Published in J Biol Chem on January 21, 2005
IMP dehydrogenase: structure, mechanism, and inhibition. Chem Rev (2009) 1.99
An enzymatic atavist revealed in dual pathways for water activation. PLoS Biol (2008) 1.52
Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain. Infect Immun (2006) 1.32
A kinetic alignment of orthologous inosine-5'-monophosphate dehydrogenases. Biochemistry (2008) 1.11
Phospholipase A2 and phospholipase B activities in fungi. Biochim Biophys Acta (2006) 0.99
Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases. Chem Biol (2010) 0.96
De novo GTP biosynthesis is critical for virulence of the fungal pathogen Cryptococcus neoformans. PLoS Pathog (2012) 0.94
Adaptive evolution of drug targets in producer and non-producer organisms. Biochem J (2012) 0.86
A new class of IMP dehydrogenase with a role in self-resistance of mycophenolic acid producing fungi. BMC Microbiol (2011) 0.86
Allosteric activation via kinetic control: potassium accelerates a conformational change in IMP dehydrogenase. Biochemistry (2011) 0.82
A yeast model for target-primed (non-LTR) retrotransposition. BMC Genomics (2007) 0.81
The Cys319 loop modulates the transition between dehydrogenase and hydrolase conformations in inosine 5'-monophosphate dehydrogenase. Biochemistry (2010) 0.81
The dynamic determinants of reaction specificity in the IMPDH/GMPR family of (β/α)(8) barrel enzymes. Crit Rev Biochem Mol Biol (2012) 0.79
Crystallization and preliminary X-ray analysis of mycophenolic acid-resistant and mycophenolic acid-sensitive forms of IMP dehydrogenase from the human fungal pathogen Cryptococcus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.78
Repurposing FDA approved drugs against the human fungal pathogen, Candida albicans. Ann Clin Microbiol Antimicrob (2015) 0.77
Purine Acquisition and Synthesis by Human Fungal Pathogens. Microorganisms (2017) 0.76
Kinetically controlled drug resistance: how Penicillium brevicompactum survives mycophenolic acid. J Biol Chem (2011) 0.75
A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. N Engl J Med (2006) 7.42
The diploid genome sequence of Candida albicans. Proc Natl Acad Sci U S A (2004) 6.34
A human-curated annotation of the Candida albicans genome. PLoS Genet (2005) 3.04
Metabolic specialization associated with phenotypic switching in Candidaalbicans. Proc Natl Acad Sci U S A (2002) 2.69
Gene transfer in the evolution of parasite nucleotide biosynthesis. Proc Natl Acad Sci U S A (2004) 2.05
Regulatory networks affected by iron availability in Candida albicans. Mol Microbiol (2004) 2.02
New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling. Blood (2008) 1.97
Spectrum and frequency of mutations in IMPDH1 associated with autosomal dominant retinitis pigmentosa and leber congenital amaurosis. Invest Ophthalmol Vis Sci (2006) 1.96
A twisted base? The role of arginine in enzyme-catalyzed proton abstractions. Arch Biochem Biophys (2005) 1.59
An enzymatic atavist revealed in dual pathways for water activation. PLoS Biol (2008) 1.52
Molecular profiling of pediatric mature B-cell lymphoma treated in population-based prospective clinical trials. Blood (2008) 1.47
Differential expression of Candida albicans secreted aspartyl proteinase and phospholipase B genes in humans correlates with active oral and vaginal infections. J Infect Dis (2003) 1.44
Targeting a prokaryotic protein in a eukaryotic pathogen: identification of lead compounds against cryptosporidiosis. Chem Biol (2008) 1.43
Cryptosporidium parvum IMP dehydrogenase: identification of functional, structural, and dynamic properties that can be exploited for drug design. J Biol Chem (2004) 1.43
The structural basis of Cryptosporidium -specific IMP dehydrogenase inhibitor selectivity. J Am Chem Soc (2010) 1.35
Think globally, act locally, and collaborate internationally: global health sciences at the University of California, San Francisco. Acad Med (2008) 1.34
Triazole inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. J Med Chem (2009) 1.33
Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain. Infect Immun (2006) 1.32
A screening pipeline for antiparasitic agents targeting cryptosporidium inosine monophosphate dehydrogenase. PLoS Negl Trop Dis (2010) 1.29
Structure-activity studies of the inhibition of FabI, the enoyl reductase from Escherichia coli, by triclosan: kinetic analysis of mutant FabIs. Biochemistry (2003) 1.28
Autosomal dominant retinitis pigmentosa mutations in inosine 5'-monophosphate dehydrogenase type I disrupt nucleic acid binding. Biochem J (2005) 1.27
Detecting hierarchical structure in molecular characteristics of disease using transitive approximations of directed graphs. Bioinformatics (2008) 1.26
Similarities of ordered gene lists. J Bioinform Comput Biol (2006) 1.26
Toward defining the human parotid gland salivary proteome and peptidome: identification and characterization using 2D SDS-PAGE, ultrafiltration, HPLC, and mass spectrometry. Biochemistry (2005) 1.22
Transcriptome analysis of Neisseria meningitidis during infection. J Bacteriol (2003) 1.22
Crystal structure of a ternary complex of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase: NAD+ orients the active site loop for catalysis. Biochemistry (2002) 1.21
Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo. Biochem J (2004) 1.19
Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma. Haematologica (2008) 1.15
Azole drugs are imported by facilitated diffusion in Candida albicans and other pathogenic fungi. PLoS Pathog (2010) 1.14
Candida albicans modulates host defense by biosynthesizing the pro-resolving mediator resolvin E1. PLoS One (2007) 1.13
Is Arg418 the catalytic base required for the hydrolysis step of the IMP dehydrogenase reaction? Biochemistry (2005) 1.13
CD30-induced signaling is absent in Hodgkin's cells but present in anaplastic large cell lymphoma cells. Am J Pathol (2008) 1.11
A kinetic alignment of orthologous inosine-5'-monophosphate dehydrogenases. Biochemistry (2008) 1.11
Optimization of benzoxazole-based inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. J Med Chem (2013) 1.09
The immunosuppressive agent mizoribine monophosphate forms a transition state analogue complex with inosine monophosphate dehydrogenase. Biochemistry (2003) 1.09
Inactivation of Kex2p diminishes the virulence of Candida albicans. J Biol Chem (2002) 1.09
Substitution of the conserved Arg-Tyr dyad selectively disrupts the hydrolysis phase of the IMP dehydrogenase reaction. Biochemistry (2004) 1.07
Microarray-based genomic profiling reveals novel genomic aberrations in follicular lymphoma which associate with patient survival and gene expression status. Genes Chromosomes Cancer (2009) 1.06
Functional analysis of a vacuolar ABC transporter in wild-type Candida albicans reveals its involvement in virulence. Mol Microbiol (2002) 1.04
Analysis of the heat shock response of Neisseria meningitidis with cDNA- and oligonucleotide-based DNA microarrays. J Bacteriol (2002) 1.04
Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis. Antimicrob Agents Chemother (2013) 1.03
Inhibitor mediated protein degradation. Chem Biol (2012) 1.02
Using supramolecular hydrogels to discover the interactions between proteins and molecular nanofibers of small molecules. Chem Commun (Camb) (2012) 1.02
Selective and potent urea inhibitors of cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. J Med Chem (2012) 1.01
Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH. Bioorg Med Chem Lett (2012) 1.00
Phospholipase A2 and phospholipase B activities in fungi. Biochim Biophys Acta (2006) 0.99
Inactivation of the phospholipase B gene PLB5 in wild-type Candida albicans reduces cell-associated phospholipase A2 activity and attenuates virulence. Int J Med Microbiol (2006) 0.99
Multivalent glycocluster design through directed evolution. Angew Chem Int Ed Engl (2011) 0.97
Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases. Chem Biol (2010) 0.96
Polynucleotide phosphorylase protects Escherichia coli against oxidative stress. Biochemistry (2009) 0.95
Expression and function of the human androgen-responsive gene ADI1 in prostate cancer. Neoplasia (2007) 0.95
Co-evolution of tRNA 3' trailer sequences with 3' processing enzymes in bacteria. RNA (2005) 0.95
IMP dehydrogenase type 1 associates with polyribosomes translating rhodopsin mRNA. J Biol Chem (2008) 0.95
Guanidine derivatives rescue the Arg418Ala mutation of Tritrichomonas foetus IMP dehydrogenase. Biochemistry (2005) 0.94
Prodrug activation by Cryptosporidium thymidine kinase. J Biol Chem (2010) 0.94
Association and familial segregation of CTG18.1 trinucleotide repeat expansion of TCF4 gene in Fuchs' endothelial corneal dystrophy. Invest Ophthalmol Vis Sci (2014) 0.94
Phthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum. Bioorg Med Chem Lett (2012) 0.94
Global screening of potential Candida albicans biofilm-related transcription factors via network comparison. BMC Bioinformatics (2010) 0.93
Bacillus anthracis inosine 5'-monophosphate dehydrogenase in action: the first bacterial series of structures of phosphate ion-, substrate-, and product-bound complexes. Biochemistry (2012) 0.93
Transcriptome-based antigen identification for Neisseria meningitidis. Vaccine (2003) 0.92
Conformational distributions of protease-serpin complexes: a partially translocated complex. Biochemistry (2006) 0.92
Stem cell-like gene expression in ovarian cancer predicts type II subtype and prognosis. PLoS One (2013) 0.92
Specific effects of potassium ion binding on wild-type and L358P cytochrome P450cam. Biochemistry (2006) 0.91
High Myc activity is an independent negative prognostic factor for diffuse large B cell lymphomas. Int J Cancer (2011) 0.91
Synthesis, in vitro evaluation and cocrystal structure of 4-oxo-[1]benzopyrano[4,3-c]pyrazole Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase (CpIMPDH) inhibitors. J Med Chem (2014) 0.91
Substitution of methionine 63 or 83 in S100A9 and cysteine 42 in S100A8 abrogate the antifungal activities of S100A8/A9: potential role for oxidative regulation. FEMS Immunol Med Microbiol (2008) 0.90
SOCS1 mutation subtypes predict divergent outcomes in diffuse large B-Cell lymphoma (DLBCL) patients. Oncotarget (2013) 0.89
Characterization of RNA damage under oxidative stress in Escherichia coli. Biol Chem (2012) 0.88
Gene expression signature of normal cell-of-origin predicts ovarian tumor outcomes. PLoS One (2013) 0.87
Therapeutic implications of GIPC1 silencing in cancer. PLoS One (2010) 0.87
Adaptive evolution of drug targets in producer and non-producer organisms. Biochem J (2012) 0.86
Expression, purification and characterization of low-glycosylation influenza neuraminidase in α-1,6-mannosyltransferase defective Pichia pastoris. Mol Biol Rep (2011) 0.86
Detecting common gene expression patterns in multiple cancer outcome entities. Biomed Microdevices (2005) 0.84
Comparison of functional domains in vertebrate-type ferredoxins. Biochemistry (2002) 0.83
Analogs of 1-phosphonooxy-2,2-dihydroxy-3-oxo-5-(methylthio)pentane, an acyclic intermediate in the methionine salvage pathway: a new preparation and characterization of activity with E1 enolase/phosphatase from Klebsiella oxytoca. Bioorg Med Chem (2004) 0.83
Cell compatible trimethoprim-decorated iron oxide nanoparticles bind dihydrofolate reductase for magnetically modulating focal adhesion of mammalian cells. J Am Chem Soc (2011) 0.83
Retinal isoforms of inosine 5'-monophosphate dehydrogenase type 1 are poor nucleic acid binding proteins. Arch Biochem Biophys (2008) 0.83
Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes. Nat Chem Biol (2011) 0.83
The outer membrane protein A (OmpA) of Yersinia pestis promotes intracellular survival and virulence in mice. Microb Pathog (2011) 0.83
Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues. J Med Chem (2007) 0.82
iBBiG: iterative binary bi-clustering of gene sets. Bioinformatics (2012) 0.82
Allosteric activation via kinetic control: potassium accelerates a conformational change in IMP dehydrogenase. Biochemistry (2011) 0.82
The Cys319 loop modulates the transition between dehydrogenase and hydrolase conformations in inosine 5'-monophosphate dehydrogenase. Biochemistry (2010) 0.81
Mushroom tyrosinase oxidizes tyrosine-rich sequences to allow selective protein functionalization. Chembiochem (2012) 0.80
A novel modified peptide derived from membrane-proximal external region of human immunodeficiency virus type 1 envelope significantly enhances retrovirus infection. J Pept Sci (2013) 0.79
Comparative trajectories of active and S195A inactive trypsin upon binding to serpins. J Biol Chem (2002) 0.79
CAD presurgical nasoalveolar molding effects on the maxillary morphology in infants with UCLP. Oral Surg Oral Med Oral Pathol Oral Radiol (2013) 0.78
Short-lived protease serpin complexes: partial disruption of the rat trypsin active site. Protein Sci (2007) 0.78
Towards a pathological mechanism for IMPDH1-linked retinitis pigmentosa. Adv Exp Med Biol (2012) 0.78
Ataxia telangiectasia-mutated gene is a possible biomarker for discrimination of infiltrative deep penetrating nevi and metastatic vertical growth phase melanoma. Cancer Epidemiol Biomarkers Prev (2007) 0.78
[Expression in Pichia pastoris and properties of human serum albumin-interferon alpha2b chimera]. Sheng Wu Gong Cheng Xue Bao (2006) 0.77
Sex-linked differences in cataract progression in Emory mice. Exp Eye Res (2002) 0.77
Novel methylenephosphophosphonate analogues of mycophenolic adenine dinucleotide. Inhibition of inosine monophosphate dehydrogenase. J Med Chem (2006) 0.77
Regulation of nonproteolytic active site formation in plasminogen. Biochemistry (2007) 0.77
Permeability of exendin-4-loaded chitosan nanoparticles across MDCK cell monolayers and rat small intestine. Biol Pharm Bull (2014) 0.77
Generation of mature Nα-terminal acetylated thymosin α 1 by cleavage of recombinant prothymosin α. ScientificWorldJournal (2013) 0.77