Thomas Unger

Author PubWeight™ 151.37‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. Arterioscler Thromb Vasc Biol 2008 5.44
2 Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection. N Engl J Med 2005 4.84
3 Quantitative real-time RT-PCR data analysis: current concepts and the novel "gene expression's CT difference" formula. J Mol Med (Berl) 2006 4.00
4 Optimal treatment of obesity-related hypertension: the Hypertension-Obesity-Sibutramine (HOS) study. Circulation 2007 3.59
5 Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity. Circulation 2004 2.64
6 A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein. Circ Res 2006 2.50
7 Impact of sex on cardiovascular outcome in patients at high cardiovascular risk: analysis of the Telmisartan Randomized Assessment Study in ACE-Intolerant Subjects With Cardiovascular Disease (TRANSCEND) and the Ongoing Telmisartan Alone and in Combination With Ramipril Global End Point Trial (ONTARGET). Circulation 2012 2.25
8 Protective arms of the renin-angiotensin-system in neurological disease. Clin Exp Pharmacol Physiol 2013 2.18
9 The endothelium and vascular inflammation in diabetes. Diab Vasc Dis Res 2007 2.00
10 The beta-lactam antibiotic, ceftriaxone, dramatically improves survival, increases glutamate uptake and induces neurotrophins in stroke. J Hypertens 2008 1.91
11 Candesartan but not ramipril pretreatment improves outcome after stroke and stimulates neurotrophin BNDF/TrkB system in rats. J Hypertens 2008 1.81
12 Angiotensin AT1/AT2 receptors: regulation, signalling and function. Blood Press 2003 1.79
13 Regulation of transport of the angiotensin AT2 receptor by a novel membrane-associated Golgi protein. Arterioscler Thromb Vasc Biol 2004 1.75
14 Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction? Circulation 2008 1.72
15 PPARgamma-activating angiotensin type-1 receptor blockers induce adiponectin. Hypertension 2005 1.60
16 Molecular characterization of new selective peroxisome proliferator-activated receptor gamma modulators with angiotensin receptor blocking activity. Diabetes 2005 1.58
17 Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation. Hypertension 2009 1.54
18 Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury. FASEB J 2005 1.54
19 Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappaB. Hypertension 2010 1.50
20 Angiotensin receptor blockers: therapeutic targets and cardiovascular protection. Blood Press 2005 1.49
21 Hypertension in overweight and obese primary care patients is highly prevalent and poorly controlled. Am J Hypertens 2004 1.48
22 Angiotensin II and the fibroproliferative response to acute lung injury. Am J Physiol Lung Cell Mol Physiol 2003 1.46
23 High prevalence and poor control of hypertension in primary care: cross-sectional study. J Hypertens 2004 1.43
24 Impact of telmisartan on cardiovascular outcome in hypertensive patients at high risk: a Telmisartan Randomised AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease subanalysis. J Hypertens 2014 1.40
25 Contributions of inflammation and cardiac matrix metalloproteinase activity to cardiac failure in diabetic cardiomyopathy: the role of angiotensin type 1 receptor antagonism. Diabetes 2007 1.39
26 Metabolic actions of estrogen receptor beta (ERbeta) are mediated by a negative cross-talk with PPARgamma. PLoS Genet 2008 1.35
27 RAS blockade with ARB and ACE inhibitors: current perspective on rationale and patient selection. Clin Res Cardiol 2008 1.34
28 Acidic pH and capsaicin activate mechanosensitive group IV muscle receptors in the rat. Pain 2004 1.27
29 The PHARAO study: prevention of hypertension with the angiotensin-converting enzyme inhibitor ramipril in patients with high-normal blood pressure: a prospective, randomized, controlled prevention trial of the German Hypertension League. J Hypertens 2008 1.27
30 Excitatory and modulatory effects of inflammatory cytokines and neurotrophins on mechanosensitive group IV muscle afferents in the rat. Pain 2005 1.19
31 Non-peptide AT2-receptor agonists. Curr Opin Pharmacol 2010 1.15
32 Cardiac c-kit+AT2+ cell population is increased in response to ischemic injury and supports cardiomyocyte performance. Stem Cells 2009 1.15
33 Novel therapeutic targets for hypertension. Nat Rev Cardiol 2010 1.13
34 Sex-specific influence of angiotensin type 2 receptor stimulation on renal function: a novel therapeutic target for hypertension. Hypertension 2011 1.12
35 Chronic pretreatment with candesartan improves recovery from focal cerebral ischaemia in rats. J Hypertens 2003 1.11
36 Irbesartan for the treatment of hypertension in patients with the metabolic syndrome: a sub analysis of the Treat to Target post authorization survey. Prospective observational, two armed study in 14,200 patients. Cardiovasc Diabetol 2007 1.10
37 Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies. Lancet Neurol 2010 1.10
38 Angiotensin II accelerates functional recovery in the rat sciatic nerve in vivo: role of the AT2 receptor and the transcription factor NF-kappaB. FASEB J 2003 1.10
39 AT2 receptor agonists: hypertension and beyond. Curr Opin Nephrol Hypertens 2012 1.09
40 Identification of noncytotoxic and IL-10-producing CD8+AT2R+ T cell population in response to ischemic heart injury. J Immunol 2010 1.08
41 Direct angiotensin II type 2 receptor stimulation in Nω-nitro-L-arginine-methyl ester-induced hypertension: the effect on pulse wave velocity and aortic remodeling. Hypertension 2012 1.07
42 Adenosine triphosphate as a stimulant for nociceptive and non-nociceptive muscle group IV receptors in the rat. Neurosci Lett 2003 1.05
43 Sex differences in physiological cardiac hypertrophy are associated with exercise-mediated changes in energy substrate availability. Am J Physiol Heart Circ Physiol 2011 1.04
44 Genetic kininogen deficiency contributes to aortic aneurysm formation but not to atherosclerosis. Physiol Genomics 2004 1.02
45 PPARgamma activation attenuates T-lymphocyte-dependent inflammation of adipose tissue and development of insulin resistance in obese mice. Cardiovasc Diabetol 2010 1.02
46 Liver-specific peroxisome proliferator-activated receptor alpha target gene regulation by the angiotensin type 1 receptor blocker telmisartan. Diabetes 2008 1.01
47 The past, present and future of angiotensin II type 2 receptor stimulation. J Renin Angiotensin Aldosterone Syst 2009 0.99
48 Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren. J Hypertens 2008 0.99
49 Sensitization of rat dorsal horn neurons by NGF-induced subthreshold potentials and low-frequency activation. A study employing intracellular recordings in vivo. Brain Res 2007 0.99
50 Comparison between single and combined treatment with candesartan and pioglitazone following transient focal ischemia in rat brain. Brain Res 2008 0.98
51 Angiotensin receptor blockers and cerebral protection in stroke. J Hypertens Suppl 2006 0.97
52 The evolving story of the RAAS in hypertension, diabetes and CV disease: moving from macrovascular to microvascular targets. Fundam Clin Pharmacol 2009 0.96
53 Effects of orally applied candesartan cilexetil on central responses to angiotensin II in conscious rats. J Hypertens 2002 0.95
54 Pathophysiologic and therapeutic importance of tissue ACE: a consensus report. Cardiovasc Drugs Ther 2002 0.94
55 Angiotensin type 2 receptor stimulation ameliorates left ventricular fibrosis and dysfunction via regulation of tissue inhibitor of matrix metalloproteinase 1/matrix metalloproteinase 9 axis and transforming growth factor β1 in the rat heart. Hypertension 2013 0.94
56 AT2-receptor stimulation enhances axonal plasticity after spinal cord injury by upregulating BDNF expression. Neurobiol Dis 2012 0.93
57 Cardiac inflammation after local irradiation is influenced by the kallikrein-kinin system. Cancer Res 2012 0.93
58 Transition from atherosclerosis to aortic aneurysm in humans coincides with an increased expression of RAS components. Atherosclerosis 2009 0.92
59 Neuroprotection with angiotensin receptor antagonists: a review of the evidence and potential mechanisms. Am J Cardiovasc Drugs 2005 0.91
60 Telmisartan prevents aneurysm progression in the rat by inhibiting proteolysis, apoptosis and inflammation. J Hypertens 2008 0.91
61 Angiotensin II induces peroxisome proliferator-activated receptor gamma in PC12W cells via angiotensin type 2 receptor activation. J Neurochem 2005 0.91
62 The angiotensin AT2 receptor in left ventricular hypertrophy. J Hypertens 2010 0.90
63 Contribution of bradykinin and nitric oxide to AT2 receptor-mediated differentiation in PC12 W cells. J Neurochem 2003 0.89
64 Impact of the AT(2) receptor agonist C21 on blood pressure and beyond. Curr Hypertens Rep 2012 0.89
65 Aldosterone synthase inhibitors in cardiovascular and renal diseases. Nephrol Dial Transplant 2014 0.89
66 Endothelial dysfunction and its role in diabetic vascular disease. Endocrinol Metab Clin North Am 2006 0.89
67 Direct stimulation of angiotensin II type 2 receptor enhances spatial memory. J Cereb Blood Flow Metab 2011 0.88
68 AT(2) receptor and tissue injury: therapeutic implications. Curr Hypertens Rep 2014 0.87
69 Signal transduction of the (pro)renin receptor as a novel therapeutic target for preventing end-organ damage. Hypertens Res 2009 0.87
70 Regulation of peroxisome proliferator-activated receptor gamma activity by losartan metabolites. Hypertension 2005 0.87
71 The possible role of the NO-cGMP pathway in nociception: different spinal and supraspinal action of enzyme blockers on rat dorsal horn neurones. Pain 2005 0.87
72 Cannabinoid receptor 1 inhibition improves cardiac function and remodelling after myocardial infarction and in experimental metabolic syndrome. J Mol Med (Berl) 2013 0.86
73 Cardiovascular protection for all individuals at high risk: evidence-based best practice. Clin Res Cardiol 2008 0.86
74 Are angiotensin receptor blockers neuroprotective? Curr Hypertens Rep 2004 0.86
75 New therapeutic pathways in the RAS. J Renin Angiotensin Aldosterone Syst 2012 0.85
76 The angiotensin AT2 receptor in inflammation. Drug News Perspect 2010 0.85
77 Over-expression of angiotensin converting enzyme-1 augments cardiac hypertrophy in transgenic rats. Hum Mol Genet 2004 0.85
78 Differential effects of olmesartan and ramipril on inflammatory response after myocardial infarction in rats. Blood Press 2006 0.85
79 Estrogen receptor alpha supports cardiomyocytes indirectly through post-infarct cardiac c-kit+ cells. J Mol Cell Cardiol 2009 0.85
80 Vasoactive peptides, their receptors and drug development. Basic Clin Pharmacol Toxicol 2004 0.85
81 Low-dose lithium combined with captopril prevents stroke and improves survival in salt-loaded, stroke-prone spontaneously hypertensive rats. J Hypertens 2005 0.85
82 The (pro)renin receptor ((P)RR) can act as a repressor of Wnt signalling. Biochem Pharmacol 2012 0.85
83 Effects of nonpersistence with medication on outcomes in high-risk patients with cardiovascular disease. Am Heart J 2013 0.84
84 Adapter proteins and promoter regulation of the angiotensin AT2 receptor--implications for cardiac pathophysiology. J Renin Angiotensin Aldosterone Syst 2009 0.84
85 Key advances in antihypertensive treatment. Nat Rev Cardiol 2012 0.84
86 Effective treatment of hypertension by AT(1) receptor antagonism: the past and future of telmisartan. Expert Rev Cardiovasc Ther 2006 0.83
87 Cardiac PPARalpha expression in patients with dilated cardiomyopathy. Eur J Heart Fail 2005 0.83
88 HYDRA: possible determinants of unsatisfactory hypertension control in German primary care patients. Blood Press 2004 0.83
89 p38 MAP kinase negatively regulates angiotensin II-mediated effects on cell cycle molecules in human coronary smooth muscle cells. Biochem Biophys Res Commun 2003 0.83
90 How do disorder, reorganization, and localization influence the hole mobility in conjugated copolymers? J Am Chem Soc 2013 0.82
91 Emerging drugs which target the renin-angiotensin-aldosterone system. Expert Opin Emerg Drugs 2011 0.82
92 Poly(ADP-ribose) polymerase-1 (PARP-1) transcriptionally regulates angiotensin AT2 receptor (AT2R) and AT2R binding protein (ATBP) genes. Biochem Pharmacol 2009 0.82
93 Pathophysiological activity in rat dorsal horn neurones in segments rostral to a chronic spinal cord injury. Brain Res 2003 0.82
94 Effects of aliskiren on stroke in rats expressing human renin and angiotensinogen genes. PLoS One 2010 0.82
95 Inhibiting angiotensin type 1 receptors as a target for diabetes. Expert Opin Ther Targets 2008 0.82
96 ANG III induces expression of inducible transcription factors of AP-1 and Krox families in rat brain. Am J Physiol Regul Integr Comp Physiol 2005 0.81
97 The promyelocytic leukemia zinc finger (PLZF) protein exerts neuroprotective effects in neuronal cells and is dysregulated in experimental stroke. Brain Pathol 2011 0.81
98 The metabolic syndrome: cluster with a self-fulfilling loop? J Hypertens 2006 0.81
99 Activity profile of calpains I and II in chronically infarcted rat myocardium--influence of the calpain inhibitor CAL 9961. Br J Pharmacol 2002 0.81
100 Kinins are involved in the antiproteinuric effect of angiotensin-converting enzyme inhibition in experimental diabetic nephropathy. Int Immunopharmacol 2003 0.81
101 Perspective: A tale of two receptors. Nature 2013 0.80
102 Effects of endothelin ETA receptor blocker LU 135252 on cardiac remodeling and survival in a hypertensive rat model of chronic heart failure. Acta Pharmacol Sin 2006 0.80
103 High-dose treatment with telmisartan induces monocytic peroxisome proliferator-activated receptor-γ target genes in patients with the metabolic syndrome. Hypertension 2011 0.80
104 Stimulation of the Angiotensin II AT2 Receptor is Anti-inflammatory in Human Lipopolysaccharide-Activated Monocytic Cells. Inflammation 2015 0.80
105 Bradykinin B1 and B2 receptors differentially regulate cardiac Na+-H+ exchanger, Na+-Ca2+ exchanger and Na+-HCO3- symporter. Eur J Pharmacol 2003 0.79
106 Prevention and intervention studies with telmisartan, ramipril and their combination in different rat stroke models. PLoS One 2011 0.79
107 Angiotensin II type 2 receptor agonists--where should they be applied? Expert Opin Investig Drugs 2012 0.79
108 PLZF and the (pro)renin receptor. J Mol Med (Berl) 2008 0.79
109 Reduction (TELMAR) as assessed by magnetic resonance imaging in patients with mild-to-moderate hypertension--a prospective, randomised, double-blind comparison of telmisartan with metoprolol over a period of six months rationale and study design. J Renin Angiotensin Aldosterone Syst 2003 0.79
110 Mast cell-derived TNF-α and histamine modify IL-6 and IL-8 expression and release from cutaneous tumor cells. Exp Dermatol 2011 0.78
111 Effect of angiotensin AT2 receptor stimulation on vascular cyclic GMP production in normotensive Wistar Kyoto rats. Int J Biochem Cell Biol 2003 0.78
112 AT2 receptors targeting cardiac protection post-myocardial infarction. Curr Hypertens Rep 2014 0.78
113 Angiotensin II AT(1)-receptor induces biglycan in neonatal cardiac fibroblasts via autocrine release of TGFbeta in vitro. Cardiovasc Res 2003 0.78
114 Identification of a zinc finger homoeodomain enhancer protein after AT(2) receptor stimulation by differential mRNA display. Arterioscler Thromb Vasc Biol 2002 0.77
115 Ethanol-induced downregulation of the angiotensin AT2 receptor in murine fibroblasts is mediated by PARP-1. Alcohol 2010 0.77
116 High-mobility group A1 protein: a new coregulator of peroxisome proliferator-activated receptor-γ-mediated transrepression in the vasculature. Circ Res 2011 0.77
117 Characterization of new PPARgamma agonists: benzimidazole derivatives-importance of positions 5 and 6, and computational studies on the binding mode. Bioorg Med Chem 2010 0.77
118 Novel therapy approach in primary stroke prevention: simultaneous inhibition of endothelin converting enzyme and neutral endopeptidase in spontaneously hypertensive, stroke-prone rats improves survival. Neurol Res 2011 0.77
119 Distinct signal transduction pathways downstream of the (P)RR revealed by microarray and ChIP-chip analyses. PLoS One 2013 0.77
120 Regulation of tyrosine phosphatases in the adventitia during vascular remodelling. Biochem Biophys Res Commun 2009 0.77
121 Rats with chronic spinal cord transection as a possible model for the at-level pain of paraplegic patients. Neurosci Lett 2002 0.76
122 The pharmacological rationale behind polypharmacy in heart failure. Heart Fail Monit 2008 0.76
123 Calcium channel blockade limits transcriptional, translational and functional up-regulation of the cardiac calpain system after myocardial infarction. Eur J Pharmacol 2002 0.76
124 Angiotensin AT2 receptor ligands: do they have potential as future treatments for neurological disease? CNS Drugs 2002 0.76
125 Mast cells and the power of local RAS activation. Nephrol Dial Transplant 2006 0.76
126 Characterization of new PPARgamma agonists: analysis of telmisartan's structural components. ChemMedChem 2009 0.76
127 Effect of high-dose valsartan on inflammatory and lipid parameters in patients with Type 2 diabetes and hypertension. Diabetes Res Clin Pract 2010 0.76
128 A polymorphic microsatellite repeat within the ECE-1c promoter is involved in transcriptional start site determination, human evolution, and Alzheimer's disease. J Neurosci 2012 0.76
129 Acute stress and long-lasting blood pressure elevation: a possible cause of established hypertension? J Hypertens 2005 0.75
130 Angiotensin receptors and autophagy: live and let die. Hypertension 2009 0.75
131 Does the AT2-receptor mediate anti-atherosclerotic actions? J Hypertens 2005 0.75
132 Angiotensin II receptor expression: from maturation to pathogenesis. Am J Physiol Regul Integr Comp Physiol 2003 0.75
133 The angiotensin type 2 receptor and the kidney. Curr Opin Nephrol Hypertens 2017 0.75
134 Risk factors: Plasma renin activity predicts renal impairment. Nat Rev Nephrol 2012 0.75
135 Comment on "protective arms of the renin-angiotensin system in neurological disease": Reply. Clin Exp Pharmacol Physiol 2013 0.75
136 [Cooperation between university-industry]. Med Klin (Munich) 2004 0.75
137 Differential effect of acute angiotensin II type 1 receptor blockade on the vascular and adrenal response to exogenous angiotensin II in humans. Am J Hypertens 2003 0.75
138 Comparison of cardioprotective effects of mibefradil and ramipril in stroke-prone spontaneously hypertensive rats. Acta Pharmacol Sin 2004 0.75
139 Angiotensin in the kidney: a key to understanding hypertension? Cell Metab 2007 0.75
140 Prevention of coronary artery disease: recent advances in the management of hypertension. Curr Atheroscler Rep 2013 0.75
141 Challenges in improving prognosis and therapy: the Ongoing Telmisartan Alone and in Combination with Ramipril Global End point Trial programme. Expert Opin Pharmacother 2004 0.75
142 [Pathophysiological and clinical implications of AT(1)/AT(2) angiotensin II receptors in heart failure and coronary and renal failure]. Drugs 2002 0.75
143 Introduction: Reducing cardiovascular risk: ONTARGET--a new standard in cardiovascular protection. J Hypertens Suppl 2009 0.75
144 Moderate correlations of in vitro versus in vivo pharmacokinetics questioning the need of early microsomal stability testing. Pharmacology 2012 0.75
145 Plasma renin and cardiovascular risk: what is the evidence for an association? Cardiology 2013 0.75
146 Pharmacoeconomics and quality of life analysis of telmisartan in hypertension treatment. Expert Rev Pharmacoecon Outcomes Res 2007 0.75
147 An update on telmisartan/hydrochlorothiazide combinations for the management of hypertensive patients with additional cardiovascular risk factors. Expert Rev Cardiovasc Ther 2013 0.75
148 Advances in cardiovascular research. 15th Annual Meeting of the European Council for Cardiovascular Research (ECCR). La Colle sur Loup, France, 8–10 October 2010. Expert Rev Cardiovasc Ther 2011 0.75
149 Cleaved high molecular weight kininogen, a novel factor in the regulation of matrix metalloproteinases in vascular smooth muscle cells. Biochem Pharmacol 2009 0.75
150 Characterization of new PPARgamma agonists: benzimidazole derivatives - the importance of position 2. ChemMedChem 2009 0.75
151 Inflammation in the genesis of hypertension and its complications--the role of angiotensin II. Nephrol Dial Transplant 2007 0.75
152 Tissue-Specific Expression of a Rat Renin Transcript Lacking the Coding Sequence for the Prefragment and Its Stimulation by Myocardial Infarction. Endocrinology 2000 0.75
153 The cardiovascular continuum refined: A hypothesis. Blood Press 2010 0.75
154 Heart rate and blood pressure interactions in the development of erectile dysfunction in high-risk cardiovascular patients. Eur J Prev Cardiol 2013 0.75
155 Telmisartan and hydrochlorothiazide combination therapy for the treatment of hypertension. Curr Med Res Opin 2010 0.75