Published in Development on January 01, 2005
The genetics of early telencephalon patterning: some assembly required. Nat Rev Neurosci (2008) 2.40
Decision by division: making cortical maps. Trends Neurosci (2009) 1.97
Lrp4 modulates extracellular integration of cell signaling pathways in development. PLoS One (2008) 1.60
Cholesterol modification restricts the spread of Shh gradient in the limb bud. Proc Natl Acad Sci U S A (2006) 1.30
Clinical, genetic and imaging findings identify new causes for corpus callosum development syndromes. Brain (2014) 1.26
Scan-statistic approach identifies clusters of rare disease variants in LRP2, a gene linked and associated with autism spectrum disorders, in three datasets. Am J Hum Genet (2012) 1.23
Pathogenesis of holoprosencephaly. J Clin Invest (2009) 1.12
Mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma. PLoS Genet (2011) 1.11
Cholesterol: its regulation and role in central nervous system disorders. Cholesterol (2012) 1.08
Lipoprotein receptors--an evolutionarily ancient multifunctional receptor family. Biol Chem (2010) 1.07
More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration. Neuron (2014) 1.04
Genomic expression during human myelopoiesis. BMC Genomics (2007) 1.02
Embryonic fibroblasts from mice lacking Tgif were defective in cell cycling. Mol Cell Biol (2006) 1.01
LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer's disease. Front Physiol (2012) 0.96
Megalin/LRP2 expression is induced by peroxisome proliferator-activated receptor -alpha and -gamma: implications for PPARs' roles in renal function. PLoS One (2011) 0.96
The COOH terminus of megalin regulates gene expression in opossum kidney proximal tubule cells. Am J Physiol Cell Physiol (2008) 0.96
The iron exporter ferroportin 1 is essential for development of the mouse embryo, forebrain patterning and neural tube closure. Development (2010) 0.95
A review of Donnai-Barrow and facio-oculo-acoustico-renal (DB/FOAR) syndrome: clinical features and differential diagnosis. Birth Defects Res A Clin Mol Teratol (2009) 0.94
Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development. Dev Dyn (2011) 0.86
Roles of bone morphogenetic protein signaling and its antagonism in holoprosencephaly. Am J Med Genet C Semin Med Genet (2010) 0.85
Lrp4: A novel modulator of extracellular signaling in craniofacial organogenesis. Am J Med Genet A (2010) 0.84
Microarray analysis of E9.5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex. BMC Genomics (2008) 0.83
Dietary fat impacts fetal growth and metabolism: uptake of chylomicron remnant core lipids by the placenta. Am J Physiol Endocrinol Metab (2011) 0.83
Epithelial trafficking of Sonic hedgehog by megalin. J Histochem Cytochem (2006) 0.82
Crosstalk between intracellular and extracellular signals regulating interneuron production, migration and integration into the cortex. Front Cell Neurosci (2015) 0.81
Regulation of bone morphogenetic protein 9 (BMP9) by redox-dependent proteolysis. J Biol Chem (2014) 0.81
Megalin-deficiency causes high myopia, retinal pigment epithelium-macromelanosomes and abnormal development of the ciliary body in mice. Cell Tissue Res (2014) 0.80
Bone morphogenetic protein-4: a novel therapeutic target for pathological cardiac hypertrophy/heart failure. Heart Fail Rev (2014) 0.79
Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head. J Biol Chem (2013) 0.79
Low-density Lipoprotein Receptor-related Proteins in a Novel Mechanism of Axon Guidance and Peripheral Nerve Regeneration. J Biol Chem (2015) 0.78
Low Density Lipoprotein Receptor Related Proteins as Regulators of Neural Stem and Progenitor Cell Function. Stem Cells Int (2016) 0.77
Lrp4 domains differentially regulate limb/brain development and synaptic plasticity. PLoS One (2015) 0.76
In-depth phenotyping of a Donnai-Barrow patient helps clarify proximal tubule dysfunction. Pediatr Nephrol (2015) 0.76
New horizons for lipoprotein receptors: communication by β-propellers. J Lipid Res (2013) 0.75
Foxg1-Cre Mediated Lrp2 Inactivation in the Developing Mouse Neural Retina, Ciliary and Retinal Pigment Epithelia Models Congenital High Myopia. PLoS One (2015) 0.75
Prevention of neural tube defects in Lrp mutant mouse embryos by folic acid supplementation. Birth Defects Res A Clin Mol Teratol (2016) 0.75
Functional Roles of the Interaction of APP and Lipoprotein Receptors. Front Mol Neurosci (2017) 0.75
Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development. Dis Model Mech (2016) 0.75
Genome resequencing and bioinformatic analysis of SNP containing candidate genes in the autoimmune vitiligo Smyth line chicken model. BMC Genomics (2014) 0.75
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet (2007) 9.80
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol (2002) 8.60
Sortilin is essential for proNGF-induced neuronal cell death. Nature (2004) 5.62
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat Cell Biol (2002) 5.02
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc Natl Acad Sci U S A (2005) 4.34
Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates. Nat Genet (2009) 3.86
Role of endocytosis in cellular uptake of sex steroids. Cell (2005) 3.49
The role of Axin2 in calvarial morphogenesis and craniosynostosis. Development (2005) 2.63
Cubilin is essential for albumin reabsorption in the renal proximal tubule. J Am Soc Nephrol (2010) 2.42
Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell (2009) 2.17
Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria. Kidney Int (2008) 2.14
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nat Neurosci (2007) 2.10
Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export. Cell Metab (2010) 1.94
SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1. J Biol Chem (2007) 1.88
Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme. J Neurosci (2006) 1.83
Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease. J Clin Invest (2010) 1.79
WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Hum Mol Genet (2002) 1.70
Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation. Sci Transl Med (2014) 1.67
Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer. Proc Natl Acad Sci U S A (2006) 1.64
Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. Biochemistry (2006) 1.63
p75NTR--live or let die. Curr Opin Neurobiol (2005) 1.59
Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb. Genes Dev (2003) 1.55
The low-density lipoprotein receptor gene family: a cellular Swiss army knife? Trends Cell Biol (2002) 1.54
Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing. J Neurosci (2012) 1.52
PET imaging of leptin biodistribution and metabolism in rodents and primates. Cell Metab (2009) 1.47
Sortilin: a receptor to regulate neuronal viability and function. Trends Neurosci (2012) 1.45
Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease. J Neurosci (2008) 1.39
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. Nat Neurosci (2010) 1.29
Binding site structure of one LRP-RAP complex: implications for a common ligand-receptor binding motif. J Mol Biol (2006) 1.27
Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect. FASEB J (2002) 1.26
Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis. J Biol Chem (2008) 1.24
Megalin deficiency offers protection from renal aminoglycoside accumulation. J Biol Chem (2001) 1.23
Endocytosis provides a major alternative pathway for lysosomal biogenesis in kidney proximal tubular cells. Proc Natl Acad Sci U S A (2007) 1.21
Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin. J Am Soc Nephrol (2002) 1.21
CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia. Am J Hum Genet (2011) 1.20
Essential role of the apolipoprotein E receptor-2 in sperm development. J Biol Chem (2003) 1.19
Establishment of a neuroepithelial barrier by Claudin5a is essential for zebrafish brain ventricular lumen expansion. Proc Natl Acad Sci U S A (2010) 1.17
LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals. Dev Cell (2012) 1.14
Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development. FEBS Lett (2004) 1.13
Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease. EMBO J (2011) 1.10
LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche. J Cell Sci (2010) 1.10
Elucidation of megalin/LRP2-dependent endocytic transport processes in the larval zebrafish pronephros. J Cell Sci (2006) 1.08
Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression. J Neurosci (2009) 1.08
Sorting receptor SORLA--a trafficking path to avoid Alzheimer disease. J Cell Sci (2013) 1.07
Megalin is essential for renal proximal tubule reabsorption of (111)In-DTPA-octreotide. J Nucl Med (2005) 1.07
Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits. FASEB J (2012) 1.07
Megalin-mediated reuptake of retinol in the kidneys of mice is essential for vitamin A homeostasis. J Nutr (2005) 1.05
Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis. Proc Natl Acad Sci U S A (2012) 1.02
Transgenic overexpression of the sarcoplasmic reticulum Ca2+ATPase improves reticular Ca2+ handling in normal and diabetic rat hearts. FASEB J (2002) 1.02
Mutation of megalin leads to urinary loss of selenoprotein P and selenium deficiency in serum, liver, kidneys and brain. Biochem J (2010) 1.02
SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2. Mol Cell Biol (2010) 1.01
Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca2+ and Mg2+ wasting. Am J Physiol Renal Physiol (2010) 1.01
Lipoprotein receptors in Alzheimer's disease. Trends Neurosci (2006) 1.00
Hyporesponsiveness to glucocorticoids in mice genetically deficient for the corticosteroid binding globulin. Mol Cell Biol (2006) 1.00
A splice variant of the Wilms' tumour suppressor Wt1 is required for normal development of the olfactory system. Development (2005) 1.00
Kidney-specific inactivation of the megalin gene impairs trafficking of renal inorganic sodium phosphate cotransporter (NaPi-IIa). J Am Soc Nephrol (2004) 0.98
Lipoproteins and their receptors in embryonic development: more than cholesterol clearance. Development (2007) 0.96
Differential binding of ligands to the apolipoprotein E receptor 2. Biochemistry (2003) 0.94
Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein. J Neurosci (2013) 0.92
The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain. J Neurosci (2013) 0.90
Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B(12). Am J Physiol Renal Physiol (2002) 0.89
Identification of Alzheimer disease risk genotype that predicts efficiency of SORL1 expression in the brain. Arch Neurol (2012) 0.89
From holoprosencephaly to osteopathology: role of multifunctional endocytic receptors in absorptive epithelia. Ann Med (2003) 0.88
Expression profiling confirms the role of endocytic receptor megalin in renal vitamin D3 metabolism. Kidney Int (2002) 0.87
The sorting receptor Sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells. Immunity (2012) 0.86
The structure of MESD45-184 brings light into the mechanism of LDLR family folding. Structure (2011) 0.86
Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development. Dev Dyn (2011) 0.86
alpha-Tropomyosin mutations Asp(175)Asn and Glu(180)Gly affect cardiac function in transgenic rats in different ways. Am J Physiol Regul Integr Comp Physiol (2004) 0.86
Diabetes increases pancreatic fibrosis during chronic inflammation. Exp Biol Med (Maywood) (2014) 0.85
Risk factors for pancreatic ductal adenocarcinoma specifically stimulate pancreatic duct glands in mice. Am J Pathol (2013) 0.83
SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes. Mol Cell Biol (2013) 0.83
Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin. Am J Physiol Renal Physiol (2003) 0.83
Identification of a linear epitope in sortilin that partakes in pro-neurotrophin binding. J Biol Chem (2010) 0.82
The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family. J Struct Funct Genomics (2007) 0.82
Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. J Cell Sci (2003) 0.82
The soluble intracellular domain of megalin does not affect renal proximal tubular function in vivo. Kidney Int (2010) 0.81
Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: a control mechanism for thyroid hormone release. Proc Natl Acad Sci U S A (2003) 0.81
Localization of the low-density lipoprotein receptor-related protein regions involved in binding to the A2 domain of coagulation factor VIII. Thromb Haemost (2007) 0.81
SorLA is a molecular link for retromer-dependent sorting of the Amyloid precursor protein. Commun Integr Biol (2012) 0.81
Multi-compartmental modeling of SORLA's influence on amyloidogenic processing in Alzheimer's disease. BMC Syst Biol (2012) 0.81
Contribution of protein Z and protein Z-dependent protease inhibitor in generalized Shwartzman reaction. Crit Care Med (2013) 0.80
Endocytic receptor-mediated control of morphogen signaling. Development (2012) 0.80
Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction. PLoS One (2013) 0.79
SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease. J Alzheimers Dis (2013) 0.79
Sorting receptor sortilin-a culprit in cardiovascular and neurological diseases. J Mol Med (Berl) (2014) 0.79
Melatonin restores muscle regeneration and enhances muscle function after crush injury in rats. J Pineal Res (2011) 0.79
SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity. J Clin Invest (2016) 0.79
APP involvement in retinogenesis of mice. Acta Neuropathol (2010) 0.79