Published in Oncogene on April 06, 2000
Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome mice. Science (2011) 3.49
STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice. J Clin Invest (2008) 2.95
Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. J Clin Invest (2006) 2.03
Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation. J Clin Invest (2009) 1.95
Smad4-mediated TGF-beta signaling in tumorigenesis. Int J Biol Sci (2010) 1.47
Smad4 is critical for self-renewal of hematopoietic stem cells. J Exp Med (2007) 1.25
From germline towards somatic mutations in the pathophysiology of vascular anomalies. Hum Mol Genet (2009) 1.23
Frequent loss of SMAD4/DPC4 protein in colorectal cancers. Gut (2002) 1.18
Identification of the modifier of Min 2 (Mom2) locus, a new mutation that influences Apc-induced intestinal neoplasia. Genome Res (2002) 1.10
Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice. Blood (2013) 1.10
TGFβ signaling in head and neck squamous cell carcinoma. Oncogene (2010) 1.08
Critical interactions between TGF-beta signaling/ELF, and E-cadherin/beta-catenin mediated tumor suppression. Oncogene (2006) 1.08
SMAD4 immunohistochemistry reflects genetic status in juvenile polyposis syndrome. Clin Cancer Res (2010) 1.08
Smad2 functions as a co-activator of canonical Wnt/beta-catenin signaling pathway independent of Smad4 through histone acetyltransferase activity of p300. Cell Signal (2008) 1.08
LKB1, the multitasking tumour suppressor kinase. J Clin Pathol (2005) 1.07
Mouse models of gastric cancer. Cancers (Basel) (2013) 1.07
Connection between inflammation and carcinogenesis in gastrointestinal tract: focus on TGF-beta signaling. World J Gastroenterol (2010) 1.06
Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice. J Clin Invest (2011) 1.05
Impaired transforming growth factor beta signalling in Barrett's carcinogenesis due to frequent SMAD4 inactivation. Gut (2005) 1.03
Two sides of the story? Smad4 loss in pancreatic cancer versus head-and-neck cancer. FEBS Lett (2012) 0.98
Regulation of lymphocyte development by cell-type-specific interpretation of Notch signals. Mol Cell Biol (2008) 0.94
Transforming growth factor-beta signaling and ubiquitinators in cancer. Endocr Relat Cancer (2008) 0.93
Gastric tumor development in Smad3-deficient mice initiates from forestomach/glandular transition zone along the lesser curvature. Lab Invest (2012) 0.90
Autoimmune gastritis mediated by CD4+ T cells promotes the development of gastric cancer. Cancer Res (2013) 0.90
Alterations in the Smad pathway in human cancers. Front Biosci (Landmark Ed) (2012) 0.89
TGFβ signaling promotes juvenile granulosa cell tumorigenesis by suppressing apoptosis. Mol Endocrinol (2014) 0.85
Induction of follistatin precedes gastric transformation in gastrin deficient mice. Biochem Biophys Res Commun (2008) 0.84
Cooperativity of E-cadherin and Smad4 loss to promote diffuse-type gastric adenocarcinoma and metastasis. Mol Cancer Res (2014) 0.83
SPSB1, a Novel Negative Regulator of the Transforming Growth Factor-β Signaling Pathway Targeting the Type II Receptor. J Biol Chem (2015) 0.82
Mice develop normally in the absence of Smad4 nucleocytoplasmic shuttling. Biochem J (2007) 0.82
Molecular imaging of gastric neoplasia with near-infrared fluorescent activatable probes. Mol Imaging (2012) 0.82
Haploinsufficiency of Tumor Suppressor Genes is Driven by the Cumulative Effect of microRNAs, microRNA Binding Site Polymorphisms and microRNA Polymorphisms: An In silico Approach. Cancer Inform (2012) 0.82
Postnatal ablation of osteoblast Smad4 enhances proliferative responses to canonical Wnt signaling through interactions with β-catenin. J Cell Sci (2013) 0.81
Histologic variations in juvenile polyp phenotype correlate with genetic defect underlying juvenile polyposis. Am J Surg Pathol (2011) 0.81
cDNA suppression subtraction library for screening down-regulated genes in gastric carcinoma. World J Gastroenterol (2003) 0.81
Genetic variations in the SMAD4 gene and gastric cancer susceptibility. World J Gastroenterol (2010) 0.81
A novel mouse Smad4 mutation reduces protein stability and wild-type protein levels. Mamm Genome (2006) 0.81
TGF-β signaling and its role in the regulation of hematopoietic stem cells. Syst Synth Biol (2015) 0.79
Mice lacking neurofibromin develop gastric hyperplasia. Am J Physiol Gastrointest Liver Physiol (2009) 0.79
Gastric Lgr5(+) stem cells are the cellular origin of invasive intestinal-type gastric cancer in mice. Cell Res (2016) 0.78
miRNA-558 promotes gastric cancer progression through attenuating Smad4-mediated repression of heparanase expression. Cell Death Dis (2016) 0.78
Serial observations on an orthotopic gastric cancer model constructed using improved implantation technique. World J Gastroenterol (2011) 0.78
Smad4 haploinsufficiency: a matter of dosage. Pathogenetics (2008) 0.76
Activation of cAMP-responsive-element-binding protein by PI3 kinase and p38 MAPK is essential for elevated expression of transforming growth factor β2 in cancer cells. J Interferon Cytokine Res (2010) 0.76
Self-renewal molecular mechanisms of colorectal cancer stem cells. Int J Mol Med (2016) 0.75
TGF-β signaling in liver and gastrointestinal cancers. Cancer Lett (2016) 0.75
Sleeping Beauty transposon mutagenesis identifies genes that cooperate with mutant Smad4 in gastric cancer development. Proc Natl Acad Sci U S A (2016) 0.75
Partial Müllerian Duct Retention in Smad4 Conditional Mutant Male Mice. Int J Biol Sci (2016) 0.75
Effect of deleted pancreatic cancer locus 4 gene transfection on biological behaviors of human colorectal carcinoma cells. World J Gastroenterol (2005) 0.75
Haploinsufficient tumor suppressor genes. Adv Med Biol (2017) 0.75
The sequence of the human genome. Science (2001) 101.55
A whole-genome assembly of Drosophila. Science (2000) 38.48
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med (1999) 16.91
Global surveillance for antituberculosis-drug resistance, 1994-1997. World Health Organization-International Union against Tuberculosis and Lung Disease Working Group on Anti-Tuberculosis Drug Resistance Surveillance. N Engl J Med (1998) 10.78
Standard short-course chemotherapy for drug-resistant tuberculosis: treatment outcomes in 6 countries. JAMA (2000) 8.42
Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Nat Genet (1999) 8.17
The genome of the natural genetic engineer Agrobacterium tumefaciens C58. Science (2001) 6.90
p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes. Mol Cell Biol (2000) 6.23
Global trends in resistance to antituberculosis drugs. World Health Organization-International Union against Tuberculosis and Lung Disease Working Group on Anti-Tuberculosis Drug Resistance Surveillance. N Engl J Med (2001) 6.05
Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proc Natl Acad Sci U S A (1994) 5.74
Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol (1999) 5.58
Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J (1999) 5.49
Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest (2000) 5.48
CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature (1997) 5.45
Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell (1999) 5.28
Identification of mycobacterial species by comparative sequence analysis of the RNA polymerase gene (rpoB). J Clin Microbiol (1999) 5.28
NF-AT components define a family of transcription factors targeted in T-cell activation. Nature (1994) 4.90
Cell fate determination in the vertebrate retina. Proc Natl Acad Sci U S A (1996) 4.81
The Human Connectome Project: a data acquisition perspective. Neuroimage (2012) 4.64
Monitoring community responses to the SARS epidemic in Hong Kong: from day 10 to day 62. J Epidemiol Community Health (2003) 4.45
Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc Natl Acad Sci U S A (2001) 4.30
Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes. Nature (1999) 4.14
B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat Immunol (2001) 4.10
A transcriptional hierarchy involved in mammalian cell-type specification. Nature (1992) 4.08
Effect of mobile phone intervention for diabetes on glycaemic control: a meta-analysis. Diabet Med (2011) 4.04
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med (1997) 3.89
A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc Natl Acad Sci U S A (1996) 3.89
von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA). Haemophilia (2008) 3.83
Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx. Science (1998) 3.72
Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN-RpoS regulatory pathway. Proc Natl Acad Sci U S A (2001) 3.65
[Occurrence of tertian malaria in a male patient who has never been abroad]. Korean J Parasitol (1994) 3.59
Randomised clinical trial: the efficacy of a 10-day sequential therapy vs. a 14-day standard proton pump inhibitor-based triple therapy for Helicobacter pylori in Korea. Aliment Pharmacol Ther (2011) 3.56
Rad23 links DNA repair to the ubiquitin/proteasome pathway. Nature (1998) 3.54
Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase. Cell (1993) 3.54
A double mass extinction at the end of the paleozoic era. Science (1994) 3.53
Determinants of drug-resistant tuberculosis: analysis of 11 countries. Int J Tuberc Lung Dis (2001) 3.51
Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. Genome Res (1998) 3.44
Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers. Cancer Res (1999) 3.40
Establishment and characterization of a cell line of human breast carcinoma origin. Eur J Cancer (1979) 3.37
Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell (2001) 3.37
Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4. J Biol Chem (2000) 3.37
Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev Cell (2001) 3.30
TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. J Cell Biol (2001) 3.22
FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung. Development (1998) 3.21
Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo. J Biol Chem (1994) 3.18
The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing. Cell (1995) 3.17
Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1. Cell (1997) 3.10
Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res (2000) 3.03
Genomic instability in Gadd45a-deficient mice. Nat Genet (1999) 3.01
A new dynamin-like protein, ADL6, is involved in trafficking from the trans-Golgi network to the central vacuole in Arabidopsis. Plant Cell (2001) 3.01
Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci U S A (2001) 2.93
Pro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem (1998) 2.93
Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes. Proc Natl Acad Sci U S A (1994) 2.91
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development (1998) 2.90
The seventh nationwide tuberculosis prevalence survey in Korea, 1995. Int J Tuberc Lung Dis (1998) 2.90
Trend of anti-tuberculosis drug resistance in Korea, 1994-2004. Int J Tuberc Lung Dis (2007) 2.85
Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts. J Biol Chem (2001) 2.85
Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat Genet (2001) 2.82
CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. Proc Natl Acad Sci U S A (1999) 2.81
An essential Saccharomyces cerevisiae gene homologous to SNF2 encodes a helicase-related protein in a new family. Mol Cell Biol (1992) 2.78
Nonradioactive method to study genetic profiles of natural bacterial communities by PCR-single-strand-conformation polymorphism. Appl Environ Microbiol (1996) 2.78
Genetic enhancement of inflammatory pain by forebrain NR2B overexpression. Nat Neurosci (2001) 2.72
Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers. Br J Cancer (2006) 2.67
Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins. Circulation (2001) 2.66
ATP is essential for protein translocation into Escherichia coli membrane vesicles. Proc Natl Acad Sci U S A (1985) 2.65
Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization. Cell (2000) 2.64
Species identification of mycobacteria by PCR-restriction fragment length polymorphism of the rpoB gene. J Clin Microbiol (2000) 2.62
Mutation of the Bacillus subtilis alkyl hydroperoxide reductase (ahpCF) operon reveals compensatory interactions among hydrogen peroxide stress genes. J Bacteriol (1996) 2.57
Minor groove RNA triplex in the crystal structure of a ribosomal frameshifting viral pseudoknot. Nat Struct Biol (1999) 2.57
A prospective 4-year follow-up study of attention-deficit hyperactivity and related disorders. Arch Gen Psychiatry (1996) 2.55
Measuring tuberculosis burden, trends, and the impact of control programmes. Lancet Infect Dis (2008) 2.55
Is maternal smoking during pregnancy a risk factor for attention deficit hyperactivity disorder in children? Am J Psychiatry (1996) 2.54
The FixL protein of Rhizobium meliloti can be separated into a heme-binding oxygen-sensing domain and a functional C-terminal kinase domain. Proc Natl Acad Sci U S A (1992) 2.51
Proteases for cell suicide: functions and regulation of caspases. Microbiol Mol Biol Rev (2000) 2.48
A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling. J Cell Biol (1999) 2.46
Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor. J Exp Med (2000) 2.45
The complete DNA sequence of myxoma virus. Virology (1999) 2.44
Xa21D encodes a receptor-like molecule with a leucine-rich repeat domain that determines race-specific recognition and is subject to adaptive evolution. Plant Cell (1998) 2.43
A homeodomain protein related to caudal regulates intestine-specific gene transcription. Mol Cell Biol (1994) 2.42
SecA protein is required for secretory protein translocation into E. coli membrane vesicles. Cell (1988) 2.41
A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability. Oncogene (1998) 2.39
Laparoscopic resection of gastric diverticulum. J Laparoendosc Adv Surg Tech A (1999) 2.39
Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean. Nature (2001) 2.39
Solution structure of a bovine immunodeficiency virus Tat-TAR peptide-RNA complex. Science (1995) 2.35
Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5. Development (1999) 2.34
Capsule endoscopy structured terminology (CEST): proposal of a standardized and structured terminology for reporting capsule endoscopy procedures. Endoscopy (2005) 2.34
Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice. Oncogene (2001) 2.33
APP processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron (2001) 2.31
Retracted Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue. Nature (2000) 2.31
Primitive deuterostomes from the Chengjiang Lagerstätte (Lower Cambrian, China). Nature (2001) 2.31
Seventh cervical nerve root transfer from the contralateral healthy side for treatment of brachial plexus root avulsion. J Hand Surg Br (1992) 2.30
Trafficking of phosphatidylinositol 3-phosphate from the trans-Golgi network to the lumen of the central vacuole in plant cells. Plant Cell (2001) 2.28
LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response. J Immunol (2000) 2.27