Published in Mol Cell Biol on January 01, 1997
Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis. J Cell Physiol (2000) 2.47
Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis. Mol Cell Biol (1999) 2.17
Mystique is a new insulin-like growth factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses Anchorage-independent growth. Mol Biol Cell (2005) 1.36
Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase. J Biol Chem (2009) 1.33
Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration. Mol Cell Biol (2006) 1.27
Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts. Mol Cell Biol (2002) 1.27
A quantitative study of the recruitment potential of all intracellular tyrosine residues on EGFR, FGFR1 and IGF1R. Mol Biosyst (2008) 1.19
The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal. Mol Cell Biol (1997) 1.15
The insulin-like growth factor I receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase. Mol Cell Biol (2006) 1.10
Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation. Cell Mol Life Sci (2013) 1.08
Protein kinase C-delta is an important signaling molecule in insulin-like growth factor I receptor-mediated cell transformation. Mol Cell Biol (1998) 1.02
Functional roles and clinical values of insulin-like growth factor-binding protein-5 in different types of cancers. Chin J Cancer (2012) 1.01
The insulin receptor: a new target for cancer therapy. Front Endocrinol (Lausanne) (2011) 0.99
Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma. Dig Dis Sci (2003) 0.98
Antiproliferative and proapoptotic effect of ascorbyl stearate in human pancreatic cancer cells: association with decreased expression of insulin-like growth factor 1 receptor. Dig Dis Sci (2003) 0.96
Insulin-like growth factor-1 isoforms in rat hepatocytes and cholangiocytes and their involvement in protection against cholestatic injury. Lab Invest (2008) 0.92
Nuclear IGF1R is a transcriptional co-activator of LEF1/TCF. EMBO Rep (2012) 0.91
Identification of an IGF-1R kinase regulatory phosphatase using the fission yeast Schizosaccharomyces pombe and a GFP tagged IGF-1R in mammalian cells. Mol Pathol (2002) 0.88
Apoptosis contributes to amphotericin B-induced nephrotoxicity. Antimicrob Agents Chemother (2001) 0.87
Cellular distribution of the IGF-1R in corneal epithelial cells. Exp Eye Res (2011) 0.85
INTS6/DICE1 inhibits growth of human androgen-independent prostate cancer cells by altering the cell cycle profile and Wnt signaling. Cancer Cell Int (2009) 0.84
IGF-1/IGFBP-1 increases blastocyst formation and total blastocyst cell number in mouse embryo culture and facilitates the establishment of a stem-cell line. BMC Cell Biol (2003) 0.84
Antisense oligonucleotide suppression of human IGF-1R inhibits the growth and survival of in vitro cultured epithelial ovarian cancer cells. J Ovarian Res (2013) 0.80
Extracellular vimentin interacts with insulin-like growth factor 1 receptor to promote axonal growth. Sci Rep (2015) 0.79
Serine phosphorylation of the insulin-like growth factor I (IGF-1) receptor C-terminal tail restrains kinase activity and cell growth. J Biol Chem (2012) 0.79
Effects of somatic mutations in the C-terminus of insulin-like growth factor 1 receptor on activity and signaling. J Signal Transduct (2012) 0.78
Caenorhabditis elegans DAF-2 as a Model for Human Insulin Receptoropathies. G3 (Bethesda) (2016) 0.76
IGF-I activates caspases 3/7, 8 and 9 but does not induce cell death in colorectal cancer cells. BMC Cancer (2009) 0.76
Type I insulin-like growth factor receptor signaling in hematological malignancies. Oncotarget (2017) 0.76
Mechanism of immortalization. Age (Omaha) (1999) 0.75
Acute ethanol increases IGF-I-induced phosphorylation of ERKs by enhancing recruitment of p52-Shc to the Grb2/Shc complex. J Cell Physiol (2016) 0.75
Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain. J Biol Chem (2016) 0.75
Induction of apoptosis in fibroblasts by c-myc protein. Cell (1992) 16.95
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature (1988) 14.66
A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res (1995) 7.95
Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J (1986) 6.62
Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature (1992) 5.50
Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature (1992) 4.75
A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. EMBO J (1995) 3.70
Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr Rev (1995) 3.58
c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J (1994) 3.58
Induction of apoptosis by the Bcl-2 homologue Bak. Nature (1995) 3.56
Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts. Mol Cell Biol (1994) 2.65
Multiple extracellular signals are required for long-term oligodendrocyte survival. Development (1993) 2.55
A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis. Nature (1994) 2.51
Contenders in FasL/TNF death signaling. Cell (1995) 2.21
Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation. Mol Cell Biol (1990) 1.90
Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. Mol Cell Biol (1995) 1.77
Analysis of insulin-like growth factor I gene expression in malignancy: evidence for a paracrine role in human breast cancer. Mol Endocrinol (1989) 1.65
The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo. Cancer Res (1995) 1.46
Insulin-like growth factor-I inhibits apoptosis in IL-3-dependent hemopoietic cells. J Immunol (1992) 1.42
Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system. Mol Cell Biol (1994) 1.41
A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor. Mol Cell Biol (1994) 1.39
Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis. Cancer Res (1995) 1.36
Prognostic value of receptors for insulin-like growth factor 1, somatostatin, and epidermal growth factor in human breast cancer. Cancer Res (1989) 1.32
Insulin-like growth factor-I can mediate autocrine proliferation of human small cell lung cancer cell lines in vitro. J Clin Invest (1988) 1.26
Characterization of insulinlike growth factor I receptors in human colon cancer. Gastroenterology (1992) 1.18
The role of the IGF-I receptor in the growth and transformation of mammalian cells. Cell Prolif (1994) 1.16
Autocrine function for insulin-like growth factor I in human small cell lung cancer cell lines and fresh tumor cells. Cancer Res (1990) 1.15
Presence of somatomedin receptors on primary human breast and colon carcinomas. Cancer Lett (1987) 1.15
Different effects on mitogenesis and transformation of a mutation at tyrosine 1251 of the insulin-like growth factor I receptor. J Biol Chem (1995) 1.14
Correlation between apoptosis, tumorigenesis, and levels of insulin-like growth factor I receptors. Cancer Res (1995) 1.11
Mutational analysis of the mitogenic and transforming activities of the insulin-like growth factor I receptor. Oncogene (1996) 1.09
Mitogenicity and transforming activity of the insulin-like growth factor-I receptor with mutations in the tyrosine kinase domain. J Biol Chem (1994) 1.07
Expression of insulin-like growth factor receptors I and II in normal human lung and in lung cancer. J Cancer Res Clin Oncol (1993) 1.06
Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system. J Biol Chem (1995) 1.03
Insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the platelet-derived growth factor receptor. J Cell Physiol (1995) 0.99
Insulin-like growth factors: putative muscle-derived trophic agents that promote motoneuron survival. J Neurobiol (1993) 0.99
Structure-function relationship of the insulin-like growth factor-I receptor tyrosine kinase. J Biol Chem (1993) 0.98
Growth factor and peptide receptors in small cell lung cancer. Life Sci (1993) 0.98
Effect of mutations at serines 1280-1283 on the mitogenic and transforming activities of the insulin-like growth factor I receptor. J Biol Chem (1996) 0.94
Dissociation of mitogenesis and transforming activity by C-terminal truncation of the insulin-like growth factor-I receptor. Exp Cell Res (1995) 0.91
Effect of a mutation at tyrosine 950 of the insulin-like growth factor I receptor on the growth and transformation of cells. Cancer Res (1995) 0.88
Expression of type I, but not type II insulin-like growth factor receptor on both undifferentiated and differentiated HT29 human colon carcinoma cell line. J Clin Endocrinol Metab (1992) 0.81
Levels of circulating peptide and steroid hormones in men with lung cancer. Neoplasma (1994) 0.81
The IGF-I receptor protects tumor cells from apoptosis induced by high concentrations of serum. Biochem Biophys Res Commun (1996) 0.81
Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol Cell Biol (1985) 25.52
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity (2000) 16.03
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science (1997) 13.61
The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant. Nat Cell Biol (2000) 9.87
A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity (2001) 9.45
A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res (1995) 7.95
Integrating genotype and phenotype information: an overview of the PharmGKB project. Pharmacogenetics Research Network and Knowledge Base. Pharmacogenomics J (2001) 5.94
Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature (1992) 5.50
Reliable and global measurement of fluorescence resonance energy transfer using fluorescence microscopes. Biophys J (2001) 5.28
HuR regulates p21 mRNA stabilization by UV light. Mol Cell Biol (2000) 4.96
The urea reduction ratio and serum albumin concentration as predictors of mortality in patients undergoing hemodialysis. N Engl J Med (1993) 4.88
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci U S A (2001) 4.58
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature (2006) 4.57
Diffusion of the Interspecies Electron Carriers H(2) and Formate in Methanogenic Ecosystems and Its Implications in the Measurement of K(m) for H(2) or Formate Uptake. Appl Environ Microbiol (1989) 4.53
The cpr5 mutant of Arabidopsis expresses both NPR1-dependent and NPR1-independent resistance. Plant Cell (1997) 4.47
Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity (2000) 4.44
Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol (2001) 4.39
Visual identification of individual transfected cells for electrophysiology using antibody-coated beads. Biotechniques (1994) 4.24
Oncogenic activity of the c-Myc protein requires dimerization with Max. Cell (1993) 4.10
Junction adhesion molecule is a receptor for reovirus. Cell (2001) 4.00
Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex. Genes Dev (1998) 3.84
Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4. J Biol Chem (2000) 3.75
Role of nitric oxide in the vascular effects of local warming of the skin in humans. J Appl Physiol (1985) (1999) 3.65
Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury. J Biol Chem (1996) 3.65
Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nat Cell Biol (2001) 3.63
Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates. Proc Natl Acad Sci U S A (1997) 3.59
c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J (1994) 3.58
Microinjection of monoclonal antibody to protein p53 inhibits serum-induced DNA synthesis in 3T3 cells. Proc Natl Acad Sci U S A (1982) 3.58
Induction of apoptosis by the Bcl-2 homologue Bak. Nature (1995) 3.56
Interaction between the origin recognition complex and the replication licensing system in Xenopus. Cell (1996) 3.45
Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max. Nature (1992) 3.43
Response regulator output in bacterial chemotaxis. EMBO J (1998) 3.40
Alternative initiation of translation and time-specific phosphorylation yield multiple forms of the essential clock protein FREQUENCY. Cell (1997) 3.32
Several log increase in therapeutic transgene delivery by distinct adeno-associated viral serotype vectors. Mol Ther (2000) 3.32
The protein encoded by the human proto-oncogene c-myc. Proc Natl Acad Sci U S A (1984) 3.31
Blocker protection in the pore of a voltage-gated K+ channel and its structural implications. Nature (2000) 3.26
Proto-oncogene PML controls genes devoted to MHC class I antigen presentation. Nature (1998) 3.22
Restricted expression of EBV latent genes and T-lymphocyte-detected membrane antigen in Burkitt's lymphoma cells. EMBO J (1986) 3.07
Subsequent pulmonary embolism: risk after a negative helical CT pulmonary angiogram--prospective comparison with scintigraphy. Radiology (2000) 3.06
Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak. J Cell Biol (1997) 3.03
IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways. EMBO J (1998) 2.99
Activation of a mitogen-activated protein kinase pathway is involved in disease resistance in tobacco. Proc Natl Acad Sci U S A (2001) 2.98
Subcellular localization of proteins encoded by oncogenes of avian myeloblastosis virus and avian leukemia virus E26 and by chicken c-myb gene. Cell (1984) 2.98
Studies on the interaction of the human c-myc protein with cell nuclei: p62c-myc as a member of a discrete subset of nuclear proteins. Cell (1985) 2.95
Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. J Clin Invest (1997) 2.93
Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses. J Exp Med (1999) 2.92
Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles. J Virol (1997) 2.91
Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export. EMBO J (1998) 2.90
Characterization of the human cysteinyl leukotriene 2 receptor. J Biol Chem (2000) 2.89
Role of the p53 protein in cell proliferation as studied by microinjection of monoclonal antibodies. Mol Cell Biol (1984) 2.88
Search for a resonance decaying into WZ boson pairs in pp collisions. Phys Rev Lett (2010) 2.83
Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene (2012) 2.82
Structure of the adenylyl cyclase catalytic core. Nature (1997) 2.81
Interlocked feedback loops contribute to the robustness of the Neurospora circadian clock. Proc Natl Acad Sci U S A (2001) 2.77
Inhibition of cellular proliferation by antisense oligodeoxynucleotides to PCNA cyclin. Science (1988) 2.74
Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes. J Cell Biol (2001) 2.73
Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells. J Neurochem (2000) 2.71
The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. Immunity (2000) 2.70
Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts. Mol Cell Biol (1994) 2.65
Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis. Curr Biol (1999) 2.65
The regulation of reactive oxygen species production during programmed cell death. J Cell Biol (1998) 2.62
Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor. Proc Natl Acad Sci U S A (1993) 2.58
The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Sci (1998) 2.58
The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max. EMBO J (1993) 2.57
Microinjected c-myc as a competence factor. Science (1985) 2.56
Identification and preliminary characterization of a protein motif related to the zinc finger. Proc Natl Acad Sci U S A (1993) 2.55
The C termini of Arabidopsis cryptochromes mediate a constitutive light response. Cell (2000) 2.53
Nitric oxide and cutaneous active vasodilation during heat stress in humans. J Appl Physiol (1985) (1998) 2.53
Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis. Science (1997) 2.52
Isolation of monoclonal antibodies specific for products of avian oncogene myb. Mol Cell Biol (1984) 2.50
The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem J (1998) 2.50
Uncoupling PR gene expression from NPR1 and bacterial resistance: characterization of the dominant Arabidopsis cpr6-1 mutant. Plant Cell (1998) 2.48
On the use of thiol-modifying agents to determine channel topology. Neuropharmacology (1996) 2.47
Zinc inhibition of mitochondrial aconitase and its importance in citrate metabolism of prostate epithelial cells. J Biol Chem (1997) 2.47
Increased thermal stability of proteins in the presence of naturally occurring osmolytes. Biochemistry (1992) 2.47
Profiling serine hydrolase activities in complex proteomes. Biochemistry (2001) 2.46
The Drosophila caspase DRONC is regulated by DIAP1. EMBO J (2000) 2.46
Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas. Oncogene (2012) 2.41
A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis. Neurology (2011) 2.39
Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia (2011) 2.37
Establishment, maintenance and description of cell lines from the tick Ixodes scapularis. J Parasitol (1994) 2.36
Design of allele-specific inhibitors to probe protein kinase signaling. Curr Biol (1998) 2.36
Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron (1997) 2.34
Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice. Proc Natl Acad Sci U S A (1996) 2.34
Eradication of large colon tumor xenografts by targeted delivery of maytansinoids. Proc Natl Acad Sci U S A (1996) 2.34
Coding sequence and growth regulation of the human vimentin gene. Mol Cell Biol (1986) 2.34
The transcriptome of the arbuscular mycorrhizal fungus Glomus intraradices (DAOM 197198) reveals functional tradeoffs in an obligate symbiont. New Phytol (2011) 2.29
Insulin-like growth factors and cancer. Ann Intern Med (1995) 2.29
The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes Dev (1997) 2.26
Acute motor axonal neuropathy: a frequent cause of acute flaccid paralysis in China. Ann Neurol (1993) 2.23
Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures. J Cell Biol (2001) 2.23
Odd-parity superconductivity in Sr2RuO4. Science (2004) 2.22
Systemic gene expression after intravenous DNA delivery into adult mice. Science (1993) 2.21
Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc Natl Acad Sci U S A (2001) 2.21
Coiled-coil domain-mediated FRQ-FRQ interaction is essential for its circadian clock function in Neurospora. EMBO J (2001) 2.19
Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity (1999) 2.18
Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis. Mol Cell Biol (1999) 2.17
Human albumin therapy of acute ischemic stroke: marked neuroprotective efficacy at moderate doses and with a broad therapeutic window. Stroke (2001) 2.16