Published in J Biol Chem on January 17, 2005
Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells. J Biol Chem (2008) 2.42
IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis. FEBS Lett (2009) 2.35
Protein scaffolds in MAP kinase signalling. Cell Signal (2008) 1.94
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression. Semin Cancer Biol (2008) 1.91
The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells. J Biol Chem (2007) 1.82
Identification of six new susceptibility loci for invasive epithelial ovarian cancer. Nat Genet (2015) 1.47
ADP-ribosylation factor 6 regulates glioma cell invasion through the IQ-domain GTPase-activating protein 1-Rac1-mediated pathway. Cancer Res (2009) 1.40
Rhamm-/- fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repair. J Cell Biol (2006) 1.28
Two faces of chondroitin sulfate proteoglycan in spinal cord repair: a role in microglia/macrophage activation. PLoS Med (2008) 1.28
Characterization of a Cdc42 protein inhibitor and its use as a molecular probe. J Biol Chem (2013) 1.24
Role of versican, hyaluronan and CD44 in ovarian cancer metastasis. Int J Mol Sci (2011) 1.22
Hormone response in ovarian cancer: time to reconsider as a clinical target? Endocr Relat Cancer (2012) 1.20
Hyaluronan: a simple polysaccharide with diverse biological functions. Acta Biomater (2013) 1.12
MAPK scaffold IQGAP1 binds the EGF receptor and modulates its activation. J Biol Chem (2011) 1.09
Tissue-specific pathways for estrogen regulation of ovarian cancer growth and metastasis. Cancer Res (2010) 1.07
The hyaluronan receptor for endocytosis mediates hyaluronan-dependent signal transduction via extracellular signal-regulated kinases. J Biol Chem (2008) 1.05
Fibrinogen induces endothelial cell permeability. Mol Cell Biochem (2007) 1.05
gamma-Aminbuturic acid A receptor mitigates homocysteine-induced endothelial cell permeability. Endothelium (2007) 1.00
IQGAP1 integrates Ca2+/calmodulin and B-Raf signaling. J Biol Chem (2008) 1.00
The biology of IQGAP proteins: beyond the cytoskeleton. EMBO Rep (2015) 0.97
IQGAP1 in microbial pathogenesis: Targeting the actin cytoskeleton. FEBS Lett (2011) 0.97
Interaction of low molecular weight hyaluronan with CD44 and toll-like receptors promotes the actin filament-associated protein 110-actin binding and MyD88-NFκB signaling leading to proinflammatory cytokine/chemokine production and breast tumor invasion. Cytoskeleton (Hoboken) (2011) 0.96
Fibrinogen induces alterations of endothelial cell tight junction proteins. J Cell Physiol (2009) 0.95
CD44 standard form expression is correlated with high-grade and advanced-stage ovarian carcinoma but not prognosis. Hum Pathol (2013) 0.94
New insights on the role of hormonal therapy in ovarian cancer. Steroids (2013) 0.94
Silencing of IQGAP1 by shRNA inhibits the invasion of ovarian carcinoma HO-8910PM cells in vitro. J Exp Clin Cancer Res (2008) 0.94
Knockdown of CD44 inhibits the invasion and metastasis of hepatocellular carcinoma both in vitro and in vivo by reversing epithelial-mesenchymal transition. Oncotarget (2015) 0.93
Up-regulation of CD44 in the development of metastasis, recurrence and drug resistance of ovarian cancer. Oncotarget (2015) 0.92
Role of a serotonin precursor in development of gut microvilli. Am J Pathol (2008) 0.92
OPN/CD44v6 overexpression in laryngeal dysplasia and correlation with clinical outcome. Br J Cancer (2007) 0.91
Signaling networks regulating leukocyte podosome dynamics and function. Cell Signal (2011) 0.88
The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1. EMBO J (2010) 0.87
Exon-level transcriptome profiling in murine breast cancer reveals splicing changes specific to tumors with different metastatic abilities. PLoS One (2010) 0.87
Involvement of the MEKK1 signaling pathway in the regulation of epicardial cell behavior by hyaluronan. Cell Signal (2010) 0.86
Adenosine A1 receptor, a target and regulator of estrogen receptoralpha action, mediates the proliferative effects of estradiol in breast cancer. Oncogene (2009) 0.85
The Role of Ect2 Nuclear RhoGEF Activity in Ovarian Cancer Cell Transformation. Genes Cancer (2013) 0.85
Reciprocal modulation between microglia and astrocyte in reactive gliosis following the CNS injury. Mol Neurobiol (2013) 0.85
IQGAP1: a regulator of intracellular spacetime relativity. J Immunol (2012) 0.84
Inhibition of glycogen synthase kinase-3 increases the cytotoxicity of enzastaurin. J Invest Dermatol (2011) 0.82
IQGAP1: insights into the function of a molecular puppeteer. Mol Immunol (2015) 0.80
In Silico discovery of transcription factors as potential diagnostic biomarkers of ovarian cancer. BMC Syst Biol (2011) 0.80
The dyslipidemia-associated SNP on the APOA1/C3/A5 gene cluster predicts post-surgery poor outcome in Taiwanese breast cancer patients: a 10-year follow-up study. BMC Cancer (2013) 0.80
Type III TGFβ receptor and Src direct hyaluronan-mediated invasive cell motility. Cell Signal (2014) 0.79
Subtype specific elevated expression of hyaluronidase-1 (HYAL-1) in epithelial ovarian cancer. PLoS One (2011) 0.79
Structure and function of IQ-domain GTPase-activating protein 1 and its association with tumor progression (Review). Biomed Rep (2013) 0.79
METCAM/MUC18 is a novel tumor and metastasis suppressor for the human ovarian cancer SKOV3 cells. BMC Cancer (2016) 0.77
Cleavage of Hyaluronan and CD44 Adhesion Molecule Regulate Astrocyte Morphology via Rac1 Signalling. PLoS One (2016) 0.77
Conserved sequence repeats of IQGAP1 mediate binding to Ezrin. J Proteome Res (2013) 0.77
CD44: molecular interactions, signaling and functions in the nervous system. Front Cell Neurosci (2015) 0.77
CD44 - a novel synaptic cell adhesion molecule regulating structural and functional plasticity of dendritic spines. Mol Biol Cell (2016) 0.76
Activated ERK1/2 increases CD44 in glomerular parietal epithelial cells leading to matrix expansion. Kidney Int (2016) 0.76
A novel role of breast cancer-derived hyaluronan on inducement of M2-like tumor-associated macrophages formation. Oncoimmunology (2016) 0.75
Chronic UVB-irradiation actuates perpetuated dermal matrix remodeling in female mice: Protective role of estrogen. Sci Rep (2016) 0.75
Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells. J Biol Chem (2008) 2.42
CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion. J Biol Chem (2004) 2.20
Neonatal acute appendicitis: a proposed algorithm for timely diagnosis. J Pediatr Surg (2011) 1.74
Heregulin-mediated ErbB2-ERK signaling activates hyaluronan synthases leading to CD44-dependent ovarian tumor cell growth and migration. J Biol Chem (2007) 1.57
RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes. Mol Biol Cell (2011) 1.39
Infant botulism in Israel: knowledge enables prompt diagnosis. Isr Med Assoc J (2004) 1.39
Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord. J Neurosci (2008) 1.23
Hyaluronan-CD44 interaction stimulates keratinocyte differentiation, lamellar body formation/secretion, and permeability barrier homeostasis. J Invest Dermatol (2006) 1.07
Insulin promotes the cell surface recruitment of the SAT2/ATA2 system A amino acid transporter from an endosomal compartment in skeletal muscle cells. J Biol Chem (2002) 1.06
The influence of hyaluronan-CD44 interaction on topoisomerase II activity and etoposide cytotoxicity in head and neck cancer. Arch Otolaryngol Head Neck Surg (2007) 1.04
Hyaluronan-CD44 interaction stimulates Rac1 signaling and PKN gamma kinase activation leading to cytoskeleton function and cell migration in astrocytes. J Neurochem (2007) 0.99
Mice without uPA, tPA, or plasminogen genes are resistant to experimental choroidal neovascularization. Invest Ophthalmol Vis Sci (2003) 0.97
Modulation of signal transducer and activator of transcription 3 activities by p53 tumor suppressor in breast cancer cells. Cancer Res (2002) 0.95
Rho GTPases and cancer. Biofactors (2013) 0.88
RAC1 in keratinocytes regulates crosstalk to immune cells by Arp2/3-dependent control of STAT1. J Cell Sci (2012) 0.88
Epidemiologic, socioeconomic, and clinical factors associated with severity of respiratory syncytial virus infection in previously healthy infants. Clin Pediatr (Phila) (2006) 0.87
Regulation of membrane-type 1 matrix metalloproteinase activity by vacuolar H+-ATPases. Biochem J (2003) 0.83
Pediatric refractory partial status epilepticus responsive to topiramate. J Child Neurol (2005) 0.83
Rho GTPase knockout induction in primary keratinocytes from adult mice. Methods Mol Biol (2012) 0.76
Muscle glycogen depletion and increased oxidative phosphorylation following status epilepticus. J Child Neurol (2003) 0.75