PubRank

Motomu Shimaoka

Author PubWeight™ 60.17‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target. Science 2008 3.51
2 Activation of leukocyte beta2 integrins by conversion from bent to extended conformations. Immunity 2006 3.11
3 Identification of the target self-antigens in reperfusion injury. J Exp Med 2006 2.38
4 Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1. Proc Natl Acad Sci U S A 2007 2.27
5 Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction. Immunity 2004 1.98
6 Importance of force linkage in mechanochemistry of adhesion receptors. Biochemistry 2006 1.87
7 Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration. J Exp Med 2008 1.76
8 Transition from rolling to firm adhesion is regulated by the conformation of the I domain of the integrin lymphocyte function-associated antigen-1. J Biol Chem 2002 1.61
9 RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice. Mol Ther 2009 1.55
10 Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling. Blood 2007 1.52
11 Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring. Proc Natl Acad Sci U S A 2004 1.49
12 Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletions. Proc Natl Acad Sci U S A 2004 1.35
13 Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac-1/ICAM-1-dependent mechanism. J Immunol 2009 1.33
14 Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity. Proc Natl Acad Sci U S A 2006 1.32
15 An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin alphaLbeta2. Proc Natl Acad Sci U S A 2005 1.30
16 Rational design of intercellular adhesion molecule-1 (ICAM-1) variants for antagonizing integrin lymphocyte function-associated antigen-1-dependent adhesion. J Biol Chem 2005 1.24
17 Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin alphaXbeta2. Proc Natl Acad Sci U S A 2005 1.24
18 Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut. J Clin Invest 2007 1.23
19 Structure and allosteric regulation of the alpha X beta 2 integrin I domain. Proc Natl Acad Sci U S A 2003 1.18
20 The binding sites for competitive antagonistic, allosteric antagonistic, and agonistic antibodies to the I domain of integrin LFA-1. J Immunol 2004 1.18
21 Distinct roles for LFA-1 affinity regulation during T-cell adhesion, diapedesis, and interstitial migration in lymph nodes. Blood 2009 1.15
22 Activation-induced conformational changes in the I domain region of lymphocyte function-associated antigen 1. J Biol Chem 2002 1.14
23 Transition from rolling to firm adhesion can be mimicked by extension of integrin alphaLbeta2 in an intermediate affinity state. J Biol Chem 2006 1.12
24 Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems. FASEB J 2009 1.12
25 The integrin alpha-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activation. Proc Natl Acad Sci U S A 2004 1.11
26 Azi-isoflurane, a Photolabel Analog of the Commonly Used Inhaled General Anesthetic Isoflurane. ACS Chem Neurosci 2009 1.08
27 A small molecule agonist of an integrin, alphaLbeta2. J Biol Chem 2006 1.04
28 The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity. FASEB J 2008 1.02
29 Set positive end-expiratory pressure during protective ventilation affects lung injury. Anesthesiology 2002 0.99
30 Identification and characterization of a human monoclonal antagonistic antibody AL-57 that preferentially binds the high-affinity form of lymphocyte function-associated antigen-1. J Leukoc Biol 2006 0.98
31 Essential roles of VLA-4 in the hematopoietic system. Int J Hematol 2010 0.96
32 Open-lung protective ventilation with pressure control ventilation, high-frequency oscillation, and intratracheal pulmonary ventilation results in similar gas exchange, hemodynamics, and lung mechanics. Anesthesiology 2003 0.95
33 Binding between the integrin alphaXbeta2 (CD11c/CD18) and heparin. J Biol Chem 2007 0.95
34 Isoflurane binds and stabilizes a closed conformation of the leukocyte function-associated antigen-1. FASEB J 2012 0.94
35 Sevoflurane binds and allosterically blocks integrin lymphocyte function-associated antigen-1. Anesthesiology 2010 0.93
36 Genetic perturbation of the putative cytoplasmic membrane-proximal salt bridge aberrantly activates alpha(4) integrins. Blood 2008 0.91
37 Structural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1. Proc Natl Acad Sci U S A 2009 0.90
38 Isoflurane inhibits neutrophil recruitment in the cutaneous Arthus reaction model. J Anesth 2012 0.89
39 Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function. Anesth Analg 2011 0.86
40 [A case of previously undiagnosed methemoglobinemia exhibiting sustained low SpO2 value at the induction of general anesthesia]. Masui 2013 0.85
41 Thrombomodulin: a bifunctional modulator of inflammation and coagulation in sepsis. Crit Care Res Pract 2012 0.85
42 Antibody-mediated delivery of siRNAs for anti-HIV therapy. Methods Mol Biol 2011 0.85
43 Anti-integrin therapy for multiple sclerosis. Autoimmune Dis 2012 0.84
44 Volatile anesthetics, not intravenous anesthetic propofol bind to and attenuate the activation of platelet receptor integrin αIIbβ3. PLoS One 2013 0.82
45 Propofol shares the binding site with isoflurane and sevoflurane on leukocyte function-associated antigen-1. Anesth Analg 2013 0.80
46 The connection between metal ion affinity and ligand affinity in integrin I domains. Biochim Biophys Acta 2007 0.79
47 Detection of intestinal inflammation by MicroPET imaging using a (64)Cu-labeled anti-beta(7) integrin antibody. Inflamm Bowel Dis 2010 0.79
48 Systemic siRNA delivery to leukocyte-implicated diseases. Cell Cycle 2009 0.79
49 Astroglial integrins in the development and regulation of neurovascular units. Pain Res Treat 2012 0.77
50 Lentiviral gene transfer method to study integrin function in T lymphocytes. Methods Mol Biol 2012 0.75
51 Integrin-targeted stabilized nanoparticles for an efficient delivery of siRNAs in vitro and in vivo. Methods Mol Biol 2012 0.75
52 Conformational regulation of integrin activation in drug discovery. Rinsho Ketsueki 2014 0.75
53 [Control of activation of a cell adhesion molecule, integrin]. Masui 2006 0.75