Published in Nat Struct Mol Biol on January 16, 2005
Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets. Pharmacol Rev (2011) 1.98
Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange. Structure (2005) 1.98
Kinetic scaffolding mediated by a phospholipase C-beta and Gq signaling complex. Science (2010) 1.78
Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc Natl Acad Sci U S A (2008) 1.72
The crystal structure of a self-activating G protein alpha subunit reveals its distinct mechanism of signal initiation. Sci Signal (2011) 1.40
Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors. Mol Pharmacol (2009) 1.38
A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration. J Biol Chem (2010) 1.32
A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins. Biochemistry (2006) 1.27
Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins. Proc Natl Acad Sci U S A (2007) 1.17
Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation. J Biol Chem (2010) 1.09
Recognition of the activated states of Galpha13 by the rgRGS domain of PDZRhoGEF. Structure (2008) 1.09
Comparative genomics uncovers novel structural and functional features of the heterotrimeric GTPase signaling system. Gene (2010) 1.08
Minimal determinants for binding activated G alpha from the structure of a G alpha(i1)-peptide dimer. Biochemistry (2006) 1.06
On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF. BMC Struct Biol (2009) 1.04
Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF. Protein Sci (2011) 1.04
Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13. J Biochem (2011) 0.99
Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain. J Biol Chem (2012) 0.97
Activation of leukemia-associated RhoGEF by Galpha13 with significant conformational rearrangements in the interface. J Biol Chem (2008) 0.96
Novel mechanisms of endothelial dysfunction in diabetes. J Cardiovasc Dis Res (2010) 0.95
A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells. Cell Signal (2009) 0.95
Evidence of a common mechanism of disassembly of adherens junctions through Gα13 targeting of VE-cadherin. J Exp Med (2014) 0.94
Regulation and physiological functions of G12/13-mediated signaling pathways. Neurosignals (2009) 0.93
Evolution of a signaling nexus constrained by protein interfaces and conformational States. PLoS Comput Biol (2010) 0.93
Differences in Galpha12- and Galpha13-mediated plasma membrane recruitment of p115-RhoGEF. Cell Signal (2009) 0.90
Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization. J Biol Chem (2011) 0.89
Evolution of class-specific peptides targeting a hot spot of the Galphas subunit. J Mol Biol (2008) 0.89
Identification of critical residues in G(alpha)13 for stimulation of p115RhoGEF activity and the structure of the G(alpha)13-p115RhoGEF regulator of G protein signaling homology (RH) domain complex. J Biol Chem (2011) 0.88
Insights into the molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF. J Biol Chem (2011) 0.87
Myristoylation exerts direct and allosteric effects on Gα conformation and dynamics in solution. Biochemistry (2012) 0.86
Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study. J Biol Chem (2013) 0.86
Signal activation and inactivation by the Gα helical domain: a long-neglected partner in G protein signaling. Sci Signal (2012) 0.84
Adaptive evolution of signaling partners. Mol Biol Evol (2015) 0.83
Structural determinants of RGS-RhoGEF signaling critical to Entamoeba histolytica pathogenesis. Structure (2012) 0.79
Trp fluorescence reveals an activation-dependent cation-pi interaction in the Switch II region of Galphai proteins. Protein Sci (2009) 0.79
Determinants at the N- and C-termini of Gα12 required for activation of Rho-mediated signaling. J Mol Signal (2013) 0.78
Atypical protein kinase Cλ is critical for growth factor receptor-induced dorsal ruffle turnover and cell migration. J Biol Chem (2013) 0.78
Is the model of signal amplification by GPCRs/GEFs activating multiple GTPases relevant to a broad spectrum of heterotrimeric and RAS superfamily GTPases? Cell Logist (2014) 0.77
Invited review: Activation of G proteins by GTP and the mechanism of Gα-catalyzed GTP hydrolysis. Biopolymers (2016) 0.77
Different Raf protein kinases mediate different signaling pathways to stimulate E3 ligase RFFL gene expression in cell migration regulation. J Biol Chem (2013) 0.77
Gα16 interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ signaling. BMC Struct Biol (2011) 0.77
Crystallization and preliminary X-ray crystallographic analysis of the receptor-uncoupled mutant of Galphai1. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.76
Efficacy of a novel water-soluble curcumin derivative versus sildenafil citrate in mediating erectile function. Int J Impot Res (2014) 0.75
Crystallization and preliminary X-ray crystallographic analysis of human RGS10 complexed with Galphai3. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.75
Tripping a switch: PDZRhoGEF rgRGS-bound Galpha13. Structure (2008) 0.75
A global analysis of cross-talk in a mammalian cellular signalling network. Nat Cell Biol (2006) 2.39
Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15
Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway. J Biol Chem (2007) 1.98
Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105. Sci Signal (2009) 1.85
Mechanisms for reversible regulation between G13 and Rho exchange factors. J Biol Chem (2001) 1.37
Structural and molecular characterization of a preferred protein interaction surface on G protein beta gamma subunits. Biochemistry (2005) 1.34
Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells. J Biol Chem (2004) 1.30
Origin of asymmetry in adenylyl cyclases: structures of Mycobacterium tuberculosis Rv1900c. EMBO J (2005) 1.23
Regulation of Rho guanine nucleotide exchange factors by G proteins. Adv Protein Chem (2007) 1.23
Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate. J Biol Chem (2004) 1.23
Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein α subunits. Proc Natl Acad Sci U S A (2013) 1.21
Broad specificity of mammalian adenylyl cyclase for interaction with 2',3'-substituted purine- and pyrimidine nucleotide inhibitors. Mol Pharmacol (2006) 1.20
Ric-8A catalyzes guanine nucleotide exchange on G alphai1 bound to the GPR/GoLoco exchange inhibitor AGS3. J Biol Chem (2008) 1.19
The nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gαi1. PLoS One (2011) 1.14
Inhibitors of membranous adenylyl cyclases. Trends Pharmacol Sci (2011) 1.12
Thermodynamic characterization of the binding of activator of G protein signaling 3 (AGS3) and peptides derived from AGS3 with G alpha i1. J Biol Chem (2003) 1.10
Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation. J Biol Chem (2010) 1.09
Recognition of the activated states of Galpha13 by the rgRGS domain of PDZRhoGEF. Structure (2008) 1.09
RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity. J Biol Chem (2003) 1.08
Structural basis for inhibition of mammalian adenylyl cyclase by calcium. Biochemistry (2009) 1.06
Deciphering signaling outcomes from a system of complex networks. Sci Signal (2009) 1.05
Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF. Protein Sci (2011) 1.04
Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF. J Biol Chem (2003) 1.02
Kinetic isotope effects in Ras-catalyzed GTP hydrolysis: evidence for a loose transition state. Proc Natl Acad Sci U S A (2004) 1.00
A peptide core motif for binding to heterotrimeric G protein alpha subunits. J Biol Chem (2005) 0.98
Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII. J Biol Chem (2008) 0.98
Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain. J Biol Chem (2012) 0.97
Activated RhoA is a positive feedback regulator of the Lbc family of Rho guanine nucleotide exchange factor proteins. J Biol Chem (2013) 0.95
Transition state structures and the roles of catalytic residues in GAP-facilitated GTPase of Ras as elucidated by (18)O kinetic isotope effects. Biochemistry (2009) 0.94
Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium. J Biol Chem (2008) 0.94
Distinct roles of adenylyl cyclase VII in regulating the immune responses in mice. J Immunol (2010) 0.93
Cancer. A bull's eye for targeted lung cancer therapy. Science (2004) 0.93
Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein alpha-subunit. Proc Natl Acad Sci U S A (2004) 0.90
A specific interaction of small molecule entry inhibitors with the envelope glycoprotein complex of the Junín hemorrhagic fever arenavirus. J Biol Chem (2010) 0.89
p115 Rho GTPase activating protein interacts with MEKK1. J Cell Physiol (2002) 0.88
Structure of a mitochondrial cytochrome c conformer competent for peroxidase activity. Proc Natl Acad Sci U S A (2014) 0.88
Differential inhibition of various adenylyl cyclase isoforms and soluble guanylyl cyclase by 2',3'-O-(2,4,6-trinitrophenyl)-substituted nucleoside 5'-triphosphates. J Pharmacol Exp Ther (2009) 0.87
Cell signalling: Binding the receptor at both ends. Nature (2011) 0.86
Differential interactions of the catalytic subunits of adenylyl cyclase with forskolin analogs. Biochem Pharmacol (2009) 0.84
Crystallization of complex between soluble domains of adenylyl cyclase and activated Gs alpha. Methods Enzymol (2002) 0.84
Zymosan activates protein kinase A via adenylyl cyclase VII to modulate innate immune responses during inflammation. Mol Immunol (2012) 0.83
Functional characterization of p115 RhoGEF. Methods Enzymol (2002) 0.83
Structure-activity relationships for the interactions of 2'- and 3'-(O)-(N-methyl)anthraniloyl-substituted purine and pyrimidine nucleotides with mammalian adenylyl cyclases. Biochem Pharmacol (2011) 0.81
Distinct interactions of GTP, UTP, and CTP with G(s) proteins. J Biol Chem (2002) 0.80
Ribozyme- and siRNA-mediated suppression of RGS-containing RhoGEF proteins. Methods Enzymol (2004) 0.80
Assays and characterization of mammalian phosphatidylinositol 4,5-bisphosphate-sensitive phospholipase D. Methods Enzymol (2002) 0.79
Structural basis for the high-affinity inhibition of mammalian membranous adenylyl cyclase by 2',3'-o-(N-methylanthraniloyl)-inosine 5'-triphosphate. Mol Pharmacol (2011) 0.78
A method to determine 18 O kinetic isotope effects in the hydrolysis of nucleotide triphosphates. Anal Biochem (2007) 0.77
Modeling species-specific diacylglycerol dynamics in the RAW 264.7 macrophage. J Theor Biol (2009) 0.77
Structural biology: a receptor unlocked. Nature (2007) 0.77
Cosolvent-induced transformation of a death domain tertiary structure. Proc Natl Acad Sci U S A (2002) 0.77
Biochemical reconstitution of hemorrhagic-fever arenavirus envelope glycoprotein-mediated membrane fusion. PLoS One (2012) 0.76
Regions on adenylyl cyclase VII required for selective regulation by the G13 pathway. Mol Pharmacol (2012) 0.75