Published in Nat Immunol on February 01, 2005
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How a single T cell receptor recognizes both self and foreign MHC. Cell (2007) 3.20
Induced sensitization of tumor stroma leads to eradication of established cancer by T cells. J Exp Med (2007) 3.15
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Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity. Cancer Cell (2013) 2.18
TCRs with high affinity for foreign pMHC show self-reactivity. Nat Immunol (2002) 2.12
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T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity. Immunology (2009) 1.85
Structural basis of affinity maturation and intramolecular cooperativity in a protein-protein interaction. Structure (2005) 1.70
Expression profiling using a hexamer-based universal microarray. Nat Biotechnol (2004) 1.69
Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection. Blood (2013) 1.63
Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2K(b). Nat Immunol (2003) 1.54
Neutralization of staphylococcal enterotoxin B by soluble, high-affinity receptor antagonists. Nat Med (2007) 1.52
Staphylococcal toxic shock syndrome erythroderma is associated with superantigenicity and hypersensitivity. Clin Infect Dis (2009) 1.47
Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function. Proc Natl Acad Sci U S A (2005) 1.46
Equilibrium between host and cancer caused by effector T cells killing tumor stroma. Cancer Res (2008) 1.39
Long-range cooperative binding effects in a T cell receptor variable domain. Proc Natl Acad Sci U S A (2006) 1.26
Characterization of T cell receptors engineered for high affinity against toxic shock syndrome toxin-1. J Mol Biol (2005) 1.25
High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR3. J Mol Biol (2004) 1.21
The impact of TCR-binding properties and antigen presentation format on T cell responsiveness. J Immunol (2009) 1.20
A model T-cell receptor system for studying memory T-cell development. Microbes Infect (2003) 1.19
Staphylococcal superantigens cause lethal pulmonary disease in rabbits. J Infect Dis (2010) 1.18
Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation. J Immunol (2008) 1.12
Engineering and characterization of a stabilized alpha1/alpha2 module of the class I major histocompatibility complex product Ld. J Biol Chem (2006) 1.12
Rapid method for measuring ScFv thermal stability by yeast surface display. Biotechnol Prog (2003) 1.09
The study of high-affinity TCRs reveals duality in T cell recognition of antigen: specificity and degeneracy. J Immunol (2006) 1.08
Display, engineering, and applications of antigen-specific T cell receptors. Biomol Eng (2007) 1.08
Solution mapping of T cell receptor docking footprints on peptide-MHC. Proc Natl Acad Sci U S A (2007) 1.06
Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1. EMBO J (2007) 1.03
T cell receptors: affinities, cross-reactivities, and a conformer model. Mol Immunol (2004) 1.03
Disulfide bond engineering to trap peptides in the MHC class I binding groove. J Immunol (2007) 1.02
Endogenous viral antigen processing generates peptide-specific MHC class I cell-surface clusters. Proc Natl Acad Sci U S A (2012) 1.01
Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC. Nat Struct Mol Biol (2007) 1.00
Engineering higher affinity T cell receptors using a T cell display system. J Immunol Methods (2008) 1.00
Directed evolution of a single-chain class II MHC product by yeast display. Protein Eng (2003) 0.99
Long-term persistence of CD4(+) but rapid disappearance of CD8(+) T cells expressing an MHC class I-restricted TCR of nanomolar affinity. Mol Ther (2012) 0.99
Engineering the binding properties of the T cell receptor:peptide:MHC ternary complex that governs T cell activity. Mol Immunol (2009) 0.99
Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors. Protein Eng Des Sel (2010) 0.98
Dissecting cooperative and additive binding energetics in the affinity maturation pathway of a protein-protein interface. J Biol Chem (2003) 0.97
Myxoma virus combined with rapamycin treatment enhances adoptive T cell therapy for murine melanoma brain tumors. Cancer Immunol Immunother (2011) 0.95
TCR scanning of peptide/MHC through complementary matching of receptor and ligand molecular flexibility. J Immunol (2014) 0.94
Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors. Biochemistry (2008) 0.94
Novel platform for the detection of Staphylococcus aureus enterotoxin B in foods. Appl Environ Microbiol (2012) 0.92
Estrogen induction of the granzyme B inhibitor, proteinase inhibitor 9, protects cells against apoptosis mediated by cytotoxic T lymphocytes and natural killer cells. Endocrinology (2005) 0.91
A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs). Oncoimmunology (2012) 0.91
A single, engineered protein therapeutic agent neutralizes exotoxins from both Staphylococcus aureus and Streptococcus pyogenes. Clin Vaccine Immunol (2010) 0.90
Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain ValphaVbeta fragments. Mol Immunol (2008) 0.90
Neuronal localization of indoleamine 2,3-dioxygenase in mice. Neurosci Lett (2005) 0.89
MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR. Cancer Immunol Immunother (2012) 0.88
Neutralization of multiple staphylococcal superantigens by a single-chain protein consisting of affinity-matured, variable domain repeats. J Infect Dis (2008) 0.87
Recurrence of intracranial tumors following adoptive T cell therapy can be prevented by direct and indirect killing aided by high levels of tumor antigen cross-presented on stromal cells. J Immunol (2009) 0.87
Different strategies adopted by K(b) and L(d) to generate T cell specificity directed against their respective bound peptides. J Biol Chem (2009) 0.87
High-affinity T cell receptor differentiates cognate peptide-MHC and altered peptide ligands with distinct kinetics and thermodynamics. Mol Immunol (2010) 0.87
Interaction of streptavidin-based peptide-MHC oligomers (tetramers) with cell-surface TCRs. J Immunol (2011) 0.86
Folate-mediated targeting of T cells to tumors. Adv Drug Deliv Rev (2004) 0.86
Staphylococcus aureus isolates encode variant staphylococcal enterotoxin B proteins that are diverse in superantigenicity and lethality. PLoS One (2012) 0.85
Cellular uptake followed by class I MHC presentation of some exogenous peptides contributes to T cell stimulatory capacity. Mol Immunol (2006) 0.85
Role of T cell receptor affinity in the efficacy and specificity of adoptive T cell therapies. Front Immunol (2013) 0.84
Allogeneic and syngeneic class I MHC complexes drive the association of CD8 and TCR on 2C T cells. Mol Immunol (2003) 0.83
A yeast display system for engineering functional peptide-MHC complexes. J Immunol Methods (2003) 0.83
Costimulatory strength influences the differential effects of transforming growth factor beta1 for the generation of CD8+ regulatory T cells. Mol Immunol (2008) 0.83
Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes. J Mol Biol (2013) 0.83
Molecular basis of a million-fold affinity maturation process in a protein-protein interaction. J Mol Biol (2011) 0.83
Cutting edge: inhibitory effects of CD4 and CD8 on T cell activation induced by high-affinity noncognate ligands. J Immunol (2009) 0.82
Biosensor detection systems: engineering stable, high-affinity bioreceptors by yeast surface display. Methods Mol Biol (2009) 0.82
Assessing energetic contributions to binding from a disordered region in a protein-protein interaction . Biochemistry (2010) 0.82
A novel T cell receptor single-chain signaling complex mediates antigen-specific T cell activity and tumor control. Cancer Immunol Immunother (2014) 0.81
T cell receptor engineering. Methods Enzymol (2012) 0.81
Experimental manipulations of afferent immune responses influence efferent immune responses to brain tumors. Cancer Immunol Immunother (2008) 0.81
Opposite effects of endogenous peptide-MHC class I on T cell activity in the presence and absence of CD8. J Immunol (2011) 0.80
Design and characterization of a protein superagonist of IL-15 fused with IL-15Rα and a high-affinity T cell receptor. Biotechnol Prog (2012) 0.78
Enhancing antitumor immunity: combining IL-12 with TGFbeta1 antagonism. J Immunother (2007) 0.77
The same major histocompatibility complex polymorphism involved in control of HIV influences peptide binding in the mouse H-2Ld system. J Biol Chem (2013) 0.77
Subtle changes in TCRα CDR1 profoundly increase the sensitivity of CD4 T cells. Mol Immunol (2012) 0.77
T Cell Receptor Engineering and Analysis Using the Yeast Display Platform. Methods Mol Biol (2015) 0.77
T cells use rafts for survival. Immunity (2010) 0.75
A conjugate of a tumor-targeting ligand and a T cell costimulatory antibody to treat brain tumors. Bioconjug Chem (2004) 0.75
Binding of TCR multimers and a TCR-like antibody with distinct fine-specificities is dependent on the surface density of HLA complexes. PLoS One (2012) 0.75
Analysis of superantigen binding to soluble T-cell receptors. Methods Mol Biol (2003) 0.75
Directed evolution of T-cell receptors for binding superantigens. Methods Mol Biol (2003) 0.75
Imaging membrane intercalating near infrared dyes to track multiple cell populations. J Immunol Methods (2009) 0.75