Published in J Exp Med on September 24, 2007
Extracellular histones are major mediators of death in sepsis. Nat Med (2009) 6.55
Harmful molecular mechanisms in sepsis. Nat Rev Immunol (2008) 6.03
Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J Clin Invest (2009) 1.86
Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells. Circ Res (2008) 1.85
Host innate immune responses to sepsis. Virulence (2013) 1.66
Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects. J Thromb Haemost (2012) 1.63
Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury. Thorax (2008) 1.58
Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity. Nat Med (2012) 1.58
Cytoprotective protein C pathways and implications for stroke and neurological disorders. Trends Neurosci (2011) 1.53
Increase in activated protein C mediates acute traumatic coagulopathy in mice. Shock (2009) 1.53
Regulation of the protein C anticoagulant and antiinflammatory pathways. Curr Med Chem (2010) 1.48
Levels of microparticle tissue factor activity correlate with coagulation activation in endotoxemic mice. J Thromb Haemost (2009) 1.46
Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells. Proc Natl Acad Sci U S A (2008) 1.45
Protein C anticoagulant system--anti-inflammatory effects. Semin Immunopathol (2011) 1.45
Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice. Blood (2015) 1.42
Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice. J Clin Invest (2010) 1.41
Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant. Blood (2009) 1.36
The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b. J Clin Invest (2010) 1.36
Retracted Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality. Blood (2009) 1.36
Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity. Eur J Neurosci (2009) 1.30
A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis. EMBO Mol Med (2011) 1.28
Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin. Blood (2007) 1.26
The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors. J Biol Chem (2010) 1.24
Innate immunity and coagulation. J Thromb Haemost (2011) 1.24
Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1-mediated vascular endothelial barrier enhancement. Blood (2009) 1.23
A principal component analysis of coagulation after trauma. J Trauma Acute Care Surg (2013) 1.23
Activated protein C inhibits high mobility group box 1 signaling in endothelial cells. Blood (2011) 1.22
Endothelial cell protein C receptor: a multiliganded and multifunctional receptor. Blood (2014) 1.20
Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5. Blood (2008) 1.19
An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents. Stroke (2012) 1.18
Activated protein C protects against myocardial ischemic/reperfusion injury through AMP-activated protein kinase signaling. J Thromb Haemost (2011) 1.18
Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffolds. Proc Natl Acad Sci U S A (2011) 1.16
Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity. Stroke (2008) 1.15
Protein C anticoagulant and cytoprotective pathways. Int J Hematol (2012) 1.14
Scientific and clinical challenges in sepsis. Curr Pharm Des (2009) 1.14
Modeling endotoxin-induced systemic inflammation using an indirect response approach. Math Biosci (2008) 1.13
Recombinant human activated protein C inhibits integrin-mediated neutrophil migration. Blood (2009) 1.11
Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain. Blood (2008) 1.11
Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway. J Thromb Haemost (2013) 1.10
Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1. Thromb Haemost (2009) 1.10
PROC, PROCR and PROS1 polymorphisms, plasma anticoagulant phenotypes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health Study. J Thromb Haemost (2008) 1.08
Agent-based modeling of endotoxin-induced acute inflammatory response in human blood leukocytes. PLoS One (2010) 1.08
Activation of endothelial intrinsic NF-{kappa}B pathway impairs protein C anticoagulation mechanism and promotes coagulation in endotoxemic mice. Blood (2009) 1.07
Extracellular histone release in response to traumatic injury: implications for a compensatory role of activated protein C. J Trauma Acute Care Surg (2012) 1.07
Protective mechanisms of activated protein C in severe inflammatory disorders. Br J Pharmacol (2009) 1.07
Activated protein C: biased for translation. Blood (2015) 1.05
Endothelial protein C receptor function in murine and human breast cancer development. PLoS One (2013) 1.05
In silico simulation of corticosteroids effect on an NFkB- dependent physicochemical model of systemic inflammation. PLoS One (2009) 1.04
Cytoprotective-selective activated protein C attenuates Pseudomonas aeruginosa-induced lung injury in mice. Am J Respir Cell Mol Biol (2011) 1.02
Emerging therapeutic strategies to prevent infection-related microvascular endothelial activation and dysfunction. Virulence (2013) 1.02
Immune mechanisms and novel pharmacological therapies of acute kidney injury. Curr Drug Targets (2009) 1.02
An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway. J Neurosci (2013) 1.00
Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3. Blood (2013) 0.99
Distinct functions of activated protein C differentially attenuate acute kidney injury. J Am Soc Nephrol (2008) 0.99
Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity. J Neurochem (2009) 0.99
Activated protein C action in inflammation. Br J Haematol (2009) 0.98
Sepsis: the dark side of histones. Nat Med (2009) 0.97
Species-specific anticoagulant and mitogenic activities of murine protein S. Haematologica (2009) 0.96
The occupancy of endothelial protein C receptor by its ligand modulates the par-1 dependent signaling specificity of coagulation proteases. IUBMB Life (2011) 0.95
Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor. Arterioscler Thromb Vasc Biol (2013) 0.93
Inflammatory response in microvascular endothelium in sepsis: role of oxidants. J Clin Biochem Nutr (2008) 0.92
Activated protein C ameliorates coagulopathy but does not influence outcome in lethal H1N1 influenza: a controlled laboratory study. Crit Care (2010) 0.92
Thrombomodulin/activated protein C system in septic disseminated intravascular coagulation. J Intensive Care (2015) 0.91
Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats. Stroke (2013) 0.91
The Dual Diverse Dynamic Reversible Effects of Ankaferd Blood Stopper on EPCR and PAI-1 Inside Vascular Endothelial Cells With and Without LPS Challenge. Turk J Haematol (2012) 0.90
Polyphosphate and omptins: novel bacterial procoagulant agents. J Cell Mol Med (2009) 0.89
Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1. Brain Res (2013) 0.89
Evidence of the E*-E equilibrium from rapid kinetics of Na+ binding to activated protein C and factor Xa. J Phys Chem B (2010) 0.89
Dissociation of activated protein C functions by elimination of protein S cofactor enhancement. J Biol Chem (2008) 0.88
The roles of thrombin and protease-activated receptors in inflammation. Semin Immunopathol (2011) 0.87
Activated protein C N-linked glycans modulate cytoprotective signaling function on endothelial cells. J Biol Chem (2010) 0.86
Activated protein C in sepsis: the promise of nonanticoagulant activated protein C. Curr Opin Hematol (2008) 0.86
Thrombomodulin: a bifunctional modulator of inflammation and coagulation in sepsis. Crit Care Res Pract (2012) 0.85
Enhanced expression of cell-specific surface antigens on endothelial microparticles in sepsis-induced disseminated intravascular coagulation. Shock (2015) 0.85
Activated protein C accelerates venous thrombus resolution through heme oxygenase-1 induction. J Thromb Haemost (2014) 0.85
Survival advantage of heterozygous factor V Leiden carriers in murine sepsis. J Thromb Haemost (2015) 0.85
EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice. Blood (2015) 0.84
Cytoprotective-selective activated protein C therapy for ischaemic stroke. Thromb Haemost (2014) 0.84
The Interface between Inflammation and Coagulation in Cardiovascular Disease. Int J Inflam (2012) 0.84
Enhanced effector function of CD8(+) T cells from healthy controls and HIV-infected patients occurs through thrombin activation of protease-activated receptor 1. J Infect Dis (2012) 0.83
New players in the sepsis-protective activated protein C pathway. J Clin Invest (2010) 0.83
Vascular and dendritic cell coagulation signaling in sepsis progression. J Thromb Haemost (2009) 0.83
Review of cellular and molecular pathways linking thrombosis and innate immune system during sepsis. J Res Med Sci (2010) 0.82
Dual targeting of therapeutics to endothelial cells: collaborative enhancement of delivery and effect. FASEB J (2015) 0.82
Treatment with activated protein C (aPC) is protective during the development of myocardial fibrosis: an angiotensin II infusion model in mice. PLoS One (2012) 0.82
Protein C concentrate controls leukocyte recruitment during inflammation and improves survival during endotoxemia after efficient in vivo activation. Am J Pathol (2011) 0.82
Activated protein C: A regulator of human skin epidermal keratinocyte function. World J Biol Chem (2014) 0.82
Activated protein C up-regulates procoagulant tissue factor activity on endothelial cells by shedding the TFPI Kunitz 1 domain. Blood (2011) 0.81
Thrombin down-regulates the TGF-beta-mediated synthesis of collagen and fibronectin by human proximal tubule epithelial cells through the EPCR-dependent activation of PAR-1. J Cell Physiol (2010) 0.81
Antibody SPC-54 provides acute in vivo blockage of the murine protein C system. Blood Cells Mol Dis (2013) 0.81
Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice. Blood Cells Mol Dis (2013) 0.81
Streptococcal SpeB cleaved PAR-1 suppresses ERK phosphorylation and blunts thrombin-induced platelet aggregation. PLoS One (2013) 0.81
Factor XI-deficient mice display reduced inflammation, coagulopathy, and bacterial growth during listeriosis. Infect Immun (2011) 0.81
Vascular immunotargeting to endothelial determinant ICAM-1 enables optimal partnering of recombinant scFv-thrombomodulin fusion with endogenous cofactor. PLoS One (2013) 0.81
NETWORKS, BIOLOGY AND SYSTEMS ENGINEERING: A CASE STUDY IN INFLAMMATION. Comput Chem Eng (2009) 0.81
Mutagenesis studies toward understanding the intracellular signaling mechanism of antithrombin. J Thromb Haemost (2009) 0.80
Infrared fluorescence for vascular barrier breach in vivo--a novel method for quantitation of albumin efflux. Thromb Haemost (2012) 0.80
RAGE controls activation and anti-inflammatory signalling of protein C. PLoS One (2014) 0.79
Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med (2001) 27.70
Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial. JAMA (2001) 5.86
The cytoprotective protein C pathway. Blood (2006) 5.75
Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science (2002) 5.35
Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol (2006) 4.82
Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. JAMA (2003) 4.54
Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation. Blood (2004) 3.58
Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation. J Biol Chem (2005) 3.54
Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis. J Biol Chem (2001) 3.31
Role of the thrombin receptor in development and evidence for a second receptor. Nature (1996) 3.12
Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron (2004) 2.23
ENHANCE: results of a global open-label trial of drotrecogin alfa (activated) in children with severe sepsis. Pediatr Crit Care Med (2006) 2.19
Inflammation and the activated protein C anticoagulant pathway. Semin Thromb Hemost (2006) 1.98
Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis. Crit Care Med (2001) 1.97
Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor. Biochem J (2003) 1.91
Role of substance P and the neurokinin 1 receptor in acute pancreatitis and pancreatitis-associated lung injury. Proc Natl Acad Sci U S A (1998) 1.90
PAR1 cleavage and signaling in response to activated protein C and thrombin. J Biol Chem (2005) 1.83
Cecal ligation and puncture versus colon ascendens stent peritonitis: two distinct animal models for polymicrobial sepsis. Shock (2004) 1.69
Activated protein C variants with normal cytoprotective but reduced anticoagulant activity. Blood (2004) 1.68
Patients with severe sepsis vary markedly in their ability to generate activated protein C. Blood (2004) 1.67
Essential role of gamma interferon in survival of colon ascendens stent peritonitis, a novel murine model of abdominal sepsis. Infect Immun (1998) 1.64
Biological consequences of thrombin receptor deficiency in mice. Thromb Haemost (1996) 1.53
Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognition. Arterioscler Thromb Vasc Biol (2005) 1.46
Endothelial cell PECAM-1 confers protection against endotoxic shock. Am J Physiol Heart Circ Physiol (2004) 1.44
A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse. Blood (2004) 1.35
Cause-effect relation between hyperfibrinogenemia and vascular disease. Blood (2003) 1.24
Mice with a severe deficiency of the endothelial protein C receptor gene develop, survive, and reproduce normally, and do not present with enhanced arterial thrombosis after challenge. Thromb Haemost (2002) 1.23
Is APC activation of endothelial cell PAR1 important in severe sepsis?: No. J Thromb Haemost (2005) 1.08
Influence of drotrecogin alpha (activated) infusion on the variation of Bax/Bcl-2 and Bax/Bcl-xl ratios in circulating mononuclear cells: a cohort study in septic shock patients. Crit Care Med (2007) 1.07
Nonenzymatic anticoagulant activity of the mutant serine protease Ser360Ala-activated protein C mediated by factor Va. Protein Sci (1997) 1.04
Effects of membrane and soluble EPCR on the hemostatic balance and endotoxemia in mice. Blood (2006) 1.04
Plasma TAFI levels influence the clot lysis time in healthy individuals in the presence of an intact intrinsic pathway of coagulation. Thromb Haemost (1998) 1.03
Is APC activation of endothelial cell PAR1 important in severe sepsis?: Yes. J Thromb Haemost (2005) 0.98
Comparison of apoptosis and mortality measurements in peripheral blood mononuclear cells (PBMCs) using multiple methods. Cell Prolif (2005) 0.97
Signal transduction induced by activated protein C: no role in protection against sepsis? Trends Mol Med (2006) 0.84
Knockout rats via embryo microinjection of zinc-finger nucleases. Science (2009) 12.33
HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell (2003) 9.12
The cytoprotective protein C pathway. Blood (2006) 5.75
The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J Biol Chem (2002) 4.28
Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med (2003) 4.04
Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med (2012) 3.63
Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis. Nat Med (2007) 3.35
Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall. Blood (2004) 3.31
Restricted inactivation of serum response factor to the cardiovascular system. Proc Natl Acad Sci U S A (2004) 2.98
Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo. Blood (2007) 2.92
Brava and autologous fat transfer is a safe and effective breast augmentation alternative: results of a 6-year, 81-patient, prospective multicenter study. Plast Reconstr Surg (2012) 2.70
Endothelial and antithrombotic actions of HDL. Circ Res (2006) 2.68
Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nat Med (2004) 2.45
Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis. Blood (2004) 2.41
Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation. J Clin Invest (2008) 2.39
Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets. J Exp Med (2006) 2.39
TLR2 is constitutively expressed within the kidney and participates in ischemic renal injury through both MyD88-dependent and -independent pathways. J Immunol (2007) 2.32
Microparticles in hemostasis and thrombosis. Circ Res (2011) 2.26
Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron (2004) 2.23
Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nat Med (2006) 2.22
Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia. Blood (2003) 2.20
Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation. Blood (2004) 2.16
Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice. Blood (2010) 2.10
The thrombomodulin-protein C system is essential for the maintenance of pregnancy. Nat Med (2003) 1.98
Protease-activated receptor-1 contributes to cardiac remodeling and hypertrophy. Circulation (2007) 1.97
Oxysterols direct B-cell migration through EBI2. Nature (2011) 1.94
Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor. Biochem J (2003) 1.91
Role of tissue factor in cancer. J Clin Oncol (2009) 1.91
Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J Clin Invest (2009) 1.86
Regulation of tissue factor--mediated initiation of the coagulation cascade by cell surface grp78. Arterioscler Thromb Vasc Biol (2005) 1.82
Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages. J Immunol (2008) 1.74
Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. Blood (2012) 1.72
Factor VIII ectopically targeted to platelets is therapeutic in hemophilia A with high-titer inhibitory antibodies. J Clin Invest (2006) 1.69
Activated protein C variants with normal cytoprotective but reduced anticoagulant activity. Blood (2004) 1.68
Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions. J Biol Chem (2007) 1.67
The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury. Nat Med (2005) 1.66
PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice. Arterioscler Thromb Vasc Biol (2004) 1.65
Fibrinogen alpha and gamma genes and factor VLeiden in children with thromboembolism: results from 2 family-based association studies. Blood (2009) 1.62
Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture. Blood (2009) 1.59
Chlamydia pneumoniae induces tissue factor expression in mouse macrophages via activation of Egr-1 and the MEK-ERK1/2 pathway. Circ Res (2003) 1.59
Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells. J Biol Chem (2006) 1.58
Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity. Nat Med (2012) 1.58
Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1. Circ Res (2008) 1.55
Cytoprotective protein C pathways and implications for stroke and neurological disorders. Trends Neurosci (2011) 1.53
Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease. Blood (2014) 1.53
Plasmodium falciparum picks (on) EPCR. Blood (2013) 1.53
Genetic mapping and characterization of the bleeding disorder in the fawn-hooded hypertensive rat. Thromb Haemost (2003) 1.53
A missense mutation in the sodium phosphate co-transporter Slc34a1 impairs phosphate homeostasis. J Am Soc Nephrol (2008) 1.51
Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin. J Clin Invest (2012) 1.51
Protease-activated receptor-2 regulates the innate immune response to viral infection in a coxsackievirus B3-induced myocarditis. J Am Coll Cardiol (2013) 1.50
Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury. Blood (2007) 1.49
Elevated plasma fibronectin levels associated with venous thromboembolism. Thromb Haemost (2008) 1.49
FXI is essential for thrombus formation following FeCl3-induced injury of the carotid artery in the mouse. Thromb Haemost (2002) 1.49
Monocytic microparticles activate endothelial cells in an IL-1β-dependent manner. Blood (2011) 1.48
PF4/heparin-antibody complex induces monocyte tissue factor expression and release of tissue factor positive microparticles by activation of FcγRI. Blood (2012) 1.48
Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosis. Blood (2007) 1.48
Caveolin-1-dependent apoptosis induced by fibrin degradation products. Blood (2008) 1.47
Critical review of mouse models of venous thrombosis. Arterioscler Thromb Vasc Biol (2012) 1.46
Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells. Proc Natl Acad Sci U S A (2008) 1.45
Effect of hyperhomocysteinemia on protein C activation and activity. Blood (2002) 1.45
Increased microparticle tissue factor activity in cancer patients with Venous Thromboembolism. Thromb Res (2009) 1.43
Heparin rescues factor V Leiden-associated placental failure independent of anticoagulation in a murine high-risk pregnancy model. Blood (2013) 1.43
Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice. J Clin Invest (2010) 1.41
Calsarcin-2 deficiency increases exercise capacity in mice through calcineurin/NFAT activation. J Clin Invest (2008) 1.40
Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency. Blood (2006) 1.38
ADP-ribosylation factor 6 regulates tumorigenic and invasive properties in vivo. Cancer Res (2009) 1.37
Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant. Blood (2009) 1.36
Plasminogen receptors: the sine qua non of cell surface plasminogen activation. Front Biosci (2005) 1.36
The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b. J Clin Invest (2010) 1.36
Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C. J Immunol (2005) 1.36
Retracted Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality. Blood (2009) 1.36
Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46. Blood (2012) 1.35
Rapid selection of Drosophila S2 cells with the puromycin resistance gene. Biotechniques (2003) 1.35
Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma. J Am Coll Surg (2012) 1.35
A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse. Blood (2004) 1.35
Survival advantage associated with heterozygous factor V Leiden mutation in patients with severe sepsis and in mouse endotoxemia. Blood (2003) 1.35
Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation. Blood (2012) 1.34
Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1. J Neurosci (2008) 1.33
Vascular smooth muscle-derived tissue factor is critical for arterial thrombosis after ferric chloride-induced injury. Blood (2008) 1.32
High-density lipoprotein deficiency and dyslipoproteinemia associated with venous thrombosis in men. Circulation (2005) 1.31