Published in J Clin Pathol on January 01, 2005
5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments. Mol Cell Biol (2006) 4.28
Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAF. PLoS One (2009) 2.03
Molecular biology of lung cancer. J Thorac Dis (2013) 1.67
LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome. J Med Genet (2006) 1.56
Hamartomatous polyposis syndromes. Surg Clin North Am (2008) 1.55
Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction. J Biol Chem (2009) 1.27
LKB1 regulates polarity remodeling and adherens junction formation in the Drosophila eye. Proc Natl Acad Sci U S A (2009) 1.20
Genetic and biochemical alterations in non-small cell lung cancer. Biochem Res Int (2012) 1.05
LKB1 catalytic activity contributes to estrogen receptor alpha signaling. Mol Biol Cell (2009) 1.00
Hereditary hamartomatous polyposis syndromes: understanding the disease risks as children reach adulthood. Gastroenterol Hepatol (N Y) (2010) 0.99
CCL2 is a negative regulator of AMP-activated protein kinase to sustain mTOR complex-1 activation, survivin expression, and cell survival in human prostate cancer PC3 cells. Neoplasia (2009) 0.95
Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancers. Cancer Lett (2011) 0.90
Somatic mutations of STK11 gene in human papillomavirus positive and negative penile cancer. Infect Agent Cancer (2013) 0.82
The Prognostic Value of Decreased LKB1 in Solid Tumors: A Meta-Analysis. PLoS One (2016) 0.82
A unique amidoanthraquinone derivative displays antiproliferative activity against human hormone-refractory metastatic prostate cancers through activation of LKB1-AMPK-mTOR signaling pathway. Naunyn Schmiedebergs Arch Pharmacol (2014) 0.79
Specific Alu elements involved in a significant percentage of copy number variations of the STK11 gene in patients with Peutz-Jeghers syndrome. Fam Cancer (2015) 0.77
Epithelial cell extrusion: Pathways and pathologies. Semin Cell Dev Biol (2016) 0.76
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol (2003) 12.91
Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol (2003) 11.12
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J (2004) 10.82
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature (1998) 10.35
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol (2003) 9.14
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet (1998) 7.36
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res (2002) 7.09
Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex. Nature (1994) 6.55
Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. EMBO J (1996) 6.36
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature (2002) 6.10
The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature (1998) 5.40
Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits; a syndrome of diagnostic significance. N Engl J Med (1949) 5.35
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Increased risk of cancer in the Peutz-Jeghers syndrome. N Engl J Med (1987) 4.55
Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. Mol Cell (1999) 4.45
Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis. Nat Genet (1997) 4.27
The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components. EMBO J (1992) 3.91
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell (2004) 3.87
MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J (2003) 3.77
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. EMBO J (2003) 3.62
A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity. Nature (2003) 3.47
Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest. Proc Natl Acad Sci U S A (1999) 3.46
Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex. Curr Biol (2003) 3.31
An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3. J Cell Biol (1998) 3.04
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science (2001) 2.99
Mitotic inactivation of a human SWI/SNF chromatin remodeling complex. Genes Dev (1998) 2.93
The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry. Development (2000) 2.84
AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge. Biochem J (1999) 2.75
The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis. EMBO J (1996) 2.71
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. Mol Cell (2001) 2.53
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Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1). Hum Mol Genet (2002) 2.28
LKB1 (XEEK1) regulates Wnt signalling in vertebrate development. Nat Cell Biol (2003) 2.24
LKB1, a protein kinase regulating cell proliferation and polarity. FEBS Lett (2003) 2.16
Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence. J Pathol (1999) 2.13
Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. Cancer Res (2002) 2.05
LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo. Biochem J (2000) 1.97
Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest. Mol Cell Biol (1999) 1.91
STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas. Am J Pathol (2001) 1.89
Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. J Biol Chem (2003) 1.86
BRG-1 is required for RB-mediated cell cycle arrest. Proc Natl Acad Sci U S A (2000) 1.85
Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis. Proc Natl Acad Sci U S A (2002) 1.83
Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome. Biochem J (2002) 1.80
Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer. Hum Mol Genet (1999) 1.79
The molecular basis and clinical aspects of Peutz-Jeghers syndrome. Cell Mol Life Sci (1999) 1.78
Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors. Cancer Res (1998) 1.75
Maternal-effect lethal mutations on linkage group II of Caenorhabditis elegans. Genetics (1988) 1.69
Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice. Oncogene (2000) 1.65
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LKB1 tumor suppressor protein: PARtaker in cell polarity. Trends Cell Biol (2004) 1.57
Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene. Oncogene (2004) 1.49
The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma. Clin Cancer Res (2002) 1.49
Cloning and characterization of a novel serine/threonine protein kinase expressed in early Xenopus embryos. J Biol Chem (1996) 1.48
LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1. Hum Mol Genet (2001) 1.47
Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1. Oncogene (2003) 1.43
Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome. Br J Cancer (2003) 1.33
Familial pancreatic cancer. Ann Oncol (1999) 1.33
LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest. J Biol Chem (2001) 1.28
Loss of cytoplasmic retention ability of mutant LKB1 found in Peutz-Jeghers syndrome patients. Biochem Biophys Res Commun (1999) 1.27
Peutz-Jeghers families unlinked to STK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinoma. J Med Genet (2001) 1.27
The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase. Hum Mol Genet (1999) 1.22
Genetic heterogeneity in Peutz-Jeghers syndrome. Hum Mutat (2000) 1.22
Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms. Mod Pathol (2003) 1.19
Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations. Oncogene (2004) 1.13
Somatic mutations in the STK11/LKB1 gene are uncommon in rare gynecological tumor types associated with Peutz-Jegher's syndrome. Am J Pathol (2000) 1.12
Growth and molecular profile of lung cancer cells expressing ectopic LKB1: down-regulation of the phosphatidylinositol 3'-phosphate kinase/PTEN pathway. Cancer Res (2003) 1.12
Complete germline deletion of the STK11 gene in a family with Peutz-Jeghers syndrome. Eur J Hum Genet (2004) 1.11
LKB1 protein expression in the evolution of glandular neoplasia of the lung. Clin Cancer Res (2003) 1.11
Functional analysis of LKB1/STK11 mutants and two aberrant isoforms found in Peutz-Jeghers Syndrome patients. Hum Mutat (2003) 1.06
Ovarian tumors associated with multiple endocrine neoplasias and related syndromes (Carney complex, Peutz-Jeghers syndrome, von Hippel-Lindau disease, Cowden's disease). Int J Gynecol Cancer (2002) 0.96
Mutation analysis of the STK11/LKB1 gene and clinical characteristics of an Australian series of Peutz-Jeghers syndrome patients. Clin Genet (2002) 0.93
At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation. J Biol (2003) 0.90
Mutational analysis of STK11 gene in ovarian carcinomas. Jpn J Cancer Res (1999) 0.88
Cancer: stuck at first base. Nature (2002) 0.76