PubRank

Raif S Geha

Author PubWeight™ 160.54‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 TACI is mutant in common variable immunodeficiency and IgA deficiency. Nat Genet 2005 4.08
2 Transcellular diapedesis is initiated by invasive podosomes. Immunity 2007 4.06
3 Primary immunodeficiencies: 2009 update. J Allergy Clin Immunol 2009 3.70
4 TACI and BAFF-R mediate isotype switching in B cells. J Exp Med 2005 3.31
5 Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency. Front Immunol 2011 3.05
6 Impaired IgA class switching in APRIL-deficient mice. Proc Natl Acad Sci U S A 2004 2.57
7 The mature activating natural killer cell immunologic synapse is formed in distinct stages. Proc Natl Acad Sci U S A 2003 2.56
8 Primary immune deficiencies with aberrant IgE production. J Allergy Clin Immunol 2008 2.38
9 Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL. J Immunol 2008 2.38
10 Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP. Mol Cell Biol 2004 2.36
11 Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses. Proc Natl Acad Sci U S A 2002 2.32
12 Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency. Medicine (Baltimore) 2010 2.26
13 TSLP acts on infiltrating effector T cells to drive allergic skin inflammation. Proc Natl Acad Sci U S A 2008 2.22
14 Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell 2008 2.13
15 C4b-binding protein (C4BP) activates B cells through the CD40 receptor. Immunity 2003 2.04
16 Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen. J Allergy Clin Immunol 2009 1.91
17 Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells. J Infect Dis 2003 1.91
18 Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane. J Cell Biol 2005 1.91
19 Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations. J Clin Invest 2002 1.83
20 Animal models of atopic dermatitis. J Invest Dermatol 2009 1.80
21 Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. Int Immunol 2004 1.79
22 Mechanical injury polarizes skin dendritic cells to elicit a T(H)2 response by inducing cutaneous thymic stromal lymphopoietin expression. J Allergy Clin Immunol 2010 1.78
23 CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation. J Clin Invest 2002 1.73
24 DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. Nat Immunol 2012 1.70
25 WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP). Proc Natl Acad Sci U S A 2007 1.70
26 Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation. Mol Cell 2002 1.70
27 Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge. Proc Natl Acad Sci U S A 2007 1.60
28 Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID). J Clin Invest 2007 1.58
29 Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP. Blood 2009 1.52
30 Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function. J Exp Med 2014 1.49
31 A novel homozygous mutation in recombination activating gene 2 in 2 relatives with different clinical phenotypes: Omenn syndrome and hyper-IgM syndrome. J Allergy Clin Immunol 2012 1.48
32 Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee Meeting in Budapest, 2005. J Allergy Clin Immunol 2006 1.46
33 Human nuclear factor kappa B essential modulator mutation can result in immunodeficiency without ectodermal dysplasia. J Allergy Clin Immunol 2004 1.43
34 Cellular and molecular mechanisms in atopic dermatitis. Adv Immunol 2009 1.41
35 WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation. Immunity 2002 1.41
36 The presentation and natural history of immunodeficiency caused by nuclear factor kappaB essential modulator mutation. J Allergy Clin Immunol 2004 1.40
37 IL-10 is critical for Th2 responses in a murine model of allergic dermatitis. J Clin Invest 2003 1.36
38 RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation. J Exp Med 2004 1.35
39 WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1alpha. Int Immunol 2005 1.32
40 Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol 2013 1.31
41 Human disease resulting from gene mutations that interfere with appropriate nuclear factor-kappaB activation. Immunol Rev 2005 1.28
42 A phenotypic approach for IUIS PID classification and diagnosis: guidelines for clinicians at the bedside. J Clin Immunol 2013 1.27
43 B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood 2012 1.27
44 LPS-responsive beige-like anchor (LRBA) gene mutation in a family with inflammatory bowel disease and combined immunodeficiency. J Allergy Clin Immunol 2012 1.26
45 Wiskott-Aldrich syndrome: a comprehensive review. Ann N Y Acad Sci 2013 1.25
46 Successful engraftment of donor marrow after allogeneic hematopoietic cell transplantation in autosomal-recessive hyper-IgE syndrome caused by dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol 2010 1.24
47 Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response. Proc Natl Acad Sci U S A 2009 1.23
48 Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13. J Allergy Clin Immunol 2009 1.22
49 Thymic stromal lymphopoietin. Ann N Y Acad Sci 2010 1.21
50 The H1 histamine receptor regulates allergic lung responses. J Clin Invest 2006 1.21
51 Epicutaneous sensitization with superantigen induces allergic skin inflammation. J Allergy Clin Immunol 2003 1.20
52 Differential role of SLP-76 domains in T cell development and function. Proc Natl Acad Sci U S A 2002 1.20
53 IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. J Clin Invest 2008 1.17
54 Transmembrane activator and calcium modulator and cyclophilin ligand interactor enhances CD40-driven plasma cell differentiation. J Allergy Clin Immunol 2007 1.17
55 3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation. Mol Cell Biol 2006 1.13
56 WIP participates in actin reorganization and ruffle formation induced by PDGF. J Cell Sci 2003 1.10
57 Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation. Immunity 2012 1.09
58 The C104R mutant impairs the function of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) through haploinsufficiency. J Allergy Clin Immunol 2010 1.08
59 Aspartame: review of safety. Regul Toxicol Pharmacol 2002 1.08
60 WIP regulates signaling via the high affinity receptor for immunoglobulin E in mast cells. J Exp Med 2004 1.07
61 Epicutaneous challenge of orally immunized mice redirects antigen-specific gut-homing T cells to the skin. J Clin Invest 2011 1.06
62 Impaired immune response to vaccinia virus inoculated at the site of cutaneous allergic inflammation. J Allergy Clin Immunol 2007 1.05
63 Defective nuclear translocation of nuclear factor of activated T cells and extracellular signal-regulated kinase underlies deficient IL-2 gene expression in Wiskott-Aldrich syndrome. J Allergy Clin Immunol 2005 1.05
64 The murine equivalent of the A181E TACI mutation associated with common variable immunodeficiency severely impairs B-cell function. Blood 2009 1.04
65 Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation. J Exp Med 2003 1.04
66 IPEX and the role of Foxp3 in the development and function of human Tregs. J Clin Invest 2006 1.04
67 Molecular basis of common variable immunodeficiency. J Allergy Clin Immunol 2006 1.03
68 The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen. J Clin Invest 2004 1.03
69 Heterozygous N-terminal deletion of IkappaBalpha results in functional nuclear factor kappaB haploinsufficiency, ectodermal dysplasia, and immune deficiency. J Allergy Clin Immunol 2007 1.03
70 A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP. J Exp Med 2012 1.02
71 Mast cells regulate IFN-gamma expression in the skin and circulating IgE levels in allergen-induced skin inflammation. J Allergy Clin Immunol 2002 1.02
72 Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections. N Engl J Med 2015 1.02
73 Transmembrane activator, calcium modulator, and cyclophilin ligand interactor drives plasma cell differentiation in LPS-activated B cells. J Allergy Clin Immunol 2009 0.98
74 Use of whole exome and genome sequencing in the identification of genetic causes of primary immunodeficiencies. Curr Opin Allergy Clin Immunol 2012 0.98
75 Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells. Int Immunol 2003 0.97
76 Clinical, immunologic and genetic profiles of DOCK8-deficient patients in Kuwait. Clin Immunol 2012 0.97
77 A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency. J Allergy Clin Immunol 2013 0.97
78 Immune deficiency caused by impaired expression of nuclear factor-kappaB essential modifier (NEMO) because of a mutation in the 5' untranslated region of the NEMO gene. J Allergy Clin Immunol 2010 0.96
79 B-cell receptor cross-linking delays activation-induced cytidine deaminase induction and inhibits class-switch recombination to IgE. J Allergy Clin Immunol 2007 0.95
80 12. Primary immunodeficiency diseases. J Allergy Clin Immunol 2003 0.95
81 Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficiency. J Allergy Clin Immunol 2008 0.95
82 Parental consanguinity and the risk of primary immunodeficiency disorders: report from the Kuwait National Primary Immunodeficiency Disorders Registry. Int Arch Allergy Immunol 2010 0.95
83 Filaggrin-dependent secretion of sphingomyelinase protects against staphylococcal α-toxin-induced keratinocyte death. J Allergy Clin Immunol 2012 0.94
84 Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking. Proc Natl Acad Sci U S A 2010 0.93
85 Interleukin receptor-associated kinase-4 deficiency impairs Toll-like receptor-dependent innate antiviral immune responses. J Allergy Clin Immunol 2006 0.93
86 Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells. Mol Cell Biol 2003 0.92
87 COX-2 inhibition enhances the TH2 immune response to epicutaneous sensitization. J Allergy Clin Immunol 2005 0.91
88 IgG Fc receptor polymorphisms in human disease: implications for intravenous immunoglobulin therapy. J Allergy Clin Immunol 2003 0.91
89 Immunization with modified vaccinia virus Ankara prevents eczema vaccinatum in a murine model of atopic dermatitis. J Allergy Clin Immunol 2011 0.91
90 Toll-like receptor 9, transmembrane activator and calcium-modulating cyclophilin ligand interactor, and CD40 synergize in causing B-cell activation. J Allergy Clin Immunol 2011 0.90
91 The complement component C3 plays a critical role in both Th1 and Th2 responses to antigen. J Allergy Clin Immunol 2006 0.90
92 Allergy and hypersensitivity. Nature versus nurture in allergy and hypersensitivity. Curr Opin Immunol 2003 0.90
93 WIP is critical for T cell responsiveness to IL-2. Proc Natl Acad Sci U S A 2009 0.89
94 Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis. J Allergy Clin Immunol 2013 0.89
95 The prostaglandin D₂ receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge. J Allergy Clin Immunol 2010 0.87
96 Jun N-terminal kinase is essential for CD40-mediated IgE class switching in B cells. J Allergy Clin Immunol 2005 0.87
97 Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis. Proc Natl Acad Sci U S A 2012 0.86
98 A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function. Proc Natl Acad Sci U S A 2005 0.85
99 Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity. J Clin Invest 2016 0.85
100 TACI mutation in common variable immunodeficiency and IgA deficiency. Curr Allergy Asthma Rep 2006 0.84
101 Characteristics of mycobacterial infection in patients with immunodeficiency and nuclear factor-kappaB essential modulator mutation, with or without ectodermal dysplasia. J Am Acad Dermatol 2004 0.84
102 CCL25/CCR9 interactions are not essential for colitis development but are required for innate immune cell protection from chronic experimental murine colitis. Inflamm Bowel Dis 2014 0.84
103 CD1d restricted natural killer T cells are not required for allergic skin inflammation. J Allergy Clin Immunol 2006 0.84
104 A peptide derived from the Wiskott-Aldrich syndrome (WAS) protein-interacting protein (WIP) restores WAS protein level and actin cytoskeleton reorganization in lymphocytes from patients with WAS mutations that disrupt WIP binding. J Allergy Clin Immunol 2011 0.84
105 2. Update on primary immunodeficiency diseases. J Allergy Clin Immunol 2006 0.84
106 Finding NEMO: genetic disorders of NF-[kappa]B activation. J Clin Invest 2003 0.83
107 Distinct regulatory functions of SLP-76 and MIST in NK cell cytotoxicity and IFN-gamma production. Int Immunol 2008 0.83
108 Impaired T-cell receptor activation in IL-1 receptor-associated kinase-4-deficient patients. J Allergy Clin Immunol 2010 0.81
109 Transmembrane activator and calcium-modulator and cyclophilin ligand interactor mutations in common variable immunodeficiency. Curr Opin Allergy Clin Immunol 2008 0.81
110 T-cell receptor ligation causes Wiskott-Aldrich syndrome protein degradation and F-actin assembly downregulation. J Allergy Clin Immunol 2013 0.81
111 Acute chylothorax in children: selective retention of memory T cells and natural killer cells. J Pediatr 2003 0.81
112 TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40. Int Immunol 2009 0.80
113 Functional analysis of transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) mutations associated with common variable immunodeficiency. J Allergy Clin Immunol 2011 0.79
114 A second-site mutation in the initiation codon of WAS (WASP) results in expansion of subsets of lymphocytes in an Wiskott-Aldrich syndrome patient. Hum Mutat 2006 0.79
115 A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton. J Clin Invest 2016 0.79
116 Ligation of CD46 to CD40 inhibits CD40 signaling in B cells. Int Immunol 2011 0.78
117 Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly. Infect Immun 2012 0.78
118 Common variable immunodeficiency. Pediatr Res 2009 0.77
119 Intronic SH2D1A mutation with impaired SAP expression and agammaglobulinemia. Clin Immunol 2012 0.77
120 TACI, isotype switching, CVID and IgAD. Immunol Res 2007 0.77
121 TRIF signaling is essential for TLR4-driven IgE class switching. J Immunol 2014 0.77
122 Development of skin lesions in filaggrin-deficient mice is dependent on adaptive immunity. J Allergy Clin Immunol 2013 0.76
123 Vaccinia Ig ameliorates eczema vaccinatum in a murine model of atopic dermatitis. J Invest Dermatol 2011 0.76
124 SLP-76 is required for high-affinity IgE receptor- and IL-3 receptor-mediated activation of basophils. Int Immunol 2012 0.76
125 Reply to Narra. J Allergy Clin Immunol 2009 0.75
126 Are you immunodeficient? J Allergy Clin Immunol 2005 0.75
127 A girl with severe hand swelling and abdominal cramps. Clin Chem 2008 0.75
128 Images in immunodeficiency. J Allergy Clin Immunol 2007 0.75
129 C3a receptor promotes viral containment in mice inoculated with vaccinia virus at sites of allergic skin inflammation. J Allergy Clin Immunol 2013 0.75