Published in Blood on December 30, 2004
Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C. J Exp Med (2007) 3.35
Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. J Clin Invest (2009) 2.41
Platelets, petechiae, and preservation of the vascular wall. N Engl J Med (2008) 2.25
Molecular mechanisms of endothelial hyperpermeability: implications in inflammation. Expert Rev Mol Med (2009) 2.12
'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage. Nat Immunol (2007) 1.95
Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen activator. Neurobiol Dis (2010) 1.90
Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells. Proc Natl Acad Sci U S A (2007) 1.87
Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J Clin Invest (2009) 1.86
Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells. Circ Res (2008) 1.85
Opening the flood-gates: how neutrophil-endothelial interactions regulate permeability. Trends Immunol (2009) 1.82
Targeting proteinase-activated receptors: therapeutic potential and challenges. Nat Rev Drug Discov (2012) 1.75
Signal transduction by protease-activated receptors. Br J Pharmacol (2010) 1.64
Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects. J Thromb Haemost (2012) 1.63
Serpins in thrombosis, hemostasis and fibrinolysis. J Thromb Haemost (2007) 1.60
Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury. Thorax (2008) 1.58
Cytoprotective protein C pathways and implications for stroke and neurological disorders. Trends Neurosci (2011) 1.53
Extraembryonic expression of EPCR is essential for embryonic viability. Blood (2005) 1.49
Regulation of the protein C anticoagulant and antiinflammatory pathways. Curr Med Chem (2010) 1.48
Caveolae are required for protease-selective signaling by protease-activated receptor-1. Proc Natl Acad Sci U S A (2009) 1.48
Protein C anticoagulant system--anti-inflammatory effects. Semin Immunopathol (2011) 1.45
Amicus or adversary: platelets in lung biology, acute injury, and inflammation. Am J Respir Cell Mol Biol (2008) 1.38
Endothelium--role in regulation of coagulation and inflammation. Semin Immunopathol (2011) 1.37
Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection. Blood (2011) 1.36
Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant. Blood (2009) 1.36
Retracted Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality. Blood (2009) 1.36
Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46. Blood (2012) 1.35
Protease activated receptor 1 (PAR-1) activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial protein C receptor is occupied by its natural ligand. Thromb Haemost (2008) 1.35
Sphingosine 1-phosphate in coagulation and inflammation. Semin Immunopathol (2011) 1.34
Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1. J Neurosci (2008) 1.33
Roles of protease-activated receptors in a mouse model of endotoxemia. Blood (2006) 1.32
Thrombomodulin and its role in inflammation. Semin Immunopathol (2011) 1.30
Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity. Eur J Neurosci (2009) 1.30
Endothelial cell protein C receptor cellular localization and trafficking: potential functional implications. Blood (2009) 1.28
Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin. Blood (2007) 1.26
The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors. J Biol Chem (2010) 1.24
Proteases display biased agonism at protease-activated receptors: location matters! Mol Interv (2009) 1.24
New insights into the protein C pathway: potential implications for the biological activities of drotrecogin alfa (activated). Crit Care (2005) 1.24
Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1-mediated vascular endothelial barrier enhancement. Blood (2009) 1.23
Activated protein C inhibits high mobility group box 1 signaling in endothelial cells. Blood (2011) 1.22
The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications. Blood (2009) 1.21
Endothelial cell protein C receptor: a multiliganded and multifunctional receptor. Blood (2014) 1.20
Tissue factor and cell signalling in cancer progression and thrombosis. J Thromb Haemost (2011) 1.20
The role of sphingosine-1-phosphate transporter Spns2 in immune system function. J Immunol (2012) 1.20
Regulation of macrophage procoagulant responses by the tissue factor cytoplasmic domain in endotoxemia. Blood (2007) 1.18
An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents. Stroke (2012) 1.18
Activated protein C protects against myocardial ischemic/reperfusion injury through AMP-activated protein kinase signaling. J Thromb Haemost (2011) 1.18
Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes. Blood (2011) 1.17
Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffolds. Proc Natl Acad Sci U S A (2011) 1.16
Coagulation factor Xa cleaves protease-activated receptor-1 and mediates signaling dependent on binding to the endothelial protein C receptor. J Thromb Haemost (2009) 1.15
Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1. Blood (2008) 1.15
Protein C anticoagulant and cytoprotective pathways. Int J Hematol (2012) 1.14
Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney disease. Kidney Int (2008) 1.14
Differential regulation of sphingosine kinases 1 and 2 in lung injury. Am J Physiol Lung Cell Mol Physiol (2009) 1.11
Recombinant human activated protein C inhibits integrin-mediated neutrophil migration. Blood (2009) 1.11
Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1. Thromb Haemost (2009) 1.10
Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier. J Cereb Blood Flow Metab (2008) 1.10
Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway. J Thromb Haemost (2013) 1.10
Activation of endothelial intrinsic NF-{kappa}B pathway impairs protein C anticoagulation mechanism and promotes coagulation in endotoxemic mice. Blood (2009) 1.07
Protective mechanisms of activated protein C in severe inflammatory disorders. Br J Pharmacol (2009) 1.07
Proteinase-activated receptors (PARs) - focus on receptor-receptor-interactions and their physiological and pathophysiological impact. Cell Commun Signal (2013) 1.06
Recombinant human activated protein C: current insights into its mechanism of action. Crit Care (2007) 1.06
Activated protein C: biased for translation. Blood (2015) 1.05
Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury. Crit Care (2006) 1.05
Microparticle-associated endothelial protein C receptor and the induction of cytoprotective and anti-inflammatory effects. Haematologica (2009) 1.05
Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers. Curr Pharm Des (2013) 1.03
Thrombin inhibits nuclear factor kappaB and RhoA pathways in cytokine-stimulated vascular endothelial cells when EPCR is occupied by protein C. Thromb Haemost (2009) 1.02
Recombinant human activated protein C attenuates endotoxin-induced lung injury in awake sheep. Crit Care (2008) 1.02
Cytoprotective-selective activated protein C attenuates Pseudomonas aeruginosa-induced lung injury in mice. Am J Respir Cell Mol Biol (2011) 1.02
Emerging therapeutic strategies to prevent infection-related microvascular endothelial activation and dysfunction. Virulence (2013) 1.02
Heterotrimeric G proteins, focal adhesion kinase, and endothelial barrier function. Microvasc Res (2011) 1.02
Activated protein C analog with reduced anticoagulant activity improves functional recovery and reduces bleeding risk following controlled cortical impact. Brain Res (2010) 1.00
An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway. J Neurosci (2013) 1.00
The role of thrombomodulin lectin-like domain in inflammation. J Biomed Sci (2012) 1.00
Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases. Invest Ophthalmol Vis Sci (2006) 0.99
Distinct functions of activated protein C differentially attenuate acute kidney injury. J Am Soc Nephrol (2008) 0.99
Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity. J Neurochem (2009) 0.99
Concentration dependent dual effect of thrombin in endothelial cells via Par-1 and Pi3 Kinase. J Cell Physiol (2009) 0.98
Thrombin upregulates the angiopoietin-Tie2 Axis: endothelial protein C receptor occupancy prevents the thrombin mobilization of angiopoietin 2 and P-selectin from Weibel-Palade bodies. J Thromb Haemost (2010) 0.98
Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impact. Neurosurgery (2010) 0.98
Activated protein C action in inflammation. Br J Haematol (2009) 0.98
The protein C pathway and pathologic processes. J Thromb Haemost (2009) 0.97
The occupancy of endothelial protein C receptor by its ligand modulates the par-1 dependent signaling specificity of coagulation proteases. IUBMB Life (2011) 0.95
Factor VIIa binding to endothelial cell protein C receptor protects vascular barrier integrity in vivo. J Thromb Haemost (2014) 0.94
Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation. Blood (2013) 0.94
Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor. Arterioscler Thromb Vasc Biol (2013) 0.93
Sphingosine-1-phosphate regulates the expression of adherens junction protein E-cadherin and enhances intestinal epithelial cell barrier function. Dig Dis Sci (2010) 0.92
Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats. Stroke (2013) 0.91
Pharmacological relevance and potential of sphingosine 1-phosphate in the vascular system. Br J Pharmacol (2011) 0.90
Recombinant human activated protein C ameliorates oleic acid-induced lung injury in awake sheep. Crit Care (2008) 0.90
Protease-activated receptor signalling by coagulation proteases in endothelial cells. Thromb Haemost (2014) 0.89
Factor VIIa interaction with endothelial cells and endothelial cell protein C receptor. Thromb Res (2010) 0.89
Dissociation of activated protein C functions by elimination of protein S cofactor enhancement. J Biol Chem (2008) 0.88
Protein targets of inflammatory serine proteases and cardiovascular disease. J Inflamm (Lond) (2010) 0.88
Zinc modulates the interaction of protein C and activated protein C with endothelial cell protein C receptor. J Biol Chem (2010) 0.88
Systemic versus localized coagulation activation contributing to organ failure in critically ill patients. Semin Immunopathol (2011) 0.87
The roles of thrombin and protease-activated receptors in inflammation. Semin Immunopathol (2011) 0.87
Kallikrein 6 is a novel molecular trigger of reactive astrogliosis. Biol Chem (2012) 0.87
Activated protein C in sepsis: the promise of nonanticoagulant activated protein C. Curr Opin Hematol (2008) 0.86
Activated protein C N-linked glycans modulate cytoprotective signaling function on endothelial cells. J Biol Chem (2010) 0.86
Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells. J Biol Chem (2006) 1.58
Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant. Blood (2009) 1.36
Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin. Blood (2007) 1.26
Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1. Thromb Haemost (2009) 1.10
Endothelial protein C receptor-dependent inhibition of migration of human lymphocytes by protein C involves epidermal growth factor receptor. J Immunol (2006) 1.06
Tissue factor-dependent coagulation protease signaling in acute lung injury. Crit Care Med (2003) 0.90
Activated protein C up-regulates procoagulant tissue factor activity on endothelial cells by shedding the TFPI Kunitz 1 domain. Blood (2011) 0.81
Protective signaling pathways of activated protein C in endothelial cells. Arterioscler Thromb Vasc Biol (2008) 0.80
Thrombin affects eosinophil migration via protease-activated receptor-1. Int Arch Allergy Immunol (2004) 0.78