| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism.
|
J Neurosci
|
2007
|
2.05
|
|
2
|
Cannabinoid CB1 receptor antagonism reduces conditioned reinstatement of ethanol-seeking behavior in rats.
|
Eur J Neurosci
|
2005
|
1.25
|
|
3
|
Activation of nuclear PPARγ receptors by the antidiabetic agent pioglitazone suppresses alcohol drinking and relapse to alcohol seeking.
|
Biol Psychiatry
|
2011
|
1.17
|
|
4
|
Region-specific down-regulation of Crhr1 gene expression in alcohol-preferring msP rats following ad lib access to alcohol.
|
Addict Biol
|
2007
|
1.15
|
|
5
|
Effect of the cannabinoid CB1 receptor antagonist SR-141716A on ethanol self-administration and ethanol-seeking behaviour in rats.
|
Psychopharmacology (Berl)
|
2005
|
1.15
|
|
6
|
Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat.
|
Biol Psychiatry
|
2008
|
1.14
|
|
7
|
The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat.
|
Neuropsychopharmacology
|
2005
|
1.12
|
|
8
|
Role of innate and drug-induced dysregulation of brain stress and arousal systems in addiction: Focus on corticotropin-releasing factor, nociceptin/orphanin FQ, and orexin/hypocretin.
|
Brain Res
|
2009
|
1.11
|
|
9
|
Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system.
|
Proc Natl Acad Sci U S A
|
2010
|
1.10
|
|
10
|
Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vivo studies.
|
J Pharmacol Exp Ther
|
2007
|
1.09
|
|
11
|
Stress-related neuropeptides and addictive behaviors: beyond the usual suspects.
|
Neuron
|
2012
|
1.06
|
|
12
|
Persistent increase of alcohol-seeking evoked by neuropeptide S: an effect mediated by the hypothalamic hypocretin system.
|
Neuropsychopharmacology
|
2009
|
1.04
|
|
13
|
Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat.
|
Psychopharmacology (Berl)
|
2008
|
1.01
|
|
14
|
Pharmacological blockade of corticotropin-releasing hormone receptor 1 (CRH1R) reduces voluntary consumption of high alcohol concentrations in non-dependent Wistar rats.
|
Pharmacol Biochem Behav
|
2011
|
0.98
|
|
15
|
Promising medications for cocaine dependence treatment.
|
Recent Pat CNS Drug Discov
|
2011
|
0.98
|
|
16
|
The anandamide transport inhibitor AM404 reduces ethanol self-administration.
|
Eur J Neurosci
|
2007
|
0.98
|
|
17
|
Further studies on the pharmacological profile of the neuropeptide S receptor antagonist SHA 68.
|
Peptides
|
2010
|
0.97
|
|
18
|
Activation of brain NOP receptors attenuates acute and protracted alcohol withdrawal symptoms in the rat.
|
Alcohol Clin Exp Res
|
2011
|
0.96
|
|
19
|
Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology.
|
Recent Dev Alcohol
|
2003
|
0.95
|
|
20
|
Peroxisome proliferator-activated receptor (PPAR) agonists as promising new medications for drug addiction: preclinical evidence.
|
Curr Drug Targets
|
2013
|
0.94
|
|
21
|
Role of a genetic polymorphism in the corticotropin-releasing factor receptor 1 gene in alcohol drinking and seeking behaviors of marchigian sardinian alcohol-preferring rats.
|
Front Psychiatry
|
2013
|
0.94
|
|
22
|
Microarrays--the challenge of preparing brain tissue samples.
|
Addict Biol
|
2005
|
0.92
|
|
23
|
Perinatal exposure to delta-9-tetrahydrocannabinol causes enduring cognitive deficits associated with alteration of cortical gene expression and neurotransmission in rats.
|
Addict Biol
|
2007
|
0.92
|
|
24
|
Activation of PPARγ by pioglitazone potentiates the effects of naltrexone on alcohol drinking and relapse in msP rats.
|
Alcohol Clin Exp Res
|
2013
|
0.91
|
|
25
|
Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition.
|
PLoS One
|
2011
|
0.90
|
|
26
|
A preclinical model of binge eating elicited by yo-yo dieting and stressful exposure to food: effect of sibutramine, fluoxetine, topiramate, and midazolam.
|
Psychopharmacology (Berl)
|
2009
|
0.90
|
|
27
|
Reduced limbic metabolism and fronto-cortical volume in rats vulnerable to alcohol addiction.
|
Neuroimage
|
2012
|
0.90
|
|
28
|
Increased perioculomotor urocortin 1 immunoreactivity in genetically selected alcohol preferring rats.
|
Alcohol Clin Exp Res
|
2009
|
0.89
|
|
29
|
Effect of salidroside, active principle of Rhodiola rosea extract, on binge eating.
|
Physiol Behav
|
2010
|
0.88
|
|
30
|
Modification of anxiety-like behaviors by nociceptin/orphanin FQ (N/OFQ) and time-dependent changes in N/OFQ-NOP gene expression following ethanol withdrawal.
|
Addict Biol
|
2012
|
0.88
|
|
31
|
Hypothalamic neuropeptide S receptor blockade decreases discriminative cue-induced reinstatement of cocaine seeking in the rat.
|
Psychopharmacology (Berl)
|
2012
|
0.88
|
|
32
|
Revisiting intragastric ethanol intubation as a dependence induction method for studies of ethanol reward and motivation in rats.
|
Alcohol Clin Exp Res
|
2009
|
0.87
|
|
33
|
A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats.
|
J Neurosci
|
2013
|
0.86
|
|
34
|
Hypericum perforatum CO2 extract and opioid receptor antagonists act synergistically to reduce ethanol intake in alcohol-preferring rats.
|
Alcohol Clin Exp Res
|
2003
|
0.86
|
|
35
|
Pregabalin reduces cocaine self-administration and relapse to cocaine seeking in the rat.
|
Addict Biol
|
2012
|
0.86
|
|
36
|
Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats.
|
Toxicology
|
2012
|
0.85
|
|
37
|
Role of orexin-1 receptor mechanisms on compulsive food consumption in a model of binge eating in female rats.
|
Neuropsychopharmacology
|
2012
|
0.85
|
|
38
|
Enhanced GABAergic transmission in the central nucleus of the amygdala of genetically selected Marchigian Sardinian rats: alcohol and CRF effects.
|
Neuropharmacology
|
2012
|
0.84
|
|
39
|
The dorsal subiculum mediates the acquisition of conditioned reinstatement of cocaine-seeking.
|
Neuropsychopharmacology
|
2007
|
0.83
|
|
40
|
The paraventricular nucleus of the hypothalamus is a neuroanatomical substrate for the inhibition of palatable food intake by neuropeptide S.
|
Eur J Neurosci
|
2009
|
0.83
|
|
41
|
The genetic of alcoholism: learning from 50 years of research.
|
Addict Biol
|
2006
|
0.83
|
|
42
|
AT-1001: a high-affinity α3β4 nAChR ligand with novel nicotine-suppressive pharmacology.
|
Br J Pharmacol
|
2015
|
0.83
|
|
43
|
Polymorphism in the corticotropin-releasing factor receptor 1 (CRF1-R) gene plays a role in shaping the high anxious phenotype of Marchigian Sardinian alcohol-preferring (msP) rats.
|
Psychopharmacology (Berl)
|
2014
|
0.82
|
|
44
|
Melanin-concentrating hormone receptor 1 (MCH1-R) antagonism: reduced appetite for calories and suppression of addictive-like behaviors.
|
Pharmacol Biochem Behav
|
2012
|
0.82
|
|
45
|
Neuropeptide S receptor gene expression in alcohol withdrawal and protracted abstinence in postdependent rats.
|
Alcohol Clin Exp Res
|
2009
|
0.81
|
|
46
|
The role of the neuropeptide S system in addiction: focus on its interaction with the CRF and hypocretin/orexin neurotransmission.
|
Prog Neurobiol
|
2012
|
0.81
|
|
47
|
Pregabalin reduces alcohol drinking and relapse to alcohol seeking in the rat.
|
Psychopharmacology (Berl)
|
2011
|
0.81
|
|
48
|
Effect of neuropeptide S receptor antagonists and partial agonists on palatable food consumption in the rat.
|
Peptides
|
2010
|
0.81
|
|
49
|
Role of cannabinoidergic mechanisms in ethanol self-administration and ethanol seeking in rat adult offspring following perinatal exposure to Delta9-tetrahydrocannabinol.
|
Toxicol Appl Pharmacol
|
2007
|
0.81
|
|
50
|
Effect of novel NOP receptor ligands on food intake in rats.
|
Peptides
|
2006
|
0.80
|
|
51
|
Pharmacology and toxicology of Cannabis derivatives and endocannabinoid agonists.
|
Recent Pat CNS Drug Discov
|
2010
|
0.80
|
|
52
|
Analgesic tolerance to morphine is regulated by PPARγ.
|
Br J Pharmacol
|
2014
|
0.79
|
|
53
|
Translational approach to develop novel medications on alcohol addiction: focus on neuropeptides.
|
Curr Opin Neurobiol
|
2013
|
0.79
|
|
54
|
Morphine dependence is associated with changes in neuropeptide S receptor expression and function in rat brain.
|
Peptides
|
2013
|
0.78
|
|
55
|
Effect of Hypericum perforatum CO2 extract on the motivational properties of ethanol in alcohol-preferring rats.
|
Alcohol Alcohol
|
2005
|
0.77
|
|
56
|
Caloric restriction increases the sensitivity to the hyperphagic effect of nociceptin/orphanin FQ limiting its ability to reduce binge eating in female rats.
|
Psychopharmacology (Berl)
|
2013
|
0.77
|
|
57
|
Blockade of gamma-aminobutyric acid receptors does not modify the inhibiton of ethanol intake induced by Hypericum perforatum in rats.
|
Alcohol Alcohol
|
2002
|
0.77
|
|
58
|
Neonatal exposure to permethrin pesticide causes lifelong fear and spatial learning deficits and alters hippocampal morphology of synapses.
|
J Neurodev Disord
|
2014
|
0.76
|
|
59
|
Autoradiographic analysis of 5-hydroxytryptamine 5-HT2A binding sites in the rat brain after chronic intragastric ethanol treatments.
|
Res Commun Mol Pathol Pharmacol
|
2002
|
0.76
|
|
60
|
Biomarkers of hippocampal gene expression in a mouse restraint chronic stress model.
|
Pharmacogenomics
|
2015
|
0.76
|
|
61
|
Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)NH2 analogues. 2. In vivo studies.
|
Naunyn Schmiedebergs Arch Pharmacol
|
2002
|
0.76
|
|
62
|
Pre-exposure to environmental cues predictive of food availability elicits hypothalamic-pituitary-adrenal axis activation and increases operant responding for food in female rats.
|
Addict Biol
|
2009
|
0.76
|
|
63
|
Activation of the nociceptin/orphanin FQ system is unable to reverse CRF2 receptor mediated anorexia in the rat.
|
Peptides
|
2006
|
0.75
|
|
64
|
Brain functional connectivity alterations in a rat model of excessive alcohol drinking: A resting-state network analysis.
|
Conf Proc IEEE Eng Med Biol Soc
|
2017
|
0.75
|
|
65
|
PPARc activation attenuates opioid consumption and modulates mesolimbic dopamine transmission.
|
Neuropsychopharmacology
|
2015
|
0.75
|