1
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Persistent pain and faecal urgency after stapled haemorrhoidectomy.
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Lancet
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2000
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7.09
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2
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Anal-sphincter disruption during vaginal delivery.
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N Engl J Med
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1993
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5.74
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3
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Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine.
|
Gut
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2004
|
3.80
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4
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Prospective comparison of faecal incontinence grading systems.
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Gut
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1999
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3.48
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5
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Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis.
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Gut
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2004
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3.01
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6
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Third degree obstetric anal sphincter tears: risk factors and outcome of primary repair.
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BMJ
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1994
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2.75
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7
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Randomised controlled trial of CDP571 antibody to tumour necrosis factor-alpha in Crohn's disease.
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Lancet
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1997
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2.38
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8
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Modulation of human dendritic cell phenotype and function by probiotic bacteria.
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Gut
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2004
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2.29
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9
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Adalimumab for the treatment of fistulas in patients with Crohn's disease.
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Gut
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2009
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2.20
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10
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AGA technical review on anorectal testing techniques.
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Gastroenterology
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1999
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2.05
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11
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Long-term neoplasia risk after azathioprine treatment in inflammatory bowel disease.
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Lancet
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1994
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2.04
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12
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Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience.
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Gut
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1993
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2.01
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13
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Diagnosis and treatment of chronic constipation--a European perspective.
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Neurogastroenterol Motil
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2011
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1.99
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14
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Systematic review of sacral nerve stimulation for faecal incontinence and constipation.
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Br J Surg
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2004
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1.84
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15
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The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria.
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Gut
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2003
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1.84
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16
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Long-term clinical outcome of surgery for solitary rectal ulcer syndrome.
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Br J Surg
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1998
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1.80
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17
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Pilot study of two new injectable bulking agents for the treatment of faecal incontinence.
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Colorectal Dis
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2007
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1.78
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18
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Mechanisms of action of probiotics: recent advances.
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Inflamm Bowel Dis
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2009
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1.75
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19
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Permanent sacral nerve stimulation for treatment of idiopathic constipation.
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Br J Surg
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2002
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1.75
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20
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Response to a behavioural treatment, biofeedback, in constipated patients is associated with improved gut transit and autonomic innervation.
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Gut
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2001
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1.75
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21
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Bowel dysfunction in spinal-cord-injury patients.
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Lancet
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1996
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1.74
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22
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Evaluation of Helicobacter species in inflammatory bowel disease.
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Aliment Pharmacol Ther
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2003
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1.73
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23
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Long-term results of overlapping anterior anal-sphincter repair for obstetric trauma.
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Lancet
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2000
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1.72
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24
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Clinical characteristics of chronic idiopathic intestinal pseudo-obstruction in adults.
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Gut
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1997
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1.71
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25
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Radioisotope determination of regional colonic transit in severe constipation: comparison with radio opaque markers.
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Gut
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1993
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1.71
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26
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Antibodies to tumour necrosis factor alpha as treatment for Crohn's disease.
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Lancet
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2000
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1.69
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27
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Haemorrhoids: pathology, pathophysiology and aetiology.
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Br J Surg
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1994
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1.67
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28
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Migration and maturation of human colonic dendritic cells.
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J Immunol
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2001
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1.64
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29
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The burden of constipation on quality of life: results of a multinational survey.
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Aliment Pharmacol Ther
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2007
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1.64
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30
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Cancer surveillance in longstanding ulcerative colitis: endoscopic appearances help predict cancer risk.
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Gut
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2004
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1.63
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31
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Randomized controlled trial of topical phenylephrine in the treatment of faecal incontinence.
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Br J Surg
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2000
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1.61
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32
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Gastrointestinal hormones in short bowel syndrome. Peptide YY may be the 'colonic brake' to gastric emptying.
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Gut
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1996
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1.60
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33
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An engineered human antibody to TNF (CDP571) for active Crohn's disease: a randomized double-blind placebo-controlled trial.
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Gastroenterology
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2001
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1.57
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34
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'Reversible chemical sphincterotomy' by local application of glyceryl trinitrate.
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Br J Surg
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1994
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1.55
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35
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Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study.
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Gut
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1.49
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36
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A multinational survey of prevalence and patterns of laxative use among adults with self-defined constipation.
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Aliment Pharmacol Ther
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2008
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1.49
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37
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Olsalazine is not superior to placebo in maintaining remission of inactive Crohn's colitis and ileocolitis: a double blind, parallel, randomised, multicentre study.
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Gut
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2001
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1.48
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38
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Solitary rectal ulcer syndrome.
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Br J Surg
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1998
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1.48
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39
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Internal anal sphincter repair.
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Int J Colorectal Dis
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1.47
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40
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Gender differences in the longitudinal pressure profile of the anal canal related to anatomical structure as demonstrated on three-dimensional anal endosonography.
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Br J Surg
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2000
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1.46
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41
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Peptide-containing neurons in different regions of the submucous plexus of human sigmoid colon.
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Gastroenterology
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1.44
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42
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Randomised clinical trial: the efficacy of prucalopride in patients with chronic intestinal pseudo-obstruction--a double-blind, placebo-controlled, cross-over, multiple n = 1 study.
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Aliment Pharmacol Ther
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Postoperative recurrence of Crohn's disease: impact of endoscopic monitoring and treatment step-up.
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44
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Effect of age, sex and parity on anorectal function.
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Br J Surg
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1.42
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Low dose interferon gamma for refractory Crohn's disease.
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46
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Anterior anal sphincter repair in patients with obstetric trauma.
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Br J Surg
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1.41
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47
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Biofeedback provides long-term benefit for patients with intractable, slow and normal transit constipation.
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Gut
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1998
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1.39
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48
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Myopathy of internal anal sphincter with polyglucosan inclusions.
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J Pathol
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1990
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1.39
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49
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Anal endosonography in the investigation of faecal incontinence.
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Br J Surg
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1991
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1.37
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50
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Intestinal pseudo-obstruction with deficient smooth muscle alpha-actin.
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Histopathology
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1992
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1.37
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51
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Bacterial and fungal microbiota in relation to probiotic therapy (VSL#3) in pouchitis.
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Gut
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2006
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1.36
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52
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Topical glyceryl trinitrate in the treatment of chronic anal fissure.
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Br J Surg
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1996
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1.35
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53
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Anal endosonography and correlation with in vitro and in vivo anatomy.
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Br J Surg
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1993
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1.35
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54
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The normal range and a simple diagram for recording whole gut transit time.
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Int J Colorectal Dis
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1992
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1.33
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55
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Relationship between psychological state and level of activity of extrinsic gut innervation in patients with a functional gut disorder.
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Gut
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56
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Pudendal nerve damage during labour: prospective study before and after childbirth.
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Br J Obstet Gynaecol
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1994
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1.31
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57
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Lateral ligament division during rectopexy causes constipation but prevents recurrence: results of a prospective randomized study.
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Br J Surg
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1.29
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58
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Effects of short term sacral nerve stimulation on anal and rectal function in patients with anal incontinence.
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Gut
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1.28
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MMX Multi Matrix System mesalazine for the induction of remission in patients with mild-to-moderate ulcerative colitis: a combined analysis of two randomized, double-blind, placebo-controlled trials.
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Aliment Pharmacol Ther
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1.28
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60
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Randomised controlled trial shows that glyceryl trinitrate heals anal fissures, higher doses are not more effective, and there is a high recurrence rate.
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Gut
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1999
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1.27
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61
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Effect of a novel prokinetic drug, R093877, on gastrointestinal transit in healthy volunteers.
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Gut
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1998
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1.26
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62
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Double-blind randomised controlled trial of effect of metronidazole on pain after day-case haemorrhoidectomy.
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Lancet
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1.23
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63
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Evaluation of Helicobacter pylori in reflux oesophagitis and Barrett's oesophagus.
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Gut
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1997
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1.22
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64
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Clinicopathological characteristics of colorectal carcinoma complicating ulcerative colitis.
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Gut
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65
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Review article: defining remission in ulcerative colitis.
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Aliment Pharmacol Ther
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66
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DNA viruses in the pathogenesis of sporadic chronic idiopathic intestinal pseudo-obstruction.
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Gut
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67
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Permanent sacral nerve stimulation for fecal incontinence.
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Ann Surg
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68
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Endosonography of the anal sphincters: normal anatomy and comparison with manometry.
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Clin Radiol
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69
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Sphincter injury after anal dilatation demonstrated by anal endosonography.
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Br J Surg
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1991
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1.17
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70
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Topical diltiazem and bethanechol decrease anal sphincter pressure and heal anal fissures without side effects.
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Dis Colon Rectum
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2000
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71
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Relationship of symptoms in faecal incontinence to specific sphincter abnormalities.
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Int J Colorectal Dis
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Effect of probiotic strains on interleukin 8 production by HT29/19A cells.
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Am J Gastroenterol
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73
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Unsuspected sphincter damage following childbirth revealed by anal endosonography.
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Br J Radiol
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74
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Confirmation of endosonographic detection of external anal sphincter defects by simultaneous electromyographic mapping.
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Br J Surg
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75
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Faecal incontinence after childbirth.
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Br J Obstet Gynaecol
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76
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Controlled randomised trial of visual biofeedback versus muscle training without a visual display for intractable constipation.
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Gut
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77
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Review article: mechanisms of initiation and perpetuation of gut inflammation by stress.
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Aliment Pharmacol Ther
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78
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Clin Exp Immunol
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Prospective study of the extent of internal anal sphincter division during lateral sphincterotomy.
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Dis Colon Rectum
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Br J Surg
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Aliment Pharmacol Ther
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Br J Surg
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Aliment Pharmacol Ther
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Aliment Pharmacol Ther
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88
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Clinical, microbiological, and immunological effects of fructo-oligosaccharide in patients with Crohn's disease.
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Gut
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89
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Anal sphincter trauma during instrumental delivery.
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Int J Gynaecol Obstet
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Anal endosonography for identifying external sphincter defects confirmed histologically.
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Br J Surg
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Aliment Pharmacol Ther
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A comparison between electromyography and anal endosonography in mapping external anal sphincter defects.
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Dis Colon Rectum
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Aliment Pharmacol Ther
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Vasoactive intestinal polypeptide levels in sigmoid colon in idiopathic constipation and diverticular disease.
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Gastroenterology
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95
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Injectable silicone biomaterial for faecal incontinence due to internal anal sphincter dysfunction.
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Aliment Pharmacol Ther
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Dis Colon Rectum
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Topical diltiazem and bethanechol decrease anal sphincter pressure without side effects.
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