Published in J Mol Biol on December 22, 2004
Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions. J Immunol (2008) 2.54
Monoclonal TCR-redirected tumor cell killing. Nat Med (2012) 1.57
Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function. Proc Natl Acad Sci U S A (2005) 1.46
A decade of yeast surface display technology: where are we now? Comb Chem High Throughput Screen (2008) 1.37
Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity. Protein Sci (2006) 1.31
A new generation of protein display scaffolds for molecular recognition. Protein Sci (2006) 1.29
Structure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC. Proteins (2009) 1.16
Many different Vbeta CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions. Proc Natl Acad Sci U S A (2009) 1.04
Protein-protein interaction investigated by steered molecular dynamics: the TCR-pMHC complex. Biophys J (2008) 1.00
Engineering the binding properties of the T cell receptor:peptide:MHC ternary complex that governs T cell activity. Mol Immunol (2009) 0.99
Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors. Protein Eng Des Sel (2010) 0.98
Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and function. Immunol Rev (2012) 0.98
Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors. Biochemistry (2008) 0.94
Primer sets for cloning the human repertoire of T cell Receptor Variable regions. BMC Immunol (2008) 0.93
Molecular immunology lessons from therapeutic T-cell receptor gene transfer. Immunology (2010) 0.91
Cellular uptake followed by class I MHC presentation of some exogenous peptides contributes to T cell stimulatory capacity. Mol Immunol (2006) 0.85
Structure-Based, Rational Design of T Cell Receptors. Front Immunol (2013) 0.84
Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes. J Mol Biol (2013) 0.83
Conformational changes within the HLA-A1:MAGE-A1 complex induced by binding of a recombinant antibody fragment with TCR-like specificity. Protein Sci (2009) 0.82
Specific increase in potency via structure-based design of a TCR. J Immunol (2014) 0.82
Changing the peptide specificity of a human T-cell receptor by directed evolution. Nat Commun (2014) 0.80
Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens. Front Immunol (2015) 0.80
How (specific) would like your T-cells today? Generating T-cell therapeutic function through TCR-gene transfer. Front Immunol (2012) 0.79
Understanding TR binding to pMHC complexes: how does a TR scan many pMHC complexes yet preferentially bind to one. PLoS One (2011) 0.79
To affinity and beyond: harnessing the T cell receptor for cancer immunotherapy. Hum Vaccin Immunother (2014) 0.78
A novel composite immunotoxin that suppresses rabies virus production by the infected cells. J Immunol Methods (2009) 0.78
Rebalancing immune specificity and function in cancer by T-cell receptor gene therapy. Arch Immunol Ther Exp (Warsz) (2010) 0.78
Subtle changes in TCRα CDR1 profoundly increase the sensitivity of CD4 T cells. Mol Immunol (2012) 0.77
Soluble T-cell receptors produced in human cells for targeted delivery. PLoS One (2015) 0.76
Critical biological parameters modulate affinity as a determinant of function in T-cell receptor gene-modified T-cells. Cancer Immunol Immunother (2017) 0.75
Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cells. J Exp Med (2011) 4.02
How a single T cell receptor recognizes both self and foreign MHC. Cell (2007) 3.20
Induced sensitization of tumor stroma leads to eradication of established cancer by T cells. J Exp Med (2007) 3.15
Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation. Immunity (2003) 3.04
High-content single-cell drug screening with phosphospecific flow cytometry. Nat Chem Biol (2007) 2.54
Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity. Cancer Cell (2013) 2.18
TCRs with high affinity for foreign pMHC show self-reactivity. Nat Immunol (2002) 2.12
Coordinate analysis of murine immune cell surface markers and intracellular phosphoproteins by flow cytometry. J Immunol (2005) 1.93
T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex. Immunity (2011) 1.86
T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity. Immunology (2009) 1.85
Structural basis of affinity maturation and intramolecular cooperativity in a protein-protein interaction. Structure (2005) 1.70
Expression profiling using a hexamer-based universal microarray. Nat Biotechnol (2004) 1.69
Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection. Blood (2013) 1.63
Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2K(b). Nat Immunol (2003) 1.54
Neutralization of staphylococcal enterotoxin B by soluble, high-affinity receptor antagonists. Nat Med (2007) 1.52
Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes. Proc Natl Acad Sci U S A (2007) 1.51
Staphylococcal toxic shock syndrome erythroderma is associated with superantigenicity and hypersensitivity. Clin Infect Dis (2009) 1.47
Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function. Proc Natl Acad Sci U S A (2005) 1.46
Equilibrium between host and cancer caused by effector T cells killing tumor stroma. Cancer Res (2008) 1.39
Single-cell mass cytometry adapted to measurements of the cell cycle. Cytometry A (2012) 1.33
Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding. Nat Med (2013) 1.33
Long-range cooperative binding effects in a T cell receptor variable domain. Proc Natl Acad Sci U S A (2006) 1.26
Characterization of T cell receptors engineered for high affinity against toxic shock syndrome toxin-1. J Mol Biol (2005) 1.25
The impact of TCR-binding properties and antigen presentation format on T cell responsiveness. J Immunol (2009) 1.20
A model T-cell receptor system for studying memory T-cell development. Microbes Infect (2003) 1.19
Staphylococcal superantigens cause lethal pulmonary disease in rabbits. J Infect Dis (2010) 1.18
Fluorescent cell barcoding for multiplex flow cytometry. Curr Protoc Cytom (2011) 1.16
Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation. J Immunol (2008) 1.12
Engineering and characterization of a stabilized alpha1/alpha2 module of the class I major histocompatibility complex product Ld. J Biol Chem (2006) 1.12
Rapid method for measuring ScFv thermal stability by yeast surface display. Biotechnol Prog (2003) 1.09
The study of high-affinity TCRs reveals duality in T cell recognition of antigen: specificity and degeneracy. J Immunol (2006) 1.08
Display, engineering, and applications of antigen-specific T cell receptors. Biomol Eng (2007) 1.08
Solution mapping of T cell receptor docking footprints on peptide-MHC. Proc Natl Acad Sci U S A (2007) 1.06
Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1. EMBO J (2007) 1.03
T cell receptors: affinities, cross-reactivities, and a conformer model. Mol Immunol (2004) 1.03
Disulfide bond engineering to trap peptides in the MHC class I binding groove. J Immunol (2007) 1.02
Endogenous viral antigen processing generates peptide-specific MHC class I cell-surface clusters. Proc Natl Acad Sci U S A (2012) 1.01
Engineering higher affinity T cell receptors using a T cell display system. J Immunol Methods (2008) 1.00
Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC. Nat Struct Mol Biol (2007) 1.00
Directed evolution of a single-chain class II MHC product by yeast display. Protein Eng (2003) 0.99
Long-term persistence of CD4(+) but rapid disappearance of CD8(+) T cells expressing an MHC class I-restricted TCR of nanomolar affinity. Mol Ther (2012) 0.99
Engineering the binding properties of the T cell receptor:peptide:MHC ternary complex that governs T cell activity. Mol Immunol (2009) 0.99
Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors. Protein Eng Des Sel (2010) 0.98
Dissecting cooperative and additive binding energetics in the affinity maturation pathway of a protein-protein interface. J Biol Chem (2003) 0.97
Myxoma virus combined with rapamycin treatment enhances adoptive T cell therapy for murine melanoma brain tumors. Cancer Immunol Immunother (2011) 0.95
TCR scanning of peptide/MHC through complementary matching of receptor and ligand molecular flexibility. J Immunol (2014) 0.94
Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors. Biochemistry (2008) 0.94
Viral-associated trichodysplasia: characterization of a novel polyomavirus infection with therapeutic insights. Arch Dermatol (2012) 0.92
Novel platform for the detection of Staphylococcus aureus enterotoxin B in foods. Appl Environ Microbiol (2012) 0.92
A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs). Oncoimmunology (2012) 0.91
Estrogen induction of the granzyme B inhibitor, proteinase inhibitor 9, protects cells against apoptosis mediated by cytotoxic T lymphocytes and natural killer cells. Endocrinology (2005) 0.91
A single, engineered protein therapeutic agent neutralizes exotoxins from both Staphylococcus aureus and Streptococcus pyogenes. Clin Vaccine Immunol (2010) 0.90
Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain ValphaVbeta fragments. Mol Immunol (2008) 0.90
Neuronal localization of indoleamine 2,3-dioxygenase in mice. Neurosci Lett (2005) 0.89
MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR. Cancer Immunol Immunother (2012) 0.88
Neutralization of multiple staphylococcal superantigens by a single-chain protein consisting of affinity-matured, variable domain repeats. J Infect Dis (2008) 0.87
Different strategies adopted by K(b) and L(d) to generate T cell specificity directed against their respective bound peptides. J Biol Chem (2009) 0.87
Recurrence of intracranial tumors following adoptive T cell therapy can be prevented by direct and indirect killing aided by high levels of tumor antigen cross-presented on stromal cells. J Immunol (2009) 0.87
High-affinity T cell receptor differentiates cognate peptide-MHC and altered peptide ligands with distinct kinetics and thermodynamics. Mol Immunol (2010) 0.87
Interaction of streptavidin-based peptide-MHC oligomers (tetramers) with cell-surface TCRs. J Immunol (2011) 0.86
Folate-mediated targeting of T cells to tumors. Adv Drug Deliv Rev (2004) 0.86
Cellular uptake followed by class I MHC presentation of some exogenous peptides contributes to T cell stimulatory capacity. Mol Immunol (2006) 0.85
Staphylococcus aureus isolates encode variant staphylococcal enterotoxin B proteins that are diverse in superantigenicity and lethality. PLoS One (2012) 0.85
Role of T cell receptor affinity in the efficacy and specificity of adoptive T cell therapies. Front Immunol (2013) 0.84
Molecular basis of a million-fold affinity maturation process in a protein-protein interaction. J Mol Biol (2011) 0.83
Allogeneic and syngeneic class I MHC complexes drive the association of CD8 and TCR on 2C T cells. Mol Immunol (2003) 0.83
A yeast display system for engineering functional peptide-MHC complexes. J Immunol Methods (2003) 0.83
Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes. J Mol Biol (2013) 0.83
Costimulatory strength influences the differential effects of transforming growth factor beta1 for the generation of CD8+ regulatory T cells. Mol Immunol (2008) 0.83
Biosensor detection systems: engineering stable, high-affinity bioreceptors by yeast surface display. Methods Mol Biol (2009) 0.82
Assessing energetic contributions to binding from a disordered region in a protein-protein interaction . Biochemistry (2010) 0.82
Cutting edge: inhibitory effects of CD4 and CD8 on T cell activation induced by high-affinity noncognate ligands. J Immunol (2009) 0.82
T cell receptor engineering. Methods Enzymol (2012) 0.81
Experimental manipulations of afferent immune responses influence efferent immune responses to brain tumors. Cancer Immunol Immunother (2008) 0.81
A novel T cell receptor single-chain signaling complex mediates antigen-specific T cell activity and tumor control. Cancer Immunol Immunother (2014) 0.81
Development of CD4+ T cells expressing a nominally MHC class I-restricted T cell receptor by two different mechanisms. Proc Natl Acad Sci U S A (2006) 0.80
Opposite effects of endogenous peptide-MHC class I on T cell activity in the presence and absence of CD8. J Immunol (2011) 0.80
Design and characterization of a protein superagonist of IL-15 fused with IL-15Rα and a high-affinity T cell receptor. Biotechnol Prog (2012) 0.78
Subtle changes in TCRα CDR1 profoundly increase the sensitivity of CD4 T cells. Mol Immunol (2012) 0.77
The same major histocompatibility complex polymorphism involved in control of HIV influences peptide binding in the mouse H-2Ld system. J Biol Chem (2013) 0.77
Novel hematopoietic progenitor populations revealed by direct assessment of GATA1 protein expression and cMPL signaling events. Stem Cells (2011) 0.77
Enhancing antitumor immunity: combining IL-12 with TGFbeta1 antagonism. J Immunother (2007) 0.77
T Cell Receptor Engineering and Analysis Using the Yeast Display Platform. Methods Mol Biol (2015) 0.77
T cell receptor CDRs: starring versus supporting roles. Nat Immunol (2005) 0.76
T cells use rafts for survival. Immunity (2010) 0.75
Binding of TCR multimers and a TCR-like antibody with distinct fine-specificities is dependent on the surface density of HLA complexes. PLoS One (2012) 0.75
A conjugate of a tumor-targeting ligand and a T cell costimulatory antibody to treat brain tumors. Bioconjug Chem (2004) 0.75
Modeling MEK4 Kinase Inhibitors Through Perturbed Electrostatic Potential (ESP) Charges. J Chem Inf Model (2019) 0.75
Directed evolution of T-cell receptors for binding superantigens. Methods Mol Biol (2003) 0.75
Imaging membrane intercalating near infrared dyes to track multiple cell populations. J Immunol Methods (2009) 0.75
Analysis of superantigen binding to soluble T-cell receptors. Methods Mol Biol (2003) 0.75