Stabilin protein receptors. J Biol Chem (2012) 0.89
Strategies in synthesis of heparin/heparan sulfate oligosaccharides: 2000-present. Adv Carbohydr Chem Biochem (2012) 0.88
Immobilized enzymes to convert N-sulfo, N-acetyl heparosan to a critical intermediate in the production of bioengineered heparin. J Biotechnol (2013) 0.85
Exopolysaccharides produced by marine bacteria and their applications as glycosaminoglycan-like molecules. Front Chem (2014) 0.84
Directing the biological activities of heparan sulfate oligosaccharides using a chemoenzymatic approach. Glycobiology (2011) 0.84
Tailored design and synthesis of heparan sulfate oligosaccharide analogues using sequential one-pot multienzyme systems. Angew Chem Int Ed Engl (2013) 0.83
Comamonas testosteronan synthase, a bifunctional glycosyltransferase that produces a unique heparosan polysaccharide analog. Glycobiology (2011) 0.83
Combinatorial one-pot chemoenzymatic synthesis of heparin. Carbohydr Polym (2014) 0.81
Fibroblast growth factor-based signaling through synthetic heparan sulfate blocks copolymers studied using high cell density three-dimensional cell printing. J Biol Chem (2014) 0.81
Synthesis of uridine 5'-diphosphoiduronic acid: a potential substrate for the chemoenzymatic synthesis of heparin. J Org Chem (2008) 0.81
High cell density cultivation of a recombinant Escherichia coli strain expressing a 6-O-sulfotransferase for the production of bioengineered heparin. J Appl Microbiol (2014) 0.78
Bioengineered heparin: is there a future for this form of the successful therapeutic? Bioengineered (2014) 0.78
Investigation of the substrate specificity of K5 lyase A from K5A bacteriophage. Glycobiology (2012) 0.78
Heparan sulfate domains required for fibroblast growth factor 1 and 2 signaling through fibroblast growth factor receptor 1c. J Biol Chem (2016) 0.78
Cyclic AMP (cAMP) Receptor Protein-cAMP Complex Regulates Heparosan Production in Escherichia coli Strain Nissle 1917. Appl Environ Microbiol (2015) 0.77
High cell density cultivation of recombinant Escherichia coli strains expressing 2-O-sulfotransferase and C5-epimerase for the production of bioengineered heparin. Appl Biochem Biotechnol (2015) 0.77
Heparin binding preference and structures in the fibroblast growth factor family parallel their evolutionary diversification. Open Biol (2016) 0.77
A purification process for heparin and precursor polysaccharides using the pH responsive behavior of chitosan. Biotechnol Prog (2015) 0.75
Combinatorial enzymatic synthesis of heparan sulfate. Chem Biol (2007) 0.75
Synthesis of 3-O-Sulfated Oligosaccharides to Understand the Relationship between Structures and Functions of Heparan Sulfate. J Am Chem Soc (2017) 0.75
Order out of chaos: assembly of ligand binding sites in heparan sulfate. Annu Rev Biochem (2001) 7.87
Receptor specificity of the fibroblast growth factor family. J Biol Chem (1996) 7.58
Heparin-protein interactions. Angew Chem Int Ed Engl (2002) 7.27
A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry. Cell (1999) 6.82
Regulated diversity of heparan sulfate. J Biol Chem (1998) 3.93
2003 Claude S. Hudson Award address in carbohydrate chemistry. Heparin: structure and activity. J Med Chem (2003) 3.71
Herpesviruses and heparan sulfate: an intimate relationship in aid of viral entry. J Clin Invest (2001) 3.64
Roles of heparan-sulphate glycosaminoglycans in cancer. Nat Rev Cancer (2002) 3.36
A synthetic antithrombin III binding pentasaccharide is now a drug! What comes next? Angew Chem Int Ed Engl (2004) 2.46
Heparan sulfate: growth control with a restricted sequence menu. J Clin Invest (2001) 2.35
Synthesis of thrombin-inhibiting heparin mimetics without side effects. Nature (1999) 2.27
Cell surface heparan sulfate and its roles in assisting viral infections. Med Res Rev (2002) 2.17
Heparan sulfate structure in mice with genetically modified heparan sulfate production. J Biol Chem (2004) 2.14
Minimal sequence in heparin/heparan sulfate required for binding of basic fibroblast growth factor. J Biol Chem (1993) 2.07
Structure-function analysis of soluble forms of herpes simplex virus glycoprotein D. J Virol (1996) 2.05
Enzymatic synthesis of antithrombin III-binding heparan sulfate pentasaccharide. Nat Biotechnol (2003) 2.03
Generation of "neoheparin" from E. coli K5 capsular polysaccharide. J Med Chem (2005) 2.03
Heparan sulfate oligosaccharides require 6-O-sulfation for promotion of basic fibroblast growth factor mitogenic activity. J Biol Chem (1998) 1.97
Contribution of monosaccharide residues in heparin binding to antithrombin III. Biochemistry (1985) 1.89
Heparan sulfate proteoglycans of the cardiovascular system. Specific structures emerge but how is synthesis regulated? J Clin Invest (1997) 1.75
Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1. J Biol Chem (2002) 1.74
The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity. Nat Struct Mol Biol (2004) 1.66
Simultaneous preparation and quantitation of proteoglycans by precipitation with alcian blue. Anal Biochem (1993) 1.62
Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities. J Biol Chem (1999) 1.58
Characterization of a heparan sulfate octasaccharide that binds to herpes simplex virus type 1 glycoprotein D. J Biol Chem (2002) 1.53
Enzymatic modification of heparan sulfate on a biochip promotes its interaction with antithrombin III. Biochem Biophys Res Commun (2000) 1.51
Fibroblast growth factor receptor signalling is dictated by specific heparan sulphate saccharides. Curr Biol (1999) 1.49
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3A sulfates N-unsubstituted glucosamine residues. J Biol Chem (1999) 1.45
Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1. J Biol Chem (2004) 1.41
Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups. J Biol Chem (2004) 1.39
Biosynthesis of heparin. Concerted action of late polymer-modification reactions. J Biol Chem (1980) 1.38
Crystal structure and mutational analysis of heparan sulfate 3-O-sulfotransferase isoform 1. J Biol Chem (2004) 1.38
Enzyme interactions in heparan sulfate biosynthesis: uronosyl 5-epimerase and 2-O-sulfotransferase interact in vivo. Proc Natl Acad Sci U S A (2001) 1.36
Regeneration of PAPS for the enzymatic synthesis of sulfated oligosaccharides. J Org Chem (2000) 1.33
Kinetic model for FGF, FGFR, and proteoglycan signal transduction complex assembly. Biochemistry (2004) 1.33
Characterization of heparan sulphate 3-O-sulphotransferase isoform 6 and its role in assisting the entry of herpes simplex virus type 1. Biochem J (2005) 1.31
Chemoenzymatic synthesis of classical and non-classical anticoagulant heparan sulfate polysaccharides. J Biol Chem (2003) 1.23
6-O-sulfotransferase-1 represents a critical enzyme in the anticoagulant heparan sulfate biosynthetic pathway. J Biol Chem (2001) 1.23
The biosynthesis of anticoagulant heparan sulfate by the heparan sulfate 3-O-sulfotransferase isoform 5. Biochim Biophys Acta (2004) 1.14
The effect of precursor structures on the action of glucosaminyl 3-O-sulfotransferase-1 and the biosynthesis of anticoagulant heparan sulfate. J Biol Chem (2001) 1.14
Biosynthesis of 3-O-sulfated heparan sulfate: unique substrate specificity of heparan sulfate 3-O-sulfotransferase isoform 5. Glycobiology (2003) 1.03
Substrate specificities of mouse heparan sulphate glucosaminyl 6-O-sulphotransferases. Biochem J (2003) 1.02
Synthetic oligosaccharides as heparin-mimetics displaying anticoagulant properties. Curr Pharm Des (2003) 1.02
Rapid two-step synthesis of mitrin from heparosan: a replacement for heparin. J Am Chem Soc (2003) 1.00
Production of N-sulfated polysaccharides using yeast-expressed N-deacetylase/N-sulfotransferase-1 (NDST-1). Glycobiology (2004) 0.89
Influence of phenylalanines 77 and 138 on the stereospecificity of aryl sulfotransferase IV. Drug Metab Dispos (2004) 0.80
Prevalence of chronic kidney disease in China: a cross-sectional survey. Lancet (2012) 10.53
Heparin-protein interactions. Angew Chem Int Ed Engl (2002) 7.27
Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events. Nat Biotechnol (2008) 4.46
Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci U S A (2002) 4.37
A test of climate, sun, and culture relationships from an 1810-year Chinese cave record. Science (2008) 3.94
Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. Mol Cell Biol (2007) 3.73
Magnesium-induced assembly of a complete DNA polymerase catalytic complex. Structure (2006) 3.37
Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading. Nat Neurosci (2002) 3.09
Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfate. J Biol Chem (2003) 2.94
Lessons learned from the contamination of heparin. Nat Prod Rep (2009) 2.81
Highly efficient capture of circulating tumor cells by using nanostructured silicon substrates with integrated chaotic micromixers. Angew Chem Int Ed Engl (2011) 2.79
Chemoenzymatic synthesis of homogeneous ultralow molecular weight heparins. Science (2011) 2.79
Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23. Endocrinology (2005) 2.46
Clonal vaccinia virus grown in cell culture as a new smallpox vaccine. Nat Med (2003) 2.27
Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2007) 2.25
Using an enzymatic combinatorial approach to identify anticoagulant heparan sulfate structures. Chem Biol (2007) 2.20
The proteoglycan bikunin has a defined sequence. Nat Chem Biol (2011) 2.14
Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus. J Virol (2010) 2.11
Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain. Genes Dev (2005) 2.10
A closed conformation for the Pol lambda catalytic cycle. Nat Struct Mol Biol (2004) 2.07
Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo. Exp Mol Pathol (2005) 2.07
The pgaABCD locus of Acinetobacter baumannii encodes the production of poly-beta-1-6-N-acetylglucosamine, which is critical for biofilm formation. J Bacteriol (2009) 2.06
Solution structures of chemoenzymatically synthesized heparin and its precursors. J Am Chem Soc (2008) 2.02
Flexible energy storage devices based on nanocomposite paper. Proc Natl Acad Sci U S A (2007) 2.02
Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice. J Clin Invest (2007) 2.00
The X family portrait: structural insights into biological functions of X family polymerases. DNA Repair (Amst) (2007) 1.98
Secreted NS1 of dengue virus attaches to the surface of cells via interactions with heparan sulfate and chondroitin sulfate E. PLoS Pathog (2007) 1.97
Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. Nat Genet (2011) 1.95
Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities. Hum Mol Genet (2004) 1.92
Electron detachment dissociation of glycosaminoglycan tetrasaccharides. J Am Soc Mass Spectrom (2006) 1.89
Bacterial extracellular polysaccharides involved in biofilm formation. Molecules (2009) 1.88
Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation. Mol Cell (2008) 1.88
NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors. Blood (2002) 1.87
Analysis of heparan sulfate oligosaccharides with ion pair-reverse phase capillary high performance liquid chromatography-microelectrospray ionization time-of-flight mass spectrometry. J Am Chem Soc (2002) 1.85
Disaccharide structure code for the easy representation of constituent oligosaccharides from glycosaminoglycans. Nat Methods (2008) 1.84
High-throughput microarray detection of olfactory receptor gene expression in the mouse. Proc Natl Acad Sci U S A (2004) 1.82
Limb ischemic preconditioning reduces heart and lung injury after an open heart operation in infants. Pediatr Cardiol (2009) 1.81
Striatal enriched phosphatase 61 dephosphorylates Fyn at phosphotyrosine 420. J Biol Chem (2002) 1.78
Northern Hemisphere summer monsoon intensified by mega-El Nino/southern oscillation and Atlantic multidecadal oscillation. Proc Natl Acad Sci U S A (2013) 1.75
Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1. J Biol Chem (2002) 1.74
Implementation of ion/ion reactions in a quadrupole/time-of-flight tandem mass spectrometer. Anal Chem (2006) 1.72
Morpho-regulation of ectodermal organs: integument pathology and phenotypic variations in K14-Noggin engineered mice through modulation of bone morphogenic protein pathway. Am J Pathol (2004) 1.72
A live, attenuated recombinant West Nile virus vaccine. Proc Natl Acad Sci U S A (2006) 1.72
Viral and cellular determinants of the hepatitis C virus envelope-heparan sulfate interaction. J Virol (2006) 1.71
Heparin-binding domains in vascular biology. Arterioscler Thromb Vasc Biol (2004) 1.71
ACAM2000 clonal Vero cell culture vaccinia virus (New York City Board of Health strain)--a second-generation smallpox vaccine for biological defense. Int J Infect Dis (2004) 1.70
Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity. Proc Natl Acad Sci U S A (2004) 1.70
'Cyclic alopecia' in Msx2 mutants: defects in hair cycling and hair shaft differentiation. Development (2003) 1.70
Sublethal concentrations of pleurocidin-derived antimicrobial peptides inhibit macromolecular synthesis in Escherichia coli. Antimicrob Agents Chemother (2002) 1.69
Stretch-sensitive KCNQ1 mutation A link between genetic and environmental factors in the pathogenesis of atrial fibrillation? J Am Coll Cardiol (2007) 1.67
Proline to arginine mutations in FGF receptors 1 and 3 result in Pfeiffer and Muenke craniosynostosis syndromes through enhancement of FGF binding affinity. Hum Mol Genet (2003) 1.66
A synergistic approach to protein crystallization: combination of a fixed-arm carrier with surface entropy reduction. Protein Sci (2010) 1.66
E. coli K5 fermentation and the preparation of heparosan, a bioengineered heparin precursor. Biotechnol Bioeng (2010) 1.65
Structural insight into the substrate specificity of DNA Polymerase mu. Nat Struct Mol Biol (2006) 1.64
A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology. Mol Cell (2004) 1.64
Chemoenzymatic design of heparan sulfate oligosaccharides. J Biol Chem (2010) 1.64
Deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism in mice. Arterioscler Thromb Vasc Biol (2008) 1.64
Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta. Biochemistry (2007) 1.61
Distinguishing glucuronic from iduronic acid in glycosaminoglycan tetrasaccharides by using electron detachment dissociation. Anal Chem (2007) 1.61
Merotelic kinetochore attachment: causes and effects. Trends Cell Biol (2011) 1.60
Structural basis of Rab5-Rabaptin5 interaction in endocytosis. Nat Struct Mol Biol (2004) 1.57
Energy analysis of chemistry for correct insertion by DNA polymerase beta. Proc Natl Acad Sci U S A (2006) 1.56
The involvement of heparan sulfate (HS) in FGF1/HS/FGFR1 signaling complex. J Biol Chem (2003) 1.53
Characterization of a heparan sulfate octasaccharide that binds to herpes simplex virus type 1 glycoprotein D. J Biol Chem (2002) 1.53
Interface engineered BaTiO₃/SrTiO₃ heterostructures with optimized high-frequency dielectric properties. ACS Appl Mater Interfaces (2012) 1.52
The complement protein properdin binds apoptotic T cells and promotes complement activation and phagocytosis. Proc Natl Acad Sci U S A (2008) 1.51
A role for 3-O-sulfated heparan sulfate in cell fusion induced by herpes simplex virus type 1. J Gen Virol (2004) 1.51
Liquid chromatography/mass spectrometry sequencing approach for highly sulfated heparin-derived oligosaccharides. J Biol Chem (2003) 1.51
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Am J Hum Genet (2012) 1.49
Calcitriol restores renovascular function in estrogen-deficient rats through downregulation of cyclooxygenase-2 and the thromboxane-prostanoid receptor. Kidney Int (2013) 1.49
(R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta. J Am Chem Soc (2007) 1.48
Bone morphogenic protein-4 contributes to venous endothelial dysfunction in patients with diabetes undergoing coronary revascularization. Ann Thorac Surg (2013) 1.46
Glycomics of proteoglycan biosynthesis in murine embryonic stem cell differentiation. J Proteome Res (2007) 1.46
Cathepsin L activity controls adipogenesis and glucose tolerance. Nat Cell Biol (2007) 1.46
Ionic liquid-mediated selective extraction of lignin from wood leading to enhanced enzymatic cellulose hydrolysis. Biotechnol Bioeng (2009) 1.46
Tropoelastin interacts with cell-surface glycosaminoglycans via its COOH-terminal domain. J Biol Chem (2005) 1.46
LMP2/LMP7 gene variant: a risk factor for intestinal Mycobacterium tuberculosis infection in the Chinese population. J Gastroenterol Hepatol (2011) 1.45
Quantification of heparan sulfate disaccharides using ion-pairing reversed-phase microflow high-performance liquid chromatography with electrospray ionization trap mass spectrometry. Anal Chem (2009) 1.45
Role for 3-O-sulfated heparan sulfate as the receptor for herpes simplex virus type 1 entry into primary human corneal fibroblasts. J Virol (2006) 1.44
Red fluorescent protein with reversibly photoswitchable absorbance for photochromic FRET. Chem Biol (2010) 1.43
Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation. Circulation (2009) 1.43
Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas amplification predominates in embryonal with anaplasia and alveolar subtypes. Genes Chromosomes Cancer (2002) 1.42
Identification and characterization of a glycosaminoglycan recognition element of the C chemokine lymphotactin. J Biol Chem (2004) 1.42
Disaccharide analysis of glycosaminoglycan mixtures by ultra-high-performance liquid chromatography-mass spectrometry. J Chromatogr A (2011) 1.42
Anticoagulant heparan sulfate: structural specificity and biosynthesis. Appl Microbiol Biotechnol (2006) 1.42
Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase. Cell (2006) 1.41
Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1. J Biol Chem (2004) 1.41
Electron detachment dissociation of dermatan sulfate oligosaccharides. J Am Soc Mass Spectrom (2007) 1.40
cDNA-AFLP analysis of gene expression in hickory (Carya cathayensis) during graft process. Tree Physiol (2009) 1.40
Influence of charge state and sodium cationization on the electron detachment dissociation and infrared multiphoton dissociation of glycosaminoglycan oligosaccharides. J Am Soc Mass Spectrom (2008) 1.40
Design of biologically active heparan sulfate and heparin using an enzyme-based approach. Nat Prod Rep (2009) 1.39
Negative electron transfer dissociation of glycosaminoglycans. Anal Chem (2010) 1.39