Published in Proc Natl Acad Sci U S A on January 05, 2010
Molecular regulation of lumen morphogenesis. Curr Biol (2011) 1.96
A novel transgenic zebrafish model for blood-brain and blood-retinal barrier development. BMC Dev Biol (2010) 1.44
Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation. Fluids Barriers CNS (2012) 1.44
Physiologic and anatomic characterization of the brain surface glia barrier of Drosophila. Glia (2011) 1.03
Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3/-4 protein suggests structural modifications of the toxin to target specific claudins. J Biol Chem (2011) 0.92
On the interaction of Clostridium perfringens enterotoxin with claudins. Toxins (Basel) (2010) 0.90
Mitotic cell rounding and epithelial thinning regulate lumen growth and shape. Nat Commun (2015) 0.89
Claudins in renal physiology and disease. Pediatr Nephrol (2011) 0.89
Structure and function of the ependymal barrier and diseases associated with ependyma disruption. Tissue Barriers (2014) 0.88
Claudin-3 and claudin-5 protein folding and assembly into the tight junction are controlled by non-conserved residues in the transmembrane 3 (TM3) and extracellular loop 2 (ECL2) segments. J Biol Chem (2014) 0.86
The tight junction protein claudin-b regulates epithelial permeability and sodium handling in larval zebrafish, Danio rerio. Am J Physiol Regul Integr Comp Physiol (2013) 0.86
Claudins in teleost fishes. Tissue Barriers (2013) 0.85
Na,K-ATPase β-subunit cis homo-oligomerization is necessary for epithelial lumen formation in mammalian cells. J Cell Sci (2012) 0.82
From omics to drug metabolism and high content screen of natural product in zebrafish: a new model for discovery of neuroactive compound. Evid Based Complement Alternat Med (2012) 0.81
Comparative mapping of the 22q11.2 deletion region and the potential of simple model organisms. J Neurodev Disord (2015) 0.81
A luminal glycoprotein drives dose-dependent diameter expansion of the Drosophila melanogaster hindgut tube. PLoS Genet (2012) 0.81
Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation. Dev Dyn (2012) 0.81
β1-integrin/matrix interactions support blood-brain barrier integrity. J Cereb Blood Flow Metab (2011) 0.80
Multiple roles for the Na,K-ATPase subunits, Atp1a1 and Fxyd1, during brain ventricle development. Dev Biol (2012) 0.79
Developing pressures: fluid forces driving morphogenesis. Curr Opin Genet Dev (2015) 0.78
An assay for permeability of the zebrafish embryonic neuroepithelium. J Vis Exp (2012) 0.78
The inner CSF-brain barrier: developmentally controlled access to the brain via intercellular junctions. Front Neurosci (2015) 0.77
Identification of the optic recess region as a morphogenetic entity in the zebrafish forebrain. Sci Rep (2015) 0.77
Claudins: vital partners in transcellular and paracellular transport coupling. Pflugers Arch (2016) 0.77
Functional and genetic analysis of choroid plexus development in zebrafish. Front Neurosci (2014) 0.77
Leveraging Large-scale Behavioral Profiling in Zebrafish to Explore Neuroactive Polypharmacology. ACS Chem Biol (2016) 0.76
Choroid plexus in developmental and evolutionary perspective. Front Neurosci (2014) 0.76
Ethanol alters gene expression and cell organization during optic vesicle evagination. Neuroscience (2013) 0.75
Demystification of animal symmetry: symmetry is a response to mechanical forces. Biol Direct (2017) 0.75
Claudin5a is required for proper inflation of Kupffer's vesicle lumen and organ laterality. PLoS One (2017) 0.75
Effective targeted gene 'knockdown' in zebrafish. Nat Genet (2000) 14.40
Junctions between intimately apposed cell membranes in the vertebrate brain. J Cell Biol (1969) 10.33
p53 activation by knockdown technologies. PLoS Genet (2007) 6.85
Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos. Development (1993) 5.81
Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol (2003) 5.74
The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy. J Cell Biol (1993) 4.22
Fibronectin regulates epithelial organization during myocardial migration in zebrafish. Dev Cell (2004) 3.34
Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function. Development (1998) 3.07
Genetic control of single lumen formation in the zebrafish gut. Nat Cell Biol (2007) 3.07
Structure and function of claudins. Biochim Biophys Acta (2007) 2.98
Claudins in occluding junctions of humans and flies. Trends Cell Biol (2006) 2.73
Formation of tight junction: determinants of homophilic interaction between classic claudins. FASEB J (2007) 2.43
Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation. Cell (2001) 2.42
Positional cloning of heart and soul reveals multiple roles for PKC lambda in zebrafish organogenesis. Curr Biol (2001) 2.16
Initial formation of zebrafish brain ventricles occurs independently of circulation and requires the nagie oko and snakehead/atp1a1a.1 gene products. Development (2005) 2.11
Trafficking of Crumbs3 during cytokinesis is crucial for lumen formation. Mol Biol Cell (2009) 1.70
oko meduzy and related crumbs genes are determinants of apical cell features in the vertebrate embryo. Curr Biol (2006) 1.68
nagie oko, encoding a MAGUK-family protein, is essential for cellular patterning of the retina. Nat Genet (2002) 1.64
Evidence of a paracellular pathway for ion flow in the kidney proximal tubule. Electromicroscopic demonstration of lanthanum precipitate in the tight junction. Pflugers Arch (1971) 1.54
Functional and developmental analysis of the blood-brain barrier in zebrafish. Brain Res Bull (2007) 1.51
On the self-association potential of transmembrane tight junction proteins. Cell Mol Life Sci (2006) 1.49
Extensive expansion of the claudin gene family in the teleost fish, Fugu rubripes. Genome Res (2004) 1.38
Na,K-ATPase is essential for embryonic heart development in the zebrafish. Development (2003) 1.33
Selective decrease in paracellular conductance of tight junctions: role of the first extracellular domain of claudin-5. Mol Cell Biol (2004) 1.29
Expression and phylogeny of claudins in vertebrate primordia. Proc Natl Acad Sci U S A (2001) 1.21
Nitronyl nitroxides, a novel group of protective agents against oxidative stress in endothelial cells forming the blood-brain barrier. Neuropharmacology (2002) 1.19
In vivo analysis of choroid plexus morphogenesis in zebrafish. PLoS One (2008) 1.18
Tight junctions containing claudin 4 and 6 are essential for blastocyst formation in preimplantation mouse embryos. Dev Biol (2007) 1.17
Claudins 6, 9, and 13 are developmentally expressed renal tight junction proteins. Am J Physiol Renal Physiol (2006) 1.13
oko meduzy mutations affect neuronal patterning in the zebrafish retina and reveal cell-cell interactions of the retinal neuroepithelial sheet. Development (1999) 1.03
Development and Notch signaling requirements of the zebrafish choroid plexus. PLoS One (2008) 1.00
Epithelial and endothelial barriers in the olfactory region of the nasal cavity of the rat. Histochem Cell Biol (2008) 0.94
Divergent polarization mechanisms during vertebrate epithelial development mediated by the Crumbs complex protein Nagie oko. J Cell Sci (2008) 0.90
The role of claudin-based tight junctions in morphogenesis. Ann N Y Acad Sci (2009) 0.79
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet (2007) 9.80
Sortilin is essential for proNGF-induced neuronal cell death. Nature (2004) 5.62
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc Natl Acad Sci U S A (2005) 4.34
Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO Rep (2006) 4.06
Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis. Science (2010) 3.98
Role of endocytosis in cellular uptake of sex steroids. Cell (2005) 3.49
Wnt/beta-catenin signaling controls development of the blood-brain barrier. J Cell Biol (2008) 3.22
Structure and function of claudins. Biochim Biophys Acta (2007) 2.98
Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nat Neurosci (2009) 2.85
The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. J Cell Biol (2003) 2.77
Viscoelastic properties of individual glial cells and neurons in the CNS. Proc Natl Acad Sci U S A (2006) 2.64
Formation of tight junction: determinants of homophilic interaction between classic claudins. FASEB J (2007) 2.43
Cubilin is essential for albumin reabsorption in the renal proximal tubule. J Am Soc Nephrol (2010) 2.42
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease. Hum Mol Genet (2005) 2.28
Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria. Kidney Int (2008) 2.14
Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes. Proc Natl Acad Sci U S A (2011) 2.11
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nat Neurosci (2007) 2.10
Mini-review: Transendothelial migration of leukocytes: through the front door or around the side of the house? Eur J Immunol (2004) 2.03
Mutations in VIPAR cause an arthrogryposis, renal dysfunction and cholestasis syndrome phenotype with defects in epithelial polarization. Nat Genet (2010) 2.00
RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing. Nat Med (2012) 1.97
Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex. Genes Dev (2008) 1.96
Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export. Cell Metab (2010) 1.94
SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1. J Biol Chem (2007) 1.88
Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme. J Neurosci (2006) 1.83
Peeling of the basal membrane in the human retina: ultrastructural effects. Ophthalmology (2004) 1.80
Transferrin receptor upregulation: in vitro labeling of rat mesenchymal stem cells with superparamagnetic iron oxide. Radiology (2007) 1.79
Coxsackievirus-adenovirus receptor (CAR) is essential for early embryonic cardiac development. J Cell Sci (2005) 1.79
Development of the zebrafish lymphatic system requires VEGFC signaling. Curr Biol (2006) 1.78
Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation. Sci Transl Med (2014) 1.67
Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling. FASEB J (2007) 1.63
Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. Biochemistry (2006) 1.63
Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. PLoS One (2010) 1.62
p75NTR--live or let die. Curr Opin Neurobiol (2005) 1.59
Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins. Mol Cell Biol (2002) 1.55
The low-density lipoprotein receptor gene family: a cellular Swiss army knife? Trends Cell Biol (2002) 1.54
Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing. J Neurosci (2012) 1.52
Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development. Blood (2006) 1.50
PET imaging of leptin biodistribution and metabolism in rodents and primates. Cell Metab (2009) 1.47
The cost of treatment of skeletal-related events in patients with bone metastases from lung cancer. Oncology (2004) 1.47
ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish. Hum Mol Genet (2008) 1.47
A transmembrane tight junction protein selectively expressed on endothelial cells and platelets. J Biol Chem (2002) 1.45
Sortilin: a receptor to regulate neuronal viability and function. Trends Neurosci (2012) 1.45
The tight junction protein occludin and the adherens junction protein alpha-catenin share a common interaction mechanism with ZO-1. J Biol Chem (2004) 1.42
Effect of patient exclusion criteria on the efficacy of erythropoiesis-stimulating agents in patients with cancer-related anemia. Oncologist (2005) 1.41
Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease. J Neurosci (2008) 1.39
A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells. EMBO Rep (2006) 1.35
Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence. J Neurosci (2007) 1.34
Current concepts of blood-brain barrier development. Int J Dev Biol (2011) 1.29
A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo. Blood (2007) 1.29
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. Nat Neurosci (2010) 1.29
Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect. FASEB J (2002) 1.26
LRP2/megalin is required for patterning of the ventral telencephalon. Development (2005) 1.26
Redistribution of aquaporin-4 in human glioblastoma correlates with loss of agrin immunoreactivity from brain capillary basal laminae. Acta Neuropathol (2004) 1.25
Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis. J Biol Chem (2008) 1.24
A potassium channel-linked mechanism of glial cell swelling in the postischemic retina. Mol Cell Neurosci (2004) 1.23
Megalin deficiency offers protection from renal aminoglycoside accumulation. J Biol Chem (2001) 1.23
Macrophage development from HSCs requires PU.1-coordinated microRNA expression. Blood (2011) 1.22
Endocytosis provides a major alternative pathway for lysosomal biogenesis in kidney proximal tubular cells. Proc Natl Acad Sci U S A (2007) 1.21
Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease. Proc Natl Acad Sci U S A (2010) 1.21
Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin. J Am Soc Nephrol (2002) 1.21
CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia. Am J Hum Genet (2011) 1.20
Essential role of the apolipoprotein E receptor-2 in sperm development. J Biol Chem (2003) 1.19
Serum markers support disease-specific glial pathology in major depression. J Affect Disord (2008) 1.18
Astrocytic autoantibody of neuromyelitis optica (NMO-IgG) binds to aquaporin-4 extracellular loops, monomers, tetramers and high order arrays. J Autoimmun (2012) 1.16
CD99 and CD99L2 act at the same site as, but independently of, PECAM-1 during leukocyte diapedesis. Blood (2010) 1.16
Heart and soul/PRKCi and nagie oko/Mpp5 regulate myocardial coherence and remodeling during cardiac morphogenesis. Development (2005) 1.15
LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals. Dev Cell (2012) 1.14
Labeling of human mesenchymal stromal cells with superparamagnetic iron oxide leads to a decrease in migration capacity and colony formation ability. Cytotherapy (2009) 1.14
Expression pattern of the water channel aquaporin-4 in human gliomas is associated with blood-brain barrier disturbance but not with patient survival. J Neurosci Res (2007) 1.14
Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development. FEBS Lett (2004) 1.13
Functional investigations on human mesenchymal stem cells exposed to magnetic fields and labeled with clinically approved iron nanoparticles. BMC Cell Biol (2010) 1.13
Elucidating the principles of the molecular organization of heteropolymeric tight junction strands. Cell Mol Life Sci (2011) 1.12
Under stress, the absence of intermediate filaments from Müller cells in the retina has structural and functional consequences. J Cell Sci (2004) 1.12
Extracellular matrix and the blood-brain barrier in glioblastoma multiforme: spatial segregation of tenascin and agrin. Acta Neuropathol (2002) 1.11
Molecular determinants of the interaction between Clostridium perfringens enterotoxin fragments and claudin-3. J Biol Chem (2009) 1.11
Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease. EMBO J (2011) 1.10
Redistribution of the water channel protein aquaporin-4 and the K+ channel protein Kir4.1 differs in low- and high-grade human brain tumors. Acta Neuropathol (2005) 1.10
LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche. J Cell Sci (2010) 1.10
Astrocyte mediated modulation of blood-brain barrier permeability does not correlate with a loss of tight junction proteins from the cellular contacts. Cell Tissue Res (2003) 1.09
Shaping the zebrafish heart: from left-right axis specification to epithelial tissue morphogenesis. Dev Biol (2009) 1.08
Elucidation of megalin/LRP2-dependent endocytic transport processes in the larval zebrafish pronephros. J Cell Sci (2006) 1.08
Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression. J Neurosci (2009) 1.08
Participation of the second extracellular loop of claudin-5 in paracellular tightening against ions, small and large molecules. Cell Mol Life Sci (2010) 1.07
Reversibility of symptoms in a conditional mouse model of spinocerebellar ataxia type 3. Hum Mol Genet (2009) 1.07
Megalin is essential for renal proximal tubule reabsorption of (111)In-DTPA-octreotide. J Nucl Med (2005) 1.07
Reactive glial cells: increased stiffness correlates with increased intermediate filament expression. FASEB J (2010) 1.06
In tight junctions, claudins regulate the interactions between occludin, tricellulin and marvelD3, which, inversely, modulate claudin oligomerization. J Cell Sci (2012) 1.06
EpCAM, a human tumor-associated antigen promotes Th2 development and tumor immune evasion. Blood (2009) 1.06