Published in Circ Res on January 20, 2005
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol (2010) 6.67
Akt1 in endothelial cell and angiogenesis. Cell Cycle (2006) 2.22
Bach1 Represses Wnt/β-Catenin Signaling and Angiogenesis. Circ Res (2015) 2.01
Antagonism of peripheral inflammation reduces the severity of status epilepticus. Neurobiol Dis (2008) 1.74
Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones. EMBO J (2009) 1.68
Tissue kallikrein promotes neovascularization and improves cardiac function by the Akt-glycogen synthase kinase-3beta pathway. Cardiovasc Res (2008) 1.67
VE-cadherin: at the front, center, and sides of endothelial cell organization and function. Curr Opin Cell Biol (2010) 1.49
Identification of a novel inhibitor of the canonical Wnt pathway. Mol Cell Biol (2011) 1.38
Rap1 and its effector KRIT1/CCM1 regulate beta-catenin signaling. Dis Model Mech (2009) 1.31
The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development. Dev Biol (2008) 1.31
Differentiation of the brain vasculature: the answer came blowing by the Wnt. J Angiogenes Res (2010) 1.16
LKB1 deficiency in Tie2-Cre-expressing cells impairs ischemia-induced angiogenesis. J Biol Chem (2010) 1.12
Rspo1/Wnt signaling promotes angiogenesis via Vegfc/Vegfr3. Development (2011) 1.11
Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol (2013) 1.05
Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia. J Cell Biochem (2011) 0.98
Cdc42-mediated inhibition of GSK-3β improves angio-architecture and lumen formation during VEGF-driven pathological angiogenesis. Microvasc Res (2010) 0.97
Signaling "cross-talk" is integrated by transcription factors in the development of the anterior segment in the eye. Dev Dyn (2009) 0.96
Redox regulation of SERCA2 is required for vascular endothelial growth factor-induced signaling and endothelial cell migration. Antioxid Redox Signal (2012) 0.95
Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3β and mTOR signaling pathways. PLoS One (2012) 0.94
MYC and the art of microRNA maintenance. Cold Spring Harb Perspect Med (2014) 0.94
HoxA5 stabilizes adherens junctions via increased Akt1. Cell Adh Migr (2007) 0.93
Convergence of 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A and glycogen synthase kinase-3beta/beta-catenin signaling in corpus luteum progesterone synthesis. Endocrinology (2009) 0.93
Lithium upregulates vascular endothelial growth factor in brain endothelial cells and astrocytes. Stroke (2008) 0.91
PEA-15 unphosphorylated at both serine 104 and serine 116 inhibits ovarian cancer cell tumorigenicity and progression through blocking β-catenin. Oncogenesis (2012) 0.85
Endostar, a modified recombinant human endostatin, suppresses angiogenesis through inhibition of Wnt/β-catenin signaling pathway. PLoS One (2014) 0.85
Moderate GSK-3β inhibition improves neovascular architecture, reduces vascular leakage, and reduces retinal hypoxia in a model of ischemic retinopathy. Angiogenesis (2010) 0.84
Glycogen synthase kinase 3beta induces apoptosis in cancer cells through increase of survivin nuclear localization. Cancer Lett (2008) 0.84
Enzastaurin inhibits invasion and metastasis in lung cancer by diverse molecules. Br J Cancer (2010) 0.83
Histone deacetylase inhibitors enhance endothelial cell sprouting angiogenesis in vitro. Surgery (2011) 0.81
Adeno-sh-beta-catenin abolishes ischemic preconditioning-mediated cardioprotection by downregulation of its target genes VEGF, Bcl-2, and survivin in ischemic rat myocardium. Antioxid Redox Signal (2008) 0.81
Pleiotrophin is a potential colorectal cancer prognostic factor that promotes VEGF expression and induces angiogenesis in colorectal cancer. Int J Colorectal Dis (2011) 0.80
Lenticular cytoprotection, part 2: link between glycogen synthase kinase-3β, epithelial to mesenchymal transition, and mitochondrial depolarization. Mol Vis (2014) 0.78
c-Kit+ progenitors generate vascular cells for tissue-engineered grafts through modulation of the Wnt/Klf4 pathway. Biomaterials (2015) 0.78
Novel role of NADPH oxidase in ischemic myocardium: a study with Nox2 knockout mice. Funct Integr Genomics (2011) 0.78
Discovery of Novel Antiangiogenic Marine Natural Product Scaffolds. Mar Drugs (2016) 0.78
Kaposi's sarcoma-associated herpesvirus G-protein coupled receptor activates the canonical Wnt/β-catenin signaling pathway. Virol J (2014) 0.77
Mechanical Stretching Promotes Skin Tissue Regeneration via Enhancing Mesenchymal Stem Cell Homing and Transdifferentiation. Stem Cells Transl Med (2016) 0.75
The Transcription Factor Bach1 Suppresses the Developmental Angiogenesis of Zebrafish. Oxid Med Cell Longev (2017) 0.75
Effects of trauma, hemorrhagic shock, and chronic stress on lung vascular endothelial growth factor. J Surg Res (2016) 0.75
Elevated LRP6 levels correlate with vascular endothelial growth factor in the vitreous of proliferative diabetic retinopathy. Mol Vis (2015) 0.75
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell (2004) 11.33
Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med (2006) 9.07
Adipokines in inflammation and metabolic disease. Nat Rev Immunol (2011) 8.92
Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet (2007) 6.76
Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat Med (2005) 6.04
Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J Clin Invest (2005) 5.48
Role of Akt signaling in vascular homeostasis and angiogenesis. Circ Res (2002) 4.83
Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin. Cancer Cell (2006) 4.55
Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem (2003) 4.38
Protein kinase cascades in the regulation of cardiac hypertrophy. J Clin Invest (2005) 4.31
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem (2008) 4.16
Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. Science (2010) 4.15
Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression. Circ Res (2004) 4.13
Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat Med (2004) 4.05
Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis. J Clin Invest (2005) 3.95
Obesity, adiponectin and vascular inflammatory disease. Curr Opin Lipidol (2003) 3.89
Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice. Cell Metab (2008) 3.78
Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circ Res (2004) 3.16
AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress. J Biol Chem (2003) 3.02
Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling. J Biol Chem (2004) 3.01
Vascular endothelial growth factor blockade promotes the transition from compensatory cardiac hypertrophy to failure in response to pressure overload. Hypertension (2006) 3.01
Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway. Genes Dev (2006) 2.96
Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes. Circ Res (2004) 2.91
AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. J Biol Chem (2004) 2.83
Heritability and tissue specificity of expression quantitative trait loci. PLoS Genet (2006) 2.80
Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype. J Biol Chem (2009) 2.69
Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale. Physiol Rev (2010) 2.68
Adiponectin as an anti-inflammatory factor. Clin Chim Acta (2007) 2.56
Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms: role of protein kinase A. J Biol Chem (2001) 2.52
Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart. J Biol Chem (2003) 2.52
The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP. J Biol Chem (2003) 2.51
The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling. J Biol Chem (2005) 2.44
Microvascular patterning is controlled by fine-tuning the Akt signal. Proc Natl Acad Sci U S A (2004) 2.39
Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. J Clin Invest (2007) 2.37
FGF21 is an Akt-regulated myokine. FEBS Lett (2008) 2.29
Adiponectin replenishment ameliorates obesity-related hypertension. Hypertension (2006) 2.24
Mitofusin-2 maintains mitochondrial structure and contributes to stress-induced permeability transition in cardiac myocytes. Mol Cell Biol (2011) 2.23
c-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo. Circ Res (2005) 2.23
Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice. J Clin Invest (2010) 2.12
AMP-activated protein kinase signaling stimulates VEGF expression and angiogenesis in skeletal muscle. Circ Res (2005) 2.06
Metabolic benefits of resistance training and fast glycolytic skeletal muscle. Am J Physiol Endocrinol Metab (2010) 2.06
Impaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction. Circ Res (2005) 2.04
Follistatin-like 1, a secreted muscle protein, promotes endothelial cell function and revascularization in ischemic tissue through a nitric-oxide synthase-dependent mechanism. J Biol Chem (2008) 2.03
Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth. Proc Natl Acad Sci U S A (2003) 2.01
Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart. Circulation (2008) 1.99
RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing. Nat Med (2012) 1.97
Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells. Arterioscler Thromb Vasc Biol (2003) 1.95
Adiponectin actions in the cardiovascular system. Cardiovasc Res (2006) 1.92
Adiponectin suppresses pathological microvessel formation in retina through modulation of tumor necrosis factor-alpha expression. Circ Res (2009) 1.86
Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. J Biol Chem (2002) 1.86
Cardioprotection by adiponectin. Trends Cardiovasc Med (2006) 1.86
Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics. Circulation (2008) 1.84
Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation. J Clin Invest (2008) 1.76
17beta-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling. Circ Res (2004) 1.74
Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase. J Biol Chem (2002) 1.74
Impaired clearance of apoptotic cells promotes synergy between atherogenesis and autoimmune disease. J Exp Med (2004) 1.72
Plasma adiponectin and mortality in critically ill subjects with acute respiratory failure. Crit Care Med (2010) 1.70
NADPH oxidase 4 promotes endothelial angiogenesis through endothelial nitric oxide synthase activation. Circulation (2011) 1.68
Suppression of Akt signaling induces Fas ligand expression: involvement of caspase and Jun kinase activation in Akt-mediated Fas ligand regulation. Mol Cell Biol (2002) 1.67
T-cadherin is critical for adiponectin-mediated cardioprotection in mice. J Clin Invest (2010) 1.66
Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB J (2011) 1.65
Myogenic Akt signaling regulates blood vessel recruitment during myofiber growth. Mol Cell Biol (2002) 1.63
Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes. Cell (2012) 1.60
Fas pathway is a critical mediator of cardiac myocyte death and MI during ischemia-reperfusion in vivo. Am J Physiol Heart Circ Physiol (2002) 1.56
Adiponectin protects against the development of systolic dysfunction following myocardial infarction. J Mol Cell Cardiol (2007) 1.55
Inhibition of the cardiomyocyte-specific kinase TNNI3K limits oxidative stress, injury, and adverse remodeling in the ischemic heart. Sci Transl Med (2013) 1.55
Regulation of angiogenesis by glycogen synthase kinase-3beta. J Biol Chem (2002) 1.54
Cardiomyocyte deletion of mitofusin-1 leads to mitochondrial fragmentation and improves tolerance to ROS-induced mitochondrial dysfunction and cell death. Am J Physiol Heart Circ Physiol (2011) 1.53
Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed beta-amyloid in neurons. J Neurosci (2004) 1.53
Adiponectin deficiency: a model of pulmonary hypertension associated with pulmonary vascular disease. Am J Physiol Lung Cell Mol Physiol (2009) 1.51
Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switch. Development (2007) 1.47
Integrin-linked kinase regulates endothelial cell survival and vascular development. Mol Cell Biol (2004) 1.46
The novel SPARC family member SMOC-2 potentiates angiogenic growth factor activity. J Biol Chem (2006) 1.45
Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR. Sci Signal (2009) 1.43
Impaired revascularization in a mouse model of type 2 diabetes is associated with dysregulation of a complex angiogenic-regulatory network. Arterioscler Thromb Vasc Biol (2005) 1.42
The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy. Mol Cell Biol (2006) 1.41
Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail (2011) 1.40
Adiponectin promotes revascularization of ischemic muscle through a cyclooxygenase 2-dependent mechanism. Mol Cell Biol (2009) 1.40
Akt signaling regulates side population cell phenotype via Bcrp1 translocation. J Biol Chem (2003) 1.40
Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease. Nat Genet (2008) 1.38
Akt3 overexpression in the heart results in progression from adaptive to maladaptive hypertrophy. J Mol Cell Cardiol (2005) 1.38
Molecular mechanisms of cardiovascular toxicity of targeted cancer therapeutics. Circ Res (2010) 1.37
Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice. Am J Physiol Heart Circ Physiol (2008) 1.36
CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation. J Cell Sci (2010) 1.35
Glycogen synthase kinase-3beta regulates post-myocardial infarction remodeling and stress-induced cardiomyocyte proliferation in vivo. Circ Res (2010) 1.33
Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart. J Biol Chem (2004) 1.33
Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response. J Mol Cell Cardiol (2010) 1.32
The polyphenols resveratrol and S17834 prevent the structural and functional sequelae of diet-induced metabolic heart disease in mice. Circulation (2012) 1.32
Endothelial Akt signaling is rate-limiting for rapamycin inhibition of mouse mammary tumor progression. Cancer Res (2007) 1.32
Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase Akt. J Clin Invest (2006) 1.31
Adiponectin accumulates in myocardial tissue that has been damaged by ischemia-reperfusion injury via leakage from the vascular compartment. Cardiovasc Res (2007) 1.30
Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical models. Circulation (2012) 1.30
Mobilized endothelial progenitor cells by granulocyte-macrophage colony-stimulating factor accelerate reendothelialization and reduce vascular inflammation after intravascular radiation. Circulation (2003) 1.28
Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase. Clin Transl Sci (2009) 1.28
Forkhead transcription factors and cardiovascular biology. Circ Res (2008) 1.28
Loss of mitofusin 2 promotes endoplasmic reticulum stress. J Biol Chem (2012) 1.28