Published in J Biol Chem on January 17, 2005
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol (2009) 9.63
Exploring the specificity of the PI3K family inhibitor LY294002. Biochem J (2007) 2.66
The survival kinases Akt and Pim as potential pharmacological targets. J Clin Invest (2005) 2.62
For better or for worse: the role of Pim oncogenes in tumorigenesis. Nat Rev Cancer (2010) 2.26
Metabolism, migration and memory in cytotoxic T cells. Nat Rev Immunol (2011) 2.25
Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol (2011) 2.06
PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers. Haematologica (2010) 1.83
Myocardial AKT: the omnipresent nexus. Physiol Rev (2011) 1.76
PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances. Biochem J (2012) 1.56
PIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis. J Clin Invest (2009) 1.41
Pim-1 kinase protects mitochondrial integrity in cardiomyocytes. Circ Res (2010) 1.21
Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J Med Chem (2009) 1.14
PI3Ks in lymphocyte signaling and development. Curr Top Microbiol Immunol (2010) 1.12
Why target PIM1 for cancer diagnosis and treatment? Future Oncol (2010) 1.12
Mitochondrial integrity: preservation through Akt/Pim-1 kinase signaling in the cardiomyocyte. Expert Rev Cardiovasc Ther (2009) 1.10
Nuclear and mitochondrial signalling Akts in cardiomyocytes. Cardiovasc Res (2009) 1.09
Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity. ACS Chem Biol (2008) 1.09
Activated lymphocytes as a metabolic model for carcinogenesis. Cancer Metab (2013) 1.07
A coiled-coil enabled split-luciferase three-hybrid system: applied toward profiling inhibitors of protein kinases. J Am Chem Soc (2010) 1.05
Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor. PLoS One (2009) 0.99
Staurosporine tethered peptide ligands that target cAMP-dependent protein kinase (PKA): optimization and selectivity profiling. Bioorg Med Chem (2009) 0.93
Serine-threonine kinases in TCR signaling. Nat Immunol (2014) 0.92
Regulation of Skp2 levels by the Pim-1 protein kinase. J Biol Chem (2010) 0.87
A small-molecule inhibitor of PIM kinases as a potential treatment for urothelial carcinomas. Neoplasia (2014) 0.86
Complex impacts of PI3K/AKT inhibitors to androgen receptor gene expression in prostate cancer cells. PLoS One (2014) 0.83
Pathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression. World J Gastroenterol (2014) 0.82
Stochastic detection of Pim protein kinases reveals electrostatically enhanced association of a peptide substrate. Proc Natl Acad Sci U S A (2013) 0.82
De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments. ACS Chem Biol (2013) 0.80
Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.78
Pim1 inhibition as a novel therapeutic strategy for Alzheimer's disease. Mol Neurodegener (2016) 0.78
LPS-stimulating astrocyte-conditioned medium causes neuronal apoptosis via increasing CDK11(p58) expression in PC12 cells through downregulating AKT pathway. Cell Mol Neurobiol (2013) 0.77
Computational modelling of LY303511 and TRAIL-induced apoptosis suggests dynamic regulation of cFLIP. Bioinformatics (2012) 0.77
PIM1 kinase as a promise of targeted therapy in prostate cancer stem cells. Mol Clin Oncol (2015) 0.76
Crystal structure of pim1 kinase in complex with a pyrido[4,3-d]pyrimidine derivative suggests a unique binding mode. PLoS One (2013) 0.75
Identification of quinones as novel PIM1 kinase inhibitors. Bioorg Med Chem Lett (2016) 0.75
Design and Synthesis of Potent and Selective PIM Kinase Inhibitors by Targeting Unique Structure of ATP-Binding Pocket. ACS Med Chem Lett (2017) 0.75
Pim1 kinase is upregulated in glioblastoma multiforme and mediates tumor cell survival. Neuro Oncol (2014) 0.75
In vitro evaluation of dihydropyridine-3-carbonitriles as potential cytotoxic agents through PIM-1 protein kinase inhibition. Res Pharm Sci (2017) 0.75
Increased survival with enzalutamide in prostate cancer after chemotherapy. N Engl J Med (2012) 20.79
Humans have evolved specialized skills of social cognition: the cultural intelligence hypothesis. Science (2007) 4.55
Chimpanzees recruit the best collaborators. Science (2006) 3.73
What's in it for me? Self-regard precludes altruism and spite in chimpanzees. Proc Biol Sci (2006) 3.15
Control of iron deficiency anemia in low- and middle-income countries. Blood (2013) 2.99
Spontaneous altruism by chimpanzees and young children. PLoS Biol (2007) 2.93
Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc Natl Acad Sci U S A (2002) 2.82
The structural basis for autoinhibition of FLT3 by the juxtamembrane domain. Mol Cell (2004) 2.64
The evolutionary origins of human patience: temporal preferences in chimpanzees, bonobos, and human adults. Curr Biol (2007) 2.52
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nat Med (2010) 2.50
A decade of conflict: flap coverage options and outcomes in traumatic war-related extremity reconstruction. Plast Reconstr Surg (2015) 2.17
Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism. Structure (2010) 2.10
Bonobos exhibit delayed development of social behavior and cognition relative to chimpanzees. Curr Biol (2010) 1.89
Determinants of anemia among young children in rural India. Pediatrics (2010) 1.84
Chimpanzees understand psychological states - the question is which ones and to what extent. Trends Cogn Sci (2003) 1.80
Graft reconstruction of inferior vena cava for renal cell carcinoma stage pT3b or greater. Urology (2011) 1.80
The structure of dimeric ROCK I reveals the mechanism for ligand selectivity. J Biol Chem (2005) 1.76
'Unwilling' versus 'unable': chimpanzees' understanding of human intentional action. Dev Sci (2004) 1.75
Phenotypic characterization of resistant Val36 variants of hepatitis C virus NS3-4A serine protease. Antimicrob Agents Chemother (2007) 1.66
Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23. EMBO J (2004) 1.63
Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alpha. J Biol Chem (2007) 1.61
A fruit in the hand or two in the bush? Divergent risk preferences in chimpanzees and bonobos. Biol Lett (2008) 1.59
Invasive mold infections following combat-related injuries. Clin Infect Dis (2012) 1.55
Surveillance for catheter-associated bloodstream infection in hematology units: quantifying the characteristics of a practical case definition. Infect Control Hosp Epidemiol (2008) 1.47
Known preoperative deep venous thrombosis and/or pulmonary embolus: to flap or not to flap the severely injured extremity? Plast Reconstr Surg (2013) 1.44
A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants. PLoS Comput Biol (2010) 1.42
Crystal structure of aurora-2, an oncogenic serine/threonine kinase. J Biol Chem (2002) 1.41
Reliance on head versus eyes in the gaze following of great apes and human infants: the cooperative eye hypothesis. J Hum Evol (2006) 1.41
Rapid decrease of wild-type hepatitis C virus on telaprevir treatment. Antivir Ther (2009) 1.39
Serum amyloid a is a biomarker of acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2007) 1.35
Pathogenesis of Langerhans cell histiocytosis. Annu Rev Pathol (2012) 1.31
Differences in the cognitive skills of bonobos and chimpanzees. PLoS One (2010) 1.29
Ongoing risk behavior among persons with HIV in medical care. AIDS Behav (2007) 1.29
Peer referral for HIV case-finding among men who have sex with men. AIDS (2006) 1.25
A randomized, controlled trial of inSPOT and patient-delivered partner therapy for gonorrhea and chlamydial infection among men who have sex with men. Sex Transm Dis (2011) 1.22
Patient and health system delay among patients with pulmonary tuberculosis in Beira city, Mozambique. BMC Public Health (2013) 1.15
Description of the development and validation of the Canadian Paediatric Trigger Tool. BMJ Qual Saf (2011) 1.14
Assessing the psychological health of captive and wild apes: a response to Ferdowsian et al. (2011). J Comp Psychol (2012) 1.13
Bonobos share with strangers. PLoS One (2013) 1.13
The structure of individual differences in the cognitive abilities of children and chimpanzees. Psychol Sci (2009) 1.12
Looking past the model species: diversity in gaze-following skills across primates. Curr Opin Neurobiol (2009) 1.11
Reaching around barriers: the performance of the great apes and 3-5-year-old children. Anim Cogn (2009) 1.11
Gastrointestinal infection among international travelers globally. J Travel Med (2008) 1.09
Great apes prefer cooked food. J Hum Evol (2008) 1.08
Differential changes in steroid hormones before competition in bonobos and chimpanzees. Proc Natl Acad Sci U S A (2010) 1.06
Primate energy expenditure and life history. Proc Natl Acad Sci U S A (2014) 1.05
Target-specific, histology-independent, randomized discontinuation study of lapatinib in patients with HER2-amplified solid tumors. Invest New Drugs (2010) 1.00
Chimpanzees and bonobos distinguish between risk and ambiguity. Biol Lett (2010) 0.99
Testing the social dog hypothesis: are dogs also more skilled than chimpanzees in non-communicative social tasks? Behav Processes (2009) 0.99
Syndromic surveillance for influenza in two hospital emergency departments. Relationships between ICD-10 codes and notified cases, before and during a pandemic. BMC Public Health (2011) 0.99
Soft tissue injury management with a continuous external tissue expander. Ann Plast Surg (2012) 0.98
Use of "entertainment" chimpanzees in commercials distorts public perception regarding their conservation status. PLoS One (2011) 0.98
Gallbladder carcinoma: findings at MR imaging with MR cholangiopancreatography. J Comput Assist Tomogr (2002) 0.97
Advancing measurement of patient safety culture. Health Serv Res (2008) 0.97
Psychological health of orphan bonobos and chimpanzees in African sanctuaries. PLoS One (2011) 0.97
Scoping the impact of the national child measurement programme feedback on the child obesity pathway: study protocol. BMC Public Health (2012) 0.96
A controlled study of the effectiveness of public health HIV partner notification services. AIDS (2009) 0.96
Identifying, understanding and overcoming barriers to medication error reporting in hospitals: a focus group study. BMJ Qual Saf (2012) 0.95
The development of the Canadian paediatric trigger tool for identifying potential adverse events. Healthc Q (2005) 0.95
Chimpanzees and bonobos exhibit emotional responses to decision outcomes. PLoS One (2013) 0.94
Effect of netazepide, a gastrin/CCK2 receptor antagonist, on gastric acid secretion and rabeprazole-induced hypergastrinaemia in healthy subjects. Br J Clin Pharmacol (2015) 0.94
Catheter-related bloodstream infections in hematology: time for standardized surveillance? Cancer (2007) 0.93
Letter to the Editor: Treatment as prevention: are HIV clinic patients interested in starting antiretroviral therapy to decrease HIV transmission? AIDS Patient Care STDS (2010) 0.93
A phase II trial of temsirolimus in men with castration-resistant metastatic prostate cancer. Clin Genitourin Cancer (2013) 0.93
Failure to define window of time for autologous tumor vaccination in patients with newly diagnosed or relapsed acute lymphoblastic leukemia. Exp Hematol (2005) 0.92
Models developed by three techniques did not achieve acceptable prediction of binary trauma outcomes. J Clin Epidemiol (2005) 0.89
Partner notification for gonococcal and chlamydial infections in men who have sex with men: success is underestimated by traditional disposition codes. Sex Transm Dis (2008) 0.89
Bonobos have a more human-like second-to-fourth finger length ratio (2D:4D) than chimpanzees: a hypothesized indication of lower prenatal androgens. J Hum Evol (2009) 0.89
The benefits and harms of providing parents with weight feedback as part of the national child measurement programme: a prospective cohort study. BMC Public Health (2014) 0.88
Direct and indirect reputation formation in nonhuman great apes (Pan paniscus, Pan troglodytes, Gorilla gorilla, Pongo pygmaeus) and human children (Homo sapiens). J Comp Psychol (2012) 0.87
Chimpanzees versus humans: it's not that simple. Trends Cogn Sci (2003) 0.87
A comparison of temperament in nonhuman apes and human infants. Dev Sci (2011) 0.87
Use of a continuous external tissue expander in the conversion of a type IIIB fracture to a type IIIA fracture. Orthopedics (2013) 0.87
Outcome after injury-a systematic literature search of studies using the EQ-5D. J Trauma (2009) 0.86
Integrated decision-making in response to weapons of mass destruction incidents: development and initial evaluation of a course for healthcare professionals. Prehosp Disaster Med (2006) 0.84
Chimpanzees and bonobos exhibit divergent spatial memory development. Dev Sci (2012) 0.84
Serum parathyroid hormone-related peptide is associated with systemic inflammation and adverse prognosis in gastroesophageal carcinoma. Cancer (2005) 0.84
Cognitive elements in clinical decision-making: toward a cognitive model for medical education and understanding clinical reasoning. Adv Health Sci Educ Theory Pract (2009) 0.84
Case series: mental health needs and perspectives of rural children reared by parents who abuse methamphetamine. J Am Acad Child Adolesc Psychiatry (2007) 0.83
Application of the heterochrony framework to the study of behavior and cognition. Commun Integr Biol (2010) 0.83
Murine model of surgically induced acute aortic dissection type A. J Thorac Cardiovasc Surg (2009) 0.83
Differences in the early cognitive development of children and great apes. Dev Psychobiol (2013) 0.83
The use of dilute Dakin's solution for the treatment of angioinvasive fungal infection in the combat wounded: a case series. Mil Med (2013) 0.82
Netazepide, a gastrin/CCK2 receptor antagonist, causes dose-dependent, persistent inhibition of the responses to pentagastrin in healthy subjects. Br J Clin Pharmacol (2013) 0.82
Acceptability and intention to seek medical care after hypothetical receipt of patient-delivered partner therapy or electronic partner notification postcards among men who have sex with men: the partner's perspective. Sex Transm Dis (2013) 0.82
"They mess with me, I mess with them": Understanding physical aggression in rural girls and boys from methamphetamine-involved families. Child Youth Serv Rev (2010) 0.81
4-(Benzimidazol-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: potent and selective p70S6 kinase inhibitors. Bioorg Med Chem Lett (2009) 0.81
Bonobo but not chimpanzee infants use socio-sexual contact with peers. Primates (2010) 0.81
Structure of the CoA transferase from pig heart to 1.7 A resolution. Acta Crystallogr D Biol Crystallogr (2004) 0.81
A Mental Health Intervention for Rural, Foster Children from Methamphetamine-involved Families: Experimental Assessment with Qualitative Elaboration. Child Youth Serv Rev (2010) 0.81
The 2017 international classification of the Ehlers-Danlos syndromes. Am J Med Genet C Semin Med Genet (2017) 0.81
Changes in heart rate variability, quality of life, and activity in cardiac resynchronization therapy patients: results of the HF-HRV registry. Pacing Clin Electrophysiol (2007) 0.79
Combat-related hemipelvectomy. J Surg Orthop Adv (2012) 0.79
2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2. Bioorg Med Chem Lett (2009) 0.79
A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease. Blood (2011) 0.78
Enhancing parent-child interaction during foster care visits: experimental assessment of an intervention. Child Welfare (2005) 0.78
The design, synthesis and pharmacological characterization of novel β₂-adrenoceptor antagonists. Br J Pharmacol (2011) 0.78