Published in Mol Biol Cell on January 19, 2005
DNA methylation patterns in lung carcinomas. Semin Cancer Biol (2009) 1.25
A class III PDZ binding motif in the myotilin and FATZ families binds enigma family proteins: a common link for Z-disc myopathies. Mol Cell Biol (2008) 1.17
The insulin-like growth factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth. Mol Biol Cell (2007) 1.16
Epigenetic repression of PDZ-LIM domain-containing protein 2: implications for the biology and treatment of breast cancer. J Biol Chem (2010) 1.16
Nucleocytoplasmic functions of the PDZ-LIM protein family: new insights into organ development. Bioessays (2010) 1.10
Insights into the molecular evolution of the PDZ/LIM family and identification of a novel conserved protein motif. PLoS One (2007) 1.09
NF-κB and cancer: a paradigm of Yin-Yang. Am J Cancer Res (2010) 1.08
The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system. Proc Natl Acad Sci U S A (2006) 1.06
Gene expression patterns in visual cortex during the critical period: synaptic stabilization and reversal by visual deprivation. Proc Natl Acad Sci U S A (2008) 1.05
Dietary isoflavones differentially induce gene expression changes in lymphocytes from postmenopausal women who form equol as compared with those who do not. J Nutr Biochem (2006) 1.04
Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level. BMC Cancer (2008) 1.03
Heme-binding protein HRG-1 is induced by insulin-like growth factor I and associates with the vacuolar H+-ATPase to control endosomal pH and receptor trafficking. J Biol Chem (2009) 0.97
ALP/Enigma PDZ-LIM domain proteins in the heart. J Mol Cell Biol (2009) 0.97
Human T-cell leukemia virus type I-mediated repression of PDZ-LIM domain-containing protein 2 involves DNA methylation but independent of the viral oncoprotein tax. Neoplasia (2009) 0.96
Molecular determinants of PDLIM2 in suppressing HTLV-I Tax-mediated tumorigenesis. Oncogene (2010) 0.94
Exome sequencing reveals a novel TTC19 mutation in an autosomal recessive spinocerebellar ataxia patient. BMC Neurol (2014) 0.93
Retracted Osteopontin and protein kinase C regulate PDLIM2 activation and STAT1 ubiquitination in LPS-treated murine macrophages. J Biol Chem (2010) 0.88
Bacillus anthracis edema toxin suppresses human macrophage phagocytosis and cytoskeletal remodeling via the protein kinase A and exchange protein activated by cyclic AMP pathways. Infect Immun (2009) 0.88
PDLIM2 regulates transcription factor activity in epithelial-to-mesenchymal transition via the COP9 signalosome. Mol Biol Cell (2013) 0.88
Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells. Neoplasia (2007) 0.87
1,25-Dihydroxyvitamin D3 Controls a Cohort of Vitamin D Receptor Target Genes in the Proximal Intestine That Is Enriched for Calcium-regulating Components. J Biol Chem (2015) 0.86
PDlim2 selectively interacts with the PDZ binding motif of highly pathogenic avian H5N1 influenza A virus NS1. PLoS One (2011) 0.83
Characterization of the interaction between Actinin-Associated LIM Protein (ALP) and the rod domain of alpha-actinin. BMC Cell Biol (2009) 0.81
Zasp regulates integrin activation. J Cell Sci (2012) 0.80
Pdlim7 is required for maintenance of the mesenchymal/epidermal Fgf signaling feedback loop during zebrafish pectoral fin development. BMC Dev Biol (2010) 0.79
PDLIM1 inhibits NF-κB-mediated inflammatory signaling by sequestering the p65 subunit of NF-κB in the cytoplasm. Sci Rep (2015) 0.79
Essential function for PDLIM2 in cell polarization in three-dimensional cultures by feedback regulation of the β1-integrin-RhoA signaling axis. Neoplasia (2014) 0.78
IGF-1 Receptor and Adhesion Signaling: An Important Axis in Determining Cancer Cell Phenotype and Therapy Resistance. Front Endocrinol (Lausanne) (2015) 0.77
Systematic analysis of bacterial effector-postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domain interactions demonstrates Shigella OspE protein promotes protein kinase C activation via PDLIM proteins. J Biol Chem (2014) 0.76
Hyperactive RAS/PI3-K/MAPK Signaling Cascade in Migration and Adhesion of Nf1 Haploinsufficient Mesenchymal Stem/Progenitor Cells. Int J Mol Sci (2015) 0.76
PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer. Sci Signal (2017) 0.75
Global Proteome and Phospho-proteome Analysis of Merlin-deficient Meningioma and Schwannoma Identifies PDLIM2 as a Novel Therapeutic Target. EBioMedicine (2017) 0.75
Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma. Leukemia (2016) 0.75
The Ubiquitination of NF-κB Subunits in the Control of Transcription. Cells (2016) 0.75
MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-κB and negatively regulates inflammatory responses. Sci Rep (2017) 0.75
Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol (2003) 11.12
The insulin-like growth factor system and cancer. Cancer Lett (2003) 4.91
Dynamics and segregation of cell-matrix adhesions in cultured fibroblasts. Nat Cell Biol (2000) 3.99
The LIM domain is a modular protein-binding interface. Cell (1994) 3.50
The LIM domain: regulation by association. Mech Dev (2000) 3.45
Differential regulation of cell motility and invasion by FAK. J Cell Biol (2003) 3.15
Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. Cancer Cell (2002) 3.02
The IGF-1 receptor in cancer biology. Int J Cancer (2003) 2.66
Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts. Mol Cell Biol (1994) 2.65
Structure and function of the type 1 insulin-like growth factor receptor. Cell Mol Life Sci (2000) 2.52
PDZ domains: targeting signalling molecules to sub-membranous sites. Bioessays (1997) 2.39
An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation. Cancer Res (2003) 2.12
Protein-protein interaction of zinc finger LIM domains with protein kinase C. J Biol Chem (1996) 1.90
Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs. J Biol Chem (1995) 1.84
Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin. Proc Natl Acad Sci U S A (2000) 1.83
Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility. Mol Cell Biol (1999) 1.82
Transactivation of the EGF receptor mediates IGF-1-stimulated shc phosphorylation and ERK1/2 activation in COS-7 cells. J Biol Chem (2000) 1.76
Cypher, a striated muscle-restricted PDZ and LIM domain-containing protein, binds to alpha-actinin-2 and protein kinase C. J Biol Chem (1999) 1.75
Zyxin is not colocalized with vasodilator-stimulated phosphoprotein (VASP) at lamellipodial tips and exhibits different dynamics to vinculin, paxillin, and VASP in focal adhesions. Mol Biol Cell (2001) 1.64
RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix. Mol Cell Biol (2002) 1.60
ZASP: a new Z-band alternatively spliced PDZ-motif protein. J Cell Biol (1999) 1.59
Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo. J Clin Invest (1997) 1.53
LIM domain recognition of a tyrosine-containing tight turn. J Biol Chem (1994) 1.47
Identification of a human cDNA encoding a novel protein kinase with two repeats of the LIM/double zinc finger motif. Oncogene (1994) 1.46
The TES gene at 7q31.1 is methylated in tumours and encodes a novel growth-suppressing LIM domain protein. Oncogene (2001) 1.45
The LIM motif defines a specific zinc-binding protein domain. Proc Natl Acad Sci U S A (1993) 1.37
Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling. Oncogene (2003) 1.32
RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death. J Biol Chem (2002) 1.31
Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways. J Biol Chem (2000) 1.30
A novel protein encoded by the InaD gene regulates recovery of visual transduction in Drosophila. Neuron (1995) 1.29
The roles of integrins and extracellular matrix proteins in the insulin-like growth factor I-stimulated chemotaxis of human breast cancer cells. J Biol Chem (1996) 1.27
PDZ motifs in PTP-BL and RIL bind to internal protein segments in the LIM domain protein RIL. Mol Biol Cell (1998) 1.24
Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis. Mol Cell Biol (1997) 1.24
Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain. J Biol Chem (1996) 1.23
LMP-1, a LIM-domain protein, mediates BMP-6 effects on bone formation. Endocrinology (1998) 1.19
Expression of ril, a novel LIM domain gene, is down-regulated in Hras-transformed cells and restored in phenotypic revertants. Oncogene (1995) 1.18
Actin/alpha-actinin-dependent transport of AMPA receptors in dendritic spines: role of the PDZ-LIM protein RIL. J Neurosci (2004) 1.17
Purification and characterization of an alpha-actinin-binding PDZ-LIM protein that is up-regulated during muscle differentiation. J Biol Chem (1999) 1.17
Elevated levels of p66 Shc are found in breast cancer cell lines and primary tumors with high metastatic potential. Clin Cancer Res (2000) 1.13
Characterization and in vivo functional analysis of splice variants of cypher. J Biol Chem (2002) 1.13
In vivo analyses of integrin beta 1 subunit function in fibronectin matrix assembly. J Cell Biol (1990) 1.13
Microarray analysis of insulin and insulin-like growth factor-1 (IGF-1) receptor signaling reveals the selective up-regulation of the mitogen heparin-binding EGF-like growth factor by IGF-1. J Biol Chem (2002) 1.10
Insulin-like growth factor I stimulates tyrosine phosphorylation of p130(Cas), focal adhesion kinase, and paxillin. Role of phosphatidylinositol 3'-kinase and formation of a p130(Cas).Crk complex. J Biol Chem (1998) 1.08
Pdlim2, a novel PDZ-LIM domain protein, interacts with alpha-actinins and filamin A. Invest Ophthalmol Vis Sci (2004) 1.08
Determination of a minimal deletion interval on chromosome band 8p21 in sporadic prostate cancer. Genes Chromosomes Cancer (2002) 1.07
Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein. J Cell Sci (2002) 1.06
The role of the IGF-I receptor in the regulation of matrix metalloproteinases, tumor invasion and metastasis. Horm Metab Res (2004) 1.05
Cloning of a rat cDNA encoding a novel LIM domain protein with high homology to rat RIL. Gene (1995) 1.04
IGF-I receptor-induced cell-cell adhesion of MCF-7 breast cancer cells requires the expression of junction protein ZO-1. J Biol Chem (2001) 1.04
Reduced expression of insulin-like growth factor I receptors in MCF-7 breast cancer cells leads to a more metastatic phenotype. Cancer Res (2002) 1.03
Allelic loss on chromosome arm 8p: analysis of sporadic epithelial ovarian tumors. Gynecol Oncol (1999) 1.01
Insulin-like growth factor-I signaling in human neuroblastoma cells. Oncogene (2004) 0.99
Shc and Enigma are both required for mitogenic signaling by Ret/ptc2. Mol Cell Biol (1998) 0.96
Differential regulation of focal adhesion kinase and mitogen-activated protein kinase tyrosine phosphorylation during insulin-like growth factor-I-mediated cytoskeletal reorganization. J Neurochem (1998) 0.95
The human RIL gene: mapping to human chromosome 5q31.1, genomic organization and alternative transcripts. Gene (1998) 0.94
Induction of fascin spikes in breast cancer cells by activation of the insulin-like growth factor-I receptor. Int J Biochem Cell Biol (2002) 0.92
SHC-alpha5beta1 integrin interactions regulate breast cancer cell adhesion and motility. Exp Cell Res (1999) 0.92
Interaction of hCLIM1, an enigma family protein, with alpha-actinin 2. J Cell Biochem (2000) 0.91
Coordinated regulation of fibronectin fibril assembly and actin stress fiber formation. Cell Adhes Commun (1997) 0.91
Cooperative regulation of the invasive and metastatic phenotypes by different domains of the type I insulin-like growth factor receptor beta subunit. J Biol Chem (2001) 0.88
Suppression of fibroblast cell growth by overexpression of LIM-kinase 1. FEBS Lett (1996) 0.86
Intracellular transactivation of the insulin-like growth factor I receptor by an epidermal growth factor receptor. Exp Cell Res (1996) 0.83
Genetic changes in stage pT2N0 prostate cancer studied by comparative genomic hybridization. BJU Int (2002) 0.81
Antitumor effects elicited by antisense-mediated downregulation of the insulin-like growth factor I receptor (review). Int J Mol Med (1998) 0.80
Migration mechanisms: corneal epithelial tissue and dissociated cells. Exp Eye Res (2001) 0.78
Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Neurobiol Aging (2010) 2.32
Importance of eIF2alpha phosphorylation and stress granule assembly in alphavirus translation regulation. Mol Biol Cell (2005) 2.27
RACK1, A multifaceted scaffolding protein: Structure and function. Cell Commun Signal (2011) 2.16
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Res (2013) 1.92
Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology. J Neurochem (2005) 1.67
Identification of a cytoplasmic complex that adds a cap onto 5'-monophosphate RNA. Mol Cell Biol (2009) 1.67
Potent long-term cardioprotective effects of single low-dose insulin-like growth factor-1 treatment postmyocardial infarction. Circ Cardiovasc Interv (2011) 1.62
U1 snRNP-dependent function of TIAR in the regulation of alternative RNA processing of the human calcitonin/CGRP pre-mRNA. Mol Cell Biol (2003) 1.40
Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase. J Biol Chem (2009) 1.33
RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death. J Biol Chem (2002) 1.31
Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration. Mol Cell Biol (2006) 1.27
Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts. Mol Cell Biol (2002) 1.27
Metazoan stress granule assembly is mediated by P-eIF2alpha-dependent and -independent mechanisms. RNA (2009) 1.23
Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration. J Biol Chem (2008) 1.19
The insulin-like growth factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth. Mol Biol Cell (2007) 1.16
Focal adhesion kinase and protein kinase B cooperate to suppress doxorubicin-induced apoptosis of breast tumor cells. Mol Pharmacol (2006) 1.15
RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251. J Biol Chem (2004) 1.10
Deubiquitination of NF-κB by Ubiquitin-Specific Protease-7 promotes transcription. Proc Natl Acad Sci U S A (2012) 1.06
Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level. BMC Cancer (2008) 1.03
Granzyme B leakage-induced cell death: a new type of activation-induced natural killer cell death. Eur J Immunol (2003) 1.02
Fluorescence-based cell viability screening assays using water-soluble oxygen probes. J Biomol Screen (2003) 1.01
Dynamic complex formation between HD-GYP, GGDEF and PilZ domain proteins regulates motility in Xanthomonas campestris. Mol Microbiol (2012) 1.01
Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing. Proc Natl Acad Sci U S A (2007) 1.00
Eukaryotic membrane protein overproduction in Lactococcus lactis. Curr Opin Biotechnol (2005) 0.97
Heme-binding protein HRG-1 is induced by insulin-like growth factor I and associates with the vacuolar H+-ATPase to control endosomal pH and receptor trafficking. J Biol Chem (2009) 0.97
Gene expression profiles in cells transformed by overexpression of the IGF-I receptor. Oncogene (2005) 0.95
The EphA3 receptor is expressed in a subset of rhabdomyosarcoma cell lines and suppresses cell adhesion and migration. J Cell Biochem (2008) 0.94
Impaired Shc, Ras, and MAPK activation but normal Akt activation in FL5.12 cells expressing an insulin-like growth factor I receptor mutated at tyrosines 1250 and 1251. J Biol Chem (2004) 0.94
Using real-time impedance-based assays to monitor the effects of fibroblast-derived media on the adhesion, proliferation, migration and invasion of colon cancer cells. Biosci Rep (2014) 0.93
Ribosomal 18 S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation. J Biol Chem (2010) 0.92
Insulin-like growth factor-1 activates Akt and Jun N-terminal kinases (JNKs) in promoting the survival of T lymphocytes. Immunology (2002) 0.92
High-throughput assay to measure oxygen consumption in digitonin-permeabilized cells of patients with mitochondrial disorders. Clin Chem (2009) 0.91
Optimising parameters for the differentiation of SH-SY5Y cells to study cell adhesion and cell migration. BMC Res Notes (2013) 0.91
EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion. Exp Cell Res (2004) 0.91
Sequestration of PDLIM2 in the cytoplasm of monocytic/macrophage cells is associated with adhesion and increased nuclear activity of NF-kappaB. J Leukoc Biol (2008) 0.90
RACK1 to the future--a historical perspective. Cell Commun Signal (2013) 0.90
A portrait of cisplatin-induced transcriptional changes in mouse embryonic stem cells reveals a dominant p53-like response. Mutat Res (2007) 0.88
Direct interaction between scaffolding proteins RACK1 and 14-3-3ζ regulates brain-derived neurotrophic factor (BDNF) transcription. J Biol Chem (2011) 0.88
PDLIM2 regulates transcription factor activity in epithelial-to-mesenchymal transition via the COP9 signalosome. Mol Biol Cell (2013) 0.88
A low-volume platform for cell-respirometric screening based on quenched-luminescence oxygen sensing. Biosens Bioelectron (2004) 0.86
Inhibition of transcription by B cell Leukemia 3 (Bcl-3) protein requires interaction with nuclear factor κB (NF-κB) p50. J Biol Chem (2014) 0.85
Pregnancy-specific glycoproteins bind integrin αIIbβ3 and inhibit the platelet-fibrinogen interaction. PLoS One (2013) 0.85
Restoration of complex V deficiency caused by a novel deletion in the human TMEM70 gene normalizes mitochondrial morphology. Mitochondrion (2011) 0.85
RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK. Cell Signal (2013) 0.84
Tools used to study how protein complexes are assembled in signaling cascades. Bioeng Bugs (2011) 0.83
Tim-4 inhibition of T-cell activation and T helper type 17 differentiation requires both the immunoglobulin V and mucin domains and occurs via the mitogen-activated protein kinase pathway. Immunology (2011) 0.83
Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1. PLoS Genet (2013) 0.81
Serine phosphorylation of the insulin-like growth factor I (IGF-1) receptor C-terminal tail restrains kinase activity and cell growth. J Biol Chem (2012) 0.79
Effects of RACK1 on cell migration and IGF-I signalling in cardiomyoctes are not dependent on an association with the IGF-IR. Cell Signal (2007) 0.78
Erythrocyte survival is promoted by plasma and suppressed by a Bak-derived BH3 peptide that interacts with membrane-associated Bcl-X(L). Blood (2002) 0.78
A case report of spontaneous mutation (C33>U) in the iron-responsive element of L-ferritin causing hyperferritinemia-cataract syndrome. Blood Cells Mol Dis (2009) 0.77
Extracellular matrix gene expression profiling using microfluidics for colorectal carcinoma stratification. Biomicrofluidics (2016) 0.75