PubRank

Timothy A Springer

Author PubWeight™ 208.68‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Structural basis of integrin regulation and signaling. Annu Rev Immunol 2007 8.60
2 Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling. Cell 2002 7.03
3 Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Nature 2004 5.87
4 Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins. Science 2003 5.58
5 The genome of M. acetivorans reveals extensive metabolic and physiological diversity. Genome Res 2002 4.58
6 Transcellular diapedesis is initiated by invasive podosomes. Immunity 2007 4.06
7 Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor. Science 2009 3.85
8 Conformational regulation of integrin structure and function. Annu Rev Biophys Biomol Struct 2001 3.74
9 A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them. J Cell Biol 2004 3.66
10 Integrin avidity regulation: are changes in affinity and conformation underemphasized? Curr Opin Cell Biol 2003 3.59
11 Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces. Mol Cell 2008 3.54
12 Latent TGF-β structure and activation. Nature 2011 3.42
13 RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. Dev Cell 2004 3.27
14 Activation of leukocyte beta2 integrins by conversion from bent to extended conformations. Immunity 2006 3.11
15 Structure of integrin alpha5beta1 in complex with fibronectin. EMBO J 2003 2.99
16 Integrin activation and structural rearrangement. Immunol Rev 2002 2.60
17 Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation. Nat Struct Biol 2002 2.56
18 Conversion between three conformational states of integrin I domains with a C-terminal pull spring studied with molecular dynamics. Structure 2004 2.35
19 Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other. Immunity 2003 2.34
20 A specific interface between integrin transmembrane helices and affinity for ligand. PLoS Biol 2004 2.26
21 The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2. J Cell Biol 2004 2.22
22 Integrin structures and conformational signaling. Curr Opin Cell Biol 2006 2.03
23 Archaeal surface layer proteins contain beta propeller, PKD, and beta helix domains and are related to metazoan cell surface proteins. Structure 2002 2.00
24 Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction. Immunity 2004 1.98
25 Therapeutic antagonists and conformational regulation of integrin function. Nat Rev Drug Discov 2003 1.98
26 Endothelial cells proactively form microvilli-like membrane projections upon intercellular adhesion molecule 1 engagement of leukocyte LFA-1. J Immunol 2003 1.95
27 Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand. Proc Natl Acad Sci U S A 2003 1.93
28 Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster. Nat Struct Biol 2003 1.92
29 Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor. Proc Natl Acad Sci U S A 2009 1.91
30 A mechanically stabilized receptor-ligand flex-bond important in the vasculature. Nature 2010 1.90
31 Importance of force linkage in mechanochemistry of adhesion receptors. Biochemistry 2006 1.87
32 The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3. Mol Cell 2009 1.82
33 Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration. J Exp Med 2008 1.76
34 Remodeling of the lectin-EGF-like domain interface in P- and L-selectin increases adhesiveness and shear resistance under hydrodynamic force. Nat Immunol 2006 1.74
35 Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering. Proc Natl Acad Sci U S A 2005 1.73
36 Structure of an integrin with an alphaI domain, complement receptor type 4. EMBO J 2009 1.70
37 Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor. Mol Cell Biol 2010 1.63
38 Complex between nidogen and laminin fragments reveals a paradigmatic beta-propeller interface. Nature 2003 1.61
39 Allosteric beta1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domain. J Biol Chem 2004 1.60
40 Structural transitions of complement component C3 and its activation products. Proc Natl Acad Sci U S A 2006 1.57
41 Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides. J Biol Chem 2003 1.56
42 Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling. Blood 2007 1.52
43 Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring. Proc Natl Acad Sci U S A 2004 1.49
44 Functional and structural stability of the epidermal growth factor receptor in detergent micelles and phospholipid nanodiscs. Biochemistry 2008 1.48
45 Regulation of integrin affinity on cell surfaces. EMBO J 2011 1.47
46 Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus. Immunity 2002 1.46
47 Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor. Nat Struct Mol Biol 2011 1.45
48 Highly reinforced structure of a C-terminal dimerization domain in von Willebrand factor. Blood 2014 1.44
49 Trans-cellular migration: cell-cell contacts get intimate. Curr Opin Cell Biol 2008 1.42
50 Two-dimensional kinetics regulation of alphaLbeta2-ICAM-1 interaction by conformational changes of the alphaL-inserted domain. J Biol Chem 2005 1.38
51 Complete integrin headpiece opening in eight steps. J Cell Biol 2013 1.37
52 Integrin beta3 regions controlling binding of murine mAb 7E3: implications for the mechanism of integrin alphaIIbbeta3 activation. Proc Natl Acad Sci U S A 2004 1.36
53 Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletions. Proc Natl Acad Sci U S A 2004 1.35
54 A pH-regulated dimeric bouquet in the structure of von Willebrand factor. EMBO J 2011 1.34
55 Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2. Proc Natl Acad Sci U S A 2010 1.32
56 Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity. Proc Natl Acad Sci U S A 2006 1.32
57 An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin alphaLbeta2. Proc Natl Acad Sci U S A 2005 1.30
58 Closed headpiece of integrin αIIbβ3 and its complex with an αIIbβ3-specific antagonist that does not induce opening. Blood 2010 1.29
59 Tests of the extension and deadbolt models of integrin activation. J Biol Chem 2007 1.28
60 GARP regulates the bioavailability and activation of TGFβ. Mol Biol Cell 2012 1.28
61 The critical cytoplasmic regions of the alphaL/beta2 integrin in Rap1-induced adhesion and migration. Mol Biol Cell 2003 1.26
62 Sequence and structure relationships within von Willebrand factor. Blood 2012 1.26
63 Rational design of intercellular adhesion molecule-1 (ICAM-1) variants for antagonizing integrin lymphocyte function-associated antigen-1-dependent adhesion. J Biol Chem 2005 1.24
64 Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin alphaXbeta2. Proc Natl Acad Sci U S A 2005 1.24
65 Structural basis for dimerization of ICAM-1 on the cell surface. Mol Cell 2004 1.24
66 AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes. Proc Natl Acad Sci U S A 2006 1.20
67 Structure and allosteric regulation of the alpha X beta 2 integrin I domain. Proc Natl Acad Sci U S A 2003 1.18
68 The binding sites for competitive antagonistic, allosteric antagonistic, and agonistic antibodies to the I domain of integrin LFA-1. J Immunol 2004 1.18
69 Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds. Proc Natl Acad Sci U S A 2002 1.18
70 Unexpected fold in the circumsporozoite protein target of malaria vaccines. Proc Natl Acad Sci U S A 2012 1.14
71 Activation-induced conformational changes in the I domain region of lymphocyte function-associated antigen 1. J Biol Chem 2002 1.14
72 Structural specializations of α(4)β(7), an integrin that mediates rolling adhesion. J Cell Biol 2012 1.13
73 The role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding. Biochemistry 2002 1.13
74 The relative influence of metal ion binding sites in the I-like domain and the interface with the hybrid domain on rolling and firm adhesion by integrin alpha4beta7. J Biol Chem 2004 1.13
75 Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin. J Biol Chem 2001 1.12
76 Transition from rolling to firm adhesion can be mimicked by extension of integrin alphaLbeta2 in an intermediate affinity state. J Biol Chem 2006 1.12
77 Transmission of allostery through the lectin domain in selectin-mediated cell adhesion. Proc Natl Acad Sci U S A 2008 1.12
78 The integrin alpha-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activation. Proc Natl Acad Sci U S A 2004 1.11
79 Regulation of outside-in signaling and affinity by the beta2 I domain of integrin alphaLbeta2. Proc Natl Acad Sci U S A 2006 1.10
80 Chondroitin sulfate B exerts its inhibitory effect on secondary lymphoid tissue chemokine (SLC) by binding to the C-terminus of SLC. Biochim Biophys Acta 2002 1.08
81 Intact alphaIIbbeta3 integrin is extended after activation as measured by solution X-ray scattering and electron microscopy. J Biol Chem 2011 1.07
82 Structure-guided design of a high-affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS. Sci Transl Med 2012 1.07
83 A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13. Blood 2011 1.06
84 Contribution of N-linked glycans to the conformation and function of intercellular adhesion molecules (ICAMs). J Biol Chem 2004 1.05
85 Modulation of integrin activation by an entropic spring in the {beta}-knee. J Biol Chem 2010 1.05
86 A small molecule agonist of an integrin, alphaLbeta2. J Biol Chem 2006 1.04
87 Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells. J Immunol 2012 1.04
88 Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds. J Cell Biol 2013 1.03
89 Calcium stabilizes the von Willebrand factor A2 domain by promoting refolding. Proc Natl Acad Sci U S A 2012 1.02
90 α(V)β(3) integrin crystal structures and their functional implications. Biochemistry 2012 1.02
91 Mechanisms for kinase-mediated dimerization of the epidermal growth factor receptor. J Biol Chem 2012 1.01
92 An unusual allosteric mobility of the C-terminal helix of a high-affinity alphaL integrin I domain variant bound to ICAM-5. Mol Cell 2008 1.01
93 Rationally designed integrin beta3 mutants stabilized in the high affinity conformation. J Biol Chem 2008 1.00
94 Specific and covalent labeling of a membrane protein with organic fluorochromes and quantum dots. Proc Natl Acad Sci U S A 2007 0.99
95 An internal ligand-bound, metastable state of a leukocyte integrin, αXβ2. J Cell Biol 2013 0.98
96 Identification and characterization of a human monoclonal antagonistic antibody AL-57 that preferentially binds the high-affinity form of lymphocyte function-associated antigen-1. J Leukoc Biol 2006 0.98
97 Boca-dependent maturation of beta-propeller/EGF modules in low-density lipoprotein receptor proteins. EMBO J 2004 0.98
98 Shape change in the receptor for gliding motility in Plasmodium sporozoites. Proc Natl Acad Sci U S A 2012 0.97
99 Structural basis of regulation of von Willebrand factor binding to glycoprotein Ib. J Biol Chem 2014 0.97
100 Structural plasticity in Ig superfamily domain 4 of ICAM-1 mediates cell surface dimerization. Proc Natl Acad Sci U S A 2007 0.96
101 Binding between the integrin alphaXbeta2 (CD11c/CD18) and heparin. J Biol Chem 2007 0.95
102 How natalizumab binds and antagonizes α4 integrins. J Biol Chem 2013 0.95
103 Mechanisms by which von Willebrand disease mutations destabilize the A2 domain. J Biol Chem 2013 0.95
104 Therapeutic antagonists and the conformational regulation of the beta2 integrins. Curr Top Med Chem 2004 0.93
105 Molecular basis for complement recognition by integrin αXβ2. Proc Natl Acad Sci U S A 2012 0.90
106 Engineering of single Ig superfamily domain of intercellular adhesion molecule 1 (ICAM-1) for native fold and function. J Biol Chem 2010 0.88
107 High affinity ligand binding by integrins does not involve head separation. J Biol Chem 2003 0.87
108 Structures of the Toxoplasma gliding motility adhesin. Proc Natl Acad Sci U S A 2014 0.85
109 The RGD finger of Del-1 is a unique structural feature critical for integrin binding. FASEB J 2012 0.85
110 Cation-pi interaction regulates ligand-binding affinity and signaling of integrin alpha4beta7. Proc Natl Acad Sci U S A 2010 0.84
111 The C-terminal αI domain linker as a critical structural element in the conformational activation of αI integrins. J Biol Chem 2011 0.83
112 Immunoprecipitation. Curr Protoc Neurosci 2006 0.83
113 The novel S527F mutation in the integrin beta3 chain induces a high affinity alphaIIbbeta3 receptor by hindering adoption of the bent conformation. J Biol Chem 2009 0.82
114 Development, standardization and refinement of procedures for evaluating effects of endocrine active compounds on development and sexual differentiation of Xenopus laevis. Anal Bioanal Chem 2008 0.82
115 A high affinity human antibody antagonist of P-selectin mediated rolling. Biochem Biophys Res Commun 2006 0.81
116 Induction by IL 1 and interferon-γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 1986. 137: 245-254. J Immunol 2011 0.81
117 Tests of integrin transmembrane domain homo-oligomerization during integrin ligand binding and signaling. J Biol Chem 2010 0.81
118 The connection between metal ion affinity and ligand affinity in integrin I domains. Biochim Biophys Acta 2007 0.79
119 A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J. Immunol. 1986. 137: 1270-1274. J Immunol 2011 0.79
120 Complex structure of engineered modular domains defining molecular interaction between ICAM-1 and integrin LFA-1. PLoS One 2012 0.78
121 Can we reduce the number of fish in the OECD acute toxicity test? Environ Toxicol Chem 2011 0.77
122 Domain 1 of mucosal addressin cell adhesion molecule has an I1-set fold and a flexible integrin-binding loop. J Biol Chem 2013 0.77
123 Effects of 17 beta-estradiol exposure on Xenopus laevis gonadal histopathology. Environ Toxicol Chem 2010 0.76
124 The drive to ban the NOEC/LOEC in favor of ECx is misguided and misinformed. Integr Environ Assess Manag 2013 0.75
125 Measurement of selectin tether bond lifetimes. Biophys J 2002 0.75
126 Comparison of zebrafish (Danio rerio) and fathead minnow (Pimephales promelas) as test species in the Fish Sexual Development Test (FSDT). Comp Biochem Physiol C Toxicol Pharmacol 2011 0.75
127 Statistical analysis of histopathological endpoints. Environ Toxicol Chem 2014 0.75